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Emergency Medicine Treatment and Labor Act

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141. Vestronidase alfa (Mepsevii) - Mucopolysaccharidosis VII

Adverse event BE Bioequivalence BOT-2 Bruininks-Oseretsky Test of Motor Proficiency CGI Clinical Global Impression CIM6PR Cation-independent mannose 6-phosphate receptor CL Clearance Cmax Maximum concentration CMC Chemistry, Manufacturing, and Controls CS Chondroitin sulfate DART Developmental and reproductive toxicology DMP Drug Monitoring Program DS Dermatan sulfate eIND Emergency Investigational New Drug [application] EMA European Medicines Agency ER Exposure response ERT Enzyme replacement therapy (...) Questionnaire MR Mannose receptor ODD Orphan Drug Designation PD Pharmacodynamics(s) PedsQL Pediatric Quality of Life Multidimensional Fatigue Scale PGI-C Physician Global Impression-Change PIND Pre-Investigational New Drug [application] PIP Paediatric Investigational Plan PK Pharmacokinetic(s) QOW Every other week rh-GUS Recombinant human GUS rm-GUS Recombinant mouse GUS SAE Serious adverse event SOC System Organ Class t1/2 Half-life TEAE Treatment-emergent adverse event uGAG Urinary glycosaminoglycan ULN

2018 European Medicines Agency - EPARs

142. Glibenclamide (Amglidia) - Diabetes Mellitus

dossier in accordance with Article 8(3)of Directive 2001/83/EC. The applicant applied for the following indication (wording at submission): “Amglidia is a hypoglycaemic agent indicated for the oral treatment of neonatal diabetes, for use in newborns, infants and children.” Amglidia was designated as an orphan medicinal product EU/3/15/1589 on 15 January 2016. Amglidia was designated as an orphan medicinal product in the following indication: treatment of neonatal diabetes. Following the CHMP positive (...) diabetes is less than 0.02 per 10,000 individuals in the EU and should be considered as an extremely rare disorder of genetic origin which cannot be prevented. Neonatal diabetes is a detectable condition that needs most often emergency treatment with IV fluid and insulin, the only method so far to re-establish metabolic control, and to avoid short-term risks such a ketoacidosis, dehydration and death in newborns and toddlers. Genetic testing for mutations in the genes coding for the Kir6.2 and SUR1

2018 European Medicines Agency - EPARs

143. Medicine in medieval Islam

[ ] The adoption by the newly forming Islamic society of the medical knowledge of the surrounding, or newly conquered, "heathen" civilizations had to be justified as being in accordance with the beliefs of Islam. Early on, the study and practice of medicine was understood as an act of piety, founded on the principles of Imaan (faith) and Tawakkul (trust). The Prophet not only instructed sick people to take medicine, but he himself invited expert physicians for this purpose. — As-Suyuti’s Medicine (...) who had treated him by and mentions that the prophet wanted to avoid this treatment and had asked for alternative treatments. Later on, there are reports of the fixing his teeth with a wire made of gold. He also mentions that the habit of cleaning one's teeth with a small wooden toothpick dates back to pre-islamic times. The "Prophetic medicine" was rarely mentioned by the classical authors of Islamic medicine, but lived on in the for some centuries. In his Kitab as-Ṣaidana (Book of Remedies) from

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2012 Wikipedia

144. Emergency medical services in Germany

of (ALS) treatments, they have to perform until an emergency doctor is on scene. Then the paramedics (and other medical staff on scene) act under direct medical supervision of the physician. Other (non life-threatening) emergencies are handled solely by the paramedic ambulances without a physician on scene. Emergency physician ( Notarzt ) [ ] The emergency physician, in German , must be a with a Notfallmedizin (Emergency Medicine) board certification, issued by the State Chamber of Physicians (...) . The availability of this service provides a better treatment option to those patients who, in other EMS systems, might generate low-acuity ambulance calls or visits. Occasionally, the visiting GP will contact the EMS dispatcher and order a Krankentransport , should it be determined following medical assessment, that the patient could be cared for in a safer and better manner in a hospital. Emergency telephone numbers [ ] The nationwide emergency number for the fire brigade and emergency medical services

2012 Wikipedia

145. Interventions to improve the labour market outcomes of youth: a systematic review of training, entrepreneurship promotion, employment services and subsidized employment interventions

