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1. Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness

Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness | CADTH.ca Find the information you need Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Rigid Dressings for Edema Management for Leg Amputation: A Review of Clinical and Cost-Effectiveness Published on: October 16, 2017 Project Number: RC0933 (...) -000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of rigid dressings for edema management for leg amputation? What is the cost-effectiveness of rigid dressings for edema management for leg amputation? Key Message There is a suggestion of faster recovery (reduction in time duration between amputation and prosthetic fitting or reduction in edema volume) with the use of rigid dressings

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Dexamethasone intravitreal implant (Ozurdex Allergan Inc.) for treatment of diabetic macular edema

Dexamethasone intravitreal implant (Ozurdex Allergan Inc.) for treatment of diabetic macular edema Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES (...) , Inc. Dexamethasone intravitreal implant (Ozurdex; Allergan Inc.) for treatment of diabetic macular edema . Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2016 Authors' objectives Diabetic macular edema (DME) is the main cause of loss of vision in patients with diabetes, and patients with DME typically lose several lines of visual acuity within a few years. Corticosteroids suppress inflammation, reduce leukostasis, support the barrier function of retinal endothelial cells

2017 Health Technology Assessment (HTA) Database.

3. The Effect of Complete Decongestive Therapy on Edema Volume Reduction and Pain in Women With Post Breast Surgery Lymph Edema (PubMed)

The Effect of Complete Decongestive Therapy on Edema Volume Reduction and Pain in Women With Post Breast Surgery Lymph Edema Upper extremity lymph edema is the most common side effect of breast cancer treatment that may produce significant physical and psychological morbidity. Pain is the frequent symptom of lymph edema that causes impairment of activities in daily life.The aim of this study was assessment of the effect of complex decongestive therapy (CDT) on upper extremity lymph edema (...) and pain in women with post breast surgery lymph edema.In this quasi- experimental research with before- after design, 36 women with moderate lymph edema after breast surgery participated in the program. Edema volume was measured by water displacement method; pain values were evaluated by visual analog scale (VAS). Data were recorded before intervention and 2 and 4 weeks after it. CDT included the first phase (intensive phase) and the second phase (maintenance phase). Each phase lasted 2 weeks. After

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2016 Iranian journal of cancer prevention

4. What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema?

What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? – Clinical Correlations Search What is the Evidence for Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema? February 1, 2017 7 min read By Jenna Conway, MD Peer Reviewed Introduction A 58-year-old man presents with worsening dyspnea and nonproductive cough for five days. Significant history includes a recent (...) hospitalization for congestive heart failure. He is afebrile with a blood pressure of 95/55 mmHg, heart rate of 115 beats per minute, and oxygen saturation of 85% on room air. Physical exam is notable for rales bilaterally. Chest X-ray shows bilateral pulmonary infiltrates and an enlarged cardiac silhouette suggestive of cardiogenic pulmonary edema. Standard therapy is initiated with oxygen by face mask, diuretics, and a nitrate, however, the patient’s pulmonary edema does not improve. Noninvasive ventilation

2017 Clinical Correlations

5. Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema (PubMed)

Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema Postobstructive pulmonary edema (POPE) also known as negative pressure pulmonary edema (NPPE) is an underdiagnosed entity in clinical practice and can lead to life-threatening hypoxemia. A 64-year-old male patient's perioperative course was complicated by acute hypoxemic respiratory failure, after extubation following general anesthesia, following the excision of the right vocal cord papilloma. His chest X-ray (...) showed features of pulmonary edema, EKG showed dynamic ST-T changes in the lateral leads, and echocardiography showed evidence of regional motion abnormalities. His coronaries were normal on the immediate angiogram. He was managed with lung protective mechanical ventilation strategy, diuretics, and fluid restriction. His respiratory status improved, and trachea was extubated after 10 hours of intensive care unit (ICU) stay. The case illustrates the various differentials of immediate postoperative

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2018 Case reports in critical care

6. The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema (PubMed)

The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema Breakdown of the blood-brain barrier (BBB) or inner blood-retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality (...) , or vision loss. Restoration of the barrier function with corticosteroids in the brain, or by blocking VEGF in the eye are currently the predominant treatment options for brain edema and diabetic macular edema, respectively. However, corticosteroids have side effects, and VEGF has important neuroprotective, vascular protective and wound healing functions, implying that long-term anti-VEGF therapy may also induce adverse effects. We postulate that targeting downstream effector proteins of VEGF and other

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2018 Fluids and barriers of the CNS

7. OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS. (PubMed)

OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS. In diabetic patients presenting with macular edema (ME) shortly after cataract surgery, identifying the underlying pathology can be challenging and influence management. Our aim was to develop a simple clinical classifier able to confirm a diabetic etiology using few spectral domain optical coherence tomography parameters.We analyzed spectral (...) achieved a sensitivity of 94% to 98%, specificity of 94% to 95%, and an area under the curve of 0.937 to 0.987 (depending on the method) for confirming a diabetic etiology. A simple decision flowchart achieved a sensitivity of 96%, a specificity of 95%, and an area under the curve of 0.937.Confirming a diabetic etiology for edema in cases with uncertainty between diabetic cystoid ME and pseudophakic ME was possible using few spectral domain optical coherence tomography parameters with high accuracy. We

2018 Retina

8. Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. (PubMed)

Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. To evaluate the comparative effectiveness of 3 regional corticosteroid injections for uveitic macular edema (ME): periocular triamcinolone acetonide (PTA), intravitreal triamcinolone acetonide (ITA), and the intravitreal dexamethasone implant (IDI).Multicenter

2018 Ophthalmology

9. Iluvien (Fluocinolone Acetonide Intravitreal Implant Alimera Sciences) for treatment of diabetic macular edema

Iluvien (Fluocinolone Acetonide Intravitreal Implant Alimera Sciences) for treatment of diabetic macular edema Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation HAYES, Inc.. Iluvien (Fluocinolone Acetonide Intravitreal Implant; Alimera Sciences) for treatment of diabetic macular edema. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2016 Authors' conclusions Description of Technology: Iluvien (fluocinolone acetonide intravitreal implant; Alimera Sciences) is a sterile, nonbiodegradable, intravitreal implant in a polyimide tube that is injected into the eye through a 25-gauge needle. The implant is 3.5 millimeters (mm

2016 Health Technology Assessment (HTA) Database.

10. Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial

Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial In this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints.Blinded adjudicators assigned designations for hemorrhagic transformation, neurologic deterioration, malignant edema, and edema-related death to patients from the GAMES-RP phase II randomized controlled trial of IV glyburide for large (...) hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment on additional markers of edema and clinical deterioration were examined.In the per-protocol sample, 41 patients received glyburide and 36 received placebo. There was no difference in the frequency of hemorrhagic transformation (n = 24 [58.5%] in IV glyburide vs n = 23 [63.9%] in placebo, p = 0.91) or the incidence of malignant

2019 EvidenceUpdates

11. Early Prediction of Malignant Brain Edema After Ischemic Stroke

Early Prediction of Malignant Brain Edema After Ischemic Stroke Background and Purpose- Malignant brain edema after ischemic stroke has high mortality but limited treatment. Therefore, early prediction is important, and we systematically reviewed predictors and predictive models to identify reliable markers for the development of malignant edema. Methods- We searched Medline and Embase from inception to March 2018 and included studies assessing predictors or predictive models for malignant (...) brain edema after ischemic stroke. Study quality was assessed by a 17-item tool. Odds ratios, mean differences, or standardized mean differences were pooled in random-effects modeling. Predictive models were descriptively analyzed. Results- We included 38 studies (3278 patients) with 24 clinical factors, 7 domains of imaging markers, 13 serum biomarkers, and 4 models. Generally, the included studies were small and showed potential publication bias. Malignant edema was associated with younger age (n

2019 EvidenceUpdates

12. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. (PubMed)

Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 or worse). The best approach

2019 JAMA

13. Effectiveness of edema management techniques for subacute hand edema: A systematic review. (PubMed)

Effectiveness of edema management techniques for subacute hand edema: A systematic review. Systematic review.Prolonged hand edema can have detrimental effects on range of motion and function. There is no consensus on how best to manage traumatic subacute edema. This is the first systematic review which examines the clinical effectiveness of edema treatments on hand volume.The purpose of this systematic review was to examine the evidence of effectiveness of treatments for sub-acute hand edema.A (...) studies met the inclusion criteria. Study quality ranged from 23 to 41 out of 48 points on the SEQES. A total of 16 edema interventions were evaluated across the studies. Due to heterogeneity of the patient characteristics, interventions, and outcomes assessed, it was not possible to pool the results from all studies. Therefore, a narrative best evidence synthesis was undertaken. There is low to moderate quality evidence with limited confidence in the effect estimate to support the use of manual edema

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2017 Journal of hand therapy : official journal of the American Society of Hand Therapists

14. Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. (PubMed)

Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. Rapid recognition of those at high risk for malignant edema after stroke would facilitate triage for monitoring and potential surgery. Admission data may be insufficient for accurate triage decisions. We developed a risk prediction score using clinical and radiographic variables within 24 hours of ictus to better predict potentially lethal malignant edema.Patients admitted with diagnosis (...) codes of cerebral edema and ischemic stroke, NIHSS score (National Institute of Health Stroke Score) of ≥8 and head computed tomographies within 24 hours of stroke onset were included. Primary outcome of potentially lethal malignant edema was defined as death with midline shift ≥5 mm or decompressive hemicraniectomy. We performed multivariate analyses on data available within 24 hours of ictus. Bootstrapping was used to internally validate the model, and a risk score was constructed from

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2017 Stroke

15. Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. (PubMed)

Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins. Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little is known regarding the mechanisms that involve the protective effects of melatonin in the brain and peripheral tissues after HIE (...) . The present study aimed to examine the effects of melatonin on multiple organs, and the expression of edema related proteins in a neonatal rat model of hypoxic-ischemic brain damage (HIBD).One hundred ninety-two neonatal rats were randomly divided into three subgroups that underwent a sham surgery or HIBD. After the HIBD or sham-injury, the rats received an intraperitoneal injection of melatonin or an equal volume vehicle, respectively. We investigated the effects of melatonin on brain, kidney, and colon

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2017 BMC Pediatrics

16. Anthrax Vaccine Precipitated Induces Edema Toxin-Neutralizing, Edema Factor-Specific Antibodies in Human Recipients (PubMed)

Anthrax Vaccine Precipitated Induces Edema Toxin-Neutralizing, Edema Factor-Specific Antibodies in Human Recipients Edema toxin (ET), composed of edema factor (EF) and protective antigen (PA), is a virulence factor of Bacillus anthracis that alters host immune cell function and contributes to anthrax disease. Anthrax vaccine precipitated (AVP) contains low but detectable levels of EF and can elicit EF-specific antibodies in human recipients of AVP. Active and passive vaccination of mice with EF

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2017 Clinical and vaccine immunology : CVI

17. A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease

A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease - Full Text View - ClinicalTrials.gov Hide (...) glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated

2017 Clinical Trials

18. Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis. (PubMed)

Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis. We aimed to investigate predictive factors for visual and anatomic outcomes in patients with macular edema secondary to non-infectious uveitis.We conducted a multicenter, prospective, observational, 12-month follow-up study. Participants included in the study were adults with non-infectious uveitic macular edema (UME), defined as central subfoveal thickness (CST) of >300 μm as measured (...) in the vitreo-macular interface and cystoid macular edema. In contrast, bilaterally, systemic disease and the presence of anterior chamber cells were predictive of favorable prognosis.Available treatment modalities in UME may avoid chronic UME and improve anatomic outcome. However, the proportion of functional amelioration observed during 12 months of follow-up is lower. Thicker CST, alteration in the vitreo-macular interface and cystoid macular edema may denote less favorable prognosis. Conversely

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2019 PLoS ONE

19. Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy (PubMed)

Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy To describe the presentation, clinical course and management of a patient with bilateral maculopathy associated with sertraline.We report a rare case of bilateral cystoid macular edema and subretinal fluid in a 78-year-old Asian Indian female who was on chronic sertraline therapy. The patient was initially misdiagnosed as intermediate uveitis and started on oral corticosteroids. However, multimodal (...) imaging with fluorescein angiography and optical coherence tomography ruled out ocular inflammation. There was symmetrical bilateral macular involvement and changes on macular electroretinography, which provided clues to the diagnosis of toxic maculopathy. After cessation of sertraline therapy, the retinal pathology reversed with improvement in visual acuity.Development of cystoid macular edema due to sertraline is a very rare adverse event and must be considered by psychiatrists and ophthalmologists

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2018 American journal of ophthalmology case reports

20. Pulmonary edema caused by inhalation of vapors from water‐soluble paint (PubMed)

Pulmonary edema caused by inhalation of vapors from water‐soluble paint To report the effects of inhaling vapor from water-soluble paint after a recent encounter with 16 patients treated in our emergency department.We examined a series of chest computed tomography (CT) images from the 16 affected patients. Computed tomography was carried out on days 1, 2, 5, and 19 after the inhalation event.Twelve of the patients were found to have pulmonary edema, based on their CT findings. Patients (...) with pulmonary edema were classified as its persisted period. In the severe group, its pulmonary edema persisted over 5 days include, exacerbated edema, delayed-onset edema (during the follow-up), or edema amelioration. One patient had exacerbated edema, three patients had delayed-onset edema, and one patient experienced amelioration of their edema in the severe group. In all cases, the pulmonary edema had disappeared from the CT images by day 19 after the inhalation event. Thirteen of the 16 patients had

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2018 Acute medicine & surgery

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