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4201. The Life STORRIED Study

): University of Pennsylvania Study Details Study Description Go to Brief Summary: To compare the effectiveness of 3 strategies to inform patients of their risks associated with misuse of opioid prescriptions after treatment in the ED from renal colic or musculoskeletal back pain. Randomization will be to 3 arms for the Randomized Practical Control Trial across 3 sites (A) standardized general risk information sheet only (B) standardized general risk information sheet plus a visual probabilistic risk tool (...) (C) standardized sheet plus narrative enhanced probabilistic risk tool. Condition or disease Intervention/treatment Phase Opioid Dependence Communication Risk Behavior Narrative Medicine Other: Probabilistic Risk Communication Tool (PRT) Other: Narrative Enhanced Risk Tool (NERT) Not Applicable Detailed Description: Amid a devastating public health crisis, in which 19,000 overdose deaths per year in the United States are due to prescription opioids, the investigators ask the following questions

2017 Clinical Trials

4202. Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy

/community tobacco cessation resources for patients ready to quit within six weeks, and have access to pharmacy residents for ad-hoc prescribing questions. PATIENT COACHING: Patients attend 4 phone or in-person motivational interviewing coaching sessions over 30-45 minutes for 6-8 weeks or longer as needed. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 400 participants Intervention Model: Single Group Assignment Masking: None (...) interviewing techniques. Providers also undergo training to use public/community tobacco cessation resources for patients ready to quit within six weeks, and have access to pharmacy residents for ad-hoc prescribing questions. PATIENT COACHING: Patients attend 4 phone or in-person motivational interviewing coaching sessions over 30-45 minutes for 6-8 weeks or longer as needed. Other: Communication Skills Training Undergo motivational interviewing training Other: Medical Chart Review Undergo medical chart

2017 Clinical Trials

4203. Occlusal Reduction and Postoperative Pain

to be administrated in case of severe pain and ibuprofen 400mg was prescribed in case of persistent pain. Condition or disease Intervention/treatment Phase Postoperative Pain Other: occlusal reduction Not Applicable Detailed Description: Recruitment of the study participants was done from the outpatient clinic of the Endodontic Department of the Faculty of Oral and Dental Medicine, Cairo University. Randomization was done to assign participants to the study groups by chance and not choice. 44 numbers were (...) steel hand K-files size #10 and #15. Working length was determined using an electronic apex locator and confirmed radiographically to be 1 mm shorter than radiographic apex. Mechanical preparation was done by crown-down technique using rotary Revo-S instruments and Ethylene Diamine Tetra Aceticacid gel as a lubricant. The canals were thoroughly irrigated using 3ml of 2.5% sodium hypochlorite following each instrument. After dryness of the canals using paper points, a cotton pellet was placed

2017 Clinical Trials

4204. Implementing a Paced Deep Breathing Module to Decrease Preoperative Anxiety in Gynecological Surgery Patients

to reduce anxiety also result in improved post-operative behavioral and clinical recovery. Currently, the most common method to treat preoperative anxiety is the administration of a prescription benzodiazepine. However, there is limited clinical evidence that supports the use of sedative premedication, such as with a benzodiazepine, before surgery. Complementary integrative medical therapies including music, massage, guided imagery, and deep breathing have been proposed to minimize stress and pain (...) Experimental: meditation module The patients in this arm will be offered the meditation/deep breathing module in the pre-operative area. Device: iPad a 10 minute electronic guided deep breathing module offered via an iPad Outcome Measures Go to Primary Outcome Measures : change in anxiety [ Time Frame: recorded immediately pre-intervention and immediately post-intervention (once meditation module is complete) ] rated 0-10 on a numeric rating scale Secondary Outcome Measures : patient satisfaction [ Time

2017 Clinical Trials

4205. Nurse-led Medicines' Monitoring in Care Homes: a Process Evaluation

electronic devices can enhance nurse-led monitoring. Condition or disease Intervention/treatment Dementia Behavioral: West Wales Adverse Drug Reaction (WWADR) Profile Behavioral: usual care Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 30 participants Observational Model: Case-Only Time Perspective: Prospective Official Title: Nurse-led Medicines' Monitoring in Care Homes: a Process Evaluation of the Impact and Sustainability of the West Wales (...) to correct the problem, for example by prescription changes Clinical gain (anticipated and actual) Change needed to address problems identified Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general

