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1. Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema

and eyelid swelling, itchy and dry Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema (MIB144) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 6 of 17eyes and general discomfort when wearing the mask. The third study reported limited data as it was an abstract only, but showed no progression of retinopathy (measured through retinopathy grading and best corrected visual acuity) over the course (...) Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema Noctur Noctura 400 Sleep Mask for diabetic retinopath a 400 Sleep Mask for diabetic retinopathy y and diabetic macular oedema and diabetic macular oedema Medtech innovation briefing Published: 24 April 2018 nice.org.uk/guidance/mib144 pathways Summary Summary The technology technology described in this briefing is Noctura 400 Sleep Mask. It is used for treating diabetic retinopathy (DR) and diabetic macular oedema (DMO

2018 National Institute for Health and Clinical Excellence - Advice

2. Human albumin infusion for treating oedema in people with nephrotic syndrome. (Abstract)

in the treatment of oedema, it could help clinicians to develop therapeutic strategies to improve the management of diuretic resistance associated with nephrotic syndrome.This review aimed to examine the benefits and harms of human albumin infusion for treating oedema associated with nephrotic syndrome.We searched the Cochrane Kidney and Transplant Register of Studies up to 23 June 2019 through contact with the Information Specialists using search terms relevant to this review. Studies in the Specialised (...) Human albumin infusion for treating oedema in people with nephrotic syndrome. Oedema is a common clinical symptom in people with nephrotic syndrome and human albumin has been widely used in the treatment of oedema by increasing vascular volume and this inducing diuresis. It may be used with or without diuretics such as furosemide. However, the quantitative contribution of human albumin in treating oedema is not fully understood. If human albumin were found to be effective and safe

2019 Cochrane

3. Assessment of peripheral oedema

Assessment of peripheral oedema Assessment of peripheral oedema - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of peripheral oedema Last reviewed: February 2019 Last updated: January 2019 Summary Peripheral oedema is the presence of palpable swelling resulting from increased interstitial fluid in the tissue of the extremities. Schroth BE. Evaluation and management of peripheral edema. JAAPA. 2005 Nov;18 (...) (11):29-34. http://www.ncbi.nlm.nih.gov/pubmed/16315498?tool=bestpractice.com The most severe, generalised form of oedema is called anasarca. Oedema is caused by imbalance of the equilibrium between the hydrostatic forces that push fluid into the interstitial tissue spaces and the oncotic gradient that draws fluid into the intravascular space. Starling EH. Physiologic forces involved in the causation of dropsy. Lancet. 1896;i:1267-70. Normally, the small amount of net movement of fluid

2019 BMJ Best Practice

4. Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Diastolic (...) Dysfunction and Interstitial Lung Edema in Septic Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03768752 Recruitment Status : Recruiting First Posted : December 7, 2018 Last Update Posted : February 4, 2019 See

2018 Clinical Trials

5. Urticaria and angio-oedema

for the preceding image starts]: Angio-oedema of the lips in a patient who also has urticaria From the collection of Stephen Dreskin, MD, PhD [Citation ends]. History and exam erythematous oedematous lesions pruritus resolution within 24 hours swelling of face, tongue, or lips blanching lesions stridor positive family history female sex exposure to drug trigger exposure to food trigger recent viral infection recent insect bite Diagnostic investigations FBC with differential complete metabolic panel urinalysis (...) Urticaria and angio-oedema Urticaria and angio-oedema - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Urticaria and angio-oedema Last reviewed: February 2019 Last updated: March 2018 Summary Urticaria is a skin condition characterised by erythematous, blanching, oedematous, non-painful, pruritic lesions that typically resolve within 24 hours and leave no residual markings. Angio-oedema is swelling involving

