How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,627 results for

Ectopic Pregnancy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

3601. Conservative management of ectopic pregnancy: prospective randomized clinical trial of methotrexate versus prostaglandin sulprostone by combined transvaginal and systemic administration. (PubMed)

Conservative management of ectopic pregnancy: prospective randomized clinical trial of methotrexate versus prostaglandin sulprostone by combined transvaginal and systemic administration. In a prospective randomized study, 21 patients with an unruptured tubal pregnancy were treated with local and systemic injection. On the day of diagnosis, methotrexate (MTX) (1 mg/kg) or sulprostone (500 micrograms) were injected into the gestational sac under transvaginal sonographic control. The systemic (...) . Thirteen of 14 successfully treated patients had initial hCG levels less than 5,000 mIU/mL. At subsequent hysterosalpinography, 13 of 14 patients had normal tubal configuration and patency. Three of 10 patients who desired another pregnancy had already achieved a normal intrauterine pregnancy. These results suggest that MTX and sulprostone were equally effective, and medical approach for the unruptured ectopic pregnancy may be restricted to patients with hCG less than 5,000 mIU/mL.

1991 Fertility and sterility Controlled trial quality: uncertain

3602. Return of reproductive performance after expectant management and local treatment for ectopic pregnancy. (PubMed)

Return of reproductive performance after expectant management and local treatment for ectopic pregnancy. The purpose of this study was to examine hysterosalpingographic findings and reproductive performance in patients previously managed non-surgically for ectopic pregnancy. Forty-nine patients with unruptured ectopic pregnancies were treated either by expectant management (n = 16) or medically (n = 33), using transvaginal methotrexate or sulprostone injection. The treatment was successful (...) in 35 patients (71.5%), 12 out of 16 and 23 out of 33 in the two groups respectively. For all patients, follow-up currently varies from 3 to 52 months with a median follow-up of 16.6 +/- 11.2 months and 7.3 +/- 4.3 months in the two groups respectively. Hysterosalpingography was performed in 25 out of 26 patients who desired further pregnancy. We found evidence of tubal patency on the ectopic pregnancy treated side in 23 cases (92%). In this group, no recurrent ectopic pregnancy was observed

1991 Human reproduction (Oxford, England) Controlled trial quality: uncertain

3603. Lack of resolution of ectopic pregnancy by intratubal injection of methotrexate. (PubMed)

Lack of resolution of ectopic pregnancy by intratubal injection of methotrexate. Although reports of local injection of MTX in the treatment of EP appeared to be promising, our results do not confirm the efficacy of this approach. Our experience was sufficiently discouraging to prompt discontinuation of a randomized trail; our hope is that others will add to the accumulating data base so that the role of local injection of MTX can be clarified.

1992 Fertility and sterility Controlled trial quality: uncertain

3604. Fertility outcome after conservative surgical treatment of ectopic pregnancy evaluated in a randomized trial. (PubMed)

Fertility outcome after conservative surgical treatment of ectopic pregnancy evaluated in a randomized trial. To evaluate the fertility outcome after laparoscopic surgery for ectopic pregnancy.A randomized trial versus laparotomy was performed between May 1987 and June 1989.The study was conducted in a clinical university center, the Sahlgrens Hospital.A group of 105 patients with tubal pregnancy were stratified with regard to risk determinants and age and randomized to laparoscopy (...) or laparotomy. Eighty-seven patients who desired pregnancy were evaluated for subsequent fertility outcome.Linear salpingotomy was performed in both surgical groups.We evaluated the fertility outcome after laparoscopic salpingotomy for comparison with the outcome after laparotomy.There was no difference between the groups in the overall fertility outcome. A substantially higher proportion of patients in the laparotomy group were subjected to adhesiolysis performed at a second-look laparoscopy.The fertility

1992 Fertility and sterility Controlled trial quality: uncertain

3605. Embryo transfer technique as a cause of ectopic pregnancy in in vitro fertilization. (PubMed)

Embryo transfer technique as a cause of ectopic pregnancy in in vitro fertilization. A randomized prospective study was performed to compare the effects of a midfundal versus a deep fundal transfer technique on subsequent intrauterine and ectopic PRs after IVF. The clinical intra-uterine PR after the deep fundal transfer was 12.4% per cycle with a 1.5% ectopic PR (which represented 12.2% of the pregnancies) versus 14.2% IUPs per cycle with a 0.4% ectopic rate (representing 3% of pregnancies

1993 Fertility and sterility Controlled trial quality: uncertain

3606. [Fertility after conservative surgical treatment of ectopic pregnancy, evaluated by a randomized trial]. (PubMed)