2017 Clinical Trials

4206. Improving the Recovery and Outcome Every Day After the ICU

expectancy Current chemotherapy or radiation therapy (confirmed by electronic medical record) History of dementing illnesses and other neurodegenerative disease such as Alzheimer's disease, Parkinson disease, or vascular dementia (confirmed by EMR), or current prescription of anti-dementia medication, or ruled out by Functional Activities Questionnaire (FAQ) score defining dementia History of bipolar disorder or schizophrenia (confirmed by EMR) Current alcohol consumption > 5 drinks per day (self

2017 Clinical Trials

4207. Sub-optimal Response to Anti-Tumor Necrosis Factor's in Inflammatory Bowel Disease in Emerging Markets

in this retrospective study. The study will look to identify the local barriers in prescribing anti-TNF therapy, treatment patterns and indicators of sub-optimal response to anti-TNF therapy in UC and CD participants in real-world clinical practice in the EM countries, along with the associated incidence of sub-optimal response and impact on health care resource utilization (HCRU). The will enroll approximately 2000 participants. The study consists of two periods, eligibility period followed by a data abstraction (...) . This multi-center trial will be conducted in Argentina, China, Colombia, Mexico, Russia, Saudi Arabia, Singapore, South Korea, Taiwan and Turkey. The overall time to abstract data during the data extraction period from the web-based electronic data capture (EDC) system will be approximately 1 year from March 2017 to February 2018. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 1731 participants Observational Model: Cohort Time Perspective

2017 Clinical Trials

4208. PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions

or with standard of care in the first block. In the pharmacogenomics guided prescribing arm, results of the pharmacogenomic test will be incorporated in the (electronic) medical record and may be used by physicians and pharmacists to guide drug and dose selection for 42 routinely prescribed drugs, as per the Dutch Pharmacogenomics Working Group guidelines. In the standard of care arm, patients will not receive pharmacogenomic testing. After this 18-month block, the countries switch to implementing the opposite (...) : 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subject must be ≥ 18 years old Subject must receive a first prescription (meaning no known prescription for this drug in the preceding 12 months) for one or more of 42 drugs, for which a Dutch Pharmacogenomic Working Group guideline is available, which is prescribed to them in routine care Subject is able and willing to take part and be followed-up for at least 12

2017 Clinical Trials

4209. Impact of a Pharmaceutical Care Model in the Management of Chronic Myeloid Leukemia Patients

of the study period) from electronic prescription refill database system, which was further verified by patient self-reported of having a score of greater than or equal to 6 on Malaysian Medication Adherence Scale Secondary Outcome Measures : Changes in percentage of patients who achieve major/deep molecular response to TKI [ Time Frame: Evaluated at 2 time frame, (a) 0-3 months pre-intervention until 6 months after starting intervention; (b) 0-3 months pre-intervention until 6 months after the end (...) -long treatment remains the current standard of care. It has been estimated that 3% to 56% of CML patients are not adherent to their prescribed TKI therapy. Poor adherence to TKIs could compromise the control of CML, and contributes to poorer survival. CML patients on long-term TKI therapy are prone to developing certain medication-related issues such as adverse reactions and drug interactions.Occurrence of adverse reactions even at low grades, has been shown to impact CML patient's health-related

2017 Clinical Trials

4210. Insulin Degludec Titration Using Mobile Insulin Dosing System

dosing system(MIDS), using the STEP WISE degludec titration algorithm. The eligible subjects will be started on insulin degludec (Tresiba® U-200 FlexTouch®). Subjects will use MIDS for insulin degludec titration management. The clinician will configure MIDS Prescription Instruction Form(PIF) using pre-configured Novo Nordisk, Tresiba Protocol Dosing Treatment Plan which is based on the Novo Tresiba degludec Stepwise Program. The Clinician can alter this as appropriate based on medical judgment (...) a Glooko compatible smart device, a loaner smart device can be provided for the study period. Subject is currently performing self-monitoring of blood glucose(SMBG) Exclusion Criteria: Subject has had a severe hypoglycemia episode in the last 90 days Subject has type 1 diabetes Subject does not have access to a Glooko compatible smart device (smartphone or tablet) Subject must not be using Glooko or any other electronic application for insulin titration Subject is unable to read and understand English