2018 BMJ Best Practice

6. Assessment of peripheral oedema

Assessment of peripheral oedema Assessment of peripheral oedema - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of peripheral oedema Last reviewed: February 2019 Last updated: January 2019 Summary Peripheral oedema is the presence of palpable swelling resulting from increased interstitial fluid in the tissue of the extremities. Schroth BE. Evaluation and management of peripheral edema. JAAPA. 2005 Nov;18 (...) (11):29-34. http://www.ncbi.nlm.nih.gov/pubmed/16315498?tool=bestpractice.com The most severe, generalised form of oedema is called anasarca. Oedema is caused by imbalance of the equilibrium between the hydrostatic forces that push fluid into the interstitial tissue spaces and the oncotic gradient that draws fluid into the intravascular space. Starling EH. Physiologic forces involved in the causation of dropsy. Lancet. 1896;i:1267-70. Normally, the small amount of net movement of fluid

2018 BMJ Best Practice

7. Remote examination of exudates-impact of macular oedema Full Text available with Trip Pro

Remote examination of exudates-impact of macular oedema One of the major causes of eye blindness is identified to be as diabetic retinopathy, which if not detected in earlier stage would cause a serious issue. Long-term diabetes causes diabetic retinopathy. The significant key factor leading to diabetic retinopathy is exudates which affect the retina part and causes eye defects. Thus the first and foremost task in the automated detection of macular oedema is to detect the presence (...) of these exudates. The authors use image processing techniques to detect the optic disc, exudates and the presence of macular oedema. Their method has the sensitivity 96.07%, selectivity 97.36%, and accuracy 96.62% for the exudates detection and in the case of macular oedema detection the sensitivity 97.75%, selectivity 100%, and accuracy 98.86% is achieved. The performance comparison with other methods reveals that their method can be used as a screening process for diabetic retinopathy. In addition

2018 Healthcare technology letters

8. Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. (Abstract)

Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. To evaluate the performance of ultrawide field scanning laser ophthalmoscopy (UWF-SLO) for assessing diabetic retinopathy (DR) and diabetic macular oedema (DME) in a Chinese population, compared with clinical examination.This is a retrospective cohort study. A series of 322 eyes from (...) 164 patients with DM were included. Each patient underwent both dilated fundal examination with DR and DME grading by retina specialist and non-mydriatic 200° UWF-SLO (Daytona, Optos, Dunfermline, UK). The severity of DR and DME from UWF-SLO images was further graded by ophthalmologists, according to both international clinical DR and DME disease severity scales and the standard 7-field Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Any DR, DME and vision-threatening DR (VTDR) were

2018 British Journal of Ophthalmology

9. Is Edema at the Posterior Medial Tibial Plateau Indicative of a Ramp Lesion? An Examination of 307 Patients With Anterior Cruciate Ligament Reconstruction and Medial Meniscal Tears Full Text available with Trip Pro

Is Edema at the Posterior Medial Tibial Plateau Indicative of a Ramp Lesion? An Examination of 307 Patients With Anterior Cruciate Ligament Reconstruction and Medial Meniscal Tears Medial meniscal tears are commonly seen during anterior cruciate ligament reconstruction (ACLR). A subset of these injuries includes posterior meniscocapsular junction or "ramp" tears. One criterion that may correlate with a ramp lesion is the presence of posterior medial tibial plateau (PMTP) edema.To compare (...) . Preoperative MRI scans were reviewed for PMTP edema using axial, coronal, and sagittal T2 and proton-density sequences. Differences between groups were analyzed using a 2-sample t test and chi-square test. Univariate and multivariate logistic regression models examined correlations with tear type.Overall, 307 patients had medial meniscal tears identified during ACLR (127 ramp lesions, 180 meniscal body lesions). The ramp group was 7.5 years younger than the meniscal body group (P < .01). The groups were

2018 Orthopaedic journal of sports medicine

10. Diagnostic accuracy of ultrasound findings in the dyspneic patient for distinguishing cardiogenic pulmonary edema from noncardiogenic etiologies of interstitial syndrome: a systematic review

Diagnostic accuracy of ultrasound findings in the dyspneic patient for distinguishing cardiogenic pulmonary edema from noncardiogenic etiologies of interstitial syndrome: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites (...) be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup required for analysis should be specified. For further guidance please refer to the and to pre-clinical meta-analysis. Example: The following study characteristics will be examined as potential source of heterogeneity: species (stratified per species); sex (stratified per sex); duration of index ischemia (linear); stem cell dose (linear); blinding of outcome assessment reported (stratified yes vs

