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4221. Carnitine and Liver Mitochondria Fatty Acid Processing

contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years to 40 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Age 20-40 years BMI of 24.5-35.5 kg/m2 Willingness to eat a prescribed diet of standard meals for a total of six days Willingness to undergo carnitine or placebo supplementation for two weeks Willingness to undergo study (...) significant and represent a problem for study inclusion Screening fasting glucose > 125 mg/dL Screening blood pressure >140 systolic or >90 diastolic Use of certain prescribed medications at the discretion of the MI Smoking or use of tobacco products in the last 6 months Pregnancy or breastfeeding Clinically diagnosed neuropsychiatric conditions Diets that deviate extremely from the typical western diet in terms of increased meat intake are excluded, at the discretion of the MI. Known aversion

2017 Clinical Trials

4222. Low Vision Patients' Preference for Colored Filters and Illumination for Near Reading Determined by the LuxIQ/2

have been inconsistent. Traditionally, filters and optimal illumination are prescribed clinically through a trial and error method, which involves trying various filters and lamps haphazardly to determine which if any are preferred by the patient. The investigators are proposing to evaluate whether the illumination and filters chosen in office by participants using a new assessment tool the LuxIQ/2 translate to overall patient comfort and improved speed, accuracy and print size while reading (...) consent Exclusion Criteria: Subjects who reside in areas outside of Broward and Palm Beach Counties Subjects with a score less than 21 on the TICS-M Subjects diagnosed with Dry Eye Syndrome determined by clinical signs, history of or current topical prescription medication (i.e., Restasis or Xiidra) usage, or the usage of other dry eye treatment including punctal plugs, instillation of artificial tears more than once per day and advanced dry eye treatment Subjects with poor vision who would require

2017 Clinical Trials

4223. Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model

) to comply with all study requirements for the duration of the study Agreement to undergo all study procedures, to attend all study visits and stay overnight for observations as required, up to and including the last follow-up visit Willingness to undergo a CHMI by DVI with PfSPZ Challenge Reachable (24/7) by mobile phone or electronic mail during the whole study period Agreement to refrain from blood donation during the course of the study and after the end of their involvement in the study according (...) to the use of chloroquine phosphate, atovaquone-proguanil, artemether or lumefantrine Use of any prescription drugs, herbal supplements (e.g. St John's Wort), or over-the-counter medication within 7 days or five half-lives (whichever is longer) prior to IMP administration, or an anticipated requirement for the use of these during the course of the study. (If necessary, the incidental use of NSAIDs, vitamins and topical treatments may be acceptable after approval by the study Sponsor

2017 Clinical Trials

4224. Real-time Glaucoma Medication Adherence

provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Monitoring only Patients in this arm will be given a real-time medication use monitor to use in dispensing their topical glaucoma medication for 3 months Behavioral: Medication monitoring only Patients will use an electronic medication monitoring device to record their actual medication use Experimental: Monitoring and reminder Patients in this arm (...) will be given a real-time medication use monitor to use in dispensing their topical glaucoma medication for 3 months and will receive an automated reminder (text or voice) when a missed dose is determined by the device's system Behavioral: Medication reminder Using the real-time data capture of the electronic device, an automated voice call or text message will be sent to active arm participants only when a missed dose is determined Outcome Measures Go to Primary Outcome Measures : Adherence [ Time Frame

2017 Clinical Trials

4225. Using SystemCHANGEâ„¢ to Enhance Medication Adherence in Older Adult Stroke Survivors

Luke's Neurological Consultants prescribed at least 1, once a day, antithrombotic medication able to provide informed consent able to open an electronic cap able to self-administer medications has or has access to a telephone has no cognitive impairment as determined by a score of 4 or greater on The Six- item Screener (SIS). Exclusion Criteria: Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study (...) and 2 for intervention details. Treatment participants will implement SystemCHANGE™ activities related to medication taking with the assistance of the PI while attention-control participants will receive patient education materials on stroke. Perceived health data will be collected during the intervention phase. A 1-month maintenance phase follows the intervention phase. Electronic medication monitoring continues, but no intervention is delivered to either group. Active Comparator: Attention-Control