: Number of reports for study design assessment 81 Table 11: Sample size of treatment effect estimates 83 Table 12: Summary of results by outcome category 86 Table 13: Summary of results for measures within employment outcomes 90 Table 14: Summary of results for measures within earnings outcomes 91 Table 15: Summary of results for measures within business performance outcomes 91 Table 16: Summary of results for employment outcomes by main category of intervention 93 Table 17: Summary of results (...) ” and, in this regard, targeting disadvantaged youth may act as a key factor for success. 14 The Campbell Collaboration | www.campbellcollaboration.org There is a need to strengthen the evidence base with more studies of promising programmes, especially in sub-Saharan Africa. Further research should investigate intermediate outcomes and soft skills, and should collect cost data. How up-to-date is this review? The review authors searched for studies published up to January 2015. This Campbell systematic review

2017 Campbell Collaboration

146. Wellbeing indicators across the life cycle

Interest in measuring wellbeing has emerged in part from a rejection of the use of economic measures only, such as income or GDP, to measure societal progress. In recent years there has been a shift of focus in which progress or development is not measured solely on economic indicators, but focuses on a broader range of measures of quality of life, or wellbeing. 2, 4 An important difference between the concepts of wellbeing and economic welfare is that wellbeing usually adopts a multidimensional (...) of particular interest • Consistency over time • Timeliness — minimal time lag between the collection and reporting of the data • Linked to policy or emerging issues • Able to compel interest and excite — the indicator should resonate with the intended audience. 16 The Statistics New Zealand criteria are in line with the ABS good headline indicators from Measures of Australia’s Progress 17 which were that indicators should: • Be relevant to the particular dimension of progress • Where possible, focus

2017 Sax Institute Evidence Check

147. Policy on Patient Safety

safety is prevention of harm, particularly avoidable harm, to patients during treatment and care. 2 Dental practices must be in compliance with federal laws that help protect patients from preventable injuries and potential dangers such as the transmission of disease. 3-5 Laws help regulate hazards related to chemical and environmental factors (e.g., spills, radiation) and facilities (e.g., fire prevention systems, emergency exits). 6 AAPD best practices and oral health policies provide additional (...) information regarding the delivery of safe pediatric dental care. 7-18 Furthermore, state dental practice acts and hospital credentialing committees are intended to ensure the safety of patients and the trust of the public by regulating the competency of and provision of services by dental health professionals. 19-21 Patient-centered health care systems that focus on preventing errors are critical to assuring patient safety. 21,22 Some possible sources of error in the dental office are miscommunication

2018 American Academy of Pediatric Dentistry

148. Emicizumab for Hemophilia A with Inhibitors: Effectiveness and Value

patients from self-administering intravenous infusions. People with hemophilia may be unable to enter into their career of choice; professions that involve manual labor (e.g., farming, carpentry, construction) may involve too great a risk of bleeding. Even people who are employed in professions that do not carry large bleeding risks must ensure that their work keeps them in the proximity of a medical center that is able to provide urgent/emergent treatment. There is a substantial time burden associated (...) in patient engagement and advocacy. All Council members meet strict conflict of interest guidelines and are convened to discuss the evidence summarized in ICER reports and vote on the comparative clinical effectiveness and value of medical interventions. More information about New England CEPAC is available at http://icer-review.org/programs/new-england-cepac/. The findings contained within this report are current as of the date of publication. Readers should be aware that new evidence may emerge

2018 California Technology Assessment Forum

149. Outcome Measures Framework: Information Model Report

population could be elicited and validated. It also describes how dominant definitions will be chosen as well as process measures such as treatments or procedures, and the associated outcome of the patients or participants involved. A qualitative analysis on four condition areas was conducted to measure the degree to which outcome data, as entered in clinicaltrials.gov, mapped to the framework developed in the OMF. The conditions examined were depression, asthma, rheumatoid arthritis, and cardiac surgery (...) observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes.” 1 Common purposes for patient registries include evaluating the safety, effectiveness, or quality of medical treatments, products, and services, and studying the natural history of diseases. Some registries are developed and maintained solely

2018 Effective Health Care Program (AHRQ)

150. WHO recommendations: intrapartum care for a positive childbirth experience

in labour is not recommended. b Not recommended a Integrated from WHO recommendations for prevention and treatment of maternal peripartum infections. b Integrated from WHO recommendations for augmentation of labour.5 EXECUTIVE SUMMARY Care option Recommendation Category of recommendation Routine amniotomy 28. The use of amniotomy alone for prevention of delay in labour is not recommended. a Not recommended Early amniotomy and oxytocin 29. The use of early amniotomy with early oxytocin augmentation (...) of the baby for ambient temperature is recommended. This means one to two layers of clothes more than adults, and use of hats/caps. The mother and baby should not be separated and should stay in the same room 24 hours a day. f Recommended a Integrated from WHO recommendations for the prevention and treatment of postpartum haemorrhage. b Integrated from the WHO Guideline: delayed cord clamping for improved maternal and infant health and nutrition outcomes. c Integrated from WHO Guidelines on basic newborn

