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4181. Effects of Arm Crank Versus Treadmill Exercises on Heart Rate Variability in Adult Subjects.

on arm crank (Hudson) from long sitting position for 40 minutes. Seat's height and distance were adjusted to achieve full extension of subject arms at horizontal shoulder-level position Other: Exercise Experimental: Treadmill Exercise Sixty-five participated in a treadmill moderate intensity exercise for 40 minutes. Device: Treadmill Participant practiced on an electronic computerized treadmill for 40 minutes . participant began warming up with lowest speed treadmill exercise for 5 minutes at zero (...) 25-36 years. They were asymptomatic for cardiovascular and respiratory diseases. They currently did not receive any medical prescriptions. All participants were asked to avoid strenuous exercise, give up caffeine and alcohol beverages to have sufficient rest for 2 days before measurement sessions to avoid any carry over effects of stimulants or depressants on autonomic functions Exclusion Criteria: Any participant had medical history of cardiovascular and pulmonary disorders or received any

2017 Clinical Trials

4182. Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations

, misuse, physical or psychological dependence. Demonstrates a positive alcohol breath test. Demonstrates a positive urine drug screen without disclosure of corresponding prescribed concomitant medication(s) at Screening and Study Visit Day 0. Urine glucose: a) Positive glucose urine screen. Personnel: Is an employee of the Sponsor or the study site. Is a member of the same household as another subject in this trial. Use of all over the counter (OTC) and prescription (Rx) lozenges after starting (...) and electronic cigarettes) for the duration of the study. Is unable/unwilling to stop using other nicotine replacement therapy products throughout the duration of the study. Disease: Has a medical history, which in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of the study results, e.g., known history of heart disease, recent myocardial infarction or cerebrovascular accident (i.e., within 12 weeks prior to enrollment), unstable angina, severe cardiac

2017 Clinical Trials

4183. Group Clinical Visit Adherence Intervention for HIV+ Women of Color

HIV viral load Currently prescribed HIV medications (i.e., current active HIV medication prescription in electronic medical record or pharmacy) Able to attend most/all group visits Exclusion Criteria: Untreated severe mental illness including major depressive disorder, bipolar disorder, schizophrenia, psychosis, or current suicidal ideation. Acute intoxication Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may (...) currently identify as female. Accepts Healthy Volunteers: Yes Criteria Inclusion criteria: HIV-positive Cis gender women (assigned female sex at birth and current identifies as female) ≥ 18 years old English proficiency At least one visit to community health center where received HIV primary care within the last 12 months Self-reported ARV adherence <100% in the previous 30 days Most recent HIV viral load in last 12 months detectable Prescribed HIV medications for at least 16 weeks prior to detectable

2017 Clinical Trials

4184. Do More, B'More, Live Fit

. This randomized control trial (RCT; N = 60) evaluates the Do More, B'More, Live Fit, a 6-month fitness program designed to optimize exercise habits of 12-21 year-olds with CF through structured exercises with personalized coaching, exercise equipment including the FitBit Flex, online support and motivational messages delivered electronically. The intervention incorporates fitness preferences and encompasses endurance, strength and flexibility exercises while adjusting to physical fitness needs. The hypothesis (...) by the participant) for PA at routine clinic visits, baseline and follow-up assessments at 3 and 6 month clinic visits. At the 3-month and 6-month visits, exercise is reinforced with generic encouragement, export FitBit data and review any missing data concerning for equipment failure or user error. Experimental: Exercise Intervention The baseline fitness assessment includes an additional 30-minutes for exercise prescriptions; participant FitBit daily step goal is set based on a collaborative review between

2017 Clinical Trials

4185. Positive Steps to Enhance Problem Solving Skills

as prescribed ("social-cognitive cues"). If a participants demonstrates >90% adherence they will remain on step one. Participants who continue to have difficulty adhering to their HIV medications at one month after baseline or anytime up to the end of month three (weeks five through twelve) will progress to Step 2) Five in-person, counseling sessions. Each counseling session will last approximately 50 minutes. Behavioral: Positive STEPS Step 1: 2 way SMS text messages; Step 2: Five in-person, counseling (...) the importance of adherence to antiretroviral medication effectiveness. Outcome Measures Go to Primary Outcome Measures : Improved ART adherence [ Time Frame: Baseline, 4 month, 8 month, 12 month ] Monitoring of Wisepill device for electronic adherence data Improved ART adherence [ Time Frame: Baseline, 4 month, 8 month, 12 month ] self report Reduced HIV Viral Load [ Time Frame: Baseline, 4 month, 8 month, 12 month ] Blood specimen collection tested for HIV Viral Load Secondary Outcome Measures : Improved

