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Electronic Prescription

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4121. Family Practice Notebook Updates 2018

cleansers and oral supplements No evidence of benefit in consumer products and risks of prescribed medication malabsorption, s, (neuro, ) cost grows to $6900 for s with similar efficacy to their cheaper counterparts (e.g. TCA, , topomax) (id, pharm) Biosimilar agents are similar but not identical to their reference biologic agents (e.g. Nivestym is biosimilar to Neupogen) III. Updates: November 2018 (cv, htn, peds) diagnostic criteria in children have changed as of 2017 AAP guidelines is underdiagnosed (...) as prescription items Obrexza is an expensive ($550/month) second-line adjunct for axillary sweating refractory to other topicals IV. Updates: October 2018 (prevent, hme, peds) Screen for at visits for infants <6 months of age Perform at 9, 18 and 30 months (minimum) and screening at 18 and 24 months screening at least once at age 3-5 years (hemeonc, ) Mechanisms include immune ( ), microangiopathic ( ), oxidative (e.g. ) Initial testing includes a CBC, , , Total and , Basic metabolic panel, , may be useful

2019 FP Notebook

4122. Opioid Physiology Project

: Physiological changes [ Time Frame: Physiological activity recording will start 24 to 48 hours before dental surgery date. Physiological activity will be stopped 2 days after discontinuation of opioid self-administration and will not exceed 30 days from surgery date. ] We will be measuring physiological changes from pre- to post-opioid administration through the Empatica E4 electronic wristband. This device measures 5 physiological parameters: Physical activity through an accelerometer measuring movement (...) study population will be recruited for the University of Tennessee College of Dentistry. Recruited populations will be opioid naive individuals that are scheduled for an upcoming dental surgery that will result in an opioid medication be prescribed for pain management. Criteria Inclusion Criteria: Adult (18 or over) Opioid naive Getting a dental surgery where clinicians will prescribe opioid medication Ability to consent English as primary language Willingness to wear biosensor Willingness

2017 Clinical Trials

4123. Medication Abortion Via Pharmacy Dispensing

evaluation. Women participating in this study will obtain mifepristone and misoprostol from the pharmacy instead of in the clinic. To assess feasibility, acceptability, and effectiveness of pharmacy dispensing of mifepristone, the study will survey patients, evaluate their clinical outcomes from electronic health records, and survey and interview pharmacists at study sites. Condition or disease Intervention/treatment Phase Pregnancy Related Abortion Early Drug: Mifepristone Phase 4 Detailed Description (...) : Improving access to and efficiency of abortion provision is important for patients and providers. The Risk Evaluation and Mitigation Strategy (REMS) requires that Mifeprex ® ( mifepristone) be dispensed only from a doctor's office, clinic or hospital (not from a pharmacy by prescription) by a certified health care provider and the health care provider must obtained a signed Patient Agreement Form before dispensing mifepristone. Data are needed to investigate the feasibility, acceptability

2017 Clinical Trials

4124. Achieving Self-directed Integrated Cancer Aftercare (ASICA) in Melanoma

the internet to enable people to electronically communicate the findings of their TSSE to a specialist nurse. All those who consent to take part in the study will be randomly allocated into one of two groups. One group will use the ASICA app in addition to their normal follow-up, the other group will continue to attend their routine melanoma follow-up only. Participants will be recruited from two UK sites - NHS Grampian and Cambridge University Hospitals. Study Design Go to Layout table for study (...) their skin in the past 12 months. Patients are asked whether they had any appointments with a medical professional (GP/nurse/other) for their skin in the past 12 months (yes/no answer), how many (free text) and at what setting (visit at the practice/visit at home/telephone). Patients are also asked about operations or any other treatment they may have had on their skin in the past 12 months (free text). Patients are also asked to list any prescribed medicines or non-prescribed skin products in the last

2017 Clinical Trials

4125. A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

the next four months. No Intervention: Control - No Treatment Education The Usual Care control group will only receive standard of care through their HIV clinics. Outcome Measures Go to Primary Outcome Measures : Change in Continuous Adherence [ Time Frame: change in adherence over 12 months from enrollment to 12 months post-enrollment ] Percentage of doses taken, of those prescribed, self-report and from electronic monitoring, at all post-intervention time-points Change in Categorical Adherence [ Time (...) Frame: change in adherence over 12 months from enrollment to 12 months post-enrollment ] Dichotomous percentage of doses taken, of those prescribed (dichotomized at less than or greater than or equal to 85%), self-report and from electronic monitoring, at all post-intervention time-points Change in Viral Suppression [ Time Frame: change in viral suppression over 12 months from enrollment to 12 months post-enrollment ] Viral suppression (suppressed vs not suppressed), immediately and 6-months post

