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E/M Examination Criteria

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141. Canadian Stroke Best Practice recommendations, seventh edition: acetylsalicylic acid for prevention of vascular events

Canadian Stroke Best Practice Recommendations, seventh edition: acetylsalicylic acid for prevention of vascular events Theodore Wein MD, M. Patrice Lindsay RN PhD, David J. Gladstone MD PhD, Alexandre Poppe MD CM, Alan Bell MD, Leanne K. Casaubon MD MSc, Norine Foley MSc, Shelagh B. Coutts MD MBChB, Jafna Cox MD, James Douketis MD, Thalia Field MD MHSc, Laura Gioia MD MSc, Jeffrey Habert MD, Eddy Lang MD MDCM, Shamir R. Mehta MD MSc, Christine Papoushek PharmD, William Semchuk PharmD MSc, Mikul Sharma (...) MD MSc, Jacob A. Udell MD MPH, Stephanie Lawrence BA Dip. J., Anita Mountain MD, Gord Gubitz MD, Dar Dowlatshahi MD PhD, Anne Simard MHSc BJ, Andrea de Jong RN MN, Eric E. Smith MD MPH; for the Heart and Stroke Foundation of Canada in collaboration with the Canadian Stroke Consortium n Cite as: CMAJ 2020 March 23;192:E302-11. doi: 10.1503/cmaj.191599 This article is available in French at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.191599/-/DC1 CMAJ Podcasts: author interview at https

2020 CPG Infobase

142. Canadian guidelines on opioid use disorder among older adults

Psychia- try Rep. 2016;18(9):87. Epub 2016/08/05. 45. Loreck D, Brandt NJ, DiPaula B. Managing opioid abuse in older adults: clinical considerations and challenges. J Gerontol Nurs. 2016;42(4):10–15. Epub 2016/03/31. 46. Maree RD, Marcum ZA, Saghafi E, et al. A systematic review of opioid and benzodiazepine misuse in older adults. Am J Geriatr Psychiatry. 2016;24(11):949–63. Epub 2016/10/19. 47. Burgos-Chapman I, Trevisan L, Sevarino K. Abuse of opioids and prescription medications. In: Sullivan M (...) -Agonist-Therapy 67. Nosyk B, Sun H, Evans E, et al. Defining dosing pattern charac - teristics of successful tapers following methadone maintenance treatment: results from a population-based retrospective cohort study. Addiction. 2012;107(9):1621–29. Epub 2012/03/06. 68. W alley A Y , Doe-Simkins M, Quinn E, et al. Opioid overdose pre- vention with intranasal naloxone among people who take metha- done. J Subst Abuse Treat. 2013;44(2):241–47. Epub 2012/09/18. 69. Walley AY , Xuan Z, Hackman HH, et al

2020 CPG Infobase

143. Prostate cancer screening with the PSA test

im Gesundheitswesen Im Mediapark 8 50670 Köln Germany Phone: +49 221 35685-0 Fax: +49 221 35685-1 E-mail: berichte@iqwig.de Internet: www.iqwig.de Extract of final report S19-01 Version 1.0 PSA screening 24 April 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - ii - This report was prepared in collaboration with external experts. The responsibility for the contents of the report lies solely with IQWiG. According to §139b (3) No. 2 of Social Code Book (SGB) V, Statutory Health (...) Familienmedizin DRE Digital rectal examination G-BA Gemeinsamer Bundesausschuss (Federal Joint Committee) HTA Health technology assessment IDR Incidence density ratio IQWiG Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (Institute for Quality and Efficiency in Health Care) mpMRI Multiparametric magnetic resonance imaging MRI Magnetic resonance imaging PSA Prostate-specific antigen RCT Randomized controlled trial TRUS Transrectal ultrasound Extract of final report S19-01 Version 1.0 PSA

