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Emergency Pediatric Dosing 12-14 kilogram

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21. Dyslipidaemias Full Text available with Trip Pro

acid ER extended release ESC European Society of Cardiology ESRD end-stage renal disease EU European Union FACE-BD Fondamental Academic Centers of Expertise in Bipolar Disorders FATS Familial Atherosclerosis Treatment Study FCH familial combined hyperlipidaemia FDA US Food and Drug Administration FDC fixed-dose combination FH familial hypercholesterolaemia FIELD Fenofibrate Intervention and Event Lowering in Diabetes FOCUS Fixed-Dose Combination Drug for Secondary Cardiovascular Prevention GFR (...) , CVD represents a considerable economic burden to society, and this necessitates an effective approach to CVD prevention. There is consensus in favour of an approach combining strategies to improve CV health across the population at large from childhood onwards, with actions to improve CV health in individuals at increased risk of CVD or with established CVD. Most studies assessing the cost-effectiveness of prevention of CVD combine evidence from clinical research with simulation approaches, while

2016 European Society of Cardiology

22. Akynzeo (netupitant / palonosetron)

toxicity studies established a maximum non-lethal intravenous dosage of 10 mg/kg in rats and mice and 20 mg/kg in dogs. A maximum non-lethal oral dosage of 250 mg/kg in rats, 100 mg/kg in mice and 50 mg/kg in dogs were established. Signs seen at non-lethal dosages included inactivity, tremors, ataxia and laboured respiration Repeat dose toxicity A number of preliminary, non-pivotal repeated dose toxicity studies were performed in rat and dog to examine the effects of netupitant alone and in combination (...) on clinical pharmacology 74 2.5. Clinical efficacy 74 2.5.1. Dose response studies 76 2.5.2. Main studies 76 2.5.3. Discussion on clinical efficacy 115 2.5.4. Conclusions on the clinical efficacy 118 2.6. Clinical safety 118 2.6.1. Discussion on clinical safety 143 2.6.2. Conclusions on the clinical safety 145 2.7. Pharmacovigilance 145 2.8. Risk Management Plan 146 2.9. Product information 149 2.9.1. User consultation 149 EMA/236963/2015 Page 4/153 3. Benefit-Risk Balance 149 4. Recommendations 152 EMA

2015 European Medicines Agency - EPARs

23. The Effects of Training, Innovation and New Technology on African Smallholder Farmers' Economic Outcomes and Food Security: A Systematic Review Full Text available with Trip Pro

(Terry, 2010), consensus has emerged that the increase of smallholders' productivity is key to fostering agricultural growth in Africa (AGRA, 2013; IFPRI, 2011). In summary, the importance of smallholder farming in Africa in contributing to household food security as well as providing a productive economic livelihood strategy in rural areas has established smallholder farming as a key theme in rural development and poverty reduction. 1.2 THE INTERVENTIONS There are currently a multitude (...) . Interventions that did not target smallholder farmers specifically were excluded. Farmers could have included both men and women who either owned their farms or farmed land owned by others. We did not limit by age as we acknowledge that there are large numbers of child–headed households in Africa, and it is feasible that smallholder farmers could be very young. Smallholder farms can be defined in a number of ways. Whilst farm size is often cited — most commonly less than two hectares — the productivity

2015 Campbell Collaboration

24. Developing evidence informed, employer-led workplace health

by continuous improvement policies, intervention duration/dose and employee engagement. However, these characteristics were not mentioned in any views studies or policy documents as being important to workplace health intervention success. The importance of the intervention implementer’s approach and the use of Internet technologies were discussed in views studies; however, these have yet to be evaluated in systematic reviews or integrated into policy documents. These comparisons of characteristics across (...) via booklets and/or diaries was seen as a successful tool for engaging employees. • Appropriate use of external versus peer providers: although peer providers were not discouraged, due to proximity in the working environment, participants would be less likely to seek their support, suggesting that employers may want to consider peers from external sources. Intervention duration/dose Three reviews provided insight into the role of intervention duration or dose on the potential success of workplace

