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1. Iluvien - fluocinolone acetonide intravitreal implant - diabetic macular edema

Iluvien - fluocinolone acetonide intravitreal implant - diabetic macular edema fluocinolone acetonide intravitreal implant | CADTH.ca Find the information you need fluocinolone acetonide intravitreal implant fluocinolone acetonide intravitreal implant Last Updated: September 30, 2019 Result type: Reports Project Number: SR0608-000 Product Line: Generic Name: fluocinolone acetonide intravitreal implant Brand Name: Iluvien Manufacturer: Knight Therapeutics Inc. Indications: diabetic macular edema (...) Manufacturer Requested Reimbursement Criteria 1 : Indicated for the treatment of diabetic macular edema (DME) in patients who have been previously treated with a course of corticosteroids and did not have a clinically significant rise in intraocular pressure. Submission Type: New Project Status: Active Biosimilar: No Date Recommendation Issued: September 26, 2019 Recommendation Type: Do not reimburse Fee Schedule: Schedule A The requested reimbursement criteria are provided by the applicant and do

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

2. Sodium retention and edema in nephrotic syndrome: new models and therapeutic targets

Sodium retention and edema in nephrotic syndrome: new models and therapeutic targets Sodium Retention and Edema in Nephrotic Syndrome: New Models and Therapeutic Targets – Clinical Correlations Search Sodium Retention and Edema in Nephrotic Syndrome: New Models and Therapeutic Targets July 23, 2019 4 min read By Maria Smith Peer Reviewed The mechanism of sodium retention and edema formation in patients with nephrotic syndrome has long been highly contested in the nephrology world (...) . The traditional teaching was that proteinuria leads to hypoalbuminemia, and the decreased plasma oncotic pressure results in the movement of plasma from intravascular space into the interstitial space, causing edema. This underfilling of the intravascular space leads to activation of the renin-angiotensin-aldosterone system, which would lead to renal sodium retention. This intravascular underfilling model may seem physiologically sound, but there are numerous flaws to that mechanism. First, studies have found

2019 Clinical Correlations

3. Ozurdex - dexamethasone - Diabetic macular edema

Ozurdex - dexamethasone - Diabetic macular edema dexamethasone | CADTH.ca Find the information you need dexamethasone dexamethasone Last Updated: November 27, 2018 Result type: Reports Project Number: SR0535-000 Product Line: Generic Name: dexamethasone Brand Name: Ozurdex Manufacturer: Allergan Inc. Indications: Diabetic macular edema Submission Type: New Indication Project Status: Complete Biosimilar: No Date Recommendation Issued: October 24, 2018 Recommendation Type: Do not reimburse Fee (...) 24, 2018 CDEC Final Recommendation posted October 26, 2018 Final CDR review report(s) and patient input posted November 08, 2018 Tags eye, dexamethasone, diabetic retinopathy, diabetes, Ozurdex; DME; diabetic macular edema; diabetic macular oedema Files Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2018 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

4. Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness

Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness | CADTH.ca Find the information you need Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Published on: October 16, 2017 Project Number: RC0933 (...) -000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of rigid dressings for edema management for leg amputation? What is the cost-effectiveness of rigid dressings for edema management for leg amputation? Key Message There is a suggestion of faster recovery (reduction in time duration between amputation and prosthetic fitting or reduction in edema volume) with the use of rigid dressings

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Dexamethasone intravitreal implant (Ozurdex Allergan Inc.) for treatment of diabetic macular edema

Dexamethasone intravitreal implant (Ozurdex Allergan Inc.) for treatment of diabetic macular edema Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES (...) , Inc. Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema . Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2016 Authors' objectives Diabetic macular edema (DME) is the main cause of loss of vision in patients with diabetes, and patients with DME typically lose several lines of visual acuity within a few years. Corticosteroids suppress inflammation, reduce leukostasis, support the barrier function of retinal endothelial cells

2017 Health Technology Assessment (HTA) Database.

6. The Effect of Complete Decongestive Therapy on Edema Volume Reduction and Pain in Women With Post Breast Surgery Lymph Edema (PubMed)

The Effect of Complete Decongestive Therapy on Edema Volume Reduction and Pain in Women With Post Breast Surgery Lymph Edema Upper extremity lymph edema is the most common side effect of breast cancer treatment that may produce significant physical and psychological morbidity. Pain is the frequent symptom of lymph edema that causes impairment of activities in daily life.The aim of this study was assessment of the effect of complex decongestive therapy (CDT) on upper extremity lymph edema (...) and pain in women with post breast surgery lymph edema.In this quasi- experimental research with before- after design, 36 women with moderate lymph edema after breast surgery participated in the program. Edema volume was measured by water displacement method; pain values were evaluated by visual analog scale (VAS). Data were recorded before intervention and 2 and 4 weeks after it. CDT included the first phase (intensive phase) and the second phase (maintenance phase). Each phase lasted 2 weeks. After

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2016 Iranian journal of cancer prevention

