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4241. A cost-utility analysis of mitoxantrone hydrochloride and interferon beta-Ib in the treatment of patients with secondary progressive or progressive relapsing multiple sclerosis

, which were derived from the manufacturers' package inserts; the costs associated with treating urinary tract infections in patients treated with MHCl, which were estimated using fee-for-service prescription claims data from the Oregon Medicaid programme; and the costs related to therapy intake, such as referrals to the oncology unit, echocardiograms, pre-medication with an antiemetic, and determination of clinical tests as recommended by the package insert. Outpatient charges from these tests were (...) in the USA, and have been approved by the US Food and Drug administration for the treatment of patients with MS. You should decide if these are widely used health interventions in your own setting. Validity of estimate of measure of effectiveness The authors performed an adequate review of the literature, identifying studies through electronic searches and hand searches. It would appear that the review was conducted systematically, so as to identify all relevant research and minimise biases. Further

2003 NHS Economic Evaluation Database.

4242. Elbow orthoses: a review of literature

Elbow orthoses: a review of literature Elbow orthoses: a review of literature Elbow orthoses: a review of literature Hijmans J M, Postema K, Geertzen J H CRD summary This review aimed to assess the scientific basis of the prescription of elbow orthoses. The authors concluded that current prescriptions of elbow orthoses cannot be evidence-based, because no scientific evidence on elbow orthoses is available. However, potential flaws in the conduct of the review mean that relevant evidence might (...) have been overlooked. Authors' objectives To review the available literature on elbow orthoses in patients with various diagnoses, to assess the scientific base of the prescription of elbow orthoses. Searching MEDLINE, EMBASE, the Cochrane Library and RECAL Information Services were searched from 1989 to June 2003; the search terms were reported. In addition, the references of included studies were checked for further relevant studies. Study selection Study designs of evaluations included

2004 DARE.

4243. Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension: an evidence-based review

treatment regimen and the patient’s actual dosing history. Studies that assessed other forms of noncompliance without reporting separate data for treatment compliance were excluded from the review. The outcomes assessed in the review included: amount of drug used; patient’s own estimate of compliance; percentage of time patients remembered to take their medication; mean number of repeat prescription refill requests; proportion of missed doses; the proportion of time exceeding the recommended 8-hour dose (...) that was supported by a reasonable literature search of electronic databases and other sources. However, some relevant studies might have been missed as only studies written in a limited number of European languages were eligible for inclusion. It is also unclear how extensive any efforts were to locate unpublished data. Efforts were made to reduce the risk of error and bias when selecting and extracting the study data, and the quality of the studies was assessed using published criteria, though it is not clear

2004 DARE.

4244. Seat inclinations affect the function of children with cerebral palsy: a review of the effect of different seat inclines

seat incline. CRD commentary The review question was broadly defined in terms of the participants, interventions and study designs of interest. A wide range of electronic databases and relevant journals were searched, though the restriction to English language studies might have introduced language bias. It was unclear whether the search was also restricted to published studies, so the potential for publication bias cannot be excluded. In addition, the authors did not describe any attempts (...) the assessment of seat incline need with actual seat prescription and subsequent performance of the child, rather than on which kind of incline is best. Funding Not stated. Bibliographic details McNamara L, Casey J. Seat inclinations affect the function of children with cerebral palsy: a review of the effect of different seat inclines. Disability and Rehabilitation 2007; 2(6): 309-318 Indexing Status Subject indexing assigned by CRD MeSH Adolescent; Cerebral Palsy /rehabilitation; Child; Child, Preschool

2007 DARE.

4245. Meta-analysis of oral triptan therapy for migraine: number needed to treat and relative cost to achieve relief within 2 hours

searched to identify primary studies MEDLINE and EMBASE were searched electronically. The reference lists from primary or benchmark papers and review articles were searched manually. Criteria used to ensure the validity of primary studies Not reported. Methods used to judge relevance and validity, and for extracting data The methods used to judge relevance, validity or extracting data were not reported. However, the authors stated that, although direct comparative trials are the ideal means (...) calculation. Measure of benefits used in the economic analysis The measure of benefit used for the synthesis with the costs was the number of patients with freedom of pain within 2 hours of the initial dosing. However, the NNT was calculated as the reciprocal of the measure of benefit and was multiplied by the costs in the cost-effectiveness analysis. The NNT was derived from the results of the review. Direct costs The only direct cost included was that of prescription drugs. The costs were not discounted