2016 EPPI Centre

25. Contrast-induced Nephropathy

bicarbonate versus N-acetylcysteine plus IV saline; 8 RCTs comparing a statin versus IV saline; 5 RCTs comparing a statin plus N-acetylcysteine versus N-acetylcysteine; 6 RCTs comparing statin versus statin, statin by dose, or statins plus other agents; 5 RCTs comparing an adenosine antagonist versus IV saline; 6 RCTs investigating hemodialysis or hemofiltration versus IV saline; 6 RCTs comparing ascorbic acid versus IV saline, and 3 RCTs comparing ascorbic acid to N-acetylcysteine. Although we found many (...) studies investigating other interventions, the studies were too small and too few to support conclusions regarding the comparative effectiveness of those interventions. The studies were published between 1998 and 2015. The SOE was low that high-dose [>1,200 mg/day] N-acetylcysteine had a small clinically unimportant effect in preventing CIN when compared with IV saline (pooled risk ratio [RR], 0.78; 95% confidence interval [CI], 0.59 to 1.03); and the SOE was low that low-dose [=1,200 mg/day] N

2016 Effective Health Care Program (AHRQ)

26. Assessing Fitness to Drive

the ambit of ordinary road laws. Drivers who are given special exemptions from these laws, such as emergency service vehicle drivers, should have a risk assessment and an appropriate level of medical standard applied by the employer. At a minimum, they should be assessed to the commercial vehicle standard. 1.3.2 Short-term fitness to drive This publication does not attempt to address the full range of health conditions that might impact on a person‘s fitness to drive in the short term. Some guidance (...) such as checking loads, conversing with passengers and undertaking emergency procedures) without first undertaking a task risk assessment that identifies the range of other requirements for a particular job. 1.4 Content This publication is presented in three parts. Part A comprises general information including: • the principles of assessing fitness to drive • specific considerations including - the assessment of people with multiple medical conditions or age-related change - the management of temporary

2016 Cardiac Society of Australia and New Zealand

27. Rixubis - nonacog gamma

of 0.9 IU/dL per IU/kg, the dose is calculated as follows: Required units = body weight (kg) x desired factor IX rise (%) or (IU/dL) x 1.1 dL/kg For long-term prophylaxis against bleeding in patients with severe haemophilia B, the usual doses are 40 to 60 IU of factor IX per kilogram of body weight at intervals of 3 to 4 days for patients 12 years and older. In some cases, depending upon the individual patient´s pharmacokinetics, age, bleeding phenotype and physical activity, shorter dosage intervals (...) of the required dose of factor IX for “On demand treatment” in adults is based on the empirical finding that 1 International Unit (IU) factor IX per kg body weight raises the plasma factor IX activity by 0.9 IU/dL (range from 0.5 to 1.4 IU/dL) or 0.9% of normal activity in patients 12 years and older (further information see SmPC sections 4.2; 5.2). In the paediatric population the calculation of the required dose of factor IX for on demand treatment is based on the empirical finding that 1 International Unit

2014 European Medicines Agency - EPARs

28. Management of Constipation in Adult Patients Receiving Palliative Care

advice should be sought. This guideline may also be of interest to patients with a life-limiting condition and their carers. This guideline should not be used in patients without a life-limiting illness. This guideline does not apply to children. The National Clinical Guideline and the summary National Clinical Guideline are available on the websites www.health.gov.ie/patient-safety/NCEC and www.hse.ie/palliativecareprogramme. Constipation is one of the most frequently encountered symptoms (...) in the palliative care population. It can significantly impact on a patient’s quality of life and may necessitate the use of additional medications, emergency visits and hospitalisation. The consequences of untreated constipation place a significant burden on the healthcare system. Prescribing practice lacks consistency and despite laxative therapy, up to seventy percent of patients receiving palliative care continue to experience symptomatic constipation. The expected outcome of the recommendations made

2015 National Clinical Guidelines (Ireland)

29. Royal Flying Doctor Service Western Operations Clinical manual part 1.Clinical guidelines

Version 6.0 Clinical Manual Issue Date: January 2013 Part 1 - Clinical Guidelines Table of Contents 10 OBSTETRIC 1 10.1 Pre-term Labour and Tocolysis 1 10.2 Pre-Eclampsia 4 10.3 Eclampsia 6 10.4 Antepartum Haemorrhage 7 10.5 Post-Partum Haemorrhage 8 10.6 Epidurals In-Flight 10 10.7 Obstetric Trauma 11 11 PAEDIATRICS 1 11.1 Paediatric Upper Airway Obstruction 1 11.2 Gastroenteritis / Dehydration In Children 3 11.3 Neonate Retrievals 5 11.4 Intranasal Fentanyl 7 12 RESPIRATORY 1 12.1 Pulmonary Embolism (...) 1 12.2 Acute Asthma 3 12.3 Bronchiolitis 5 13 TOXICOLOGY 1 13.1 Snakebite 1 13.2 Red-back Spider Bite (RBSB) 4 13.3 Irukandji Syndrome 6 13.4 An Approach To Poisoning 8 13.5 Paraquat Poisoning 9 13.6 Serotonin Syndrome 11 13.7 Cyanide Poisoning 12 14 TRAUMA 1 14.1 Burns 1 14.2 Hydrofluoric Acid Burns 5 14.3 Identification and Management of Pelvic Fractures 6 14.4 Crush Syndrome 8 14.5 Fractured Neck of Femur 9 14.6 Screening Adults With Suspected Cervical Spine Fractures 10 14.7 Acute Spinal