[Fertility after conservative surgical treatment of ectopic pregnancy, evaluated by a randomized trial]. In order to evaluate the fertility outcome after laparoscopic surgery for ectopic pregnancy, randomised trial of laparoscopy versus laparotomy was performed between May 1987 and June 1989. The study was conducted in a clinical university centre, Sahlgrens Hospital. A group a 105 patients with tubal pregnancy were stratified with regard to risk determinants and age randomized to laparoscopy (...) or laparotomy. Eighty-seven patients who desired pregnancy were evaluated for subsequent fertility outcome. Linear salpingotomy was performed in both groups. The fertility outcome after laparoscopic salpingotomy was compared with that following laparotomy. There was no difference between the groups in the overall fertility outcome. A substantially higher proportion of patients in the laparotomy group were subjected to adhesiolysis performed at a second-look laparoscopic surgery. Adhesiolysis at a second

1993 Ugeskrift for laeger Controlled trial quality: uncertain

3607. [Clinico-pathologic study of 285 cases of ectopic pregnancy in intrauterine devices-users and non-intrauterine devices-users]. (PubMed)

[Clinico-pathologic study of 285 cases of ectopic pregnancy in intrauterine devices-users and non-intrauterine devices-users]. Two hundred eighty five cases of ectopic pregnancy in Beijing area from Jan. 1 to Dec. 31 1990 including 150 cases of intrauterine devices (IUD) and 135 cases of non-IUD users were studied. Clinico-pathological observation included the history of pelvic inflammatory disease, the site of ectopic pregnancy, the classification of previous tubal inflammation of the ectopic (...) side and other pathologic lesions, the side of the corpus luteum of pregnancy and histology of endometrium, etc. Besides, using stereologic technique the cilia length and cilia density of endosalpinx were studied in 50 cases through image analysis system. Results showed that except for a significant higher frequency of ovarian pregnancy in IUD-users, there was no significant differences between the 2 groups. It indicated that the degree of injury of fallopian tubes and the factors causing

1994 Zhonghua fu chan ke za zhi Controlled trial quality: uncertain

3608. Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. (PubMed)

Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. To investigate whether the incidence of persistent ectopic pregnancy after linear salpingostomy can be reduced by prophylactic administration of a single dose of methotrexate postoperatively.Women who underwent linear salpingostomy for treatment of unruptured ectopic pregnancy and who agreed to participate in the study (n = 129) were randomly assigned to the prophylaxis or control group (...) , and any side effects related to methotrexate were noted. Persistent ectopic pregnancy was defined as a rise in the serum beta-hCG level or a decline of less than 20% between two consecutive measurements taken 3 days apart.A total of 116 women completed the postoperative follow-up: 54 in the prophylaxis group and 62 in the control group. Ten women had persistent ectopic pregnancy, one in the prophylaxis group (1.9%) and nine among the controls (14.5%); this difference was statistically significant (P

1997 Obstetrics and Gynecology Controlled trial quality: uncertain

3609. Laparoscopic surgery in ectopic pregnancy. (PubMed)

Laparoscopic surgery in ectopic pregnancy. A randomized, prospective clinical trial was conducted to compare the efficacy of laparoscopic treatment versus conventional conservative abdominal surgery for tubal pregnancy.Patients were stratified for age and risk determinants for ectopic pregnancy (EP). Forty-eight patients were treated by laparoscopy and 57 by laparotomy. Entry criteria were: size of the ectopic gestation < 4 cm, hemodynamic stability, accessibility for laparoscopic treatment (...) and a trained laparoscopist on duty.There was no difference between the groups regarding gestational duration, size and location of the ectopic gestation, and the mean preoperative hCG values. The groups did differ with respect to total operation time (73 min in the laparoscopy group vs. 88 min in the laparotomy group), hospital stay (2.2 days vs. 5.4 days) and convalescence period (11 days vs. 24 days). The rates of elimination of hCG were similar in the two groups, and there was no statistical difference

1997 Acta obstetricia et gynecologica Scandinavica. Supplement Controlled trial quality: uncertain

3610. Prophylactic vasopressin during laparoscopic salpingotomy for ectopic pregnancy. (PubMed)

Prophylactic vasopressin during laparoscopic salpingotomy for ectopic pregnancy. To evaluate the safety and efficacy of prophylactic mesosalpingeal vasopressin injection for hemostasis during laparoscopic salpingotomy for ectopic pregnancy.Prospective, randomized clinical study.Reproductive endocrinology and endoscopic surgery clinic of a tertiary care hospital.Forty women with ectopic pregnancy.Laparoscopic linear salpingotomy was attempted, with prophylactic mesosalpingeal dilute vasopressin (...) injection in 20 patients (study group), and without vasopressin in 20 patients (control group). The two groups were similar with regard to age, size of ectopic pregnancy, gestational age, and initial beta-hCG values. A multipuncture operative laparoscopy technique was used in all cases and bipolar electrocoagulation was used for hemostasis.The operating time was significantly shorter and the need for electrocoagulation was significantly less in the study than in the control group (p <0.05). Laparoscopic