2017 Clinical Trials

4186. Understanding the Role of Patient Behavior Change in Improving AKI Outcomes

Party): Duke University Study Details Study Description Go to Brief Summary: This study is looking to improve the safety of patients with acute kidney injury via education provided on a mobile tablet. This study will additionally examine if electronic tools, such as mobile tablets, can help. Condition or disease Intervention/treatment Phase Acute Kidney Injury Other: mHealth tool Not Applicable Detailed Description: Acute kidney injury (AKI) is an increasingly common complication of acute (...) situations may reduce AKI recurrence. For example, commonly prescribed therapies such as diuretics or ACE inhibitors may threaten the renal safety of individuals at high risk of recurrent AKI if taken when significantly volume deplete, such as during an acute gastroenteritis, and in most cases should be held until one can eat and drink normally; Nonsteroidal Anti-inflammatory Drugs (NSAIDs) may exacerbate AKI risk if taken in combination with diuretics or ACE inhibitors even when volume replete

2017 Clinical Trials

4187. Effect of Lactobacillus Casei Shirota on the Small Intestinal Microbiota (ROBIN)

adverse events to and from his general practitioner. Willing to comply with study procedures. Exclusion Criteria: Alcohol consumption > 15 units/week and > 3/day. Allergic to dairy products (milk allergy or lactose intolerance). Carrying a pacemaker or any other (implanted) medical electronic device. Drug abuse. Having diarrhea within two (2) months prior to the study start. Heavy exercise or sports training > 10 hours/week. History or presence of any clinically important disease or disorder which (...) such as vegetarian, vegan, or macrobiotic. Scheduled for an MRI scan during the study period. Unstable body weight (weight gain or loss >5kg in the past three (3) months). Use of antibiotics during the six (6) months prior to study start. Use of any prescribed or non-prescribed medication (other than paracetamol) during the three (3) weeks prior to study start. Use of laxatives and probiotic, prebiotic and fiber supplements during the two (2) months prior to study start. Personnel of research institute(s

2017 Clinical Trials

4188. Complex Multiple Risk Behavior Intervention in People Between 45 to 75 Years (EIRA Study)

to make a greater number of visits. Group intervention is carried out through health education workshops. These workshops take place 15-20 days after initiating the individual intervention and they are conducted by primary care providers in the health center. A group of 12-15 people attend in each workshop. Community intervention focuses mainly on the social prescription of resources and activities that are carried out in the community where the participant person resides. In addition the intervention (...) Frame: at the study entry and at 12 months. ] It will be measured in the routine clinical practice by validated electronic monitors and it will be expressed in units of mmHg. Effectiveness:change from baseline on lipid profile [ Time Frame: at the study entry and at 12 months. ] The lipid profile will include: low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides and total cholesterol. They will be expressed in units of mg/dl. Effectiveness: change from baseline on ankle

2017 Clinical Trials

4189. HIIT in Spinal Cord Injury

and function, and physical activity. Exercise testing includes an aerobic exercise stress test (conducted following American College of Sports Medicine guidelines using an electronic ergometer) and an anaerobic (maximum power output) test. After Visit 1, participants will exercise three times per week for six weeks, following a standard HIIT protocol. Two of those sessions will be supervised by a trainer, and one session will be completed on their own. After the six week time period, participants (...) recovery. Supervised exercise sessions: Measures include HR, BP, RPEs, Feeling Scale, and PPO. After warming up, individualized work/rest phases will be prescribed based on their PPO from their maximal aerobic test. Participants will be held at 90% PPO as a constant target intensity to start, shortening the work phase, and if necessary, lengthening the recovery phase. These parameters will be progressed each session. The trainer will determine when to change their work/rest parameters based off of HR

2017 Clinical Trials

4190. Depression Screening in Primary Care: Using HIT for Patients With Limited English

proficient patients. The HIT intervention is a provider-level intervention that consists of four components: 1) web- based training for the providers; 2) multimedia electronic screening of patients for depression and PTSD; 3) immediate notification to the health care providers and integration with the patients' electronic health records (EHR); and 4) provider clinical decision support. In a randomized controlled trial in a primary care setting, we will assess the potential of a multi-component health (...) Study Arm consisted of: 1) web-based tutorial on delivering trauma-informed care, 2) Multi-media mental health risk assessment, 3) Immediate provider notification, which included flagging patients' scores that met criteria for symptoms of depression and/or PTSD, 4) subsequent integration into the patient electronic medical record, and 5) Clinical decision support adapted from the Harvard Program in Refugee Trauma. Other: HIT Intervention Patients in the HIT intervention completed a multi-media