2017 Clinical Trials

4226. VALIDATION OF THE CHAPTER "ALLERGIES AND HYPERSENSITIVITY" OF THE INTERNATIONAL DISEASE CLASSIFICATION (CIM)

using the medical-administrative databases of 3 hospitals. Secondary Objectives: (I) To adjust the terms and links for allergic diseases and hypersensitivity and thus continue the on-line implementation process of ICD-11 based on the lessons learned on the main objective; (II) To estimate the economic impact of ICD-10 and ICD-11 transition for health care facilities; (III) To electronically align ICD-10 codes (and CM adaptation in the USA) with ICD-11. Study design All the consecutive cases (...) Inclusion Criteria: Inclusion criteria: - We here propose a study based on hospital database medical records. The cases will be selected based on pre-established (ICD-10) allergy corresponding codes: respiratory allergies (asthma, rhinitis), skin allergies (dermatitis, urticarial, angioedema), anaphylaxis, gastrointestinal allergic conditions and ocular allergies (conjunctivitis). The prescription of the medicinal product is clearly separated from the decision to include the subject in the non

2017 Clinical Trials

4227. Benign Prostatic Hyperplasia (BPH) Mobile Application Pilot Study

healthcare improvement for LUTS/BPH with the use of a (mobile) application. The hypothesis is that the (mobile) application can support the patient in medication adherence and improve the adherence by feedback and that the application can help to collect objective disease information with electronic questionnaires. Objectives: The primary objective is to assess the feasibility, and acceptability of a (mobile) application for men presenting at their physician's office with LUTS/BPH; starting with medical (...) ). Outcomes are described and compared between centers. Medication adherence [ Time Frame: 6 months ] Self-reported medication adherence by the patient via the application over the full period of the pilot. Compliance to guidelines [ Time Frame: At baseline ] Descriptive comparison between the medication prescribed by the physician and the advised medication according to the international guidelines based on the patient characteristics. Referral network [ Time Frame: At the end of the 6 months period

2017 Clinical Trials

4228. The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease

and atrial fibrillation screening. Additionally, blood and urine samples will be collected and stored in the biobank to identify new biomarkers using omic studies. Finally, a report with the exploration results and recommendations based on the current guidelines will be uploaded to the e-CAP history for the Primary care evaluation. Other: Clinical data collection Sociodemographic variables (age, sex and race), medical history of comorbidities and medical treatments will be collected from the electronic (...) doctor. The impact of this report will be evaluated as changes in medical treatment (new prescriptions or adjustment in previous prescriptions). Association of advanced glycation end-products (AGEs) and cardiovascular events in a low/moderate cardiovascular risk population. [ Time Frame: 10 years ] The relationship between the AGES and cardiovascular events will be evaluated quantifying the skin autofluorescence (SAF). SAF will be analyzed with the AGE reader™ device (DiagnOptics Technologies

2017 Clinical Trials

4229. An EPIC Based BPA to Enhance Quit Line Referral and Use

BPA that allows providers to easily refer to the Maryland Quit Line electronically, investigators will increase use of this resource. The investigators also hypothesize that adding additional educational materials and having Quit Line representatives perform educational outreach visits will further increase use of the Quit Line and will increase prescription of medications to assist with smoking cessation. Ultimately The investigators hope to improve patient care by increasing providers' use (...) detailing: This will include a single session during a clinic day in which counseling experts from the MD Quit Line will visit providers in their practice setting. Outcome Measures Go to Primary Outcome Measures : Provider electronic referrals to the Maryland Quit line [ Time Frame: 6 months ] Number of referrals made out of total eligible for referral Secondary Outcome Measures : Prescription of Pharmacotherapy for Smoking Cessation [ Time Frame: 12 months ] Nicotine replacement, Varenicline

2017 Clinical Trials

4230. Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives

training, hand hygiene programs, disinfection measures, and contact isolation. Physicians will be discouraged to prescribe proton pump inhibitors (PPIs) where not explicitly needed. The intervention bundle will be defined based on current literature. For implementation, the investigator will adapt the bundle to specific local needs, discuss with the responsible department heads and ward staff, perform training and disseminate standards of care. Other: Antibiotic Stewardship Antibiotic stewards (...) will develop local standards of procedure based on the provided training and guidelines. They will then train the responsible staff and disseminate guidelines as best suited for the local work environment, e.g. as pocket cards, posters, or electronically. Point-prevalence investigations and "antibiotic visits" will assure adherence to guidelines. Outcome Measures Go to Primary Outcome Measures : CDI incidence [ Time Frame: Baseline and every 3 months up to 144 weeks ] Significant reduction of the overall

