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141. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation

rupture of membranes . Cochrane Database Syst Rev 2014 ;: CD007062 . 30 Nijman, TAJ , van Vliet, EOG , Naaktgeboren, CA , Oude, RK , de, LT , Bax, CJ , et al. Nifedipine versus placebo in the treatment of preterm prelabor rupture of membranes: a randomised controlled trial. Assessment of perinatal outcome by use of tocolysis in early labor – APOSTEL IV trial . Eur J Obstet Gynecol Reprod Med 2016 ; 205 : 79 – 84 . 31 Lorthe, E , Goffinet, F , Marret, S , Vayssiere, C , Flamant, C , Quere, M , et al (...) : 669 – 75 . 47 Medley, N , Vogel, JP , Care, A , Alfirevic, Z . Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews . Cochrane Database of Syst Revs 2018 ; CD012505 . This guideline was produced on behalf of the Royal College of Obstetricians and Gynaecologists by: Dr AJ Thomson MRCOG, Paisley. and peer reviewed by: Professor AL David FRCOG, University College London, London; E Lorthe, RM, PhD, Paris; M Griffiths, Bedfordshire; MA Oudijk, Amsterdam

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2019 Royal College of Obstetricians and Gynaecologists

142. Is Point-of-Care Ultrasonography Effective for the Diagnosis of Urolithiasis?

Is Point-of-Care Ultrasonography Effective for the Diagnosis of Urolithiasis? Is Point-of-Care Ultrasonography Effective for the Diagnosis of Urolithiasis? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 5, Pages 517–519 Is Point-of-Care Ultrasonography Effective for the Diagnosis of Urolithiasis? x Michael Gottlieb , MD (EBEM Commentator) , x E. David Hill , MD (EBEM Commentator) , x (...) , Scopus, Web of Science, and PubMed on April 15, 2016, for literature evaluating adult emergency department (ED) patients with urolithiasis or renal colic symptoms, using a combination of key words and Medical Subject Headings terms. Bibliographies of included studies, narrative reviews, and conference abstracts were also manually examined. Study Selection Studies were considered eligible if they included patients older than 18 years and presenting to an ED with signs or symptoms suggestive

2019 Annals of Emergency Medicine Systematic Review Snapshots

143. Economic Analyses of Policies to Reduce Cervical Cancer

FOUND We identified a total of 25 relevant documents by searching five databases (Health Systems Evidence, Cochrane Library, Health Evidence, EconLit and PubMed), and the search strategy for these databases are detailed in Box 2. We applied the following inclusion criteria (as outlined by the requestor): 1) time period (2002 to present); 2) jurisdictional focus on Canada and other high- income countries with a similar socio-economic context (e.g., Group of Seven countries, Northwest Europe (...) practices (compared to screening alone), finding €8,408 euros/QALY gained.(18) One primary study examined cost-effectiveness by comparing the quadrivalent and the bivalent vaccines (cohort of 100,000 girls aged 12 years), and the cost-utility ratio for the bivalent vaccine was $31,000/QALY gained and $21,000/QALY gained for the quadrivalent vaccine.(19) Another primary study used the published data from the previous study to re-evaluate the cost-effectiveness model.(20) The author found that the model

2019 McMaster Health Forum

144. Delivering novel therapies in the 21st century

small nanoneedles (upwards of 40 per cell) to probe inside the cell and deliver biomolecules in vivo, for example to muscles to regenerate blood vessels. Stevens’ group has also pioneered a variety of methods to elucidate the cell-material interface and study what happens when drug delivery vehicles enter cells. Raman microscopy and quantitative volumetric Raman imaging, a novel technique, are used to examine cell chemistry changes and response to small molecules without labelling the cells. Single (...) , and significantly improved therapeutic efficacy. Of particular note was the radiological response of tumour types, such as colorectal, which are not known to respond to doxorubicin treatment when delivered by conventional means. Image: Professor Constantin Coussios, University of Oxford. 1. Lyon P.C., Gray M.D., Mannaris C., Folkes L.K., Stratford M., Campo L., Chung D.Y.F., Scott S., Anderson M., Goldin R., Carlisle R., Wu F., M.R. Middleton, F.V. Gleeson, C.C. Coussios (2018) Safety and feasibility

2019 Academy of Medical Sciences

145. Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario

Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario Guideline 5-3ORG Version 2 A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO) Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario J. Irish, J. Kim, J. Waldron, A. Wei, E. Winquist, J. Yoo, A. Boasie, M. Brouwers, E. Meertens, S. McNair, C. Walker-Dilks and the Expert Panel on Organizational Guidance for the Care of Patients with Head (...) and Neck Cancer in Ontario This document is an update of the organizational guidance portion of the 2009 version of the guideline (Evidence-Based Series 5-3 The Management of Head and Neck Cancer in Ontario). Report Date: April 25, 2019 For information about this document, please contact Dr. Jon Irish, the lead author, through the PEBC via: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca For information about the PEBC and the most current version of all reports, please visit

