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141. Handbook on designing and implementing an immunisation information system

. 2018: Proposed council recommendation on strengthened cooperation against vaccine-preventable diseases [18]. 1.5. Information technology, e-health, and IIS E-health in the EU Ehealth is a priority of the European Commission, and is therefore at the forefront of policies and directives related to widespread digitalisation of services in the EU [1] [19]. The definition and goals of eHealth, as per the EU Directorate General on Health, are given in Box 4. Box 4. Definition and goals of eHealth (...) boosting innovation and business growth’ [23]. Innovative digital solutions are required to meet critical health challenges such as the prevalence of chronic and infectious diseases and to ease the strain that an aging population puts on national health systems. The Commission stated that they wanted to • unlock EU added value for individuals, patients and researchers, • work with interested Member States to ensure secure cross-border transfer of health records electronically, • use e-prescriptions

2019 European Centre for Disease Prevention and Control - Technical Guidance

142. France has delisted anti-dementia agents

France has delisted anti-dementia agents MED CHECK - TIP December 2018/ Vol.4 No.12 · Page 29 -The Informed Prescriber C N o 12 M ED HECK D e ce m b e r 2 0 1 8 Dying Cochrane: Could it be resuscitated? Herpes zoster subunit vaccine Shingrix: Baloxavir (Xofluza®) for Influenza: No Value No difference from Tamiflu in efficacy, and suppresses immunity Cochrane review on HPV vaccine should be revised: Due to missing trials, adjuvant toxicity, mortality and healthy user bias Editorial Dying (...) while three resigned in protest. The remaining one is Dr. Gøtzsche. Among the five appointed officers, two remained, and one resigned in protest followed by resignation of another officer who opposed the decision. The other one abstained from voting, but later resigned so that there would be less appointed members in the board. This means that six members were in favor of the expulsion while the other six, including Dr. Gøtzsche, were against it. By excluding Dr. Gøtzsche from the Editorial C M ED

2019 Med Check - The Informed Prescriber

143. Delivering novel therapies in the 21st century

small nanoneedles (upwards of 40 per cell) to probe inside the cell and deliver biomolecules in vivo, for example to muscles to regenerate blood vessels. Stevens’ group has also pioneered a variety of methods to elucidate the cell-material interface and study what happens when drug delivery vehicles enter cells. Raman microscopy and quantitative volumetric Raman imaging, a novel technique, are used to examine cell chemistry changes and response to small molecules without labelling the cells. Single (...) , and significantly improved therapeutic efficacy. Of particular note was the radiological response of tumour types, such as colorectal, which are not known to respond to doxorubicin treatment when delivered by conventional means. Image: Professor Constantin Coussios, University of Oxford. 1. Lyon P.C., Gray M.D., Mannaris C., Folkes L.K., Stratford M., Campo L., Chung D.Y.F., Scott S., Anderson M., Goldin R., Carlisle R., Wu F., M.R. Middleton, F.V. Gleeson, C.C. Coussios (2018) Safety and feasibility

2019 Academy of Medical Sciences

144. Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario

Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario Guideline 5-3ORG Version 2 A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO) Organizational Guidance for the Care of Patients with Head and Neck Cancer in Ontario J. Irish, J. Kim, J. Waldron, A. Wei, E. Winquist, J. Yoo, A. Boasie, M. Brouwers, E. Meertens, S. McNair, C. Walker-Dilks and the Expert Panel on Organizational Guidance for the Care of Patients with Head (...) and Neck Cancer in Ontario This document is an update of the organizational guidance portion of the 2009 version of the guideline (Evidence-Based Series 5-3 The Management of Head and Neck Cancer in Ontario). Report Date: April 25, 2019 For information about this document, please contact Dr. Jon Irish, the lead author, through the PEBC via: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca For information about the PEBC and the most current version of all reports, please visit

2019 Cancer Care Ontario

145. Out-of-pocket costs associated with HIV in publicly funded high-income health care settings

insure specific populations (2). Provinces and territories decide on the eligibility criteria for public drug insurance and the level of subsidy, and select the products to be listed on their drug formularies (2). Consequently, Canadians with identical prescriptions may pay substantially different amounts and may rely on private insurance, public funders, out-of-pocket payments or a combination of these to pay for their medications (2). The aim of this review is to highlight out-of-pocket costs (...) and Nova Scotia (2). Ontario, Quebec, Saskatchewan, and Newfoundland and Labrador have multiple programs with eligibility criteria varying according to age, income or drug costs (2). The programs also differ in other ways. For example, although British Columbia, Alberta, New Brunswick and Prince Edward Island provide antiretrovirals at no cost to their residents, these provinces do not provide universal coverage of prescriptions not related to HIV (2). Coordination of benefits with private insurers

