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41. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy

for spontaneous neuraxial bleeding with these medications. 2.1 In patients scheduled to receive thrombolytic therapy, we recommend that the patient be queried and medical record reviewed for a recent history of lumbar puncture, spinal or epidural anesthesia, or ESI to allow appropriate monitoring. Guidelines detailing original contraindications to thrombolytic drugs suggest avoidance of these drugs for 10 days following puncture of noncompressible vessels (grade 1A). Remarks: There is no change (...) Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy Regional Anesthesia in the Patient Receiving Antithrombotic... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account Registered

2018 American Society of Regional Anesthesia and Pain Medicine

42. New Direct-acting Antiviral for Hepatitis C (Epclusa?

is associated with increased risk of unnecessary infection (Kcentra is partly produced from blood from non-donors). Another problem is that they are valuable medical resource that can be obtained only from blood donations. In case of emergency, they are not easily accessible. It also requires consent from patients (their families) prior to treatment. The MHLW denies causality between the drug and deaths, but this cannot be trusted [10-12]. High-risk patients are essentially the ones who need an effective (...) their pharmacologic therapies. ? The recent diabetic medicines are all costly. If the guidelines of the Japanese Diabetes Society are followed, high drug costs and medical costs would be needed. In addition, hypoglycemic attacks and cardiovascular diseases would occur frequently and life expectancy would be negatively affected, as well. On the other hand, the ACP guidance would reduce medical costs and improve health and life expectancy of patients with type 2 diabetes. ? Type 2 diabetes may develop and aggravate

2019 Med Check - The Informed Prescriber

43. Interventions to improve the labour market outcomes of youth: A systematic review of training, entrepreneurship promotion, employment services and subsidized employment interventions Full Text available with Trip Pro

and valued qualifications 7. Adequate economic, social, institutional and administrative conditions are in place Technical training programmes are popular in development cooperation because many developing countries experience a skills mismatch between their labour force and emerging segments of their economies. However, pure training programmes have not proven to be particularly successful in many contexts ( ). Therefore, most recent programmes tend to combine skills training with other types (...) outcomes of young people. The evaluation found that the reinforced counselling programme had a positive impact on the employment status of young jobseekers eight months after assignment to the treatment group, compared to untreated jobseekers. However, these positive effects appeared to have come partly at the expense of eligible workers who did not benefit from the programme, particularly in labour markets where they were competing mainly with other educated workers and in weak labour markets. Sources

2017 Campbell Collaboration

44. Vocational and business training to improve women's labour market outcomes in low? and middle?income countries: a systematic review Full Text available with Trip Pro

Vocational and business training to improve women's labour market outcomes in low? and middle?income countries: a systematic review Vocational and business training to improve women's labour market outcomes in low‐ and middle‐income countries: a systematic review - Chinen - 2017 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access (...) Vocational and business training to improve women's labour market outcomes in low‐ and middle‐income countries: a systematic review Corresponding Author E-mail address: Corresponding author Thomas de Hoop American Institutes for Research USA E‐mail: Corresponding Author E-mail address: Corresponding author Thomas de Hoop American Institutes for Research USA E‐mail: First published: 21 December 2017 Citations: Linked article: . Give access Share full text access Please review our and check

2017 Campbell Collaboration

45. Brilinta (ticagrelor) Tablets - medical review

might argue that the individual SUSARs as in these examples are impossible to interpret individually. However, all of them fall into the “(C)” category described in the CFR: “(C) An aggregate analysis of specific events observed in a clinical trial (such as known consequences of the underlying disease or condition under investigation or other events that commonly occur in the study population independent of drug therapy) that indicates those events occur more frequently in the drug treatment group (...) Brilinta (ticagrelor) Tablets - medical review CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 022433Orig1s000 MEDICAL REVIEW(S) DIVISION OF CARDIOVASCULAR AND RENAL PRODUCTS Complete Response Review Addendum Sponsor Safety Reporting Submissions: NDA 22-433 and IND 65,808 SD 632 Drug: ticagrelor (Brilinta™) Indication: reduce the rate of thrombotic events in patients with acute coronary syndromes (ACS) Sponsor: AstraZeneca Review date: June 8, 2011 Reviewer: Thomas A. Marciniak, M.D