2017 Clinical Trials

4191. Glaucoma Management Optimism for African Americans Living With Glaucoma

effectively problem-solve ongoing obstacles related to adherence. The investigators published a paper in the Journal of Glaucoma investigating determinants related to objective medication adherence as measured by an electronic dosing aid (DA). Findings revealed poorer rates of adherence among AA patients with glaucoma compared to Caucasian patients with glaucoma. Evidence for racial differences in adherence have also been increasingly documented in the glaucoma literature. In a follow-up study with focus (...) health promotion intervention Behavioral: Usual Care + Health Promotion Intervention Telephone sessions for approximately 5-6 weeks to enhance empowerment and skills for managing medication adherence. Other Name: GOAL No Intervention: Usual Care Only Usual glaucoma management only, no intervention. Outcome Measures Go to Primary Outcome Measures : Change in medication rate adherence via an electronic dosing aid [ Time Frame: Baseline, 3, 7 months, and 1 year ] Assessment in medication adherence

2017 Clinical Trials

4192. A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Orbactiv® (Oritavancin) for Infections Caused by Gram Positive Bacteria in a Real World Setting

gram positive infection, as monotherapy or part of a broader regimen. At least 60 days has elapsed since the participant received the last dose of oritavancin therapy (prior to data entry into the electronic Case Report Form). Exclusion Criteria: The participant received oritavancin as a part of a controlled clinical trial. The participant received oritavancin as a part of a Medicines Company-sponsored single or multi-centered pharmacoeconomic outcomes study. Contacts and Locations Go (...) : Identifier: ORBACTIV® (oritavancin) ORBACTIV® (oritavancin). United States Prescribing Information. The Medicines Company; Parsippany, New Jersey. October 2016 Layout table for additonal information Responsible Party: Melinta Therapeutics, Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: MDCO-ORI-15-05 First Posted: May 18, 2017 Last Update Posted: March 12, 2018 Last Verified: March 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional

2017 Clinical Trials

4193. Patients' Compliance to Home Nebulizer Therapy for Children's Asthma in China

treatment frequency (monitored by electronic chips) divided by prescribed frequency [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months ] Secondary Outcome Measures : Proportion of patients in different treatment compliance levels (<50%, 50 %≤-< 80%, 80%≤-≤120%, >120%) monitored by electric chips [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months ] Median treatment compliance (%) reported by caregivers derived using actual doses divided (...) by prescribed doses [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months ] Proportion of patients in difference compliance levels reported by caregivers [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months ] Proportion of patients by severity [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months ] Factors associated with treatment compliance [ Time Frame: From 3 June 2017 to 3 March 2018, an expected average of 3 months

2017 Clinical Trials

4194. Investigation of the Role of Pictorial Asthma Action Plans to Promote Self-management in Rural Youth With Asthma

Asthma Action Plan Not Applicable Detailed Description: Asthma is the most common chronic health condition of childhood, and continues to be associated with morbidity and mortality. Many children with persistent asthma follow a treatment plan including a prescription to take a daily inhaled corticosteroid (controller), often in conjunction with a daily oral controller medication, and a dose of an albuterol (rescue) inhaler before activity or exercise. Young people with asthma must add (...) Action Plan (AAP) to all people diagnosed with asthma, summarizing their treatment plan using a traffic light format; Green Zone for daily, symptom-free management, Yellow Zone for symptom flare, and Red Zone for extreme symptom flare. Despite evidence for the effectiveness of AAPs, they are often not prescribed for reasons including readability and accessibility for families and young people, and asthma provider perceptions of their utility and suitability. In this study, young people

2017 Clinical Trials

4195. Antimicrobial Use and Stewardship in an Outpatient Hemodialysis Unit

in an ambulatory hemodialysis population [ Time Frame: September 1 2016 - April 30 2017 ] Prevalence will be determined by the total number of antimicrobial prescriptions in the study population over the period of study. An antimicrobial prescription will be defined as any oral or intravenous antibacterial or antifungal or antiviral agent prescribed by a community or hospital prescriber to a patient receiving hemodialysis (HD) from Toronto General Hospital's outpatient HD unit. An antimicrobial prescription (...) will follow the 21-day rule.The 21-day rule is that there must be 21 or more days from the end of one antimicrobial course to the beginning of a second antimicrobial course for two courses to be reported as separate prescriptions. If antimicrobials are stopped for fewer than 21 days and then restarted, the second start is not considered a new prescription, and therefore will not be reported. Secondary Outcome Measures : Congruence of prescribed antimicrobial regimens [ Time Frame: September 1 2016 - April