2018 PROSPERO

11. Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature. (Abstract)

included: 15 eyes (15 patients) affected by PCMO; 14 healthy fellow eyes used as negative control group; 15 eyes (15 age-matched and sex-matched patients) with DMO used as positive control group. All patients underwent a complete ophthalmological examination at baseline, including OCT-A scans of the macula through AngioPlex CIRRUS-5000 (Carl Zeiss Meditec, Dublin, USA). Patients with PCMO and DMO were re-evaluated after the pharmacological resolution of cystoid macular oedema (CMO).Disruption (...) Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature. To describe optical coherence tomography angiography (OCT-A) abnormalities of patients with pseudophakic cystoid macular oedema (PCMO) before and after pharmacological resolution, compared with diabetic macular oedema (DMO) and normal eyes.In this retrospective, observational study, 44 eyes (30 patients) were

2018 British Journal of Ophthalmology

12. Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion

Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion Aflibercept for treating visual Aflibercept for treating visual impairment caused b impairment caused by macular oedema y macular oedema after br after branch retinal v anch retinal vein occlusion ein occlusion T echnology appraisal guidance Published: 28 September 2016 nice.org.uk/guidance/ta409 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms (...) due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion (TA409) © NICE 2018. All rights reserved

2016 National Institute for Health and Clinical Excellence - Technology Appraisals

13. Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Full Text available with Trip Pro

Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Diabetic macular oedema (DMO) is a thickening of the central retina, or the macula, and is associated with long-term visual loss in people with diabetic retinopathy (DR). Clinically significant macular oedema (CSMO) is the most severe form of DMO. Almost 30 years ago, the Early Treatment Diabetic Retinopathy Study (ETDRS) found that CSMO, diagnosed by means of stereoscopic fundus (...) photography, leads to moderate visual loss in one of four people within three years. It also showed that grid or focal laser photocoagulation to the macula halves this risk. Recently, intravitreal injection of antiangiogenic drugs has also been used to try to improve vision in people with macular oedema due to DR.Optical coherence tomography (OCT) is based on optical reflectivity and is able to image retinal thickness and structure producing cross-sectional and three-dimensional images of the central

2015 Cochrane

14. A system-based approach to the genetic etiologies of non-immune hydrops fetalis. (Abstract)

A system-based approach to the genetic etiologies of non-immune hydrops fetalis. A wide spectrum of genetic causes may lead to nonimmune hydrops fetalis (NIHF), and a thorough phenotypic and genetic evaluation are essential to determine the underlying etiology, optimally manage these pregnancies, and inform discussions about anticipated prognosis. In this review, we outline the known genetic etiologies of NIHF by fetal organ system affected, and provide a systematic approach to the evaluation (...) ranges from standard chromosomal microarray or karyotype to gene panels and broad approaches such as whole exome sequencing. Family and obstetric history, as well as pathology examination, can yield additional clues that are helpful in establishing a diagnosis. A systematic approach to evaluation can guide a more targeted approach to genetic evaluation, diagnosis, and management of NIHF.© 2019 John Wiley & Sons, Ltd.

2019 Prenatal diagnosis

15. Predisposing factors and neonatal outcomes for twin-twin transfusion syndrome cases developing transient donor hydrops after fetoscopic laser coagulation: a case control study. Full Text available with Trip Pro

Predisposing factors and neonatal outcomes for twin-twin transfusion syndrome cases developing transient donor hydrops after fetoscopic laser coagulation: a case control study. Transient donor hydrops (TDH) is defined as donor hydrops developed within days after laser therapy for twin-twin transfusion syndrome (TTTS) followed by resolution later. The purpose of this study was to evaluate the incidence, neonatal outcomes and predisposing factors of post laser therapy TDH in severe TTTS.A total (...) of 142 patients with severe TTTS who received laser therapy were included into this study. The pre-operative characteristics and neonatal outcomes were compared between TTTS with and without post laser therapy TDH. All live neonates received cranial ultrasound examination after delivery, mild cerebral injury was defined as exhibiting at least one of the following: intraventricular hemorrhage (IVH) grade I and II, lenticulostriate vasculopathy and subependymal pseudocysts; severe cerebral injury

