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181. Sodium zirconium cyclosilicate (Lokelma) - Hyperkalemia

of hospitalised patients, and the incidence ranges from 1 to 10%. There is no agreed definition of hyperkalaemia, since the raised level of potassium at which a treatment should be initiated has not been established. The European Resuscitation Council guidelines consider hyperkalaemia to be a serum potassium (S-K) level > 5.5 mmol/L, with mild elevations defined as 5.5 to 5.9 mmol/L, moderate as 6.0-6.4 mmol/L, and severe as = 6.5 mmol/L. The guidelines also note that extracellular potassium levels (...) the active substance, sodium zirconium cyclosilicate. The specifications have been established according to physico-chemical characteristics and properties of the crystalline active substance. The finished product is released to the market based on the above release specifications, through traditional final product release testing. The analytical methods used have been adequately described and appropriately validated in accordance with the ICH guidelines. Satisfactory information regarding the reference

2018 European Medicines Agency - EPARs

182. Bictegravir / emtricitabine / tenofovir alafenamide / fumarate (Biktarvy) - HIV Infections

inhibitor resistant IPC In-process control IQ inhibitory quotient IQ95 inhibitory quotient of 95% IR Infrared ISE Integrated Summary of Efficacy ISS Integrated Summary of Safety IV intravenous KF Karl Fischer titration LC-MS/MS liquid chromatography/tandem mass spectrometry LDH lactate dehydrogenase LDL low-density lipoprotein LLOQ lower limit of quantitation LOCF last observation carried forward LSM least-squares mean M = E missing = excluded M = F missing = failure MedDRA Medical Dictionary (...) coefficient of variation 3TC lamivudine ABC abacavir AE adverse event AIDS acquired immunodeficiency syndrome ALT alanine aminotransferase ANOVA analysis of variance anti-HBe antibody against hepatitis B e antigen anti-HBs antibody against hepatitis B surface antigen ART antiretroviral therapy ARV antiretroviral ATV atazanavir AUC area under the concentration versus time curve AUClast area under the concentration versus time curve from time zero to the last quantifiable concentration AUCtau area under

2018 European Medicines Agency - EPARs

183. Reducing Acute Care Length of Stay in Newfoundland & Labrador

& Labrador Centre for Applied Health Research, established in 1999, contributes to the effectiveness of the health and community services system of the province and the physical, social, and psychological well-being of the population. NLCAHR accomplishes this mandate by building capacity in applied health research, supporting high quality research, and fostering more effective use of research evidence by decision makers and policy makers in the province’s health system. About the Contextualized Health (...) interventions: ? based on the involvement of pharmacists; 3 ? involving the planning, coordination, and delivery of outpatient services; or ? requiring new infrastructure investments. Comparator(s) Standard or usual care. Outcome(s) Average Length of Stay (ALOS) is the primary outcome of interest for this project. ALOS is generally defined as the period of time that a patient remains in hospital for of a single episode of care, based on the number of nights the patient spent in hospital. A patient who

2018 Newfoundland and Labrador Centre for Health Information

184. Cardiac rehabilitation

be limited, and that evidence from the wider CHD literature and beyond would need to be considered. Highlighting the need for further research within CR has therefore assumed greater importance in this guideline.2 | Cardiac rehabilitation Figure 1: BACPR core components for cardiovascular disease prevention and rehabilitation 4 A U D I T A N D E VA L U AT I O N LONg -TEr m STr ATEg IES Psychosocial health Health behaviour change and education management medical r isk Lifestyle risk factor management (...) functioning in their community and through improved health behaviour, slow or reverse progression of disease” . 4 The term ‘cardiac rehabilitation’ is widely accepted to encompass the processes described in this definition, but is itself a dated and potentially misleading term. It was established at a time when patients were hospitalised for long periods after MI or cardiac surgery, advised to rest for several months, and in need of carefully monitored exercise-based rehabilitation to enable them

2017 SIGN

185. Agitation and Aggression in Long-Term Care Residents with Dementia

review of the literature. J Psychiatr Ment Health Nurs. 2014 Dec;21(10):879–88. 17. Brasure M, Jutkowitz E, Fuchs E, Nelson VA, Kane RA, Shippee T, et al. Nonpharmacologic Interventions for Agitation and Aggression in Dementia [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016. Available from: 18. Chang Y-S, Chu H, Yang C-Y, Tsai J-C, Chung M-H, Liao Y-M, et al. The efficacy of music therapy for people with dementia: A meta (...) -analysis of randomised controlled trials. J Clin Nurs. 2015 Dec;24(23–24):3425–40. 19. Disalvo D, Luckett T, Agar M, Bennett A, Davidson PM. Systems to identify potentially inappropriate prescribing in people with advanced dementia: a systematic review. BMC Geriatr. 2016 May 31;16:114. 20. Jutkowitz E, Brasure M, Fuchs E, Shippee T, Kane RA, Fink HA, et al. Care-Delivery Interventions to Manage Agitation and Aggression in Dementia Nursing Home and Assisted Living Residents: A Systematic Review and Meta