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

144. Niraparib (ovarian cancer) - Benefit assessment according to §35a Social Code Book V

No. A19-88 Address of publisher Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Im Mediapark 8 50670 Köln Germany Phone: +49 221 35685-0 Fax: +49 221 35685-1 E-mail: berichte@iqwig.de Internet: www.iqwig.de Extract of dossier assessment A19-88 Version 1.0 Niraparib (ovarian cancer) 13 January 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - ii - Medical and scientific advice No advisor on medical and scientific questions was available for the present dossier (...) (IQWiG) - vi - List of abbreviations Abbreviation Meaning ACT appropriate comparator therapy AE adverse event BRCA breast cancer associated gene CA-125 cancer antigen-125 CTCAE Common Terminology Criteria for Adverse Events ECOG PS Eastern Cooperative Oncology Group Performance Status EQ-5D European Quality of Life-5 Dimensions FACT-O Functional Assessment of Cancer Therapy-Ovarian FIGO Fédération Internationale de Gynécologie et d’Obstétrique gBRCAmut germline BRCA mutation G-BA Gemeinsamer

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

145. Psychological interventions to foster resilience in healthcare professionals

incorporated these results. Selection criteria Randomised controlled trials (RCTs) in adults aged 18 years and older who are employed as healthcare professionals, comparing any form of psychological intervention to foster resilience, hardiness or post‐traumatic growth versus no intervention, wait‐list, usual care, active or attention control. Primary outcomes were resilience, anxiety, depression, stress or stress perception and well‐being or quality of life. Secondary outcomes were resilience factors. Data (...) or a control group by a procedure similar to tossing a coin). The studies tested a range of resilience interventions in participants aged on average between 27 and 52.4 years. Healthcare professionals were the focus of 39 studies, with a total of 6892 participants. Four studies included mixed samples (1000 participants) of healthcare professionals and non‐healthcare participants. One study of resilience training for emergency workers examined 82 volunteers. Of the included studies, 19 compared a combined

2020 Cochrane

146. Asfotase alfa (hypophosphatasia) - Benefit assessment according to §35a Social Code Book V

October 2020 Internal Commission No. A19-89 Address of publisher Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Im Mediapark 8 50670 Köln Germany Phone: +49 221 35685-0 Fax: +49 221 35685-1 E-mail: berichte@iqwig.de Internet: www.iqwig.de Extract of dossier assessment A19-89 Version 1.0 Asfotase alfa (hypophosphatasia) 13 January 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - ii - Medical and scientific advice ? Anibh Das, Hannover Medical School, Germany IQWiG (...) : comparison of single-arm studies with data from medical records: asfotase alfa vs. supportive measures (infants with perinatal or infantile HPP) 22 Table 10: Inclusion criteria (study ENB-011-10) on prognostic factors – non-RCTs: comparison of single-arm studies with data from medical records: asfotase alfa vs. supportive measures (infants with perinatal or infantile HPP) 26 Table 11: Matrix of outcomes – non-RCTs: comparison of single-arm studies with data from medical records: asfotase alfa vs

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

147. Recommendations from the Canadian Association of Head and Neck Surgical Oncology for the management of head and neck cancers during the COVID-19 pandemic

of later recall where resources and appropriateness allow e. Virtual / telephone consultation should be considered for all referrals with a risk of malignancy to better ascertain severity and to guide need for face to face consultations. f. Restrict all patient face to face patient assessments to urgent and emergent interactions. g. Patients who are at higher risk for adverse outcomes following COVID-19 infection (age>70 years, known high risk comorbidities, frailty) who meet high risk cancer criteria (...) +/- performing transnasal endoscopy: 1. The examination should be performed in room with negative pressure. 2. Only treating physician or a senior learner should perform the procedure. 3. PPE should include scrubs, water impermeable gown, surgical hood, full face shield, and double gloves and N95 mask or Powered Air Purifying Respirator (PAPR) Appropriate donning and doffing protocols are critical and must be followed when using PPE. An appropriately fit-tested N95 respirator is equally important. m. Limit

