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41. IMPLEMENTATION OF AN ELECTRONIC PRESCRIPTION CHART FOR GENTAMICIN FOR NEONATAL UNITS AND POSTNATAL WARDS. (PubMed)

IMPLEMENTATION OF AN ELECTRONIC PRESCRIPTION CHART FOR GENTAMICIN FOR NEONATAL UNITS AND POSTNATAL WARDS. Since the introduction of NICE guidance for Early Onset Neonatal Sepsis (EONS)1 in August 2012, the number of locally reported prescribing and administration errors involving gentamicin has increased. This guideline introduced a new, unfamiliar regimen to staff working on the Neonatal Units and Postnatal wards. Analysis of the errors suggested 36 hourly frequency of gentamicin contributed (...) to the errors due to the complexities of prescribing on the paper drug chart. Our aim was to reduce errors involving gentamicin through the introduction of a Microsoft Excel® based electronic prescription chart.Local medication incident reports for gentamicin were analysed from 1st September 2013 to 3rd October 2014 (prior to the introduction of the new prescription chart). The new prescription chart was introduced from 5 January 2015. Incident reports continued to be monitored until 30th July 2015

2016 Archives of Disease in Childhood

42. AN ELECTRONIC PRESCRIPTION ALERTING SYSTEM-IMPROVING THE DISCHARGE MEDICINES PROCESS. (PubMed)

AN ELECTRONIC PRESCRIPTION ALERTING SYSTEM-IMPROVING THE DISCHARGE MEDICINES PROCESS. Whilst the prescribing of both in-patient and discharge medicines is electronic, there was no automatic notification to clinical pharmacists when a discharge prescription was ready to be screened. The notification required a member of medical or nursing staff to bleep their pharmacist informing them of a prescription's availability. This manual process led to a delay in pharmacist screening which impacted (...) the email body. The email is sent to named individuals within a given distribution list. The function is scalable to support all areas using Trust eDischarge Summaries.The system was introduced in April 2015. Data from before (June 2014-January 2015) and after (June 2015) implementation was compared.Prior to the introduction of an electronic alerting system the average time from a prescriber signing a prescription to clinical pharmacist screening was 93 minutes. Three months after starting the new

2016 Archives of Disease in Childhood

43. Optimized Computerized Order Entry can Reduce Errors in Electronic Prescriptions and Associated Pharmacy Calls to Clarify (CTC) (PubMed)

Optimized Computerized Order Entry can Reduce Errors in Electronic Prescriptions and Associated Pharmacy Calls to Clarify (CTC) After implementation of a system-wide EMR within our university system, e-prescribing is now commonplace.The authors conducted a study to assess whether optimization of computerized provider order entry (CPOE) can reduce errors in these electronically transmitted prescriptions and would require less frequent interventions from pharmacists, in particular the need (...) for them to "call to clarify" (CTC) details of particular prescriptions. Secondary analysis based on cost assumptions was preformed to presume cost differences before and after optimization changes.In order to generate complete, error-free prescriptions, optimization changes were implemented in the form of in line validation messages. These messages were generated if (1) an order did not specify a provider or pharmacy; (2) the DEA requirements were not met; (3) character limits were exceeded in patient

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2016 Applied clinical informatics

44. New approaches to pharmacosurveillance for monitoring prescription frequency, diversity, and co-prescription in a large sentinel network of companion animal veterinary practices in the United Kingdom, 2014–2016 (PubMed)

; this raises important questions regarding the efficacy and safety of PAs prescribed to companion animals. This study explored new approaches for describing PA prescription, diversity and co-prescription in dogs, cats and rabbits utilising electronic health records (EHRs) from a sentinel network of 457 companion animal-treating veterinary sites throughout the UK over a 2-year period (2014-2016). A novel text mining-based identification and classification methodology was utilised to semi-automatically map (...) New approaches to pharmacosurveillance for monitoring prescription frequency, diversity, and co-prescription in a large sentinel network of companion animal veterinary practices in the United Kingdom, 2014–2016 Pharmaceutical agents (PAs) are commonly prescribed in companion animal practice in the United Kingdom. However, little is known about PA prescription on a population-level, particularly with respect to PAs authorised for human use alone prescribed via the veterinary cascade

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2018 Preventive veterinary medicine

45. Interstate data sharing of prescription drug monitoring programs and associated opioid prescriptions among patients with non-cancer chronic pain. (PubMed)