2019 Ontario HIV Treatment Network

146. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

baseline to end of intervention exceeded minimal clinically important differences for the PCL-M, CAPS-IV and BDI-II. However, because these studies lacked usual care or wait-list control groups and were not specifically designed to examine differential effectiveness by TBI status we concluded that evidence is insufficient regarding treatment effectiveness among Veterans and service members with mTBI (Executive Summary Table 4). · A small, pre-post, uncontrolled, proof of concept study of hyperbaric (...) , Spoont M, Taylor B, MacDonald R, McKenzie L, Rosebush C, Wilt TJ. Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs. VA ESP Project #09-009; 2019. Available at: https

2019 Veterans Affairs Evidence-based Synthesis Program Reports

147. Preoperative or Postoperative Therapy for the Management of Patients with Stage II or III Rectal Cancer

://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905-526-6775 E-mail: ccopgi@mcmaster.ca EBS 2-4- Version 3 Section 1: Guideline Recommendations Page 5 REFERENCES 1. Simunovic M, Stewart L, Zwaal C, Johnston M; Diagnostic Imaging Guidelines Panel. Cross- sectional imaging in colorectal cancer [monograph on the Internet]. 2006 Apr 12 [cited 2008 Feb 22]. Available from: http://www.cancercare.on.ca/pdf/pebcdicrc.pdf. 2. O'Connell MJ, Colangelo LH, Beart RW, Petrelli NJ (...) , Controlled Trial (GRECCAR-6). J Clin Oncol. 2016 Nov 1;34(31):3773-3780. 4. Lefevre JH, Mineur L, Cachanado M, Rullier E, Rouanet P, De Chaisemartin C, The French Research Group of Rectal Cancer Surgery (GRECCAR). Does a longer waiting period after neoadjuvant radiochemotherapy improve the oncological prognosis of rectal cancer? Three-year follow-up results of the GRECCAR-6 randomized multicenter trial. ASCO 2019 Jan. Meeting Abstract. 5. Hong YS, Kim SY, Lee JS, Nam BH, Kim JE, Kim KP, et al. Long-term

2019 Cancer Care Ontario

148. What Signs Increase the Likelihood of Acute Aortic Dissection?

What Signs Increase the Likelihood of Acute Aortic Dissection? What Signs Increase the Likelihood of Acute Aortic Dissection? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 73, Issue 4, Pages 400–402 What Signs Increase the Likelihood of Acute Aortic Dissection? x Nicholas Chien , MD (EBEM Commentator) , x Paul E. Casey , MD (EBEM Commentator) , x Michael Gottlieb , MD (EBEM Commentator) Department (...) on historical features, physical examination findings, or basic investigations (ie, chest radiograph, WBC count, or electrocardiography), with an outcome assessing the accuracy of these features. All patients must have received a reference standard, which could include computed tomography (CT), magnetic resonance imaging (MRI), or transesophageal echocardiography. Patients with a confirmed diagnosis of acute aortic dissection before enrollment were excluded. Two authors independently reviewed studies

2019 Annals of Emergency Medicine Systematic Review Snapshots

149. Strategies to link people with undiagnosed HIV infection to HIV testing, care, and prevention services

analysis in New Zealand examined missed opportunities among adults presenting to a hospital offering risk-based screening (12). Results showed that nearly 34% of individuals who were newly diagnosed over a seven-year period had had contact with medical services prior to diagnosis, and within their estimated window of HIV infection. They also showed that these patients could have been diagnosed earlier by a median of 12 months. Furthermore, more than half of these missed opportunity visits were (...) in Seattle who met national criteria for routine HCV or HIV testing and had no documented history of prior testing (23). During the study period, the percentage of previously untested patients tested for HIV and HCV increased from between 15% and 18%, to between 31% and over 35%. Although the percentage of newly diagnosed patients did not increase during the study period (0.7% before and after), the targeted intervention was determined to be successful at increasing uptake of HIV testing (23

2019 Ontario HIV Treatment Network

150. Economic Analyses of Policies to Reduce Cervical Cancer

FOUND We identified a total of 25 relevant documents by searching five databases (Health Systems Evidence, Cochrane Library, Health Evidence, EconLit and PubMed), and the search strategy for these databases are detailed in Box 2. We applied the following inclusion criteria (as outlined by the requestor): 1) time period (2002 to present); 2) jurisdictional focus on Canada and other high- income countries with a similar socio-economic context (e.g., Group of Seven countries, Northwest Europe (...) practices (compared to screening alone), finding €8,408 euros/QALY gained.(18) One primary study examined cost-effectiveness by comparing the quadrivalent and the bivalent vaccines (cohort of 100,000 girls aged 12 years), and the cost-utility ratio for the bivalent vaccine was $31,000/QALY gained and $21,000/QALY gained for the quadrivalent vaccine.(19) Another primary study used the published data from the previous study to re-evaluate the cost-effectiveness model.(20) The author found that the model