2017 Clinical Trials

4126. Utilization of Physical Activity Recommendations Among Patients of Cardiovascular Healthcare Centres in Eastern Slovakia

prescription according to digital training and decision support system as compared to exercise prescription following the standard informative procedure among patients with cardiovascular disease. (B) to determine whether health literacy moderates effect of exercise prescription according to digital training and decision support system on the indices of exercise recommendations compliance among patients with cardiovascular disease. Condition or disease Intervention/treatment Phase Cardiovascular Diseases (...) Behavioral: The EAPC Exercise Prescription (EXPERT) Tool Behavioral: Standard Cardio-Care Lifestyle Counselling Not Applicable Detailed Description: The trial will compare the utilization of physical activity recommendation between the standard lifestyle informative procedure and the digital training and decision system informative procedure. We hypothesize that a higher rate of compliance between seven-day exercise report and physical activity recommendations will be observed in the experimental group

2017 Clinical Trials

4127. Voices in Pain Care

-Related Quality of Life and high-risk prescribing, including prescriptions over 90 morphine milligram equivalents per day and co-prescribing of benzodiazepines and opioids. Patients in the PEAT arm will receive patient materials during the intervention, developed to engage patients in chronic pain treatment, prior to Primary Care Physician office visits. In the provider-facing CDS arm, PCPs will receive computerized reminders about appropriate opioid use during office visits for enrolled patients (...) Description: Investigators will compare two strategies: (1) Engage PCPs with Clinical Decision Support at the point of care, raising active alerts through the Electronic Health Record (EHR) when there is risk of inappropriate opioid prescribing, thus leading to informed decision-making with the patient about alternative treatments; versus (2) Engage patients prior to their PCP visit using Patient Education and Activation Tools (PEATs) administered via REDCap, helping patients to prepare for their visit

2017 Clinical Trials

4128. Engaging Veterans Seeking Service-Connection Payments in Pain Treatment

by phone will occur at 12 and 36-week follow-ups, and will be corroborated with other sources of information ---the electronic health record and toxicology testing of nail clippings. Investigators hypothesize that, compared to Usual Care, SBIRT-PM will be more effective and cost-effective in improving Veterans' pain and substance use. Investigators further hypothesize that a mediator of these improvements will be use of non-pharmacological services, as extracted from VA records from structured data (...) permissive language about how pain is commonly self-medicated with substances, the clinician transitions to inquiries about use of prescription and non-prescription substances. The clinician then attempts to motivate Veterans to change their behavior if they are misusing substances. Thus, SBIRT-PM addresses the Veteran's presenting pain complaint first and nascent substance use subsequently. Behavioral: SBIRT-PM SBIRT-PM involves an initial telephone-delivered session followed by up to three calls

2017 Clinical Trials

4129. E-aid Sleep-focused TrEatment for Prevention of Major Depression (STEP-MD)

to a fixed prescribed bedtime, getting out of bed when unable to sleep, using the bed only for sleep, and restricting the amount of time spent in bed (Cronbach α = 0.50). The Cognitive Component consists of endorsement of 2 items: "Changing my expectations about sleep" and "Changing the way I think about not sleeping" (Cronbach α = 0.83) Treatment satisfaction rating scale (TSRS) [ Time Frame: changes of scale score from baseline to 6 months and 12 months ] Subjects' satisfaction to the treatment (...) Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: the diagnostic criteria for insomnia in accordance with DSM-5 18 years or older compliant and have a good understanding of research program able to fill the online informed consent form owns and have a good command on electronic gadgets (e.g., smart phones, tablets, computers, etc.) Exclusion Criteria: clear and unhealed physical, mental