2020 CPG Infobase

148. Chronic heart failure in adults: diagnosis and management

services if needed. [2018] [2018] Care after an acute e Care after an acute ev vent ent For recommendations on the diagnosis and management of acute heart failure see NICE's guideline on acute heart failure. 1.1.5 People with heart failure should generally be discharged from hospital only when their clinical condition is stable and the management plan is optimised. Timing of discharge should take into account the wishes of the person and their family or carer, and the level of care and support that can (...) if appropriate, and all health and social care professionals involved in their care. [2018] [2018] 1.2 Diagnosing heart failure Symptoms, signs and in Symptoms, signs and inv vestigations estigations 1.2.1 T ake a careful and detailed history, and perform a clinical examination and tests to confirm the presence of heart failure. [2010] [2010] 1.2.2 Measure N-terminal pro-B-type natriuretic peptide (NT-proBNP) in people with suspected heart failure. [2018] [2018] Chronic heart failure in adults: diagnosis

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

149. Age-related macular degeneration

techniques with their family members or carers (as appropriate). Monitoring for late AMD (wet activ Monitoring for late AMD (wet active e) ) 1.7.8 Offer people with late AMD (wet active) ongoing monitoring with OCT for both eyes. 1.7.9 Offer fundus examination or colour photography if OCT appearances are stable, but: there is a decline in visual acuity or or the person reports a decline in visual function. 1.7.10 Consider FFA to identify unrecognised neovascularisation if OCT appearances are stable (...) (AREDS 2001) examined the effect of antioxidant supplementation on AMD progression using the AREDS formation, which included beta carotene, vitamin E, vitamin C and zinc. Although the study showed some beneficial effects of the combined antioxidant supplementation in a subgroup of participants, the effects of each of the formula components on AMD progression were unclear. Additionally, 1 of the ingredients (beta carotene) in the AREDS 2001 formulation is associated with a possible risk of lung cancer

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

150. Chronic obstructive pulmonary disease in over 16s: diagnosis and management

Chronic obstructive pulmonary disease in over 16s: diagnosis and management Chronic obstructiv Chronic obstructive pulmonary disease in e pulmonary disease in o ov ver 16s: diagnosis and management er 16s: diagnosis and management NICE guideline Published: 5 December 2018 nice.org.uk/guidance/ng115 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations (...) is purely arbitrary response to long-term therapy is not predicted by acute reversibility testing. [2004] [2004] 1.1.19 Untreated COPD and asthma are frequently distinguishable on the basis of history (and examination) in people presenting for the first time. Whenever possible, use features from the history and examination (such as those listed in table 3) to differentiate COPD from asthma. For more information on diagnosing asthma, see the NICE guideline on asthma. [2004, amended 2018] [2004, amended

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

151. Organ donation with the use of normothermic regional perfusion in patients who die after cardiac and respiratory arrest after withdrawal of life-sustaining treatment

. The neurological tests may be similar to those described in the English guidelines for cDCD. Proposal to include further tests of heart rate and global circulation to quality assure that cardiac arrest is achieved. Include documentation of ceased breathing. Quality assure and update the entire cDCD procedure. Downloadable as PDF. In Norwegian. English summary. About this publication Year: 2019 By: Norwegian Institute of Public Health Authors Giske L, Solberg B, Tranvåg E, Dahlberg J, Halvorsen M, Hafstad E (...) will ultimately be responsible for specifying and formulating a detailed description of death criteria. The description will be crucial for how the law and accompanying regulations are to be understood. The description may be included in a brief or by including more precise provisions in existing regulations. Ethics A review of the ethical discussion in international academic literature revealed how cDCD has been a subject of debate for many years, particularly in the early phase of establishing the method

2020 Norwegian Institute of Public Health

152. Genome-Wide Sequencing for Unexplained Developmental Disabilities or Multiple Congenital Anomalies

on patient care (including clinical decision making, timing) o Impact of test results on family care (including family planning) Literature Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 29 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria. The same reviewer then examined the full-text articles and selected studies eligible for inclusion. The reviewer also examined reference lists for any (...) , metabolic, and genetic tests over a period of years without diagnosis. Genome-wide sequencing, as whole exome or whole genome sequencing, can examine the entire genetic makeup of a person in a single test, capturing genetic information that other genetic tests (such as targeted gene tests) can miss. A genetic diagnosis can help these people and their families better understand their condition and help them connect with others who have the same condition. This health technology assessment looked at how