2019 McMaster Health Forum

151. Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

. Further details on the characteristics and outcomes of these studies can be found in the Data TABLE 3. Revised International Staging System Stage ISS Criteria I ISS stage I (b 2 -M, 3.5 mg/L and serum albumin $ 3.5 g/dL) and normal LDH, no abnormal FISH II Neither stage 1 or stage III III b 2 -M. 5.5 mg/L and elevated serum LDH, or abnormal FISH: presence of t(4;14), t(14;20), or 17p deletion NOTE. Adapted with permission from Palumbo et al. 5 Abbreviations: FISH, ?uorescence in situ hybridization (...) 15 ;DavidH.Vesole,MD,PhD 16,17 ;IrwinWalker,MBBS 18 ; Alexander Whitley, MD, PhD 19 ; Tanya M. Wildes,MD 20 ; Sandy W. Wong,MD 21 ;and Tom Martin,MD 21 abstract PURPOSE To provide evidence-based recommendations on the treatment of multiple myeloma to practicing physicians and others. METHODS ASCO and Cancer Care Ontario convened an Expert Panel of medical oncology, surgery, radiation oncology,andadvocacyexpertstoconductaliteraturesearch,whichincludedsystematicreviews,meta-analyses, randomized

2019 Cancer Care Ontario

152. Impact of financial inclusion in low- and middle-income countries: a systematic review of reviews

and reviews) • Policies and Guidelines Series • Methods Series Go to the library to download these resources, at: www.campbellcollaboration.org/library/ Better evidence for a better world Colophon Title Impact of financial inclusion in low- and middle-income countries: a systematic review of reviews Authors Duvendack, Maren Mader, Philip DOI 10.4073/csr.2019.2 No. of pages 181 Citation Duvendack, M, Mader, P. (2019). Impact of financial inclusion in low- and middle- income countries: a systematic review (...) by 3ie, The International Initiative for Impact Evaluation Declarations of interest MD was lead author on one systematic review (Duvendack et al. 2011) and contributing author on one (Vaessen et al. 2014). PM conducted an overview of (only most recent) financial inclusion impact evidence in early 2017 for a consultancy (unpublished). Corresponding author Duvendack, Maren School of International Development University of East Anglia Norwich NR4 7TJ United Kingdom E-mail: m.duvendack@uea.ac.uk Mader

2019 Campbell Collaboration

153. Evidence Brief - Barriers and Facilitators to Use of Medications for Opioid Use Disorder

Evidence Synthesis Program ii TABLE OF CONTENTS Executive Summary 1 Evidence Brief 4 Introduction 4 Purpose 4 Background 4 Scope 7 Key Questions 7 Eligibility Criteria 7 Methods 8 Searches and Study Selection 8 Quality Assessment & Data Extraction 8 Strength of Evidence Assessment 9 Synthesis of Data 9 Results 10 Literature Flow 10 Literature Overview 11 Key Question 1: What are the patient, provider, and systems-level barriers and facilitators to use of buprenorphine and extended-release naltrexone (...) , and treatment providers was the most common facilitator for patients. Among providers, limited information regarding facilitators of OUD prescribing are available and one factor did not stand out as being most important. · We did not identify studies of systems-level barriers with applicability to VHA settings. · No studies directly evaluated whether barriers and facilitators vary by patient or provider characteristics or setting. · Most studies met our minimum quality criteria and findings were consistent

2019 Veterans Affairs Evidence-based Synthesis Program Reports

154. Evidence for smoking quitlines

evidence, five studies level III-3 evidence and 15 studies level IV evidence. Of these 51 studies, all examined at least one key component of quitline counselling as per the pre-specified inclusion criteria. Given the diverse reporting methods and inconsistent terminology used for smoking cessation studies, quitline interactions will be classified as either ‘quitline-initiated’ or ‘client-initiated’ depending on who initiated first contact and/or follow up calls. NHMRC level I: Systematic reviews (...) in this systematic review did not meet the criteria as individual studies for inclusion in the rapid review). Most studies were from the US (n = 15), three from Australia, two from Spain, two from the UK, one from Canada and one from China. Another systematic review by Schwindt et al. 2017 examined the impact of tobacco quitlines on persons with a mental illness, identifying four studies for inclusion with 1,412 participants. 54 The number of participants within individual studies ranged from 123 to 577