2018 Newfoundland and Labrador Centre for Health Information

186. The Lung Cancer Framework: Principles for Best Practice Lung Cancer Care in Australia

at multidisciplinary team meetings 34 ` Increased frequency of discussions regarding patient outcomes: associated with the use of PROMs. PROMs also assist patients and their doctors in developing a shared view of treatment goals, the status of the patient and the patient’s reason for visiting their doctor 25 ` An increase in referrals to psychosocial care: associated with the use of PROMs with patients affected by lung cancer 31 ` Enhanced and better-targeted information supplied to regional patients, especially (...) they are visiting Sydney, such as Sydney transport options. The Information Guide was drafted following a wide consultation process with patients and also their carer(s) to determine areas of need and what would best suit this need. Pilot testing was conducted with consumers prior to full implementation, and feedback was gathered and then actioned. Once completed, the Information Guide was distributed to a range of services located in regional centres in Dubbo and Coffs Harbour. 34 ` Cancer Council Australia’s

2018 Cancer Australia

187. Delivering best practice lung cancer care - a guide for health professionals

and patients to allow patient values and preferences to be considered when discussing treatment and care options. 28 ` Provide communication skills training for health professionals to help staff establish a rapport with patients and carers, and have more effective conversations about patients’ health, treatment and prognosis. 29 Question Prompt Lists 13,14 Decision aids 13 Delivering best practice lung cancer care 3 Principle 1: Patient-centred care To access the Lung Cancer Framework visit (...) an overview of the Lung Cancer Framework, which can be accessed at . References Delivering best practice lung cancer care 13 To access the Lung Cancer Framework visit 1. McPherson CJ, Higginson IJ, Hearn J. Effective methods of giving information in cancer: a systematic literature review of randomized controlled trials. J Public Health Med. 2001;23(3):227-234. 2. Gysels M, Higginson IJ. Interactive technologies and videotapes for patient education in cancer care: systematic review

2018 Cancer Australia

188. Frailty in Older Adults - Early Identification and Management

Fried LP. Frailty in older adults: evidence for a phenotype. J Gerontol Biol Sci Med Sci [Internet]. 2001;56. Available from: Rockwood K. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005 Aug 30;173(5):489–95. Puts MTE, Toubasi S, Atkinson E, Ayala AP, Andrew M, Ashe MC, et al. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature (...) are referred to or connected with local health care and social services. For patients with frailty who have multiple health concerns, consider using “rolling” assessments over multiple visits, targeting at least one area of concern at each visit. Polypharmacy is common in patients with frailty. Consider the benefits and harms of medications by conducting a medication review in all patients with frailty. Develop a care plan using the areas of geriatric assessment outlined in as a guide. Share the care plan

2017 Clinical Practice Guidelines and Protocols in British Columbia

189. An evaluation protocol for NIHDI conventions

/content/about-copyrights-for-kce-publications. How to refer to this document? Vandenbroeck P, Christiaens W, Marie Dauvrin M, Wickert R, Becher K, Erik Hendrickx E, Goossens J, Jenné L, Eyssen M. An evaluation protocol for NIHDI conventions. Health Services Research (HSR) Brussels: Belgian Health Care Knowledge Centre (KCE). 2018. KCE Reports 299. D/2018/10.273/22. This document is available on the website of the Belgian Health Care Knowledge Centre. KCE Report 299 An evaluation protocol for NIHDI (...) . Publication date: Domain: MeSH: NLM Classification: Language: Format: Legal depot: 13 Februar y 2018 Health Services Research (HSR) Multidisciplinary health care; Interdisciplinary health care team; Organizational innovation; Rehabilitation; Chronic diseases; Outpatient care; Long term care; Quality of health care; Organizational efficiency WA 525 English Adobe® PDF™ (A4) D/2018/10.273/21 ISSN: 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence

2018 Belgian Health Care Knowledge Centre

190. Appropriate care at the end of life

] NLM Classification: WB 310 Hospice care. Palliative care. Terminal care Language: English Format: Adobe® PDF™ (A4) Legal depot: D/2017/10.273/90 ISSN: 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence How to refer to this document? Van den Broeck K, Schmitz O, Aujoulat I, Mistiaen P, Friedel M, Genet M, Ricour C, Kohn L, Wens J. Appropriate care at the end of life. Health Services Research (...) of the questionnaire. A broad selection of Flemish and Walloon stakeholders was informed about the project and the questionnaire by e-mail. On October 18 th (Dutch) and 25 th (French) 2016, meetings were organised at KCE to inform these stakeholders in person. We requested them to help us spread the link to the questionnaire via their communication channels. In addition, we searched the internet for associations of health care professionals, patient organisations, health insurances, social services, policy