2019 Cancer Care Ontario

146. Out-of-pocket costs associated with HIV in publicly funded high-income health care settings

insure specific populations (2). Provinces and territories decide on the eligibility criteria for public drug insurance and the level of subsidy, and select the products to be listed on their drug formularies (2). Consequently, Canadians with identical prescriptions may pay substantially different amounts and may rely on private insurance, public funders, out-of-pocket payments or a combination of these to pay for their medications (2). The aim of this review is to highlight out-of-pocket costs (...) and Nova Scotia (2). Ontario, Quebec, Saskatchewan, and Newfoundland and Labrador have multiple programs with eligibility criteria varying according to age, income or drug costs (2). The programs also differ in other ways. For example, although British Columbia, Alberta, New Brunswick and Prince Edward Island provide antiretrovirals at no cost to their residents, these provinces do not provide universal coverage of prescriptions not related to HIV (2). Coordination of benefits with private insurers

2019 Ontario HIV Treatment Network

147. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

baseline to end of intervention exceeded minimal clinically important differences for the PCL-M, CAPS-IV and BDI-II. However, because these studies lacked usual care or wait-list control groups and were not specifically designed to examine differential effectiveness by TBI status we concluded that evidence is insufficient regarding treatment effectiveness among Veterans and service members with mTBI (Executive Summary Table 4). · A small, pre-post, uncontrolled, proof of concept study of hyperbaric (...) , Spoont M, Taylor B, MacDonald R, McKenzie L, Rosebush C, Wilt TJ. Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs. VA ESP Project #09-009; 2019. Available at: https

2019 Veterans Affairs Evidence-based Synthesis Program Reports

148. Preoperative or Postoperative Therapy for the Management of Patients with Stage II or III Rectal Cancer

://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905-526-6775 E-mail: ccopgi@mcmaster.ca EBS 2-4- Version 3 Section 1: Guideline Recommendations Page 5 REFERENCES 1. Simunovic M, Stewart L, Zwaal C, Johnston M; Diagnostic Imaging Guidelines Panel. Cross- sectional imaging in colorectal cancer [monograph on the Internet]. 2006 Apr 12 [cited 2008 Feb 22]. Available from: http://www.cancercare.on.ca/pdf/pebcdicrc.pdf. 2. O'Connell MJ, Colangelo LH, Beart RW, Petrelli NJ (...) , Controlled Trial (GRECCAR-6). J Clin Oncol. 2016 Nov 1;34(31):3773-3780. 4. Lefevre JH, Mineur L, Cachanado M, Rullier E, Rouanet P, De Chaisemartin C, The French Research Group of Rectal Cancer Surgery (GRECCAR). Does a longer waiting period after neoadjuvant radiochemotherapy improve the oncological prognosis of rectal cancer? Three-year follow-up results of the GRECCAR-6 randomized multicenter trial. ASCO 2019 Jan. Meeting Abstract. 5. Hong YS, Kim SY, Lee JS, Nam BH, Kim JE, Kim KP, et al. Long-term

2019 Cancer Care Ontario

149. What Signs Increase the Likelihood of Acute Aortic Dissection?

What Signs Increase the Likelihood of Acute Aortic Dissection? What Signs Increase the Likelihood of Acute Aortic Dissection? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 4, Pages 400–402 What Signs Increase the Likelihood of Acute Aortic Dissection? x Nicholas Chien , MD (EBEM Commentator) , x Paul E. Casey , MD (EBEM Commentator) , x Michael Gottlieb , MD (EBEM Commentator) Department (...) on historical features, physical examination findings, or basic investigations (ie, chest radiograph, WBC count, or electrocardiography), with an outcome assessing the accuracy of these features. All patients must have received a reference standard, which could include computed tomography (CT), magnetic resonance imaging (MRI), or transesophageal echocardiography. Patients with a confirmed diagnosis of acute aortic dissection before enrollment were excluded. Two authors independently reviewed studies

2019 Annals of Emergency Medicine Systematic Review Snapshots

150. Improving outdoor air quality and health: review of interventions

of it strong, for interventions in each of the 5 areas which can reduce emissions of harmful pollutants. Few existing studies directly examine the effects of these interventions on environmental concentrations or the resulting health outcomes. The health benefits of interventions must therefore be inferred from the reductions in emissions. Whilst this is not perfect, it is reasonable to do so, given the strength of evidence supporting the links between individual pollutants and their health impacts (...) . Studies examining the cost-benefits of interventions are unfortunately very limited. At this stage we are, therefore, unable to stratify by cost and health benefits as the original commission envisaged. Nevertheless, despite the need for more work to understand the detailed health impact of interventions and their cost-benefits, there is Review of interventions to improve outdoor air quality and public health 9 sufficient evidence to recommend action. We know that air pollution has a substantial