2017 Clinical Trials

4130. Exercise Program for Lower Limb Pronation

Phase Lower Limb Pronation Other: exercise program Not Applicable Detailed Description: Firstly, a biomechanical analysis of gait will be performed at CAMD, using a modular electronic baropodometer (Diagnostic Support Walk®), Milletrix Applicazione MFC® (Diasu, Italia) and a video camera (Diagnostic Support S.R.L., Diasu, Italy). We will measure the parameters characterizing lower limb overpronation. The parameters measured during walking will be: Fick angle, femorotibial angle and Helbing angle (...) of the gastrocnemius muscle, soleus muscle, tibialis posterior muscle and flexor of the big toe muscle. The selection of the prescribed exercises will be performed according to the principal activity of different muscles and functional impact on the gait. Previous experiences in implementing this exercises program has shown us positive results after three months of application. That is why this temporary intervention for the period was determined. Parents of children will be instructed to monitor the exercises

2017 Clinical Trials

4131. Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

(Salbutamol) MDI or nebules Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication. Drug: Standard of care therapy SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according (...) for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice. Experimental: Nemiralisib 100 µg once daily Eligible

2017 Clinical Trials

4132. Patient-Centered Opioid Tapering Study

information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Sampling Method: Non-Probability Sample Study Population Patients with chronic pain receiving treatment in a community chronic pain clinic who were also taking long term prescription opioids were invited by their prescribing physician to participate in patient-centered, voluntary opioid tapering. Criteria Inclusion Criteria: Over age 18 Chronic pain Chronic (...) study of a voluntary opioid tapering protocol conducted in community outpatients taking long term prescription opioids for chronic pain. Patients who would otherwise continue with their existing opioid prescriptions were encouraged to participate in a voluntary opioid taper program. Interested patients were identified by their pain physician, Dr. Richard Stieg, and then completed an online informed consent document and baseline self-report assessments including types and doses of opioid medications

2017 Clinical Trials

4133. Precision Pain Self-Management in Young Adults With Irritable Bowel Syndrome

regions of the world, and affects more women than men. While women report more severe IBS-related pain, both younger men and women report more severe pain compared to older adult cohorts. Direct costs of care and lost productivity in the U.S. exceed $21 billion annually, and individuals with IBS utilize more healthcare services than the general population, including outpatient visits, diagnostic testing and over-the-counter and prescription medications. Individuals with IBS report that pain (...) , 2016 Actual Primary Completion Date : October 26, 2018 Estimated Study Completion Date : December 31, 2018 Arms and Interventions Go to Arm Intervention/treatment No Intervention: Control Participants will be provided an online interactive platform to access electronic modules (total of 10) on: IBS-related pain neurophysiology and the brain-gut axis and self-management strategies. There is no additional intervention. Experimental: Personalized IBS Pain SM Participants will be enrolled in the online

2017 Clinical Trials

4134. Meeting Protein Targets in Critically Ill Patients

] Feeding interruptions; and reason for interruption, if recorded in electronic medical record/nursing flow sheets Use of inotropes/vasopressors (highest daily dose prescribed) [ Time Frame: Daily up to 7 days of ICU stay ] Use of inotropes/vasopressors will be documented as a Yes/No. Feeding tolerance [ Time Frame: Daily up to 7 days of ICU stay ] Feeding tolerance as recorded by clinicians in electronic medical record/nursing flow sheets [gastrointestinal side effects observed and documented: vomiting (...) critically ill adult patients post the introduction of a very high protein enteral nutrition formula [2016]. Outcome Measures Go to Primary Outcome Measures : Daily total protein intake [ Time Frame: Daily up to 7 days of ICU stay ] Daily total protein intake and percent prescribed protein needs met during first week of ICU admission. Secondary Outcome Measures : Daily caloric intake - Total Calories [ Time Frame: Daily up to 7 days of ICU stay ] Total calories aggregate from all sources Daily caloric

2017 Clinical Trials

4135. Real World Glycemic Effectiveness of Linagliptin

is not able to be accurately measured in electronic record data. The electronic record data capture prescriptions written by a prescriber, but it is not possible to know if patients received and adhered to their medication and there are no structured data fields to identify if and when a medication was discontinued by the patient or the provider ≥ 1 diagnosis code or procedure code representing renal transplant, solid organ transplant, or bone marrow transplant in the EHR data during the 180-day pre-index (...) Criteria: ≥ 1 written prescription for linagliptin (Tradjenta®, Jentadueto®, or Jentadueto XR®)in the EHR (electronic health record) data during the identification period ≥ 40 years of age based on the year of the index date First active date in the EHR is ≥ 180 days prior to the index date ≥ 1 diagnosis code representing T2DM (type 2 diabetes) in the EHR data during the 180-day pre-index period or on the index date ≥ 1 HbA1c value during the 180-day pre-index period or on the index date ≥ 1 HbA1c