2017 Clinical Trials

4211. Effects of Arm Crank Versus Treadmill Exercises on Heart Rate Variability in Adult Subjects.

on arm crank (Hudson) from long sitting position for 40 minutes. Seat's height and distance were adjusted to achieve full extension of subject arms at horizontal shoulder-level position Other: Exercise Experimental: Treadmill Exercise Sixty-five participated in a treadmill moderate intensity exercise for 40 minutes. Device: Treadmill Participant practiced on an electronic computerized treadmill for 40 minutes . participant began warming up with lowest speed treadmill exercise for 5 minutes at zero (...) 25-36 years. They were asymptomatic for cardiovascular and respiratory diseases. They currently did not receive any medical prescriptions. All participants were asked to avoid strenuous exercise, give up caffeine and alcohol beverages to have sufficient rest for 2 days before measurement sessions to avoid any carry over effects of stimulants or depressants on autonomic functions Exclusion Criteria: Any participant had medical history of cardiovascular and pulmonary disorders or received any

2017 Clinical Trials

4212. Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations

, misuse, physical or psychological dependence. Demonstrates a positive alcohol breath test. Demonstrates a positive urine drug screen without disclosure of corresponding prescribed concomitant medication(s) at Screening and Study Visit Day 0. Urine glucose: a) Positive glucose urine screen. Personnel: Is an employee of the Sponsor or the study site. Is a member of the same household as another subject in this trial. Use of all over the counter (OTC) and prescription (Rx) lozenges after starting (...) and electronic cigarettes) for the duration of the study. Is unable/unwilling to stop using other nicotine replacement therapy products throughout the duration of the study. Disease: Has a medical history, which in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of the study results, e.g., known history of heart disease, recent myocardial infarction or cerebrovascular accident (i.e., within 12 weeks prior to enrollment), unstable angina, severe cardiac

2017 Clinical Trials

4213. Group Clinical Visit Adherence Intervention for HIV+ Women of Color

HIV viral load Currently prescribed HIV medications (i.e., current active HIV medication prescription in electronic medical record or pharmacy) Able to attend most/all group visits Exclusion Criteria: Untreated severe mental illness including major depressive disorder, bipolar disorder, schizophrenia, psychosis, or current suicidal ideation. Acute intoxication Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may (...) currently identify as female. Accepts Healthy Volunteers: Yes Criteria Inclusion criteria: HIV-positive Cis gender women (assigned female sex at birth and current identifies as female) ≥ 18 years old English proficiency At least one visit to community health center where received HIV primary care within the last 12 months Self-reported ARV adherence <100% in the previous 30 days Most recent HIV viral load in last 12 months detectable Prescribed HIV medications for at least 16 weeks prior to detectable

2017 Clinical Trials

4214. Do More, B'More, Live Fit

. This randomized control trial (RCT; N = 60) evaluates the Do More, B'More, Live Fit, a 6-month fitness program designed to optimize exercise habits of 12-21 year-olds with CF through structured exercises with personalized coaching, exercise equipment including the FitBit Flex, online support and motivational messages delivered electronically. The intervention incorporates fitness preferences and encompasses endurance, strength and flexibility exercises while adjusting to physical fitness needs. The hypothesis (...) by the participant) for PA at routine clinic visits, baseline and follow-up assessments at 3 and 6 month clinic visits. At the 3-month and 6-month visits, exercise is reinforced with generic encouragement, export FitBit data and review any missing data concerning for equipment failure or user error. Experimental: Exercise Intervention The baseline fitness assessment includes an additional 30-minutes for exercise prescriptions; participant FitBit daily step goal is set based on a collaborative review between

2017 Clinical Trials

4215. Positive Steps to Enhance Problem Solving Skills

as prescribed ("social-cognitive cues"). If a participants demonstrates >90% adherence they will remain on step one. Participants who continue to have difficulty adhering to their HIV medications at one month after baseline or anytime up to the end of month three (weeks five through twelve) will progress to Step 2) Five in-person, counseling sessions. Each counseling session will last approximately 50 minutes. Behavioral: Positive STEPS Step 1: 2 way SMS text messages; Step 2: Five in-person, counseling (...) the importance of adherence to antiretroviral medication effectiveness. Outcome Measures Go to Primary Outcome Measures : Improved ART adherence [ Time Frame: Baseline, 4 month, 8 month, 12 month ] Monitoring of Wisepill device for electronic adherence data Improved ART adherence [ Time Frame: Baseline, 4 month, 8 month, 12 month ] self report Reduced HIV Viral Load [ Time Frame: Baseline, 4 month, 8 month, 12 month ] Blood specimen collection tested for HIV Viral Load Secondary Outcome Measures : Improved