2017 Clinical Trials

4231. Therapeutic Approaches for Subjects With Scapula Dyskinesis

into specific patterns of scapular dyskinesis. After the evaluation of scapular dyskinesis, the kinematics and surface EMG (sEMG) data will be collected during 5 trials of the same arm movements and 3 selected exercises. Other: Conscious control+biofeedback In electromyography (EMG) biofeedback training, electronic equipment is used to reveal instantaneously certain physiological events. Active Comparator: Conscious control group Conscious correction of scapular orientation will be taught to the subjects (...) three positive of five tests, including Neer's test, Hawkin's test, Empty can test, tenderness in tendon of rotator cuff and resisted external test. Each patient will need a prescription of the physician or orthopedic surgeon for diagnosing impingement symptoms Exclusion criteria: - Shoulder pain onset due to trauma, a history of shoulder fractures or dislocation, cervical radiculopathy, degenerative joint disease of the shoulder, surgical interventions on the shoulder, or inflammatory arthropathy

2017 Clinical Trials

4232. Multidisciplinary Team Care in Rheumatoid Arthritis

] Medication adherence Patient experience (using the standard hospital electronic patient experience survey, e-PES) [ Time Frame: 3 months ] patient experience Foot pain (using the Manchester foot disability index, MFI) [ Time Frame: 3 months ] Foot pain Proportion of patients who achieve adherence to guidelines for vaccination [ Time Frame: 6 months ] vaccination Proportion of patients who achieve adherence to guidelines for cardiovascular risk management [ Time Frame: 6 months ] Cardiovascular risk (...) assessment Proportion of patients who achieve adherence to guidelines for bone health optimisation [ Time Frame: 6 months ] Bone health Proportion of patients who achieve adherence to guidelines for cancer screening [ Time Frame: 6 months ] Cancer screening Utilisation of healthcare resources (clinic visits, laboratory, imaging, procedures, prescriptions, calls to the nurse helpline) measured as total dollar cost (from the hospital perspective) [ Time Frame: 6 months ] Utilisation of resources Days off

2017 Clinical Trials

4233. Computerized Antibiotic Stewardship Study

a system designed to help doctors to use antibiotics more appropriately. Under COMPASS (COMPuterized Antibiotic Stewardship Study), doctors in three Swiss hospitals will receive tips on the use of antibiotics that are integrated directly into electronic health record and will also be given regular feedback on their use of antibiotics. Parallel to this, data on the antimicrobial prescription practices of a control group which is not using the system will be collected. Condition or disease Intervention (...) University of Geneva, Switzerland Ente Ospedaliero Cantonale, Ticino, Switzerland Information provided by (Responsible Party): Benedikt Huttner, University Hospital, Geneva Study Details Study Description Go to Brief Summary: Prescribing antibiotics frequently poses problems in practice, since patients don't always receive the right dosage of the right antibiotic for the right period of time. This promotes the emergence and spread of antibiotic resistance. The investigators of this trial aim to develop

2017 Clinical Trials

4234. Smartphone GUIded MeDication AdherencE and Rehabilitation in Patients With Coronary Artery Disease

. Condition or disease Intervention/treatment Phase Coronary Artery Disease Acute Coronary Syndrome Other: BrightHeart® Not Applicable Detailed Description: Cardiac rehabilitation as a means to improve lifestyle-based risk factor modification, remains poorly prescribed and utilized, often due to the lack of access to programs, poor insurance coverage, cost, or patient or physician motivational factors. Low-cost solutions that can improve patient adherence to medications, risk factor reduction (...) . ] The proportion of days coverd (PDC) expressed as a percentage but considered as a continuous variable of the composite of the prescribed P2Y12 receptor antagonist and/or the statin. Secondary Outcome Measures : Medication adherence II [ Time Frame: Baseline through End of Study visit - approximately 90 days per participant. ] Proportion of participants with PDC ≥ 80% of the composite of the P2Y12 receptor antagonist and/or the statin Medication adherence III [ Time Frame: Baseline through End of Study visit

2017 Clinical Trials

4235. Pharmacokinetics of Oral Capsule in Healthy Japanese vs. Caucasian Subjects

-containing products in any form (e.g., gum, patch, electronic cigarettes) within 3 months prior to the planned first day of dosing. Use of prescription medications within 14 days or 10 half-lives (whichever is longer) prior to Day 1 of the dosing period, or any over-the-counter (OTC) medication (including multivitamin, herbal, or homeopathic preparations, excluding hormonal contraception, hormone-replacement therapy, and/or an occasional dose of acetaminophen) within 7 days prior to Day 1 of the dosing