2019 Sax Institute Evidence Check

155. Guidelines on Chronic Coronary Syndromes

by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. A great number of guidelines have been issued in recent years by the European Society of Cardiology (ESC), as well as by other societies and organizations. Because of their impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the user. The recommendations for formulating and issuing ESC Guidelines can be found (...) with a high suspicion of an extracardiac cause of chest pain, and in multimorbid patients in whom the echocardiography result has no consequence for further patient management. c Consider exercise ECG to assess symptoms, arrhythmias, exercise tolerance, BP response, and event risk in selected patients. d Ability to exercise, individual test-related risks, and likelihood of obtaining diagnostic test result. e High clinical likelihood and symptoms inadequately responding to medical treatment, high event

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2019 European Society of Cardiology

156. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD

, Gerasimos Filippatos, Diederick E Grobbee, Tina Birgitte Hansen, Heikki V Huikuri, Isabelle Johansson, Peter Jüni, Maddalena Lettino, Nikolaus Marx, Linda G Mellbin, Carl J Östgren, Bianca Rocca, Marco Roffi, Naveed Sattar, Petar M Seferović, Miguel Sousa-Uva, Paul Valensi, David C Wheeler, ESC Scientific Document Group, 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force for diabetes, pre-diabetes, and cardiovascular (...) works by this author on: , Victor Aboyans France Search for other works by this author on: , Clifford J Bailey United Kingdom Search for other works by this author on: , Antonio Ceriello Italy Search for other works by this author on: , Victoria Delgado Netherlands Search for other works by this author on: , Massimo Federici Italy Search for other works by this author on: , Gerasimos Filippatos Greece Search for other works by this author on: , Diederick E Grobbee Netherlands Search for other works

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2019 European Society of Cardiology

157. Effects of trauma-informed approaches in schools: A systematic review

review sought to examine the effects trauma‐informed schools on trauma symptoms/mental health, academic performance, behavior, and socioemotional functioning. Although we conducted a comprehensive search to find studies testing trauma‐informed approaches in schools, no studies met the inclusion criteria. 1.3 What are the main findings of this review? No studies met criteria for this review, indicating that there is a lack of evidence of trauma‐informed approaches in schools. 1.4 What do the findings (...) interventions for adolescents (e.g., Black, Woodworth, Tremblay, & Carpenter, ; Cary & McMillen, ) and those that examine school‐based interventions for specific trauma‐related disorders, such as PTSD (e.g., Rolfsnes & Idsoe, ); however, these reviews are examining effects of trauma‐specific interventions rather than trauma‐informed approaches. By virtue of these studies' primary research questions and inclusion criteria, the scope of these reviews were not designed to examine effects of a trauma‐informed

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2019 Campbell Collaboration

158. Cognitive-behavioural treatment for amphetamine-type stimulants (ATS)-use disorders

they did not fulfil the eligibility criteria. 6.2 Overall completeness and applicability of evidence The review included only two trials and the results found no clear evidence of the benefits of CBT for ATS‐use disorders. Both of the included studies examined relatively uncommon approaches such as a one‐session brief therapy and a web‐based therapy. Therefore, the evidence obtained in this review could not be applicable across the wide range of treatment modalities and settings. 6.3 Quality (...) of Psychology, Mejiro University, Tokyo, Japan Faculty of International Relations, University of Shizuoka, Shizuoka, Japan Corresponding Author E-mail address: Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan Correspondence Rintaro Mori, Department of Health Policy National Center for Child Health and Development 2‐10‐1 Okura Setagaya‐ku 157‐0074 Tokyo Tokyo Japan. Email: Criminology, Law and Society, George Mason University, Fairfax, Virginia, USA Department

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2019 Campbell Collaboration

160. Identifying How Area-based Socio-economic Indicators are Measured in Canada

. Zandy M, Li, Zhang R, Kao D, Fahra R, Turcotte K. Area-based socioeconomic disparities in mortality due to unintentional injeury and youth suicide in British Columbia, 2009-2013. Policy and Practice 2019;39(2): 2009-13. 6. Allin S, Pichora E, Perumal N, Jin J, Catley C, Polsky J. Comparing individual and area-based income measures: Impact on analysis of inequality in smoking, obesity, and diabetes rates in Canadian 2003- 2013. Canadian Journal of Public Health 2018;109(3): 410-8. 7. Matheson F, Dunn (...) M, Partridge M. Low-income dynamics in Canadian communities: A place-based approach. Growth and Change 2009;2008(39): 2. 13. Webb S, Janus M, Duku E, Raos R, Brownell M, Forer B. Neighbourhood socioeconomic status indices and early childhood development. Population Health 2017;3: 48-56. 14. Hanley G, Morgan S. On the validity of area-based income measures to proxy household income. BMC Health Services Research 2008;8: 1-7. 15. Schuunerman N, Bell N, Dunn J, Oliver L. Deprivation indices

2019 McMaster Health Forum

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