2011 FDA - Drug Approval Package

46. Preterm labour and birth

://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 10 of 27likelihood of birth within 48 hours. Act on the results as follows: if cervical length is more than 15 mm, explain to the woman that it is unlikely that she is in preterm labour and: think about alternative diagnoses discuss with her the benefits and risks of going home compared with continued monitoring and treatment in hospital advise her that if she does decide to go home, she should return if symptoms suggestive of preterm labour (...) persist or recur if cervical length is 15 mm or less, view the woman as being in diagnosed preterm labour and offer treatment as described in sections 1.8 and 1.9. 1.7.5 Consider fetal fibronectin testing as a diagnostic test to determine likelihood of birth within 48 hours for women who are 30 +0 weeks pregnant or more if transvaginal ultrasound measurement of cervical length is indicated but is not available or not acceptable. Act on the results as follows: if fetal fibronectin testing is negative

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

47. Occupational Therapy for people Undergoing total hip replacement

and successful interventions in the whole of medical practice. The success of hip replacement is entirely dependent upon a multidisciplinary team approach, with occupational therapy being a core part of its success. The updated guidance reflects changes in practice and in particular the requirement for reduction in length of stay. The trend for patients undergoing hip arthroplasty at younger ages continues, as does the increasing numbers of total hip replacements being performed year on year. National (...) then be developed and a treatment plan jointly agreed.The occupational therapy role 12 Occupational therapy for adults undergoing total hip replacement The home situation is discussed from the perspective that the service user is expert in this domain and their specific needs and choices. The service user can inform the occupational therapist about specific heights of their furniture (chair, bed and toilet) so that equipment may be prescribed to compensate for lack of function, or to enable activities

2018 Publication 1554

48. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

with men NASA national AIDS spending assessment NAT nucleic acid amplification testing NCD noncommunicable disease NNRTI non-nucleoside reverse-transcriptase inhibitor NRTI nucleoside reverse-transcriptase inhibitor NVP nevirapine OI opportunistic infection OST opioid substitution therapy PCP Pneumocystis jirovecii pneumonia PCR polymerase chain reaction PDR pre-treatment HIV drug resistance PEN Package of Essential NCD interventions PI protease inhibitor PITC provider-initiated testing and counselling (...) not so identified.xiii Definition of key terms Serodiscordant couples are couples in which one partner is living with HIV and the other is HIV-negative. A couple refers to two people in an ongoing sexual relationship; each of these people is referred to as a partner in the relationship. How individuals define their relationships will vary according to their cultural and social context. Antiretroviral therapy ARV (antiretroviral) drugs refer to the medicines used to treat HIV. ART (antiretroviral

2016 World Health Organisation HIV Guidelines

49. Integrating collaborative TB and HIV services within a comprehensive package of care for people who inject drugs

). • Guidelines for the programmatic management of drug-resistant tuberculosis – emergency update 2008 (7). • Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence (8). • WHO policy on TB infection control in health-care facilities, congregate settings and households (9). • Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings (10). • mhGAP intervention guide for mental, neurological (...) services within a comprehensive package of care for people who inject drugs | Consolidated Guidelines I. Acronyms AIDS acquired immunodeficiency syndrome APRI aminotransferase/platelet ratio index ART antiretroviral therapy ASSIST Alcohol, Smoking and Substance Involvement Screening T est CHB chronic hepatitis B CI confidence interval CPT co-trimoxazole preventive therapy DAA direct-acting antiviral (drug) DIH drug-induced hepatotoxicity DNA deoxyribonucleic acid FIB-4 Fibrosis-4 score GRC Guideline

2016 World Health Organisation HIV Guidelines

50. Occupational therapy for people with Parkinson's - best practice guide

found in the human body. Much more research is needed if scientists are to understand how stem cells work and how they can be used to produce a viable treatment for Parkinson’s (Astradsson and Aziz 2016). • Gene therapy is a new approach to treating medical conditions, in essence using genes as drugs. It works by introducing normal genes into the cells of people with certain disorders to overcome the effects of defective genes, which may cause, or have a part to play in the development (...) of treatments for Parkinson’s, including evaluation of the impact of occupational therapy. This evidence has informed the National Institute for Health and Care Excellence (NICE) Parkinson’s disease in adults guideline (NICE 2017), which updates their recommendations about diagnosis, medical and non-medical treatments for people living with Parkinson’s. Access to occupational therapy from the time of diagnosis is also highlighted in a set of five Parkinson’s-specific Quality Standards (QS164, NICE 2018