Interstate data sharing of prescription drug monitoring programs and associated opioid prescriptions among patients with non-cancer chronic pain. All fifty states have implemented prescription drug monitoring programs (PDMPs) to reduce misuse and diversion of controlled drugs. Interstate PDMP data sharing has been called for by clinical practitioners, but evidence to support the effectiveness of PDMP data sharing is lacking. This study examined whether PDMP interstate data sharing (...) with bordering states was associated with prescriptions of opioids. This was a cross-sectional study that included patients with non-cancer chronic pain from the 2014 National Ambulatory Medical Care Survey (weighted N = 66,198,751; unweighted N = 2846). Multinomial logistic regression was performed to examine the association between PDMP interstate data sharing status and patients' being prescribed opioids for pain treatment, controlling for covariates guided by the Eisenberg's model of physician decision

2018 Preventive Medicine

46. CEO Statement: Electronic cigarettes (e-cigarettes)

CEO Statement: Electronic cigarettes (e-cigarettes) CEO Statement: Electronic cigarettes | NHMRC NHMRC Tagline NHMRC Tagline Publication date Publication date Content type Filtered by: All Publications News Page Search Quick links Toggle navigation Main navigation Funding One researcher has the potential to improve millions of lives. We provide funding for research through our grant system, with a transparent peer-review process to determine how funding is allocated. May 07 2018 May 07 2018 (...) and help them protect intellectual property. Jun 14 2018 Jul 25 2018 About us At NHMRC we are excited by the huge potential benefits of the research we fund and by the opportunities we have to ensure Australians have access to evidence-based, authoritative health advice. We create pathways to a healthier future through our research funding, our health guidelines and the ethical standards we set and uphold. Jul 25 2018 Jul 25 2018 CEO Statement: Electronic cigarettes CEO Statement: Electronic cigarettes

2018 National Health and Medical Research Council

47. Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications. (PubMed)

Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications. The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further (...) propose CDSS.A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio.The MEmind web-application reported that antipsychotics

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2016 PLoS ONE

48. Electronic prescribing: risk of potentially harmful errors

physician order entry, CPOE). Some of these errors are similar to those seen with handwritten prescriptions, while others are specific to electronic prescribing and arise through complex mechanisms. Software bugs, computer failure and unreliable or slow internet connections can lead to errors and data loss. The way information is displayed on the screen, often too dense, is also a source of errors. Inputting text outside a field subject to checks – which is often used to bypass a problem – runs the risk (...) Electronic prescribing: risk of potentially harmful errors Prescrire IN ENGLISH - Spotlight ''Electronic prescribing: risk of potentially harmful errors'', 1 July 2016 {1} {1} {1} | | > > > Electronic prescribing: risk of potentially harmful errors Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Electronic prescribing: risk of potentially harmful

2016 Prescrire

49. Prescribing and Dispensing Policies to Address Harms Associated With Prescription Drug Abuse

-resistant prescription pads or electronic PDMPs. Some Canadian, US, and New Zealand jurisdictions have payer incentives for pharmacist activities that address suspected misuse and abuse, such as refusing to fill a prescription. Some jurisdictions also restrict patients to a limited number of pharmacies or prescribers for accessing opioids, stimulants, and benzodiazepines. Prescription Drug–Monitoring Programs Most Canadian jurisdictions have some form of PDMP, or have programs in development. 1 (...) Prescribing and Dispensing Policies to Address Harms Associated With Prescription Drug Abuse Prescribing and Dispensing Policies to Address Harms Associated With Prescription Drug Abuse | CADTH.ca Find the information you need Prescribing and Dispensing Policies to Address Harms Associated With Prescription Drug Abuse Prescribing and Dispensing Policies to Address Harms Associated With Prescription Drug Abuse Published on: October 28, 2015 Project Number: ES0291-000 Product Line: Research Type

2015 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

50. Secure Prescription Pads for Prescribing of Medications Prone to Abuse and Misuse

study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Secure Prescription Pads for Prescribing (...) Secure Prescription Pads for Prescribing of Medications Prone to Abuse and Misuse Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

51. Short-Term Prescription Refills for Patients Receiving Chronic Drug Therapy

study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Short-Term Prescription Refills for Patients (...) Short-Term Prescription Refills for Patients Receiving Chronic Drug Therapy Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

52. Prescription opioid use disorder and heroin use among youth nonmedical prescription opioid users from 2002 to 2014 (PubMed)