2014 Clinical Practice Guidelines Portal

30. Assessment and Management of Foot Ulcers for People with Diabetes, Second Edition

skin changes Ulceration Amputation Poor healing • Self-care deficit • Poor glucose control • Improper footwear • Obesity • Lack of timely resources Infection17 BEST PRACTICE GUIDELINES • www.RNAO.ca BACKGROUND Assessment and Management of Foot Ulcers for People with Diabetes, Second Edition The management of persons with foot ulcers is complex. According to Weir (2010), diabetic foot ulcers should be regarded a medical emergency. Principles of clinical management of the person with diabetic foot

2013 Registered Nurses' Association of Ontario

31. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

230 Annex 2. Algorithm for the 2013 recommendations for adults and adolescents 232 Annex 3. Algorithm for the 2013 recommendations for pregnant and breastfeeding women 234 Annex 4. Algorithm for the 2013 recommendations for children 236 Annex 5. Algorithm for early infant diagnosis 237 Annex 6. r eadiness assessment checklist: moving towards Ar T for pregnant and breastfeeding women 238 Annex 7. Dosages of recommended antiretroviral drugs 242 13. References 25111 Abbreviations and acronyms 3TC (...) for adults, adolescents, children and infants are used to ensure consistency within these consolidated guidelines, as well as with other WHO guidelines. It is recognized that other agencies may use different definitions. An adult is a person older than 19 years of age unless national law defines a person as being an adult at an earlier age. An adolescent is a person aged 10 to 19 years inclusive. A child is a person 19 years or younger unless national law defines a person to be an adult at an earlier age

2013 World Health Organisation HIV Guidelines

32. Phase I Open-label Study to Evaluate Pharmacokinetics of TAK-272 in Patients With Renal or Hepatic Impairment

, 1.5, 2, 3, 4, 5, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120 hours post dose; up to 120 hours) post-dose ] Cmax: Maximum Observed Plasma Concentration for TAK-272F and Its Metabolite M-I [ Time Frame: Day 1: Pre-dose and at multiple time points (0.5, 1, 1.5, 2, 3, 4, 5, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120 hours post dose; up to 120 hours) post-dose ] AUC∞: Area Under the Plasma Concentration-time Curve From Time 0 to Infinity for TAK-272F and Its Metabolite M-I [ Time Frame: Day 1: Pre-dose (...) and at multiple time points (0.5, 1, 1.5, 2, 3, 4, 5, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120 hours post dose; up to 120 hours) post-dose ] AUClast,u: Area Under the Unbound Plasma Concentration-time Curve From Time 0 to Time of Last Quantifiable Concentration for TAK-272F [ Time Frame: Day 1: Pre-dose and at multiple time points (0.5, 1, 1.5, 2, 3, 4, 5, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120 hours post dose; up to 120 hours) post-dose ] AUClast,u is the area under the concentration-time curve of the unbound

2015 Clinical Trials

33. “Cat-upuncture”? What did those poor cats ever do to deserve this?

is because a competent adult is free to choose to have himself stuck full of needles that won't do him any good. On the other hand, animals, like children, have to rely on their adult human guardians to decide what's best for them. When a dog owner chooses to have his fine furry friend stuck full of needles, my reaction is almost as intense as it is when a parent subjects her child to quackery. So this time around, I was annoyed when somehow this article, entitled , by Lauren Gill in—of all newspapers (...) ) on 04 Mar 2016 to post comments By Lighthorse (not verified) on 04 Mar 2016 on 'chiropractic vet' Loren Weaver, which Orac discussed in 12/14. That one is a straight 'human interest' puff piece, with no hint whatsoever of any of the skeptical stones Gill has tucked under the mattress. The question skeptics may be thinking is 'but do Gill's readers catch any of the fairly subtle critique, or just interpret the piece as warm-cutesy essentially identical to the chiropractic vet story?' The answer