2017 Clinical Trials

4216. Understanding the Role of Patient Behavior Change in Improving AKI Outcomes

Party): Duke University Study Details Study Description Go to Brief Summary: This study is looking to improve the safety of patients with acute kidney injury via education provided on a mobile tablet. This study will additionally examine if electronic tools, such as mobile tablets, can help. Condition or disease Intervention/treatment Phase Acute Kidney Injury Other: mHealth tool Not Applicable Detailed Description: Acute kidney injury (AKI) is an increasingly common complication of acute (...) situations may reduce AKI recurrence. For example, commonly prescribed therapies such as diuretics or ACE inhibitors may threaten the renal safety of individuals at high risk of recurrent AKI if taken when significantly volume deplete, such as during an acute gastroenteritis, and in most cases should be held until one can eat and drink normally; Nonsteroidal Anti-inflammatory Drugs (NSAIDs) may exacerbate AKI risk if taken in combination with diuretics or ACE inhibitors even when volume replete

2017 Clinical Trials

4217. Effect of Lactobacillus Casei Shirota on the Small Intestinal Microbiota (ROBIN)

adverse events to and from his general practitioner. Willing to comply with study procedures. Exclusion Criteria: Alcohol consumption > 15 units/week and > 3/day. Allergic to dairy products (milk allergy or lactose intolerance). Carrying a pacemaker or any other (implanted) medical electronic device. Drug abuse. Having diarrhea within two (2) months prior to the study start. Heavy exercise or sports training > 10 hours/week. History or presence of any clinically important disease or disorder which (...) such as vegetarian, vegan, or macrobiotic. Scheduled for an MRI scan during the study period. Unstable body weight (weight gain or loss >5kg in the past three (3) months). Use of antibiotics during the six (6) months prior to study start. Use of any prescribed or non-prescribed medication (other than paracetamol) during the three (3) weeks prior to study start. Use of laxatives and probiotic, prebiotic and fiber supplements during the two (2) months prior to study start. Personnel of research institute(s

2017 Clinical Trials

4218. Complex Multiple Risk Behavior Intervention in People Between 45 to 75 Years (EIRA Study)

to make a greater number of visits. Group intervention is carried out through health education workshops. These workshops take place 15-20 days after initiating the individual intervention and they are conducted by primary care providers in the health center. A group of 12-15 people attend in each workshop. Community intervention focuses mainly on the social prescription of resources and activities that are carried out in the community where the participant person resides. In addition the intervention (...) Frame: at the study entry and at 12 months. ] It will be measured in the routine clinical practice by validated electronic monitors and it will be expressed in units of mmHg. Effectiveness:change from baseline on lipid profile [ Time Frame: at the study entry and at 12 months. ] The lipid profile will include: low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides and total cholesterol. They will be expressed in units of mg/dl. Effectiveness: change from baseline on ankle

2017 Clinical Trials

4219. HIIT in Spinal Cord Injury

and function, and physical activity. Exercise testing includes an aerobic exercise stress test (conducted following American College of Sports Medicine guidelines using an electronic ergometer) and an anaerobic (maximum power output) test. After Visit 1, participants will exercise three times per week for six weeks, following a standard HIIT protocol. Two of those sessions will be supervised by a trainer, and one session will be completed on their own. After the six week time period, participants (...) recovery. Supervised exercise sessions: Measures include HR, BP, RPEs, Feeling Scale, and PPO. After warming up, individualized work/rest phases will be prescribed based on their PPO from their maximal aerobic test. Participants will be held at 90% PPO as a constant target intensity to start, shortening the work phase, and if necessary, lengthening the recovery phase. These parameters will be progressed each session. The trainer will determine when to change their work/rest parameters based off of HR

2017 Clinical Trials

4220. Depression Screening in Primary Care: Using HIT for Patients With Limited English

proficient patients. The HIT intervention is a provider-level intervention that consists of four components: 1) web- based training for the providers; 2) multimedia electronic screening of patients for depression and PTSD; 3) immediate notification to the health care providers and integration with the patients' electronic health records (EHR); and 4) provider clinical decision support. In a randomized controlled trial in a primary care setting, we will assess the potential of a multi-component health (...) Study Arm consisted of: 1) web-based tutorial on delivering trauma-informed care, 2) Multi-media mental health risk assessment, 3) Immediate provider notification, which included flagging patients' scores that met criteria for symptoms of depression and/or PTSD, 4) subsequent integration into the patient electronic medical record, and 5) Clinical decision support adapted from the Harvard Program in Refugee Trauma. Other: HIT Intervention Patients in the HIT intervention completed a multi-media

2017 Clinical Trials

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