Prescription opioid use disorder and heroin use among youth nonmedical prescription opioid users from 2002 to 2014 27614657 2018 04 04 2018 11 13 1873-6327 65 2017 02 Addictive behaviors Addict Behav Prescription opioid use disorder and heroin use among 12-34 year-olds in the United States from 2002 to 2014. 236-241 S0306-4603(16)30314-8 10.1016/j.addbeh.2016.08.033 Martins Silvia S SS Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th St., New York (...) , NY 10032, USA. Electronic address: ssm2183@columbia.edu. Segura Luis E LE Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th St., New York, NY 10032, USA. Electronic address: les2196@cumc.columbia.edu. Santaella-Tenorio Julian J Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th St., New York, NY 10032, USA. Electronic address: js4222@cumc.columbia.edu. Perlmutter Alexander A Department of Epidemiology

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2016 Addictive behaviors

53. Continued Statin Prescriptions After Adverse Reactions and Patient Outcomes: A Cohort Study. (PubMed)

Continued Statin Prescriptions After Adverse Reactions and Patient Outcomes: A Cohort Study. Many patients discontinue statin treatment, often after having a possible adverse reaction. The risks and benefits of continued statin therapy after an adverse reaction are not known.To examine the relationship between continuation of statin therapy (any prescription within 12 months after an adverse reaction) and clinical outcomes.Retrospective cohort study.Primary care practices affiliated with 2 (...) academic medical centers.Patients with a presumed adverse reaction to a statin between 2000 and 2011.Information on adverse reactions to statins was obtained from structured electronic medical record data or natural-language processing of narrative provider notes. The primary composite outcome was time to a cardiovascular event (myocardial infarction or stroke) or death.Most (81%) of the adverse reactions to statins were identified from the text of electronic provider notes. Among 28 266 study patients

2017 Annals of Internal Medicine

54. Zolpidem in comatose patients: Prescriptions on clinical practice and time for a new randomized clinical trial. (PubMed)

Zolpidem in comatose patients: Prescriptions on clinical practice and time for a new randomized clinical trial. 30682515 2019 01 25 1878-8769 2019 Jan 22 World neurosurgery World Neurosurg Zolpidem in comatose patients: Prescriptions on clinical practice and time for a new randomized clinical trial. S1878-8750(19)30146-9 10.1016/j.wneu.2019.01.049 Welling Leonardo C LC Neurological Surgery Department. State University of Ponta Grossa. Brazil. Welling Mariana S MS Neurology Department. State (...) University of Ponta Grossa. Brazil. Figueiredo Eberval G EG Neurological Surgery Department. University of Sao Paulo. Brazil. Electronic address: ebgadelha@yahoo.com. eng Journal Article 2019 01 22 United States World Neurosurg 101528275 1878-8750 2019 1 26 6 0 2019 1 27 6 0 2019 1 27 6 0 aheadofprint 30682515 S1878-8750(19)30146-9 10.1016/j.wneu.2019.01.049

2019 World neurosurgery

55. Identifying Factors That Predict the Prescription of Non-vitamin K Antagonist Oral Anticoagulants in Older Individuals With Atrial Fibrillation. (PubMed)

Identifying Factors That Predict the Prescription of Non-vitamin K Antagonist Oral Anticoagulants in Older Individuals With Atrial Fibrillation. Factors that influence decision of non-vitamin K antagonist oral anticoagulants (NOACs) use among older atrial fibrillation (AF) patients in long-term care (LTC) facilities have not been well studied. The aim of this study was to assess whether increased frailty influenced physicians to prescribe NOACs over warfarin.We retrospectively reviewed (...) the electronic medical record (EMR) and pharmacy data of 25 LTC facilities in Ontario, Canada, in May 2015. The diagnosis of AF was ascertained from EMR and confirmed by complete chart review of a random sample of the cohort. A score of ≥2 on the Changes in Health, End-stage disease, Signs, and Symptoms (CHESS) scale was used as a surrogate marker of frailty.Multivariable logistic regression model was used to assess whether a higher frailty score is associated with the use of NOACs in comparison to warfarin

2019 Journal of the American Medical Directors Association

56. Long-term assessment of NSAID prescriptions and potential nephrotoxicity risk in adult kidney transplant recipients. (PubMed)

retrospectively followed in the VA system from 2001-10 that assessed for risk of AKI with NSAID prescriptions. NSAID prescriptions, patient characteristics and eGFRs were abstracted from the VA comprehensive electronic health record. NSAID exposure was assessed by duration, dosage and type. AKI events were defined by ≥50% decrease in eGFR. Risk was estimated using longitudinal multivariable generalized logistic regression model.5,100 patients were included with a total of 29,980 years of follow up; 671 NSAID (...) Long-term assessment of NSAID prescriptions and potential nephrotoxicity risk in adult kidney transplant recipients. NSAID use is recommended to be avoided in kidney transplantation (KTX), with a paucity of studies assessing their safety within this population. This study aims to use a large cohort of Veterans Affairs (VA) KTX recipients to assess the risk of acute kidney injury (AKI) with NSAID use.This is a ten-year longitudinal cohort study of adult kidney transplant recipients