2017 Clinical Trials

4196. A Study to Evaluate the Effects of a Turmeric and Black Cumin Seed Formulation on Cholesterol Levels

reading in English Exclusion Criteria: Having smoked any cigarette, electronic cigarette, cigar, pipe, or recreational drug in the past 30 days History of allergy or sensitivity to any component of the study products Donation of blood within 30 days prior Baseline/screening Participation in another study within 30 days prior to Baseline/screening Being pregnant, planning on becoming pregnant during study participation or breast feeding Having the following medical condition(s): diabetes, hypotension (...) , hypertension (changed antihypertensive medication or dose in the preceding 3 months and/or likely to do so during the study), cardiovascular disease (arrhythmia, edema with or without congestive heart failure, heart attack, stroke, abnormal EKG), gastrointestinal disease requiring daily prescribed medication (gastroesophageal reflux, gastritis, and peptic or duodenal ulcer), gallbladder disease or gallstones, biliary obstruction (past or present), endocrine disease (hyper- or hypothyroidism), psychiatric

2017 Clinical Trials

4197. Medication Adherence Research in COPD Patients

by COPD patients. One possible explanation for this gap is low rates of medication adherence; some studies report that only 25% of COPD patients take at least 80% of their prescribed medications. Pharmacy refill records indicate that adherence to COPD medications is significantly lower than adherence rates seen in other chronic illnesses including hypertension, diabetes, and congestive heart failure. Significant negative long term health outcomes may be magnified by non-adherence to prescribed (...) information Study Type : Observational Estimated Enrollment : 360 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Longitudinal Determinants of Medication Adherence in COPD Actual Study Start Date : May 1, 2017 Estimated Primary Completion Date : May 1, 2022 Estimated Study Completion Date : May 1, 2022 Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Medication Adherence [ Time Frame: 5 years ] Measured by electronic medication monitoring

2017 Clinical Trials

4198. Study Using the CervicalStim Device Following Cervical Fusion

with prescribed use revision rate [ Time Frame: 12 months ] how many subjects had to be revised at the same level(s) during the course of the study SF-36 [ Time Frame: 12 months ] used to assess the effect of PEMF therapy on the subject's quality of life Neck Disability Index (NDI) [ Time Frame: 12 months ] used to assess the effect of PEMF therapy on the reduction of neck pain EQ-5D [ Time Frame: 12 months ] used to assess the effect of PEMF therapy on quality of life as well as economic impact VAS pain (...) ). a. When the android version of the mobile app for the CervicalStim device becomes available (estimated to be Dec. 2017), subjects who have reliable access to devices using android operating systems will be eligible for study inclusion. Able and willing to complete electronic questionnaires and able to read and understand study instructions in English. Able and willing to comply with the study plan and able to understand and sign the study-specific Informed Consent Form (ICF). Exclusion Criteria

2017 Clinical Trials

4199. Study Using the SpinalStim Device Following Lumbar Fusion Surgery

Electromagnetic Field one group all of whom will be treated with the PEMF device Device: SpinalStim PEMF osteogenesis stimulator Outcome Measures Go to Primary Outcome Measures : fusion rate [ Time Frame: 12 months ] number of subjects with fused lumbar vertebrae, determined by X-rays and CT scans Secondary Outcome Measures : Device compliance [ Time Frame: 6 months ] actual minutes per day device was used compared with prescribed treatment time revision rate [ Time Frame: 12 months ] how many subjects had (...) . 2017), subjects who have reliable access to devices using android operating systems will be eligible for study inclusion. Able and willing to complete electronic questionnaires and able to read and understand study instructions in English Able and willing to comply with the study plan and able to understand and sign the study-specific ICF. Exclusion Criteria: Scoliosis greater than 30 degrees Current alcoholism or drug abuse, and/or any known current addiction to pain medications or medical

2017 Clinical Trials

4200. SMS-Based Follow-Ups to Improve Post-Discharge Surgical Outcomes

confused, resulting in poor patient care post-discharge and high 30-day readmission rates. Medication adherence represents a crucial area for follow-up, as it is a major determinant of high-quality outcomes for post-operative care. Specifically, over 50% of patients in the U.S. either forget to or don't correctly take their prescription medications. Non-adherence causes nearly 10% of all hospital admissions in the U.S. and 125,000 annual deaths. In a survey of 10,000 patients, the most common reported (...) reason for missing medications was forgetfulness (24%), followed by perceived side effects (20%), high drug costs (17%), and perception that a prescribed medication would have little effect on their disease (14%). The majority of the factors contributing to non-adherence could therefore be resolved by longitudinally addressing forgetfulness and misconceptions about medication effectiveness, options for treatment, and side effects. An SMS patient engagement case-management platform (Memora Health

2017 Clinical Trials

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