2018 Belgian Health Care Knowledge Centre

191. Evidence Brief: Use of Performance Measures as Criteria for Selecting Community Cardiac and Orthopedic Surgical Providers for the Veterans Choice Program

a national dissemination strategy for all ESP products; and interfaces with stakeholders to effectively engage the program. Comments on this evidence report are welcome and can be sent to Nicole Floyd, ESP CC Program Manager, at Recommended citation: Peterson K, Anderson J, Bourne D, Boundy E, Helfand M. Evidence Brief: Use of Performance Measures as Criteria for Selecting Community Cardiac and Orthopedic Surgical Providers for the Veterans Choice Program. VA ESP Project #09-199 (...) Synthesis Program (ESP) was established in 2007 to provide timely and accurate syntheses of targeted healthcare topics of particular importance to clinicians, managers, and policymakers as they work to improve the health and healthcare of Veterans. QUERI provides funding for four ESP Centers, and each Center has an active University affiliation. Center Directors are recognized leaders in the field of evidence synthesis with close ties to the AHRQ Evidence-based Practice Centers. The ESP is governed

2017 Veterans Affairs Evidence-based Synthesis Program Reports

192. Metformin Use in Patients with Historical Contraindications or Precautions

Affairs and should not be distributed outside the agency. Metformin Use in Patients with Contraindications or Precautions Evidence-based Synthesis Program i PREFACE The VA Evidence-based Synthesis Program (ESP) was established in 2007 to provide timely and accurate syntheses of targeted healthcare topics of particular importance to clinicians, managers, and policymakers as they work to improve the health and healthcare of Veterans. QUERI provides funding for four ESP Centers, and each Center has (...) in 2009 to expand the capacity of QUERI/HSR&D and is charged with oversight of national ESP program operations, program development and evaluation, and dissemination efforts. The ESP CC establishes standard operating procedures for the production of evidence synthesis reports; facilitates a national topic nomination, prioritization, and selection process; manages the research portfolio of each Center; facilitates editorial review processes; ensures methodological consistency and quality of products

2017 Veterans Affairs Evidence-based Synthesis Program Reports

193. How to improve the Organisation of Mental healthcare for older adults in Belgium?

depot: D/2018/10.273/31 ISSN: 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence How to refer to this document? Adriaenssens J, Farfan-Portet M-I, Benahmed N, Kohn L, Dubois D, Devriese S, Eyssen M, Ricour C. How to improve the Organisation of Mental healthcare for older adults in Belgium?. Health Services Research (HSR) Brussels: Belgian Health Care Knowledge Centre (KCE). 2018. KCE Reports 301 (...) – Estimated number of consultations per 100 000 residents per age category (2008-2015) 156 Figure 40 – Number of visits to GP per patients (2008-2015) 157 KCE Report 301 How to improve the Organisation of Mental healthcare for older adults in Belgium? 9 LIST OF TABLES Table 1 – Crude percentage of the population of mental health indicators from the National Health Survey 25 Table 2 – Alzheimer Europe regarding number of people with dementia in Belgium 26 Table 3 – Number of suicide per 100 000 residents

2018 Belgian Health Care Knowledge Centre

194. Payment methods for hospital stays with a large variability in the care process

Payments) IPPS Inpatient prospective payment system LFSS Social Security Financing Act LOS Length-of-Stay MDC Major Diagnostic Categories MS-DRG Medicare Severity – Diagnosis Related Group NCSP NOMESCO Classification of Surgical Procedures NHS National Health Service England ONDAM Objectif National des Dépenses d'Assurance Maladie (National Health Insurance Expenditure Objective) OPCS Office of Population Consensus and Surveys OPPS Outpatient PPS OPS Operationen- und Prozedurenschlüssel (German (...) the centralisation of specific services at particular providers? • How are outliers defined and what mechanisms for reimbursement exist? In most countries outpatient care, mental care, long-term care, rehabilitation and ambulatory emergencies are not financed through DRG-based hospital payments. Therefore they are outside the scope of this study which has a focus on acute care. The same applies to payments for non-patient related hospital activities such as research or training. Finally, an evaluation of whether