2019 Public Health England

151. Caffeinated energy drinks and effects in UK young people

: • Be published in English (since the team does not have capacity to search for and examine evidence in all languages we will include only those available in English language); • Be published since 2013; • Be a systematic review (as a minimum: searched two sources and stated inclusion criteria); • Be about CED consumption. CEDs contain caffeine, sugar or sweeteners and other ingredients with a nutritional or physiological function, and do not include soft drinks that only contain caffeine for flavouring (...) and in tables. Review quality was evaluated using AMSTAR 2 criteria and overall strength of evidence was assessed. We supplemented these data by searching for primary research published from 2016 and briefly describing their study characteristics. The overview protocol was registered in PROSPERO (CRD42018096292). Findings We included 13 systematic reviews, covering 74 primary studies relevant to young people, of which just two studies are UK-based. Nearly one-third of young people frequently consume energy

2019 EPPI Centre

152. Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries

the quality of those studies and the strength of the findings. Our search identified 5,521 potentially relevant studies derived from both academic databases and grey literature sources. Based on preliminary screening of abstracts, we retrieved the full texts of 216 studies for mapping. Of these, we excluded 198 studies; 176 did not meet the inclusion criteria (related to study design, population, language, publication date, geography, focus, and sectors) and after excluding based on the inclusion criteria (...) , an additional 22 did not meet quality criteria (related to rigour in sampling, data collection, data analysis, and whether findings are supported by the data). This left 18 studies for the final systematic review. The vast majority of these studies were from sub-Saharan Africa (n=16), followed by East Asia (n=3), South Asia (n=1) and Latin America (n=1). The studies focused on three sectors: commercial agriculture (n=11), trade (n=12), and mining (n=4). SUMMARY OF EVIDENCE The conceptual framework presented

2019 EPPI Centre

153. MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation

MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov

2010 Clinical Trials

154. Simplified guideline for prescribing medical cannabinoids in primary care

Review Group. Ms Nickel, Ms Perry, Drs McCormack and Noël, Mr Ramji, and Drs Ton and Allan comprised the Knowledge Translation Team. Competing interests This guideline received no external funding and no members of the Prescribing Guideline Committee or any other authors have a financial conflict of interest. The full disclosure is available at CFPlus.* Correspondence Dr G. Michael Allan; e-mail michael.allan@ualberta.ca References 1. Rotermann M, Langlois K. Prevalence and correlates of marijuana (...) . ? The guideline suggests that clinicians could consider medical cannabinoids for refractory neuropathic pain and refractory pain in palliative care, chemotherapy-induced nausea and vomiting, and spasticity in multiple sclerosis and spinal cord injury after reasonable trials of standard therapies have failed. If considering medical cannabinoids and criteria are met, the guideline recommends nabilone or nabiximols be tried first. Harms are generally more common than benefits are, and it is important to discuss

2018 CPG Infobase

155. Deprescribing benzodiazepine receptor agonists

. Recommendations are meant to assist with, not dictate, decision making in conjunction with patients and families. Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia Evidence-based clinical practice guideline Lise M. Bjerre MD PhD CCFP Barbara Farrell PharmD ACPR FCSHP Matthew Hogel PhD Lyla Graham MD Geneviève Lemay MD MSc FRCPC Lisa McCarthy PharmD MSc Lalitha Raman-Wilms PharmD FCSHP Carlos Rojas-Fernandez PharmD Samir Sinha MD DPhil FRCPC Wade Thompson RPh MSc (...) version of the algorithm are available at www.cfp.ca. Go to the full text of the article online and click on the CFPlus tab.Vol 64: JANUARY | JANVIER 2018 | Canadian Family Physician | Le Médecin de famille canadien 19 Deprescribing antipsychotics for BPSD and insomnia CLINICAL PRACTICE GUIDELINES the Cochrane Dementia and Cognitive Improvement Group, who updated the search for this review in March of 2015, and concluded that no additional studies that met their inclusion criteria had been published