2003 NHS Economic Evaluation Database.

4248. A systematic review of the evidence for incentive schemes to encourage positive health and other social behaviours in young people

expressed in this publication are not necessarily those of the EPPI- Centre or the funders. Responsibility for the views expressed remains solely with the authors. ELECTRONIC VERSION ISBN: 0-9551548-6-3 978-0-9551548-6-7 © Copyright Authors of the systematic reviews on the EPPI-Centre website ( hold the copyright for the text of their reviews. The EPPI- Centre owns the copyright for all material on the website it has developed, including the contents of the databases, manuals (...) in health, education and other social behaviours. 2.3.2 Identification of studies Because of the challenges of searching for literature on this topic across a number of subject domains, a range of sources were used to identify reports of relevant research. These included searches of electronic bibliographic databases and registers; scanning of indexes of key journals; checking reference lists of key papers; checking for references on key websites; use of personal contacts and contact with our

2006 EPPI Centre

4249. Optical devices for adults with low vision: a systematic review of published studies of effectiveness

. The prevalence of vision loss both in the general and veteran populations is projected to increase dramatically over the next 20 years. With this trend is a growing need for low vision services targeted at detecting visual impairment and mitigating the functional consequences associated with age-related vision loss to improve quality of life. - Provision of low vision services, including low vision devices, to veterans is a priority for VA. Popular among veterans and practitioners are electronic optical (...) devices such as closed circuit TV (CCTV), computer assistive technologies, and non-electronic hand held models. However, advocates for visually impaired veterans have expressed concern over the quality of scientific evidence supporting the use of many low vision devices, particularly newly emerging electronic devices. - A multidisciplinary task force of VA vision care experts has been charged with developing a process for evidence-based new technology evaluation and dissemination of information in VA

2003 Health Technology Assessment (HTA) Database.

4251. A controlled comparison study to evaluate different management strategies for workplace trauma Copyright © 2006 British Occupational Health Research Foundation No part of this publication may be reproduced or used in any form by any means– graphic, electronic or mechanical including photocopying, recording, taping or information storage or retrieval systems – without prior permission in writing from the British Occupational Health Research Foundation. British Library Cataloguing-in-Publication Data A catalogue record for this publication is available from the British Library ISBN 1

2006 British Occupational Health Research Foundation

4252. Workplace interventions for people with common mental health problems

that described non-work based interventions; our main criteria were that the study passed the critical appraisal process and that employment was among the outcome measures. As a consequence there are several studies where the intervention was targeted at practitioners such as primary care physicians, but the outcomes were focused on return to work or remaining in employment for people with common mental health problems. Electronic searches produced more than 15000 references. Subsidiary searches included

2005 British Occupational Health Research Foundation

4253. Evaluation of the Uptake of Advice, Directives and Guidelines to the NHS Concerning Patient Safety by the SABS System

patient safety by the Safety Alert Broadcast System Executive Summary Overview The Safety Alert Broadcast System (SABS) was established in 2004 as one of the responses to the recommendations in the Department of Health’s (DH) 2001 report Building a safer NHS for patients, itself the implementation plan following the DH’s 2000 report An organisation with a memory. SABS is an electronic system developed by the DH to disseminate patient safety alerts issued to the NHS from the Medicines and Healthcare (...) products Regulatory Agency (MHRA); the National Patient Safety Agency (NPSA); DH Estates and Facilities Division (DHE&F) and the DH itself (which has issued two). The aim of the SABS system is to bring the different types of alerts together into one electronic system and to streamline the way in which the alerts are issued. The system also requires trusts to feedback to the Patient Safety Team the relevance of the alert to the organisation, the action taken, and the date of the completion of the action

2007 York Health Economics Consortium

4254. Intermediate care - Hospital at Home in COPD

geographically removed from hospital. Some of the studies were slightly more prescriptive and required an ECG to be performed, 4 or excluded subjects with any respiratory failure 28 or those with newly diagnosed type 2 respiratory failure. 5 [Level of evidence III] Recommendations HaH should not be offered to patients with: N (R2) Impaired level of consciousness. [Grade C] N (R3) Acute confusion. [Grade C] N (R4) pH ,7.35, if arterial blood gases have been measured. [Grade C] N (R5) Acute changes on chest (...) recorded. Oxygen saturation was measured by oximetry. The studies on the role of oral steroids in exacerbations have used changes in FEV 1 as an outcome measure and have shown that this measurement can detect recovery from an exacerba- tion. 40 Furthermore, a low FEV 1 value at admission associated with failure to improve over the first few days of an exacerbation in hospital was highly predictive of a poor clinical outcome. 41 In some HaH studies spirometry was carried out using portable electronic