2018 Belgian Health Care Knowledge Centre

195. Community-based approaches to adolescent obesity

-to-face, weekly 90min sessions C: Face-to-face, one visit to receive educational material I: Mindful Eating Intervention – mindfulness meditation, and combined instruction, discussion and eating skills practice C: Nutrition and exercise information handouts 6 weeks program duration 6 weeks FU (I & C) 10 weeks FU (I only) n=37 (I n=14; C n=23) IC: 14- 17yo IC: girls 100%F IC: BMI >90 th %ile Mean BMI (all): 35.7±7.6 kg/m 2 Mean BMI (I): 37.7±7.6 kg/m 2 Mean BMI ©: 34.3±6.2 kg/m 2 NR IC: Latino (...) . 2015 49 RCT, II Strong NS US, University research setting Face-to-face group sessions (1.5h ea) Nutr + PA + Beh + Cog E: enhanced, smaller groups activities to practice peer support skills, Peer support between sessions via Facebook: chats (10- 15 min with group leader or peer), and check-in with 3 peers S: standard (program 16 w program, weekly for 1 m, then fortnightly for 1 m, then monthly for 2 m measures during and post- program at 4 w + 16 w Randomis ed n = 41 (E: n = 23 S: n = 18) Outcome

2017 Sax Institute Evidence Check

196. Homelessness at Transition

to the inclusions of an acknowledgement of the source. It may not be reproduced for commercial USge or sale. Reproduction for purposes other than those indicated above requires written permission from the copyright owners. Enquiries regarding this report may be directed to the: Manager Knowledge Exchange Program Sax Institute Phone: +61 2 91889500 Suggested Citation: Conroy, E, Williams, M. Homelessness at transition: An Evidence Check rapid review (...) : inadequate housing for needs or delays in transfer to more suitable housing; safety concerns within the household or neighbourhood; and financial difficulties in part due to tenancies being established with debt. • Chronic homelessness may influence tenancy sustainment via social isolation. • Substance use and other mental health problems, including hoarding and squalor, were mentioned in a few studies but the evidence regarding these factors is equivocal. • Few insights were available about risk factors

2017 Sax Institute Evidence Check

197. Examining the Effects of Value-based Physician Payment Models

segments. In the first segment the primary-care physician acts as gatekeeper to speciality care and there are three payment types within this segment: 1) a capitation fee for each patient registered in the practice, which is based on age (under or over 65) and deprivation status (established through patients’ postal codes); 2) fees for each consultation and home visit; and 3) fees for practice nurses that provide mental health care (but the physician needs a contract in order to receive this payment (...) System) are used for outpatient ambulatory care. Medicare assigns bundled payment rates that are based on the median cost of services in the procedure group and geographical variation in wages.(38) It is important to note that there is significant variation in how state Medicaid agencies remunerate healthcare providers (e.g., Medicaid fees for an office visit can be five times higher in one state than another).(38) In addition, many state reimbursement methods employ a fee schedule that incorporates

2017 McMaster Health Forum

198. Sexual offender treatment for reducing recidivism among convicted sex offenders

to the library to download these resources, at: Better evidence for a better world Colophon Title Sexual offender treatment for reducing recidivism among convicted sex offenders: a systematic review and meta-analysis Institution The Campbell Collaboration Authors Schmucker, Martin Lösel, Friedrich DOI 10.4073/csr.2017.8 No. of pages 75 Last updated 28 July 2017 Citation Schmucker, M, Lösel, F. Sexual offender treatment for reducing recidivism among convicted sex (...) offenders: a systematic review and meta-analysis. Campbell Systematic Reviews 2017:8 DOI: 10.4073/csr.2017.8 ISSN 1891-1803 Copyright © M. Schmucker & F. Lösel This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Roles and responsibilities Martin Schmucker and Friedrich Lösel contributed to the writing and revising

2017 Campbell Collaboration

199. Enhancing Equitable Access to Assistive Technologies in Canada

to assist in accessing primary care as well as transitioning across care settings. • Element 2 – Helping citizens get the most out of government-funded programs o This could include providing public financing based on need for different types of assistive technologies, streamlining existing government approaches that provide access to assistive technologies, and establishing transparent and flexible criteria to define what technologies are covered. o While there is no evidence evaluating public

2017 McMaster Health Forum

200. Identifying and Assessing Core Components of Collaborative-care Models for Treating Mental and Physical Health Conditions

from Ontario found that individuals with schizophrenia and diabetes received diabetes care that was significantly sub-optimal compared with those without schizophrenia in relation to guideline-concordant testing for HbA1c, lipid testing and eye exams);(16) • overuse of some types of services (such as increased rates of intensive-care-unit admissions, ambulatory care, and emergency department visits);(14; 16) and • high risk of medical errors.(17) While there are a number of reasons for the delivery (...) Association, which highlighted the advantages of collaboration between family physicians and psychiatrists,(21) as well as the Government of Canada’s Primary Health Care Transition Fund and the resulting establishment of the Canadian Collaborative Mental Health Initiative in 2004. These initiatives led to an increased awareness of the need for greater collaboration between primary care and mental health care, as well as an increased uptake of such initiatives in practice.(22; 23) However, while the focus

2017 McMaster Health Forum

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