2016 Respectful Insolence

34. Kuvan® in Phenylketonuria Patients Less Than 4 Years Old

for Study: up to 4 Years (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Male or female PKU infants and young children less than (<) 4 years of age at the scheduled Day 1 visit of the 26-week study period (taking into consideration the maximum of 21 days in the screening period) Confirmed clinical and biochemical PKU, including at least two previous blood Phe levels greater than or equal to (>=) 400 micromol per liter (mcmol/L) obtained on 2 separate (...) ): BioMarin Pharmaceutical Study Details Study Description Go to Brief Summary: This is a Phase 3b, multicenter, open-label, randomized, controlled study to evaluate efficacy, safety and population pharmacokinetics of sapropterin dihydrochloride (Kuvan®) in less than 4 year-old infants and children with phenylketonuria (PKU). Condition or disease Intervention/treatment Phase Phenylketonuria Drug: Kuvan® Other: Phenylalanine (Phe)-restricted diet Phase 3 Study Design Go to Layout table for study

2011 Clinical Trials

35. Pain Management Options During Labour

epidural – medication is adjusted to allow for ambulation. Use a low-dose technique so there is no motor block or risk of postural hypotension. The woman should meet the criteria for walking epidurals (see section 7.6, page 25). H. Local Anesthetic Agents The drug concentration and volume of local anesthetics, opioids, and epinephrine used to initiate epidural analgesia will depend on the stage of labour and the woman's preference/need for analgesia. For example, in early labour 12 - 14 ml of 0.1 (...) effects on the preterm infant due to decreased capacity to metabolize medications. Facilities providing planned maternal-child care services should ensure that equipment for both adult and neonatal resuscitation is immediately available in the labour and birth area. Nursing, medical and midwifery personnel should be skilled in both adult and neonatal resuscitation. The following tables provide an overview of analgesia use during labour in BC from April 1, 2001 to March 31, 2006. They were compiled

2007 British Columbia Perinatal Health Program

36. Eating disorders toolkit, a practice based guide to the inpatient management of adolescents with eating disorders, with special reference to regional and rural areas

. If urgent medical assistance is required, presentation to the emergency department should be the first contact point. TREATMENT OPTIONS AND TREATMENT SETTINGS ? Community-based care is the preferred treatment option and should involve establishing a multidisciplinary approach to treatment (including a General practitioner (GP), therapist and dietitian, with involvement of a paediatrician and child and adolescent psychiatrist). ? Specialist consultation should be sought for most cases of AN. ? The role (...) Child and Family team (along with local GP and dietitian) may be an option. ? For patients with EDNOS and BN, request for consultation will depend on the severity of the illness, availability of specialist services and the experience, interest, skill and time of the clinicians involved. ? Local hospital admissions may be required via the emergency department if the young person is medically or psychologically unwell. Referral to a specialist unit or back to the community may occur following

2008 Clinical Practice Guidelines Portal

37. Effectiveness of Arginine as a Treatment for Sickle Cell Anemia

assigned to receive twice daily doses of either a low dose of arginine, a high dose of arginine, or placebo for 12 weeks. Study visits will occur at baseline, three times during Month 1, and Weeks 8, 12, 14, and 16. Each study visit will include an echocardiogram to measure heart activity, blood collection, and a medical history review to identify adverse events, pain medication usage, headaches, emergency department visits, and hospitalizations. Study Design Go to Layout table for study information (...) by the National Library of Medicine related topics: related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Low Dose 0.05 g/kg/day Arginine Drug: Arginine Depending on the weight of the child or adult, the patients took any where between 4-10 capsules 2 times a day. Patients weighing less than 45 kilograms were on the low dose active (or placebo) so the capsules were smaller. Patients greater than or equal to 45 kgs were on the high dose active

2007 Clinical Trials

38. Canadian clinical practice guidelines on the management and prevention of obesity in adults and children

, weight and waist circumference [grade A, level 3]. Classification of overweight and obesity in adults and children 3. We recommend measuring body mass index (BMI; weight in kilograms divided by height in metres squared) in all adults [grade A, level 3 4–6 ] and in all chil- dren and adolescents (aged 2 years and older). We rec- ommend using the growth charts of the US Centers for Disease Control and Prevention for BMI to screen chil- dren and adolescents for overweight (= 85th to 102 cm† Women, WC (...) . 19,20 Further- more, childhood and adolescent BMI is associated with the risk of adulthood obesity 3,21 and long-term mortality risk. 22,23 The use of BMI-for-age to evaluate overweight and obesity in children

2007 CPG Infobase

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