7. What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema?

What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? – Clinical Correlations Search What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? February 1, 2017 7 min read By Jenna Conway, MD Peer Reviewed Introduction A 58-year-old man presents with worsening dyspnea and nonproductive cough for five days. Significant history includes a recent (...) hospitalization for congestive heart failure. He is afebrile with a blood pressure of 95/55 mmHg, heart rate of 115 beats per minute, and oxygen saturation of 85% on room air. Physical exam is notable for rales bilaterally. Chest X-ray shows bilateral pulmonary infiltrates and an enlarged cardiac silhouette suggestive of cardiogenic pulmonary edema. Standard therapy is initiated with oxygen by face mask, diuretics, and a nitrate, however, the patient’s pulmonary edema does not improve. Noninvasive ventilation

2017 Clinical Correlations

8. Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema (PubMed)

Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema Postobstructive pulmonary edema (POPE) also known as negative pressure pulmonary edema (NPPE) is an underdiagnosed entity in clinical practice and can lead to life-threatening hypoxemia. A 64-year-old male patient's perioperative course was complicated by acute hypoxemic respiratory failure, after extubation following general anesthesia, following the excision of the right vocal cord papilloma. His chest X-ray (...) showed features of pulmonary edema, EKG showed dynamic ST-T changes in the lateral leads, and echocardiography showed evidence of regional motion abnormalities. His coronaries were normal on the immediate angiogram. He was managed with lung protective mechanical ventilation strategy, diuretics, and fluid restriction. His respiratory status improved, and trachea was extubated after 10 hours of intensive care unit (ICU) stay. The case illustrates the various differentials of immediate postoperative

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2018 Case reports in critical care

9. The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema (PubMed)

The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema Breakdown of the blood-brain barrier (BBB) or inner blood-retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality (...) , or vision loss. Restoration of the barrier function with corticosteroids in the brain, or by blocking VEGF in the eye are currently the predominant treatment options for brain edema and diabetic macular edema, respectively. However, corticosteroids have side effects, and VEGF has important neuroprotective, vascular protective and wound healing functions, implying that long-term anti-VEGF therapy may also induce adverse effects. We postulate that targeting downstream effector proteins of VEGF and other

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2018 Fluids and barriers of the CNS

10. OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS. (PubMed)

OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS. In diabetic patients presenting with macular edema (ME) shortly after cataract surgery, identifying the underlying pathology can be challenging and influence management. Our aim was to develop a simple clinical classifier able to confirm a diabetic etiology using few spectral domain optical coherence tomography parameters.We analyzed spectral (...) achieved a sensitivity of 94% to 98%, specificity of 94% to 95%, and an area under the curve of 0.937 to 0.987 (depending on the method) for confirming a diabetic etiology. A simple decision flowchart achieved a sensitivity of 96%, a specificity of 95%, and an area under the curve of 0.937.Confirming a diabetic etiology for edema in cases with uncertainty between diabetic cystoid ME and pseudophakic ME was possible using few spectral domain optical coherence tomography parameters with high accuracy. We

2018 Retina

11. Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. (PubMed)

Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. To evaluate the comparative effectiveness of 3 regional corticosteroid injections for uveitic macular edema (ME): periocular triamcinolone acetonide (PTA), intravitreal triamcinolone acetonide (ITA), and the intravitreal dexamethasone implant (IDI).Multicenter

2018 Ophthalmology

12. Iluvien (Fluocinolone Acetonide Intravitreal Implant Alimera Sciences) for treatment of diabetic macular edema

Iluvien (Fluocinolone Acetonide Intravitreal Implant Alimera Sciences) for treatment of diabetic macular edema Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation HAYES, Inc.. Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: Iluvien (fluocinolone acetonide intravitreal implant; Alimera Sciences) is a sterile, nonbiodegradable, intravitreal implant in a polyimide tube that is injected into the eye through a 25-gauge needle. The implant is 3.5 millimeters (mm

2016 Health Technology Assessment (HTA) Database.

13. Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial

Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial In this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints.Blinded adjudicators assigned designations for hemorrhagic transformation, neurologic deterioration, malignant edema, and edema-related death to patients from the GAMES-RP phase II randomized controlled trial of IV glyburide for large (...) hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment on additional markers of edema and clinical deterioration were examined.In the per-protocol sample, 41 patients received glyburide and 36 received placebo. There was no difference in the frequency of hemorrhagic transformation (n = 24 [58.5%] in IV glyburide vs n = 23 [63.9%] in placebo, p = 0.91) or the incidence of malignant

2019 EvidenceUpdates

14. Early Prediction of Malignant Brain Edema After Ischemic Stroke

Early Prediction of Malignant Brain Edema After Ischemic Stroke Background and Purpose- Malignant brain edema after ischemic stroke has high mortality but limited treatment. Therefore, early prediction is important, and we systematically reviewed predictors and predictive models to identify reliable markers for the development of malignant edema. Methods- We searched Medline and Embase from inception to March 2018 and included studies assessing predictors or predictive models for malignant (...) brain edema after ischemic stroke. Study quality was assessed by a 17-item tool. Odds ratios, mean differences, or standardized mean differences were pooled in random-effects modeling. Predictive models were descriptively analyzed. Results- We included 38 studies (3278 patients) with 24 clinical factors, 7 domains of imaging markers, 13 serum biomarkers, and 4 models. Generally, the included studies were small and showed potential publication bias. Malignant edema was associated with younger age (n