2018 Parkinson's UK

51. Biologic therapy for psoriasis

drugs in pregnancy and breastfeeding 21 British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017 5 · The BTS guideline for managing TB in patients due to start anti-TNF-alpha treatment 22 · The BHIVA guidelines for routine investigation and monitoring of adult HIV-1-positive individuals 2016 23 · The 2016 EULAR updated guideline for the treatment of systemic sclerosis 24 3 Methods This guideline has been developed using the BAD recommended methodology 25 (...) non-biologic therapy approaches (for example inpatient topical therapy, phototherapy or standard systemic therapy) á When to consider dose escalation R22 Consider escalating the dose of biologic therapy in adults, where this is feasible and funded (see table) when an inadequate primary response may be due to insufficient drug dosing (for example, in people who are obese or whose psoriasis relapses during the treatment cycle). Take into account that this may be associated with an increased risk

2017 British Association of Dermatologists

52. Induction of labour: misoprostol vaginal delivery system

) for the induction of labour in women with an unfavourable cervix, from 36 weeks' gestation, in whom induction is clinically indicated. The manufacturer has advised that the UK launch is expected in quarter 4, 2014 (Ferring Pharmaceuticals: personal communication, January 2014). Currently, only short-acting oral preparations of misoprostol are available and none is licensed for the induction of labour in the UK. In practice, oral misoprostol tablets are sometimes administered vaginally to induce labour (...) that the UK launch is expected in quarter 4, 2014 (Ferring Pharmaceuticals: personal communication, January 2014). Currently, only short-acting oral preparations of misoprostol are available and none of these is licensed for the induction of labour in the UK. In practice, oral misoprostol tablets are sometimes Induction of labour: misoprostol vaginal delivery system (ESNM38) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page

2014 National Institute for Health and Clinical Excellence - Advice

53. Primary Care Guidance for Persons With Human Immunodeficiency Virus: 2020 Update by the HIV Medicine Association of the Infectious Diseases Society of America

• Prior HIV care • Nadir CD4 cell count and highest viral load • Current and past exposure to antiretroviral drugs ◦ Use of pre- or postexposure prophylaxis (including medications and date of last use) ◦ ART for prevention of perinatal transmission ◦ Prior antiretroviral treatmentDrug regimens taken and HIV RNA level while on those regimens • Duration of therapy • Reasons for changing regimens (eg, virologic failure, tolerability, simplification) and adherence challenges • Past medical record (...) of activities that may have resulted in exposure • Prior HIV care • Nadir CD4 cell count and highest viral load • Current and past exposure to antiretroviral drugs ◦ Use of pre- or postexposure prophylaxis (including medications and date of last use) ◦ ART for prevention of perinatal transmission ◦ Prior antiretroviral treatmentDrug regimens taken and HIV RNA level while on those regimens • Duration of therapy • Reasons for changing regimens (eg, virologic failure, tolerability, simplification

2020 Infectious Diseases Society of America

54. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

therapy 3. Pharmaceutical equivalence and clinical interchangeability between lamivudine and emtricitabine 4. Use of efavirenz during pregnancy as part of first-line antiretroviral therapy: a public health perspective 5. Optimizing antiretroviral drugs for children: medium- and long-term priorities 6. Changing role of CD4 cell counts in HIV care and treatment 7. Scaling up viral load testing in resource-limited settings Supplementary sections to Chapter 9 – Guidance on operations and service delivery (...) diagnosis coverage remains low, and this acts as one major bottleneck to improve the ART coverage among children. Within this context, and in accordance with the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection (1), The Global Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive (2) and the Treatment 2.0 Initiative (3), WHO convened an expert review meeting in September 2013 to evaluate emerging

2014 World Health Organisation HIV Guidelines

55. Preparing Emerging Leaders for Alternative Futures in Health Systems Across Canada

and linguistic minority populations); • occupation or labour-market experiences more generally (e.g., those in “precarious work” arrangements); • gender; • religion; • educational level (e.g., health literacy); • socio-economic status (e.g., economically disadvantaged populations); and • social capital/social exclusion. • The evidence brief strives to address all leaders, emerging leaders and potential future leaders, but (where possible) it also gives particular attention to people who have been (...) . This list is also not exhaustive and should act as a jumping-off point for deliberations about the ways in which the health system may change. The six expected futures are: 1) emerging leaders increasingly operate within a rapid-learning health-system orientation at all levels (self- management, clinical encounter, program, organization, sub-region, region and provincial/federal government); 2) emerging leaders are increasingly based in the home-and-community-care and primary-care sectors and more

