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Emergency Pediatric Dosing 8-9 kilogram

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1. Emergency Pediatric Dosing 8-9 kilogram

Emergency Pediatric Dosing 8-9 kilogram Emergency Pediatric Dosing 8-9 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 8-9 kilogram Emergency Pediatric Dosing 8-9 kilogram Aka: Emergency Pediatric Dosing 8-9 kilogram , Broselow Red II. Criteria: Body habitus Age: 7-10 months Length: 66.5 to 74 cm Weight: 8-9 kg (mean 8.5 kg) III. Findings: Vital Signs (normal) : 110-185/minute : 25-40/minute Systolic : 65-105 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.17 mg Induction (Sedation) 2.5 mg 17 mg 25 mg Paralytic 17 mg 9 mg 0.9 mg Sedation

2018 FP Notebook

2. Emergency Pediatric Dosing 24-28 kilogram

Emergency Pediatric Dosing 24-28 kilogram Emergency Pediatric Dosing 24-28 kilogram Aka: Emergency Pediatric Dosing 24-28 kilogram , Broselow Orange II. Criteria: Body habitus Age: 7-9 years Length: 122-137 cm Weight: 24-28 kg (mean 27 kg) III. Findings: Vital Signs (normal) : 60-120/minute : 12-25/minute Systolic : 90-115 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Induction (Sedation) 8 mg 53 mg 80 mg Paralytic 53 mg 27 mg 2.7 mg Sedation Maintenance 1.3 mg (...) Emergency Pediatric Dosing 24-28 kilogram Emergency Pediatric Dosing 24-28 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4

2018 FP Notebook

3. Emergency Pediatric Dosing 10-11 kilogram

Emergency Pediatric Dosing 10-11 kilogram Emergency Pediatric Dosing 10-11 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 10-11 kilogram Emergency Pediatric Dosing 10-11 kilogram Aka: Emergency Pediatric Dosing 10-11 kilogram , Broselow Purple II. Criteria: Body habitus Age: 11-18 months Length: 74 to 84.5 cm Weight: 10-11 kg (mean 10.5 kg) III. Findings: Vital Signs (normal) : 110-170/minute : 20-30/minute Systolic : 70-110 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Induction (Sedation) 3.2 mg 20 mg 32 mg Paralytic 20 mg 10 mg 1 mg Sedation Maintenance

2018 FP Notebook

4. Emergency Pediatric Dosing 6-7 kilogram

Emergency Pediatric Dosing 6-7 kilogram Emergency Pediatric Dosing 6-7 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 6-7 kilogram Emergency Pediatric Dosing 6-7 kilogram Aka: Emergency Pediatric Dosing 6-7 kilogram , Broselow Pink II. Criteria: Body habitus Age: 3-6 months Length: 59.5 to 66.5 cm Weight: 6-7 kg (mean 6.5 kg) III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.13 mg Induction (Sedation) 2 mg 13 mg 20 mg Paralytic 13 mg 7 mg 0.7 mg Sedation

2018 FP Notebook

5. Emergency Pediatric Dosing 5 kilogram

Emergency Pediatric Dosing 5 kilogram Emergency Pediatric Dosing 5 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency (...) Pediatric Dosing 5 kilogram Emergency Pediatric Dosing 5 kilogram Aka: Emergency Pediatric Dosing 5 kilogram , Broselow Grey 5 kg II. Criteria: Body habitus Age: 0-2 months Length: 57-61 cm Weight: 5 kg III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 1.5 mg 10 mg 15 mg Paralytic 10 mg 5 mg 0.5 mg Sedation Maintenance 0.25 mg Equipment ET Size

2018 FP Notebook

6. Emergency Pediatric Dosing 4 kilogram

Pediatric Dosing 4 kilogram Emergency Pediatric Dosing 4 kilogram Aka: Emergency Pediatric Dosing 4 kilogram , Broselow Grey 4 kg II. Criteria: Body habitus Age: 0-2 months Length: 52-57 cm Weight: 4 kg III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 1.2 mg 8 mg 12 mg Paralytic 8 mg 4 mg 0.4 mg Sedation Maintenance 0.2 mg Equipment ET Size (...) Emergency Pediatric Dosing 4 kilogram Emergency Pediatric Dosing 4 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency

2018 FP Notebook

7. Emergency Pediatric Dosing 3 Kilogram

Pediatric Dosing 3 Kilogram Emergency Pediatric Dosing 3 Kilogram Aka: Emergency Pediatric Dosing 3 Kilogram , Broselow Grey 3 kg II. Criteria: Body habitus Age: 0-2 months Length: 46-52 cm Weight: 3 kg III. Findings: Vital Signs (normal) : 90-165/minute : 40-60/minute Systolic : 40-60 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 0.9 mg 6 mg 9 mg Paralytic 6 mg 3 mg 0.3 mg Sedation Maintenance 0.15 mg Equipment ET Size (...) Emergency Pediatric Dosing 3 Kilogram Emergency Pediatric Dosing 3 Kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency

2018 FP Notebook

8. Emergency Pediatric Dosing 8-9 kilogram

Emergency Pediatric Dosing 8-9 kilogram Emergency Pediatric Dosing 8-9 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 8-9 kilogram Emergency Pediatric Dosing 8-9 kilogram Aka: Emergency Pediatric Dosing 8-9 kilogram , Broselow Red II. Criteria: Body habitus Age: 7-10 months Length: 66.5 to 74 cm Weight: 8-9 kg (mean 8.5 kg) III. Findings: Vital Signs (normal) : 110-185/minute : 25-40/minute Systolic : 65-105 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.17 mg Induction (Sedation) 2.5 mg 17 mg 25 mg Paralytic 17 mg 9 mg 0.9 mg Sedation

2015 FP Notebook

9. Emergency Adult Dosing 80 kilogram

Emergency Adult Dosing 80 kilogram Emergency Adult Dosing 80 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency Adult (...) Dosing 80 kilogram Emergency Adult Dosing 80 kilogram Aka: Emergency Adult Dosing 80 kilogram II. Criteria: Body habitus Weight: 80 kg III. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 120 mg 250 mcg Induction (Sedation) 24 mg (most common induction agent) 120 mg (preferred in or ) 120 mg (avoid in ) 250 mg (rarely used for induction) 24 mg (rarely used for induction) Paralytic 120 mg 80 mg 8 mg Sedation Maintenance 4 mg Equipment ET Size cuffed (preferred

2018 FP Notebook

10. Emergency Pediatric Dosing 10-11 kilogram

Emergency Pediatric Dosing 10-11 kilogram Emergency Pediatric Dosing 10-11 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 10-11 kilogram Emergency Pediatric Dosing 10-11 kilogram Aka: Emergency Pediatric Dosing 10-11 kilogram , Broselow Purple II. Criteria: Body habitus Age: 11-18 months Length: 74 to 84.5 cm Weight: 10-11 kg (mean 10.5 kg) III. Findings: Vital Signs (normal) : 110-170/minute : 20-30/minute Systolic : 70-110 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Induction (Sedation) 3.2 mg 20 mg 32 mg Paralytic 20 mg 10 mg 1 mg Sedation Maintenance

2015 FP Notebook

11. Emergency Pediatric Dosing 5 kilogram

Emergency Pediatric Dosing 5 kilogram Emergency Pediatric Dosing 5 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency (...) Pediatric Dosing 5 kilogram Emergency Pediatric Dosing 5 kilogram Aka: Emergency Pediatric Dosing 5 kilogram , Broselow Grey 5 kg II. Criteria: Body habitus Age: 0-2 months Length: 57-61 cm Weight: 5 kg III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 1.5 mg 10 mg 15 mg Paralytic 10 mg 5 mg 0.5 mg Sedation Maintenance 0.25 mg Equipment ET Size

2015 FP Notebook

12. Emergency Pediatric Dosing 4 kilogram

Pediatric Dosing 4 kilogram Emergency Pediatric Dosing 4 kilogram Aka: Emergency Pediatric Dosing 4 kilogram , Broselow Grey 4 kg II. Criteria: Body habitus Age: 0-2 months Length: 52-57 cm Weight: 4 kg III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 1.2 mg 8 mg 12 mg Paralytic 8 mg 4 mg 0.4 mg Sedation Maintenance 0.2 mg Equipment ET Size (...) Emergency Pediatric Dosing 4 kilogram Emergency Pediatric Dosing 4 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency

2015 FP Notebook

13. Emergency Pediatric Dosing 6-7 kilogram

Emergency Pediatric Dosing 6-7 kilogram Emergency Pediatric Dosing 6-7 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Emergency Pediatric Dosing 6-7 kilogram Emergency Pediatric Dosing 6-7 kilogram Aka: Emergency Pediatric Dosing 6-7 kilogram , Broselow Pink II. Criteria: Body habitus Age: 3-6 months Length: 59.5 to 66.5 cm Weight: 6-7 kg (mean 6.5 kg) III. Findings: Vital Signs (normal) : 120-180/minute : 40-60/minute Systolic : 65-95 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.13 mg Induction (Sedation) 2 mg 13 mg 20 mg Paralytic 13 mg 7 mg 0.7 mg Sedation

2015 FP Notebook

14. Emergency Pediatric Dosing 3 Kilogram

Pediatric Dosing 3 Kilogram Emergency Pediatric Dosing 3 Kilogram Aka: Emergency Pediatric Dosing 3 Kilogram , Broselow Grey 3 kg II. Criteria: Body habitus Age: 0-2 months Length: 46-52 cm Weight: 3 kg III. Findings: Vital Signs (normal) : 90-165/minute : 40-60/minute Systolic : 40-60 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 0.1 mg Induction (Sedation) 0.9 mg 6 mg 9 mg Paralytic 6 mg 3 mg 0.3 mg Sedation Maintenance 0.15 mg Equipment ET Size (...) Emergency Pediatric Dosing 3 Kilogram Emergency Pediatric Dosing 3 Kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency

2015 FP Notebook

15. Emergency Pediatric Dosing 24-28 kilogram

Emergency Pediatric Dosing 24-28 kilogram Emergency Pediatric Dosing 24-28 kilogram Aka: Emergency Pediatric Dosing 24-28 kilogram , Broselow Orange II. Criteria: Body habitus Age: 7-9 years Length: 122-137 cm Weight: 24-28 kg (mean 27 kg) III. Findings: Vital Signs (normal) : 60-120/minute : 12-25/minute Systolic : 90-115 mmHg IV. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Induction (Sedation) 8 mg 53 mg 80 mg Paralytic 53 mg 27 mg 2.7 mg Sedation Maintenance 1.3 mg (...) Emergency Pediatric Dosing 24-28 kilogram Emergency Pediatric Dosing 24-28 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4

2015 FP Notebook

16. Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants

Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric (...) Description: This study will enroll participants with major depressive disorder (MDD) presenting with suicidal ideation who are assessed to be at imminent risk for suicide. The study will be conducted in 4 phases: a screening evaluation performed within 48 hours prior to Day 1 intranasal dose; a 25-day double-blind treatment phase (Days 1-25); an 8‑week initial post-treatment phase (Days 25-81); and a subsequent phase to complete a full 6‑month post-treatment follow-up (Days 81-200). Efficacy, safety

2017 Clinical Trials

17. Emergency Adult Dosing 80 kilogram

Emergency Adult Dosing 80 kilogram Emergency Adult Dosing 80 kilogram Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Emergency Adult (...) Dosing 80 kilogram Emergency Adult Dosing 80 kilogram Aka: Emergency Adult Dosing 80 kilogram II. Criteria: Body habitus Weight: 80 kg III. Medications: Rapid Sequence Intubation (RSI) and intubation and ventilation Pretreatment 120 mg 250 mcg Induction (Sedation) 24 mg (most common induction agent) 120 mg (preferred in or ) 120 mg (avoid in ) 250 mg (rarely used for induction) 24 mg (rarely used for induction) Paralytic 120 mg 80 mg 8 mg Sedation Maintenance 4 mg Equipment ET Size cuffed (preferred

2015 FP Notebook

18. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures

to children. Abbreviations: AAP — American Academy of Pediatrics AAPD — American Academy of Pediatric Dentistry ASA — American Society of Anesthesiologists BIS — bispectral index CPAP — continuous positive airway pressure ECG — electrocardiography EEG — electroencephalogram/electroencephalography EMS — emergency medical services LMA — laryngeal mask airway MRI — magnetic resonance imaging OSA — obstructive sleep apnea PALS — pediatric advanced life support Introduction The number of diagnostic and minor (...) surgical procedures performed on pediatric patients outside of the traditional operating room setting has increased in the past several decades. As a consequence of this change and the increased awareness of the importance of providing analgesia and anxiolysis, the need for sedation for procedures in physicians’ offices, dental offices, subspecialty procedure suites, imaging facilities, emergency departments, other inpatient hospital settings, and ambulatory surgery centers also has increased markedly

2019 American Academy of Pediatrics

19. Principles of Pediatric Patient Safety: Reducing Harm Due to Medical Care

of or method of using a treatment, 11% involved patient misidentification, and 7% involved delays or errors in diagnosis. , , Pediatric errors in emergency department (ED) settings may be attributable to multiple factors, including incorrect patient identification, lack of experience of many ED staff with pediatric patients versus with adults, and challenges with performing technical procedures in and calculating medication doses for children. , Other sources of error include communication between (...) of absorption and excretion ability, dependence on others for medication administration, and need for specially compounded formulations. Accurate weight scales that only measure in metric units (kilograms or grams), standardized equipment throughout a system, drug dose range limits, programmable “smart” infusion pumps for hospitals, and standardized order sets should be used. , Drug shortages have recently become an additional safety risk. Clinical pharmacists who are trained in pediatrics are invaluable

2019 American Academy of Pediatrics

20. The economic evaluation of early intervention with Anti-Tumor Necrosis Factor-? treatments in pediatric Crohn's disease

cost-utility ratio IFX Infliximab IM Immunomodulator ISPOR International Society For Pharmacoeconomics and Outcomes Research MOHLTC Ontario Ministry of Health and Long-Term Care kcal Calorie kg Kilogram mg Milligram MTA Material transfer agreement MTX Methotrexate NICE National Institute for Health and Care Excellence (United Kingdom) OCCI Ontario Case Costing Initiative OR Odds ratio PCDAI Pediatric Crohn’s Disease Activity Index PGA Physician Global Assessment QALY Quality-adjusted life year RCT (...) -TNF-a Interventions and How They Might Work 7 1.4 Clinical Efficacy of Anti-TNF-a Treatments in Pediatric Crohn’s Disease 8 1.4.1 Studies and Reviews of the Clinical Efficacy of Anti-TNF-a Treatments 8 1.5 Economic Evaluations and Health Technology Assessments of Anti-TNF-a Treatments in Crohn’s Disease 13 1.6 Treatment Pathway in Crohn’s Disease 18 1.7 Theoretical Framework 19 1.8 The Problem 23 1.9 Primary Objective 23 1.10 Secondary Objective 24 1.11 Research Design 25 Methods 27 vi 2.1

2019 SickKids Reports

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