2017 Clinical Trials

4236. Intragastric Balloon in Obese Adolescents With Comorbidities

inclusion criteria must be met. The subject must have: attained approximately 95% of adult stature, as demonstrated by Tanner Stage IV or more and growth charts demonstrating the taper/plateau of height as a marker for achieving 95% of the subject's adult stature. Height will be measured by trained staff to the nearest 0.1 cm using a stadiometer attached to a wall and documented in the subject's electronic medical record (EMR). In the absence of previous growth charts, skeletal maturity (...) or gastrinoma, or they have any endocrine disorders that affect metabolic status of the subjects, such as hypo/hyperthyroidism, type 1 diabetes, Cushing's disease, or adrenal insufficiency, as documented in the electronic medical record (EMR) through an evaluation by the pediatric endocrinologist who will order additional testing if needed, or they have prior gastrointestinal surgery with sequelae, i.e. obstruction, and/or adhesive peritonitis or known abdominal adhesions and/or history of abdominal

2017 Clinical Trials

4237. Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice

, and will only evaluate the studies of pediatric patients who have already been prescribed an advanced MRI for clinical neurological purposes. The only difference for the subject in participating in this study is that the data and information about their scan can be used and disclosed for research purposes, i.e. understanding if the time of the scan, patient comfort, and quality of the data are feasible. Standard MRI's have been extremely beneficial in the diagnosis and assessment of disease, injury (...) , etc.) Patient dropout rate, including: Change of mind Cost of study is too much Failure to finish the scan Usability of data, including: Movement artifact Patient requiring re-scan for any reason The scan will consist of two to five advanced MRI sequences that will average between 7-15 minutes each, in addition to a routine 5 minute standard MRI sequence. The variability in the number of advanced sequences depends on the prescription and patient history. All sequences are performed using a 1.5

2017 Clinical Trials

4238. Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Clinical Practice

that have already been prescribed an advanced MRI for clinical neurological purposes. The only difference for the subject in participating in this study is that the data and information about their scan can be used and disclosed for research purposes, which is understanding if the time of the scan, patient comfort, and quality of the data are feasible. Standard MRI's have been extremely beneficial in the diagnosis and assessment of disease, injury, and anomalies throughout the body. Adding advanced MRI (...) of mind Cost of study is too much Failure to finish the scan Usability of data, including: Movement artifact Patient requiring re-scan for any reason The scan will consist of several advanced MRI sequences that will average between 7-15 minutes each, in addition to a routine 5 minute standard MRI sequence. The variability in the number of advanced sequences depends on the prescription and patient history. All sequences are performed using an FDA-approved MRI scanner. Condition or disease Functional

2017 Clinical Trials

4239. A Mobile Application for Post-op Analgesic Consumption

will receive standard of care which includes prescription of postoperative narcotic and NSAID analgesics and usual postoperative instructions.For the mobile group, the Medable Axon Software developed by Stanford University will be used to customize a mobile application that will be used one week post surgery to monitor postoperative analgesic consumption and disposal practices, pain control, and patient satisfaction, In the control group, case report forms will be used to gather data from the electronic (...) by (Responsible Party): Boston University Study Details Study Description Go to Brief Summary: Surgical extraction of third molars is one of the most common outpatient procedures performed by oral surgeons. The prescription of postoperative narcotic and NSAID analgesics is the standard of care practice to relieve symptoms of pain, swelling, and trismus after these procedures. The majority of these patients do not return for follow up unless they experience a problem. There is limited data on whether

2017 Clinical Trials

4240. A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)

treatment period (Day 1 [Visit 2] to Week 12 [Visit 5]), and a follow up visit (Week 15 [Visit 6]) 3 weeks after the last dose of study drug. The study will be performed on an ambulatory basis. The screening visit (Visit 1) will occur up to 35 days prior to randomization. Eligibility will be assessed via physical examination, clinical laboratory testing, vital signs, ECG, Pap smear, mammography, and endometrial biopsy. Subjects will receive an electronic diary in which to record daily vasomotor symptoms (...) during the duration of the screening period. Subjects must have ≥7 consecutive days of vasomotor symptom recordings to participate in the study. Subjects are encouraged to continue recording for the duration of the whole screening period. The electronic diary will be reviewed by study site staff on Day 1 (Visit 2) to confirm study eligibility. Subjects may be rescreened 1 time upon approval of the medical monitor. During the treatment period, subjects will return to the study site every 4 weeks

2017 Clinical Trials

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