2018 CPG Infobase

156. Management of stable angina

are only classified as having IHD if they have one of the above criteria. 198 The rates of major cardiac complications postoperatively in patients with 0, 1, 2, 3 or more risk factors were 0.5%, 1.3%, 4% and 9%, respectively. 198 Patients identified at high risk of cardiac complications using the RCRI may undergo further risk-stratification with non-invasive testing or other risk-reduction management strategies. These risk-reduction strategies may involve preoperative revascularisation or medical (...) with potential cost-effectiveness implications, based on the following criteria, where it was judged particularly important to gain an understanding of the additional costs and benefits of different treatment strategies: y treatments which may have a significant resource impact y opportunities for significant disinvestment or resource release y the potential need for significant service redesign y cost-effectiveness evidence could aid implementation of a recommendation. A systematic literature search

2018 SIGN

157. Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines

topreventfurthereventsinpatientswithapriorischemic stroke.Dualantiplatelettherapywithaspirinandclopi- dogrel was examined as a potential alternative to oral anticoagulation in the Aortic Arch Related Cerebral HazardTrial(ARCH). 63 Afteramedianof3.4yearsof follow-up,theriskoftheprimaryoutcome,acomposite ofcerebralinfarction,myocardialinfarction,peripheral embolism, vascular death, or intracranial hemorrhage wasnotsigni?cantlylowerinthedualtherapygroup. Similarly, the e?ectiveness of anticoagulation com- paredwith antiplatelet therapyforstroke (...) Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines Guidelines Canadian stroke best practice recommendations: Secondary prevention of stroke, sixth edition practice guidelines, update 2017 Theodore Wein 1,2 , M Patrice Lindsay 3 , Robert Co ˆte ´ 1,2 , Norine Foley 4,6 , Joseph Berlingieri 5 , Sanjit Bhogal 6 , Aline Bourgoin 7 , Brian H Buck 8 , Jafna Cox 9 , Dion Davidson 10 , Dar Dowlatshahi 11 , Jim Douketis 12,13 , John Falconer

2018 CPG Infobase

158. Proton beam therapy in adults

/ author Indication(s) of interest for this report Search date N studies General conclusions as reported by the authors Olsen DR 2007 7 Hepatocellular carcinoma March 2006 1 The evidence on clinical efficacy of proton therapy relies to a large extent on non-controlled studies, and thus is associated with low level of evidence according to standard health technology assessment and evidence based medicine criteria. Lodge M 2007 6 Head and neck cancer Hepatocellular carcinoma Pancreatic cancer January (...) Criteria for Adverse Events Database of Abstracts of Reviews of Effects EUnetHTA Planned and Ongoing Projects database Excerpta Medica database Grading of Recommendations Assessment, Development and Evaluation Gray Gray Equivalents Hyperfractionated acceleration radiotherapy Hepatocellular carcinoma Hazard ratio Health technology assessment Institute for Clinical and Economic Review IMRT Intensity-modulated radiation therapy KCE Report 307 Proton beam therapy in adults 5 INAHTA International Network

2019 Belgian Health Care Knowledge Centre

159. Assessment of elevated creatinine

of creatinine). It is inaccurate in high GFR states (due to the lack of actual eGFR values above 60 mL/minute/1.73 m²). Studies suggest that the Cockroft-Gault and MDRD formulas correctly assigned only 64% and 62% of patients, respectively, to their actual CKD classification GFR group. Based on US National Health and Nutrition Examination Surveys (NHANES 1988-1994; 1999-2004) and US population census data (2000), this suggests that around 10 million people (38%) may have been misclassified in the US. Botev (...) accurate results for serum creatinine, but is available only in selected laboratories. The Jaffe method is subject to interference by a large number of substances and may overestimate serum creatinine by up to 25%, depending on the severity of renal dysfunction. Enzymatic methods are subject to less interference than the Jaffe method, but in a study of Japanese children, age, sex, and body length appeared to affect reference serum creatinine levels determined by enzymatic methods. Uemura O, Honda M

2018 BMJ Best Practice

160. Overview of thyroid dysfunction

nodules, resulting in hyperthyroidism that generally does not remit spontaneously. Nodules function independently of TSH and are almost always benign. However, non-functioning thyroid nodules in the same goitre may be malignant. Worldwide, iodine deficiency is the most common cause of nodular goitre. Tonacchera M, Vitti P, De Servi M, et al. Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis. J Endocrinol Invest. 2003;26(2 Suppl):2-6. http (...) presents as a single large nodule and is almost always benign. Krohn K, Führer D, Holzapfel HP, et al. Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations. J Clin Endocrinol Metab. 1998 Jan;83(1):130-4. http://www.ncbi.nlm.nih.gov/pubmed/9435429?tool=bestpractice.com Worldwide, iodine deficiency is the most common cause of nodular goitre. Tonacchera M, Vitti P, De Servi M, et al. Gain of function TSH receptor mutations and iodine deficiency: implications

2018 BMJ Best Practice

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