2019 McMaster Health Forum

56. Daxas - roflumilast (medical review)

Daxas - roflumilast (medical review) CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 022522Orig1s000 MEDICAL REVIEW(S) Summary Basis for Regulatory Action Date May 17, 2010 From Curtis J Rosebraugh, MD, MPH Director, Office of Drug Evaluation II Subject Summary Review NDA/BLA # Supp # 22-522 Applicant Name Nycomed/Forest Laboratories Proprietary / Established (USAN) Names Daxas roflumilast Dosage Forms / Strength Tablet 500 mcg Proposed Indication(s) Maintenance treatment of chronic (...) ) are main stays of therapy currently available for the treatment of COPD. Bronchodilators are used to treat the reversible bronchoconstriction associated with COPD. Many types of bronchodilators are available in the US for COPD, either as a single agent or in combination with ICS or a second bronchodilator of different mechanism. Examples of bronchodilators available include the short and the long-acting beta agonists such as albuterol, salmeterol, formoterol and the anti-muscarinic agents

2010 FDA - Drug Approval Package

57. Improving Cardiac Arrest Diagnostic Accuracy of Emergency Medical Dispatchers

: Cohort Time Perspective: Prospective Official Title: Improving the Cardiac Arrest Diagnostic Accuracy of 9-1-1 Emergency Medical Dispatchers Study Start Date : June 2013 Actual Primary Completion Date : September 2014 Actual Study Completion Date : December 2014 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Training site All emergency medical dispatchers at a central ambulance communication centre in Ontario (...) % in Ontario. It has been shown that since the ambulance dispatch centres in Ontario implemented dispatch-assisted CPR instructions (given to callers while emergency vehicles were on the way), there was a significant increase in use. Emergency medical dispatchers can identify about 70% of OOHCA cases over the phone. Agonal breathing (laboured breathing preceding death) may be misinterpreted as a sign of life, and is responsible for as much as 50% of missed diagnoses. There is no specific training

2013 Clinical Trials

58. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

approaches to HIV prevention to achieve maximum impact on reducing HIV transmission and acquisition. ART (ANTIRETROVIRAL THERAPY) ARV (antiretroviral) drugs refer to the medicines themselves and not to their use. ART refers to the use of a combination of three or more Ar V drugs to achieve viral suppression. This generally refers to lifelong treatment. Synonyms are combination Ar T and highly active Ar T. ART for prevention is used to describe the HIV prevention benefits of A r T. Eligible for ART refers (...) Library Cataloguing-in-Publication Data Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: r ecommendations for a public health approach June 2013. 1.HIV infections – drug therapy. 2.HIV infections – prevention and control. 3.Anti-r etroviral agents – therapeutic use. 4.Guideline. I.World Health Organization. ISBN 978 92 4 150572 7 (NLM classification: WC 503.2) © World Health Organization 2013 All rights reserved. Publications of the World Health

2013 World Health Organisation HIV Guidelines

59. Guideline for Admission to Midwife-led Units in Northern Ireland & Northern Ireland Normal Labour & Birth Care Pathway

and agree. The guideline was also peer reviewed and informed by two Professors of Midwifery with expertise in the normalisation of labour and birth within MLU settings, an obstetrician and a midwife lecturer. Updating the Guideline In keeping with GAIN requirements these guidelines will be reviewed in 2018 or sooner in light of any emerging evidence. Funding The GDG was commissioned by GAIN to develop this guideline. 9 PLANNING PLACE OF BIRTH This guideline predominantly relates to women (...) with a straightforward singleton pregnancy (1) at the point of labour (2) . It is important to note that at each point of maternity care, all women should be assessed to ensure that they are receiving care from the most appropriate professional; that is, continue with midwife-led care (MLC), transfer to consultant-led care or transfer back to MLC (3) ; in particular, women who have been referred for investigation(s) or treatment which has been resolved. If there is any uncertainty, multidisciplinary discussion

2016 Regulation and Quality Improvement Authority

60. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV

to the medicines used to treat HIV. ART (antiretroviral therapy) refers to the use of a combination of three or more ARV drugs for treating HIV infection. ART involves lifelong treatment. Use of ARV drugs for HIV prevention refers to the HIV prevention benefits of ARV drugs and includes ARV drugs given to the mother or infant for preventing the mother-to-child transmission of HIV (PMTCT), ARV drugs to reduce the transmission of HIV among serodiscordant couples and ARV drugs to prevent people from acquiring HIV (...) 2015WHO Library Cataloguing-in-Publication Data Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. 1.HIV Infections – drug therapy. 2.Anti-Retroviral Agents – administration and dosage. 3.Anti-Retroviral agents – therapeutic use. 4.Time-to-Treatment. 5.Guideline. I.World Health Organization. ISBN 978 92 4 150956 5 (NLM classification: WC 503.2) © World Health Organization 2015 All rights reserved. Publications of the World Health Organization are available

2015 World Health Organisation HIV Guidelines

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