2019 EvidenceUpdates

15. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. (PubMed)

Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 or worse). The best approach

2019 JAMA

16. Is interferential current effective in the management of pain, range of motion, and edema following total knee arthroplasty surgery? A randomized double-blind controlled trial

Is interferential current effective in the management of pain, range of motion, and edema following total knee arthroplasty surgery? A randomized double-blind controlled trial To investigate the effectiveness of interferential current implementation following total knee arthroplasty surgery.Double-blind randomized controlled study.Orthopedics and traumatology in-patient clinic.From an initial enrollment of 132 patients, 113 who met the study inclusion criteria were randomly separated into two (...) stimulation was applied.Patients were assessed in respect of pain, range of motion (ROM), edema, and the amount of paracetamol used at baseline and on the 5th and 30th days after surgery.No significant difference was determined between the groups in respect of pain, ROM, and edema at days 0, 5, and 30. At the end of the 5th day, the amount of paracetamol used was significantly lower in the interferential current group ( P < 0.05).In this study, both groups showed significant improvements in pain, ROM

2019 EvidenceUpdates

17. Delayed Resolution of Cerebral Edema Is Associated With Poor Outcome After Nontraumatic Subarachnoid Hemorrhage

Delayed Resolution of Cerebral Edema Is Associated With Poor Outcome After Nontraumatic Subarachnoid Hemorrhage Background and Purpose- Global cerebral edema occurs in up to 57% of patients with subarachnoid hemorrhage (SAH) and is associated with prolonged hospital stay and poor outcome. Recently, admission brain edema was successfully graded using a simplified computed tomography-based semiquantitative score (subarachnoid hemorrhage early brain edema score [SEBES]). Longitudinal evaluation (...) of the SEBES grade may discriminate patients with rapid and delayed edema resolution after SAH. Here, we aimed to describe the resolution of brain edema and to study the relationship between this radiographic biomarker and hospital course and outcome after SAH. Methods- For the current observational cohort study, computed tomography scans of 283 consecutive nontraumatic SAH patients admitted to the neurological intensive care unit of a tertiary hospital were graded based on the absence of visible sulci

2019 EvidenceUpdates

18. Effectiveness of edema management techniques for subacute hand edema: A systematic review. (PubMed)

Effectiveness of edema management techniques for subacute hand edema: A systematic review. Systematic review.Prolonged hand edema can have detrimental effects on range of motion and function. There is no consensus on how best to manage traumatic subacute edema. This is the first systematic review which examines the clinical effectiveness of edema treatments on hand volume.The purpose of this systematic review was to examine the evidence of effectiveness of treatments for sub-acute hand edema.A (...) studies met the inclusion criteria. Study quality ranged from 23 to 41 out of 48 points on the SEQES. A total of 16 edema interventions were evaluated across the studies. Due to heterogeneity of the patient characteristics, interventions, and outcomes assessed, it was not possible to pool the results from all studies. Therefore, a narrative best evidence synthesis was undertaken. There is low to moderate quality evidence with limited confidence in the effect estimate to support the use of manual edema

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2017 Journal of hand therapy : official journal of the American Society of Hand Therapists

19. Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. (PubMed)

Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. Rapid recognition of those at high risk for malignant edema after stroke would facilitate triage for monitoring and potential surgery. Admission data may be insufficient for accurate triage decisions. We developed a risk prediction score using clinical and radiographic variables within 24 hours of ictus to better predict potentially lethal malignant edema.Patients admitted with diagnosis (...) codes of cerebral edema and ischemic stroke, NIHSS score (National Institute of Health Stroke Score) of ≥8 and head computed tomographies within 24 hours of stroke onset were included. Primary outcome of potentially lethal malignant edema was defined as death with midline shift ≥5 mm or decompressive hemicraniectomy. We performed multivariate analyses on data available within 24 hours of ictus. Bootstrapping was used to internally validate the model, and a risk score was constructed from

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2017 Stroke

20. Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. (PubMed)

Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little is known regarding the mechanisms that involve the protective effects of melatonin in the brain and peripheral tissues after HIE (...) . The present study aimed to examine the effects of melatonin on multiple organs, and the expression of edema related proteins in a neonatal rat model of hypoxic-ischemic brain damage (HIBD).One hundred ninety-two neonatal rats were randomly divided into three subgroups that underwent a sham surgery or HIBD. After the HIBD or sham-injury, the rats received an intraperitoneal injection of melatonin or an equal volume vehicle, respectively. We investigated the effects of melatonin on brain, kidney, and colon

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2017 BMC Pediatrics

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