2019 Transplantation

57. Intervention to reduce benzodiazepine prescriptions in primary care, study protocol of a hybrid type 1 cluster randomised controlled trial: the BENZORED study. (PubMed)

prescription and BZD deprescribing, monthly feedback about their BZD prescribing practices and access to a support web page. Outcome measures for each GP are the defined daily dosage per 1000 inhabitants per day and the proportion of long-term BZD users at 12 months. Data will be collected from the electronic prescription database of the public health system, and will be subjected to intention-to-treat analysis. Implementation will be evaluated by mixed methods following the five domains (...) Intervention to reduce benzodiazepine prescriptions in primary care, study protocol of a hybrid type 1 cluster randomised controlled trial: the BENZORED study. Benzodiazepines (BZDs) are mainly used to treat anxiety and sleep disorders, and are often prescribed for long durations, even though prescription guidelines recommend short-term use due to the risk of dependence, cognitive impairment, and falls and fractures. Education of general practitioners (GPs) regarding the prescription of BZDs

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2019 BMJ open

58. Examining the effect of prescription sequence on developing adverse drug reactions: The case of renal failure in diabetic patients. (PubMed)

emergent sequential pattern mining techniques to electronic health records.Using longitudinal medication and diagnosis records from more than 377,000 diabetic patients, in this study, we assessed the possible effect of prescription sequences in developing acute renal failure as a prevalent ADR among this group of patients. Relying on emergent sequential pattern mining, two statistical case-control approaches were designed and employed for this purpose.The results taken from the two employed approaches (...) Examining the effect of prescription sequence on developing adverse drug reactions: The case of renal failure in diabetic patients. While the effect of medications in development of Adverse Drug Reactions (ADRs) have been widely studied in the past, the literature lacks sufficient coverage in investigating whether the sequence in which [ADR-prone] drugs are prescribed (and administered) can increase the chances of ADR development. The present study investigates this potential effect by applying

2019 International journal of medical informatics

59. Preoperative Exposure to Benzodiazepines or Sedative/hypnotics Increases the Risk of Greater Filled Opioid Prescriptions After Surgery. (PubMed)

of opioids, benzodiazepines, and sedative/hypnotics filled 6 months before and after the procedure. Patients were grouped into exposed or naïve cohorts depending on whether a prescription was filled 6 months before surgery. Smoking history (current or previous smoking was considered positive) and a history of mood and pain disorders (as noted in the medical history), were collected from the outpatient and the operating room electronic medical record.After controlling for age, gender, and other (...) Preoperative Exposure to Benzodiazepines or Sedative/hypnotics Increases the Risk of Greater Filled Opioid Prescriptions After Surgery. The effect of the preoperative exposure to controlled substances such as benzodiazepines and sedative/hypnotics on prolonged opioid consumption after hand surgery is not known.(1) Is preoperative exposure to benzodiazepines and sedative/hypnotics associated with greater numbers of filled postoperative opioid prescriptions after hand surgery? (2) Is a positive

2019 Clinical Orthopaedics and Related Research

60. The utility of a statewide prescription drug-monitoring database vs the Current Opioid Misuse Measure for identifying drug-aberrant behaviors in emergency department patients already on opioids. (PubMed)

The utility of a statewide prescription drug-monitoring database vs the Current Opioid Misuse Measure for identifying drug-aberrant behaviors in emergency department patients already on opioids. The most recent guidelines on prescribing opioids from the United States Centers for Disease Control recommend that clinicians not prescribe opioids as first-line therapy for chronic non-cancer pain. If an opioid prescription is considered for a patient already on opioids, prescribers are encouraged (...) to check the statewide prescription drug monitoring database (PDMP). Some additional guidelines recommend screening tools such as the Current Opioid Misuse Measure (COMM) which may also help identify drug-aberrant behaviors.To compare the PDMP and the Current Opioid Misuse Measure (COMM), a commonly-recommended screening tool for patients on opioids, in detecting drug-aberrant behaviors in patients already taking opioids at the time of ED presentation.Patients on opioids were enrolled prospectively

2019 American Journal of Emergency Medicine

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