1996 The Journal of the American Association of Gynecologic Laparoscopists Controlled trial quality: uncertain

3611. Low-dose oral methotrexate with expectant management of ectopic pregnancy. (PubMed)

Low-dose oral methotrexate with expectant management of ectopic pregnancy. To investigate recovery times and need for laparoscopy in women with ectopic pregnancy who were treated for 5 days 2.5 mg/day of oral methotrexate or placebo.Sixty women with ectopic pregnancy among patients of an outpatient clinic specializing in early pregnancy disorders were selected for medical treatment in a double-blind, placebo-controlled study. The diagnosis was made by transvaginal sonography and serum hCG (...) determinations, either at admission or after repeated examinations. Women were recruited for the study if they had mild symptoms: the hCG increase was less than 50% within 2 days, the diameter of the ectopic pregnancy was less than 40 mm, there were no signs of intra-abdominal bleeding by transvaginal sonography, and there were no secondary reasons for laparoscopy. Either 2.5 mg of methotrexate or placebo was given orally for 5 days. Serum hCG was determined after 2 days, and hCG, red blood cell count, white

1996 Obstetrics and Gynecology Controlled trial quality: uncertain

3612. Local injection of methotrexate dissolved in saline versus methotrexate suspensions for the conservative treatment of ectopic pregnancy. (PubMed)

Local injection of methotrexate dissolved in saline versus methotrexate suspensions for the conservative treatment of ectopic pregnancy. To compare the local injection of methotrexate (MTX) dissolved in saline and MTX suspensions for the laparoscopic treatment of ectopic pregnancy in terms of success rate and postoperative tubal patency. A total of 26 patients with unruptured ectopic pregnancies were selected from among 60 women with ectopic pregnancies admitted to the Nagasaki University (...) clinic. Of these patients, 12 were treated with MTX dissolved in saline solution (solution group) and 14 with MTX suspensions consisting of lipiodol (LPD) with phosphatidylcholine (PC) added as a dispersing stabilizer (suspension group). Except for one case treated under transvaginal guidance, all the patients were treated by laparoscopy. Persistent ectopic pregnancy was recognized in seven cases (58%) in the solution group but in only two cases (14%) in the suspension group. Moreover, rupture

1995 Human reproduction (Oxford, England) Controlled trial quality: uncertain

3613. [Role of conservative therapy and medical treatment in ectopic pregnancy: literature review and clinical trial comparing medical treatment and conservative laparoscopic treatment]. (PubMed)

[Role of conservative therapy and medical treatment in ectopic pregnancy: literature review and clinical trial comparing medical treatment and conservative laparoscopic treatment]. to compare methotrexate (MTX) to laparoscopic salpingotomy for conservative management of ectopic pregnancy (EP).prospective randomized study.eighty-nine patients were randomized into 2 groups using a random number table. Inclusion criteria were an EP visualized by ultrasound with a pretherapeutic score < or = 13 (...) as assessed by 6 criteria graded from 1 to 3: gestational age, hCG level, P level, abdominal pain, volume of the hemoperitoneum, and diameter of the hematosalpinx.1 mg/kg of MTX injected transvaginally into the ectopic pregnancy without anaesthesia or IM administration (1.5 mg/kg) when EP cannot be safely or easily punctured (group 1) versus laparoscopic salpingotomy (group 2).the success rates defined by hCG levels returned to normal (< 10 mlU/mL) were 43 out of 46 in group 1 and 40 out of 43 in group 2

1996 Contraception, fertilité, sexualité (1992) Controlled trial quality: uncertain

3614. Treatment of ectopic pregnancy by local injection of hypertonic glucose: a randomized trial comparing administration guided by transvaginal ultrasound or laparoscopy. (PubMed)

Treatment of ectopic pregnancy by local injection of hypertonic glucose: a randomized trial comparing administration guided by transvaginal ultrasound or laparoscopy. To study local treatment of ectopic pregnancy by injection of hyperosmolar (50%) glucose, guided either by transvaginal ultrasound or by laparoscopy.Eighty women were randomized, 39 into the sonography and 41 into the laparoscopy group. Criteria for inclusion were 1) ectopic pregnancy < or = 4 cm seen by transvaginal ultrasound, 2 (...) %), and in 25 patients (89.3%) the treated tube was open.Local injection of hyperosmolar glucose guided by transvaginal ultrasound by one skilled investigator is an effective treatment for ectopic pregnancy. Most women preserve tubal patency after treatment.