2017 Clinical Trials

4136. Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF

exercise capacity [ Time Frame: 1 year ] Subjects will perform the maximal exercise tests on an electronically braked cycle ergometer using the Godfrey protocol. Expired gases will be collected using a Parvo Medics True One metabolic cart for determination of exercise capacity (VO2 peak). Secondary Outcome Measures : Flow mediated dilation [ Time Frame: 1 year ] The brachial artery FMD test will be performed according to the recent tutorial on the ultrasonic assessment of FMD and shear rate (...) (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population CF patients who are homozygous F508del and have been prescribed Orkambi. Criteria Inclusion Criteria: Patients diagnosed with Cystic Fibrosis (homozygous deltaF508del) Prescribed Orkambi Men and women (> 18 yrs. old) Boys and girls (7 -17 yrs. old) FEV1 percent predicted > 40% Resting oxygen saturation (room air) >85% Patients with or without CFRD

2017 Clinical Trials

4137. Pharmacokinetics of Lidocaine in Healthy Adults

. They must have refrained from regular and habitual use of nicotine-containing substances, including tobacco products (e.g., cigarettes, cigars, chewing tobacco, gum, patch or electronic cigarettes) over the previous 12 months and must have not used any nicotine-containing products in the previous 30 days. Subjects who are within their ideal body weight (BMI between 18-29.9 kg/m2). Subjects deemed to be healthy as judged by the Medically Accountable Investigator (MAI), as determined by medical history (...) or have a positive serum pregnancy test at enrollment or positive urine pregnancy test at any time during the study. Smokers. A "smoker", for the purposes of the study, will be defined as an individual who has regularly and habitually used nicotine-containing substances, including tobacco products (e.g., cigarettes, cigars, chewing tobacco, gum, patch or electronic cigarettes) over the past 12 months. Occasional recreational use (less than once monthly) will not warrant exclusion unless the individual

2017 Clinical Trials

4138. Supporting Our Valued Adolescents Pilot Randomized Controlled Trial

referrals from the adolescent healthcare provider (AHCP) and contacts patients who do not schedule for within-CAYAH appointments.The study will send an extra email to the parent and adolescent that contains the content of the depart summary as well as a list of psychoeducational materials, how to contact the AHCP, CAYAH social worker, and crisis resources and the AHCP's treatment recommendation which are obtained from the electronic health record. Also, each individual will receive a phone call from (...) materials, how to contact the AHCP, CAYAH social worker, and crisis resources and the AHCP's treatment recommendation which are obtained from the electronic health record. Also, each individual will receive a phone call from a research assistant who will communicate the information in the email and offer to inform the social worker or AHCP of questions the patient or parent may have. Outcome Measures Go to Primary Outcome Measures : Study retention [ Time Frame: 6 weeks ] proportion of dyads accessing 6

2017 Clinical Trials

4139. Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma

expiratory flow (PEF) at Week 52. Home PEF testing will be performed by the subject in the morning upon awakening and in the evening at bedtime using an electronic, hand-held spirometer. Each timepoint is calculated as weekly means. Change from baseline in weekly mean number of night time awakenings [ Time Frame: Baseline, Week 52 ] Change from baseline in weekly mean number of night time awakenings at Week 52. Each timepoint is calculated as weekly mean number of awakenings due to asthma based on daily (...) staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 12 Years to 80 Years (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age. 12-80 Documented physician-diagnosed asthma for at least 12 months Subjects who have received a physician-prescribed asthma controller medication with medium or high dose ICS for at least 12 months. Documented treatment

2017 Clinical Trials

4140. Gabapentin Regimens and Their Effects on Opioid Consumption

printed or in electronic form — about narcotic medications. The instructions will explain when to use such medications and how to taper off their consumption. Following discharge, patients will take gabapentin as directed by their discharge instructions, and in the process track their opioid consumption on their own in their diaries. They will also document their pain, nausea and satisfaction levels according to the visual analogue scale (VAS). At the first post-operative appointment, patients' levels (...) of opioid use will be verified and compared to the amount recorded in each diary; the actual number of tablets consumed will be compared with the documented amounts and with the prescriptions they received. Patients receiving a new prescription will also receive a matching diary for the total length of opioid treatment, including further directions on how to wean themselves off their medications. Outcome measures will be collected at both post-operative visits, the first occurring 8-10 days after

2017 Clinical Trials

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