2018 World Health Organisation Guidelines

151. WHO recommendations: non-clinical interventions to reduce unnecessary caesarean sections

and New Zealand College of Obstetricians and Gynaecologists (RANZCOG), Royal College of Obstetricians and Gynaecologists (RCOG) and Society for Maternal–Fetal Medicine (SMFM). 2.10 Quality assessment and synthesis of the evidence Evidence on the effectiveness and safety of non-clinical interventions to reduce unnecessary caesareans The assessment of risk of bias in the studies included in the Cochrane review (RCT s, nRCT s, controlled before- and-after studies and interrupted time series studies

2018 World Health Organisation Guidelines

152. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy

Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy Regional Anesthesia in the Patient Receiving Antithrombotic... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account Registered (...) Articles & Issues Collections For Authors Journal Info > > Regional Anesthesia in the Patient Receiving Antithrombotic... Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Regional Anesthesia and Pain Medicine. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request

2018 American Society of Regional Anesthesia and Pain Medicine

153. Elagolix for Treating Endometriosis

with endometriosis. 15 Inadequate control of pain due to endometriosis may result in chronic opioid use with its known risks. Given the limitations of currently available treatments, new therapies are needed. A new agent, elagolix (investigational, AbbVie) is under FDA review for patients with endometriosis. Elagolix is a short-acting, oral, nonpeptide, GnRH antagonist that rapidly suppresses the pituitary- ovarian hormones and produces a dose-dependent suppression of ovarian estrogen production that varies from (...) partial to full suppression depending on the frequency and dose given. 16,17 In contrast, GnRH agonists act by initially stimulating the pituitary gland to release female hormones and can worsen symptoms of endometriosis during the first 10 to 14 days of treatment before persistent binding to the GnRH receptor leads to full suppression of ovarian hormones. By not producing the initial surge in LH and FSH associated with GnRH agonists, elagolix does not result in an initial increase in symptoms

2018 California Technology Assessment Forum

154. Optimizing Postpartum Care

care as needed, concluding with a com- prehensive postpartum visit no later than 12 weeks after birth. ACOG COMMITTEE OPINION Number 736 • May 2018 (Replaces Committee Opinion Number 666, June 2016) Presidential Task Force on Redefining the Postpartum Visit Committee on Obstetric Practice The Academy of Breastfeeding Medicine, the American College of Nurse-Midwives, the National Association of Nurse Practitioners in Women’s Health, the Society for Academic Specialists in General Obstetrics (...) and Gynecology, and the Society for Maternal–Fetal Medicine endorse this document. This Committee Opinion was developed by the American College of Obstetricians and Gynecologists’ Presidential Task Force on Redefining the Postpartum Visit and the Committee on Obstetric Practice in collaboration with task force members Alison Stuebe, MD, MSc; Tamika Auguste, MD; and Martha Gulati, MD, MS. Optimizing Postpartum Care ABSTRACT: The weeks following birth are a critical period for a woman and her infant, setting

2018 American College of Obstetricians and Gynecologists

155. Psychodynamic Psychotherapy with Children

maternal repre- sentations and more positive expectations of the mother-child relationship. Muratori et al., 53(ct) in a 2-year follow up of psychodynamic psychotherapy for internalizing disorders in children, studied the ef?cacy of a time-limited (11-week) combined individual and parent-focused psychodynamic psychotherapy for children compared with treatment as usual in the community. At the 2-year follow-up, the Child Behavior Checklist results indicated that psychodynamic psychotherapy acted on both (...) , and criteria for termination. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(5): 541–557. Key Words: Practice Parameter, child psychodynamic psychotherapy, indications, psychotherapeutic processes, parent work. P sychodynamic psychotherapy is a basic skill and training requirement in adult, child and adolescent psychiatry. 1 To some, this basic skill is endangered. 2,3 Individual psy- chodynamic psychotherapy, alone or in combina- tion with other treatments, is used to treat child and adolescent disorders