1995 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: uncertain

3615. Intra-amniotic methotrexate versus CO2 laser laparoscopic salpingotomy in the management of tubal ectopic pregnancy--a prospective randomized trial. (PubMed)

Intra-amniotic methotrexate versus CO2 laser laparoscopic salpingotomy in the management of tubal ectopic pregnancy--a prospective randomized trial. Tubal pregnancy can be safely and effectively managed by MTX or CO2 laparoscopic salpingotomy techniques. Methotrexate may be superior because of its simplicity, requiring only basic laparoscopic skills, whereas laparoscopic salpingotomy necessitates operative laparoscopic input.

1994 Fertility and sterility Controlled trial quality: uncertain

3616. Transvaginal intra-amniotic injection of methotrexate in early ectopic pregnancy. Advantages over the laparoscopic approach. (PubMed)

Transvaginal intra-amniotic injection of methotrexate in early ectopic pregnancy. Advantages over the laparoscopic approach. Methotrexate (MTX, 100 mg) was administered to 36 patients with early ectopic pregnancy locally, either under laparoscopic control into the distended fallopian tube (group A, n = 16), or transvaginally into the gestational sac directly, under ultrasound guidance (group B, n = 20). In cases with persistent beta-hCG levels (n = 7), an additional 50 mg of MTX solution

1994 Early human development Controlled trial quality: uncertain

3617. Ultrasound-guided injection of methotrexate versus laparoscopic salpingotomy in ectopic pregnancy. (PubMed)

Ultrasound-guided injection of methotrexate versus laparoscopic salpingotomy in ectopic pregnancy. To compare local injection of methotrexate (MTX) under sonographic control to laparoscopic salpingotomy for conservative management of ectopic pregnancy (EP).Prospective randomized study.Forty patients were randomized into two groups using a random number table. Inclusion criteria were an EP visualized by ultrasound with a pretherapeutic score < or = 13 as assessed by six criteria graded from 1

1995 Fertility and sterility Controlled trial quality: uncertain

3618. Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility. (PubMed)

Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility. Methotrexate treatment was compared to laparoscopic salpingotomy for conservative management of ectopic pregnancy in a prospective randomized study. One hundred patients were randomized into two groups using random numbers. Inclusion criteria were an ectopic pregnancy visualized by ultrasound with a pre-therapeutic score <13 as assessed by the following six (...) criteria, graded from 1 to 3: gestational age, human chorionic gonadotrophin (HCG) concentration, progesterone concentration, abdominal pain, haemoperitoneal volume and diameter of the haematosalpinx. The treatments were either 1 mg/kg of methotrexate injected transvaginally into the ectopic pregnancy without anaesthesia or administered i.m. when the pregnancy could not safely or easily be punctured (group 1), or laparoscopic salpingotomy (group 2). Success was defined as the return to normal (<10 mIU

1998 Human reproduction (Oxford, England) Controlled trial quality: uncertain

3619. Time length of negativization of hCG serum values after either surgical or medical treatment of ectopic pregnancy. (PubMed)

Time length of negativization of hCG serum values after either surgical or medical treatment of ectopic pregnancy. The aim of this study was to compare the time length until the human chorionic gonadotropin titer became negative after medical or surgical treatment of ectopic pregnancy.Prospective, randomized study. PARTECIPANTS AND INTERVENTIONS: We compared time to resolution in 30 cases of tubal pregnancies successfully treated, 15 underwent laparoscopic linear salpingostomy (group 1) and 15

1998 Panminerva medica Controlled trial quality: uncertain

3620. An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy. (PubMed)

An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy. To compare the direct and indirect costs of single dose systemic methotrexate with laparoscopic surgery for the treatment of unruptured ectopic pregnancy.A cost minimisation study undertaken alongside a randomised trial.Departments of Obstetrics and Gynaecology in three hospitals in Auckland, New Zealand.Sixty-two women with an ectopic pregnancy randomised (...) intervention in women receiving methotrexate.This economic evaluation shows that treating suitable women with an ectopic pregnancy using systemic methotrexate therapy results in a significant reduction in direct costs. The indirect costs borne by the woman and her carers are only likely to be reduced in women with pretreatment serum beta-hCG concentrations under 1,500 IU/L.

2001 BJOG Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>