2019 BMC Pregnancy and Childbirth

16. Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops. (Abstract)

Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops. Endolymphatic hydrops (EH) has been reported in ears with otosclerosis. The objective of this study was to investigate the clinical features of ears with otosclerosis and EH on magnetic resonance imaging (MRI) and identify predictors for the presence of EH.Retrospective study.University hospital.Forty-six ears from 37 patients with otosclerosis were included in the present study.The subjects were divided into three groups (...) , those with no, mild, or significant EH, based on 3-T MRI with intravenous injection of gadolinium. Hearing levels and the extent of otosclerotic lesions graded based on the computed tomography (CT) findings were compared among the groups. Moreover, to examine the vascular activity of the disease, intraoperative measurements of blood flow were also evaluated.Imaging, hearing levels, and blood flow values.The overall rate of EH was 58.7% (27 of 46 ears); cochlear EH (52.2%) was more frequent than

2019 Otology and Neurotology

17. The Biomechanics of Lesion Formation in Endolymphatic Hydrops: Single and Double Hit Mechanisms. (Abstract)

of the constraint functions was used to examine the nature of the interaction and determine how pressure and elasticity influence the hydropic process.The graphic analysis shows how bulge and stretch phenomena interact to achieve an equilibrium point that satisfies both physical requirements. Nominal values of pressure and elasticity are projected to result in a stable membrane equilibrium in the precritical zone with the modest isolated increases in either parameter alone compatible with stability. However (...) The Biomechanics of Lesion Formation in Endolymphatic Hydrops: Single and Double Hit Mechanisms. The vestibular membranes of the cochlea and saccule are subject to two simultaneous constraints as they deform in endolymphatic hydrops. Boundary tethers impose a bulge-type constraint during pressure-induced transverse membrane displacement, while inherent elasticity imposes a stretch-type constraint during stress-induced longitudinal membrane distention.The aim of this study is to reconcile

2019 Otology and Neurotology

18. Diagnosis and treatment of upper airway oedema caused by acute angio-oedema in the emergency department: a French consensus statement. (Abstract)

important questions. Responses were rated using a two-round Delphi methodology. The 11 recommendations were related to triage on admission, a step-by-step diagnostic protocol, definition of attack severity, discouragement of instrumental examination, prioritization of treatment for severe attacks according to clinical signs and anticipation of access to specific treatments by the hospital. Angio-oedema of the upper airways can be fatal and requires anticipation by the emergency department. A search (...) Diagnosis and treatment of upper airway oedema caused by acute angio-oedema in the emergency department: a French consensus statement. Angio-oedema is a transitory, localized, noninflammatory oedema of subcutaneous tissue or mucous. When the oedema affects the mouth, lips, tongue or larynx, it can result in fatal asphyxiation in the absence of specific treatment. Oedema secondary to plasma extravasation is usually mediated by either histamine or bradykinin. As laboratory tests are not available

2017 European Journal of Emergency Medicine

19. Physical Examination Tools Used to Identify Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Scoping Review Full Text available with Trip Pro

Physical Examination Tools Used to Identify Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Scoping Review Juvenile idiopathic arthritis (JIA) is the most common form of rheumatic disease in childhood and adolescents, affecting between 16 and 150 per 100,000 young persons below the age of 16. The lower limb is commonly affected in JIA, with joint swelling and tenderness often observed as a result of active synovitis.The objective of this scoping review is to identify (...) the existence of physical examination (PE) tools to identify and record swollen and tender lower limb joints in children with JIA.Two reviewers individually screened the eligibility of titles and abstracts retrieved from the following online databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL. Studies that proposed and validated a comprehensive lower limb PE tool were included in this scoping review.After removal of duplicates, 1232 citations were retrieved, in which

2018 Arthritis

20. Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI. (Abstract)

Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI. The objective of this study was to investigate the relationship between endolymphatic hydrops (EH) and hearing level or vestibular symptoms by focusing on EH herniation into the semicircular canal (SCC).Retrospective study.University hospital.The study included 1,548 ears of 775 patients who underwent magnetic resonance imaging (MRI) examination in our university hospital to investigate possible EH

2018 Otology and Neurotology

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