2020 Health Quality Ontario

153. Auditory Brainstem Implantation for Adults With Neurofibromatosis 2 or Severe Inner Ear Abnormalities

• Adults with NF2 who are not candidates for cochlear implantation • Adults with severe inner ear abnormalities who are not candidates for cochlear implantation Interventions • Auditory brainstem implantation Outcome Measures • Sound recognition • Speech perception • Subjective benefits of hearing • Quality of life • Adverse events Literature Screening A single reviewer reviewed the abstracts and, for those studies meeting the eligibility criteria, we obtained full-text articles. We also examined (...) presentations of 12 pictured words: 4 monosyllables, 4 trochees (a stressed and unstressed syllable), and 4 spondees (two stressed syllables). Two scores were obtained that reflected the number of times that patients recognized the correct stress pattern (MTS stress) and the number or words correctly identified (MTS words). e Statistically significant when compared with chance level (i.e., patients could get the correct answers by randomly guessing). f The NU-CHIPS test examines word recognition

2020 Health Quality Ontario

154. Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non–Small Cell Lung Cancer

(Intervention) Inclusion Criteria • Liquid biopsy (alone or as a triage test in combination with tissue biopsy) for detection of the EGFR T790M mutation via plasma tests that use cell-free ctDNA Exclusion Criteria • Studies examining liquid biopsy at any other time in the clinical pathway (i.e., diagnosis of EGFR-sensitizing mutations) • Liquid biopsy used for any other resistance mutations (Kirsten rat sarcoma viral oncogene, anaplastic lymphoma kinase, etc.) Reference Standard/Comparator Inclusion (...) , and then obtained the full text of studies that appeared eligible for the review according to the inclusion criteria. The single reviewer then examined the full-text articles and selected studies that were eligible for inclusion. Clinical Evidence March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 5, pp. 1–176, March 2020 18 Data Extraction We extracted relevant data on study characteristics and risk-of-bias items using a data form to collect information about the following: • Source (e.g

2020 Health Quality Ontario

155. Continual Long-Term Physiotherapy After Stroke

evidence. We also analyzed the budget impact of publicly funding continual long-term physiotherapy after stroke in Ontario. To contextualize the potential value of continual long-term physiotherapy after stroke, we spoke with people who had been diagnosed with stroke, as well as their caregivers. Results We did not find any published studies that met the specific clinical inclusion criteria. We did not identify any studies that compared the cost-effectiveness of continual long-term versus short- term (...) be able to continue with physiotherapy. March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 7, pp. 1–70, March 2020 4 TABLE OF CONTENTS LIST OF TABLES 6 LIST OF FIGURES 6 OBJECTIVE 7 BACKGROUND 7 Health Condition 7 Clinical Need and Target Population 7 Health Service Under Review 8 Physiotherapy After Stroke 8 Ontario Context 8 Expert Consultation 9 PROSPERO Registration 9 CLINICAL EVIDENCE 10 Research Questions 10 Methods 10 Clinical Literature Search 10 Eligibility Criteria 10

2020 Health Quality Ontario

156. Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer

Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 42 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria. A single reviewer then examined the full-text articles and selected studies eligible for inclusion. The reviewer also examined reference lists for any additional relevant studies not identified through the search. Data Extraction We extracted relevant data on study characteristics and risk (...) the Cochrane Risk of Bias tool, Prediction model Risk Of Bias ASsessment Tool (PROBAST), or Risk of Bias Assessment tool for Non-randomized Studies (RoBANS), depending on the type of study and outcome of interest, and the quality of the body of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group criteria. We also performed a literature survey of the quantitative evidence of preferences and values of patients and providers for GEP tests. We

2020 Health Quality Ontario

157. Transcatheter Aortic Valve Implantation in Patients With Severe, Symptomatic Aortic Valve Stenosis at Intermediate Surgical Risk