2018 American Academy of Child and Adolescent Psychiatry

156. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association

. Tweet , and Malissa J. Wood and On behalf of the American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council Originally published 22 Feb 2018 Circulation. 2018;137:e523–e557 You are viewing the most recent version of this article. Previous versions: Abstract Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary (...) , MD, PhD, FAHA , and MD MDOn behalf of the American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council Sharonne N. Hayes , Esther S.H. Kim , Jacqueline Saw , David Adlam , Cynthia Arslanian-Engoren , Katherine E. Economy , Santhi K. Ganesh , Rajiv Gulati , Mark E. Lindsay , Jennifer H. Mieres , Sahar Naderi , Svati Shah , David E. Thaler , Marysia S

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2018 American Heart Association

157. Elagolix for Treating Endometriosis

treatments, new therapies are needed. A new agent, elagolix (Orilissa™, AbbVie) was approved by the FDA for the management of moderate-to-severe pain associated with endometriosis on July 23, 2018. 16 Elagolix is a short-acting, oral, nonpeptide, GnRH antagonist that rapidly suppresses the pituitary- ovarian hormones and produces a dose-dependent suppression of ovarian estrogen production that varies from partial to full suppression depending on the frequency and dose given. 17,18 In contrast, GnRH (...) agonists act by initially stimulating the pituitary gland to release female hormones and can worsen symptoms of endometriosis during the first 10 to 14 days of treatment before persistent binding to the GnRH receptor leads to full suppression of ovarian hormones. By not producing the initial surge in LH and FSH associated with GnRH agonists, elagolix does not result in an initial increase in symptoms and the need to treat with hormonal contraceptives. Moreover, GnRH agonists must be administered

2018 California Technology Assessment Forum

158. Management of Strongyloidiasis

helminthiases, it needs additional diagnostic tools beyond microscopy and requires different treatment. In areas in which preventive anthelmintic chemotherapy with ivermectin has been used to control onchocerciasis or lymphatic filariasis, there has been a noticeable reduction in the prevalence of strongyloidiasis [ – ]. The WHO Essential Medicines Committee has included ivermectin in its list, including in combination with albendazole, for strongyloidiasis. Some 900 million people are now receiving (...) , because of the risk of hyperinfection—a potentially fatal complication. Reliable diagnosis of patients at risk is needed for accurate recognition and treatment before immunosuppressive therapy is initiated, or in patients with HTLV-I or human immunodeficiency virus (HIV) infection. If emergency immunosuppression is required in a patient who may have previously undiagnosed strongyloidiasis, and diagnostic tests are not rapidly available (very few hospitals can do same-day serology), presumptive

2018 World Gastroenterology Organisation

159. Perineal care

6.2.1 Types of repair 23 6.2.2 OASIS repair 24 7 Puerperal genital haematoma 25 7.1 Diagnosis of puerperal haematoma 25 7.2 Treatment of puerperal haematoma 26 8 Postpartum perineal care 27 8.1 Management of pain and bowel function 27 8.2 Antibiotics 27 8.3 Promoting perineal recovery 28 8.4 Follow up after perineal injury 29 8.5 Previous OASIS and decision making 30 8.5.1 Risk factors for recurrence of OASIS 31 9 Clinical measures not supported by evidence 31 10 Female genital mutilation (FGM) 32 (...) around 35 weeks gestation o One to two times per week o For around five minutes per session 39 4.2 Pelvic floor muscle training (PFMT) Table 10. Pelvic floor muscles training Aspect Consideration Risks and benefits · When commenced in early pregnancy, effective in reducing urinary incontinence in late pregnancy and first six months postpartum 40 · Greater positive effect if treatment closely supervised with adequate exercise regimen to strengthen muscles 40 · Effective treatment for existing urinary

2018 Queensland Health

160. Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Chronic Pain

, with higher dosages and more frequent infusions associated with greater risks. Larger studies, evaluating a wider variety of conditions, are needed to better quantify efficacy, improve patient selection, refine the therapeutic dose range, determine the effectiveness of nonintravenous ketamine alternatives, and develop a greater understanding of the long-term risks of repeated treatments. From the * Departments of Anesthesiology & Critical Care Medicine, Neurology, and Physical Medicine & Rehabilitation (...) ramifications for pain medicine providers. Despite the recent surge in use in the context of mood disorders, there is a relative paucity of clinical data compared with its use as an anesthetic and analgesic agent, but the mood-enhancing effects appear to emerge in approximately 4 hours, after most of the drug has been cleared from circulation, and persist for up to 2 weeks, long after the acute analgesic effects dissipate. Similar to its use as an analgesic, a variety of routes of administration have been

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2018 American Society of Regional Anesthesia and Pain Medicine

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