2007 British Thoracic Society

4255. Evidence Based Research: Effectiveness of Grabrail Orientations During the Sit-to-Stand Transfer

on the body and areas which require further research. Design: To complete this research project a systematic review protocol was adopted. This is a rigorous process ensuring that all relevant and available literature on a given topic is located, reviewed and analysed. A specific search strategy was developed to ensure a comprehensive search of all data sources was completed. The data included in this review was obtained from a variety of sources including electronic databases, the World Wide Web (...) , & Robitaille, 1993). Thus grabrail prescription and installation, has the potential to minimise the effects that disability or old age have on the performance of the sit to stand transfer. The primary purpose of the majority of grabrails installed in the bathroom and toilet is to assist a difficult transfer in a wet environment. Provision of grabrails at toilets are often seen as a prerequisite for safe and independent toileting, particularly in the older population (Sanford et al., 1995). Therefore

2006 Home Modification Information Clearinghouse

4256. Coatings: Evidence Based Research: Selecting Coatings for Tiled Floors

Coatings: Evidence Based Research: Selecting Coatings for Tiled Floors Evidence Based Research: Selecting Coatings for Tiled Floors K. Whitfield, C. Bridge & S. Mathews Abstract: Objectives: To determine the occupational risk and safety factors surrounding the prescription of coating products to improve the slip resistance of glazed tiles surfaces particularly bathroom surfaces within the homes of persons with mobility impairment. Design: Systematic review of electronic and other published

2005 Home Modification Information Clearinghouse

4257. Evidence Based Research: Selecting Diameters for Grabrails

Evidence Based Research: Selecting Diameters for Grabrails Diameter: Evidence based research: Selecting diameters for grabrails: January 2006 F ISBN: 1 86487 761 8 Objectives: To determine the suitability of grabrails with a 25mm outside diameter for supporting older people in their homes. Design: Systematic review of electronic and other published literature. Main outcome measures: Hand size and grasp type are critical measures (...) ). Appropriate prescription of grabrails must consider the person, the intended activity and the specific context or environment where the activity occurs. Inappropriate prescription or design of grabrails has social and economic costs including non-use of the rail, secondary disability, injury to carers, premature admission to residential care, and decreased independence (Bridge, 1998; Clemson & Martin, 1996; Cooper, 1991; Hunter, 1992; O'Meara, 2004; Sanford, Arch & Megrew, 1995; Sanford, 2001). Hence

2006 Home Modification Information Clearinghouse

4258. Evidence Based Research: Use of Reeded (Ribbed) Timber for Decks, Ramps and Paths

Evidence Based Research: Use of Reeded (Ribbed) Timber for Decks, Ramps and Paths Reeded Timber: Evidence based research: May 2003 F ISBN: 1 86487 568 2 ! Objectives: To determine the occupational risk and safety factors surrounding the prescription of reeded decking ramps in the homes of persons with mobility impairment. Design: Systematic review of electronic and other published literature. Main outcome measures: Co-efficient of friction (COF

2003 Home Modification Information Clearinghouse

4259. A compliance questionnaire could discriminate among patients for drug taking behaviour and correct dosing in rheumatic diseas

Clinical prediction guide A compliance questionnaire could discriminate among patients for drug taking behaviour and correct dosing in rheumatic diseases Free John F Steiner , MD, MPH Statistics from de Klerk E, van der Heijde D, Landewé R, et al . The compliance-questionnaire-rheumatology compared with electronic medication event monitoring: a validation study. J Rheumatol 2003 ; 30 : 2469 –75. Q In patients with rheumatic diseases, how well does the compliance questionnaire rheumatology (...) (CQR) predict compliance with taking medications and correct dosing compared with an electronic medication event monitoring system (MEMS)? Clinical impact ratings GP/FP/Primary care ★★★☆☆☆☆ Internal medicine ★★★★☆☆☆ Rheumatology ★★★★★★☆ METHODS Design: cohort study to validate a previously derived self administered questionnaire. Setting: outpatient rheumatology wards of 3 hospitals in the Netherlands. Patients: 127 patients (mean age 61 y, 57% women) who had rheumatoid arthritis and were taking

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2005 Evidence-Based Medicine (Requires free registration)

4260. BPG for the Subcutaneous Administration of Insulin in Adults with Type 2 Diabetes

endorsement of any of these products. Copyright With the exception of those portions of this document for which a specific prohibition or lim- itation against copying appears, the balance of this document may be produced, reproduced and published, in any form, including in electronic form, for educational or non-commercial purposes, without requiring the consent or permission of the Registered Nurses Association of Ontario, provided that an appropriate credit or citation appears in the copied work

2004 Registered Nurses' Association of Ontario

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