: No. 2, pp. 1–121, March 2020 14 Literature Screening A single reviewer conducted an initial screening of titles and abstracts using DistillerSR management software (Evidence Partners, Ottawa, Canada), and then obtained the full text of studies that appeared eligible for the review according to the inclusion criteria. The author then examined the full text articles and selected studies that were eligible for inclusion. The author also examined reference lists for any additional relevant studies (...) BACKGROUND 10 Health Condition 10 Clinical Need and Target Population 10 Current Treatment Options 10 Health Technology Under Review 11 Regulatory Information 12 Ontario Context 12 PROSPERO Registration 12 CLINICAL EVIDENCE 13 Research Question 13 Methods 13 Clinical Literature Search 13 Literature Screening 14 Inclusion Criteria 14 Exclusion Criteria 14 Outcomes of Interest 15 Data Extraction 15 Evidence Synthesis and Statistical Analysis 15 Critical Appraisal of Evidence 16 Expert Consultation 16

2020 Health Quality Ontario

158. Extracorporeal Membrane Oxygenation for Cardiac Indications in Adults

/complications/adverse events, short- and long-term • Quality of life, short- and long-term • Time in intensive care • Length of stay in hospital Literature Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 16 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria. A single reviewer then examined the full-text articles and selected studies eligible for inclusion. Clinical Evidence March 2020 Ontario (...) recent systematic review (n = 4) Studies included in quantitative synthesis (meta-analysis) (n = 15 a ) Clinical Evidence March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 8, pp. 1–121, March 2020 20 Systematic Reviews Five systematic reviews initially met our inclusion criteria. 8,23,24 The reviews were published between 2016 and 2017 and examined the effectiveness of ECMO for the treatment of cardiac arrest (ECPR) 23,24 , or both cardiac arrest and cardiogenic shock. 8,25,26

2020 Health Quality Ontario

159. Toolkit to support the generation of robust estimates of hepatitis C prevalence

of HCV infection in chronically HCV infected individuals 52 Table 13. Linkage to care and treatment of HCV positive individuals 52 TECHNICAL REPORT Technical protocol for hepatitis C prevalence surveys in the general population v Abbreviations HCV Hepatitis C virus HCVcAg HCV core antigen HES Health examination survey LIA Line immunoassay MSM Men who have sex with men MPES Multi-parameter evidence synthesis PWID People who inject drugs TECHNICAL REPORT Technical protocol for hepatitis C prevalence (...) methodological step of the protocol, the a) minimum requirements are listed, along with b) the gold standard and c) suggested options for possible expansion of the survey. The minimum requirements refer to criteria that must be met, while the gold standard should still be aimed for. Suggestions on how to further expand the survey are given if sufficient resources are available. The SPHERE-C protocol consists of two parts: ? Part A: Selection of survey approach and context ? Part B: Planning and conducting

2020 European Centre for Disease Prevention and Control - Technical Guidance

160. Financial education for HIV?vulnerable youth, orphans, and vulnerable children: A systematic review of outcome evidence Full Text available with Trip Pro

as a basis for aggregation. Context (C) examined the conditions of setting and target population issues including, where available, sex‐disaggregated gender, the average age of participants, setting (school or community), geographic location (urban, rural, peri‐urban). The mechanisms (M) analyzed and clustered the treatment arms to examine individual components of interventions. Outcomes (O) were analyzed by both outcome direction (positive, no effect, mixed) and type (HIV‐related; self‐efficacy (...) ‐vulnerable youth, orphans, and vulnerable children: A systematic review of outcome evidence Corresponding Author E-mail address: Sisters Ink, Halifax, Nova Scotia, Canada Correspondence Nanci Lee, Sisters Ink, 5516 Falkland Street, Halifax, NS, B3K1A3 Canada. Email: Sisters Ink, Halifax, Nova Scotia, Canada Universidad Iberoamericana, Mexico City, Mexico Sisters Ink, Halifax, Nova Scotia, Canada Stephen Lewis Foundation, Toronto, Canada Corresponding Author E-mail address: Sisters Ink, Halifax, Nova

2020 Campbell Collaboration

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