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Dysuria in Children

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141. Use of a Diurnal Indwelling Urethral Catheter to Improve Quality of Life

of a Diurnal Indwelling Urethral Catheter to Improve Quality of Life The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03573726 Recruitment Status : Completed First Posted : June 29, 2018 Last Update Posted : June 29, 2018 Sponsor: Shriners Hospitals for Children Information provided by (Responsible Party (...) ): Eric A Kurzrock, Shriners Hospitals for Children Study Details Study Description Go to Brief Summary: This is an interventional study examining the effects of closed diurnal indwelling catheterization (CDIC) for neurogenic bladder management. Condition or disease Intervention/treatment Phase Spina Bifida Neurogenic Bladder Other: Closed diurnal indwelling catheter (CDIC) Not Applicable Detailed Description: This is an interventional study examining the effects of indwelling diurnal catheter use

2018 Clinical Trials

142. Enuresis Alarm

for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: children ages 5-15 years Diagnosis of Primary Monosymptomatic Nocturnal Enuresis >2 wet nights per week Score of 7 or below on questions 1-6 and 9-13 on Vancouver Dysfunctional Elimination Questionnaire Patients/parents compliance in recording data > 50% of nights Exclusion Criteria: Known comorbid conditions: daytime incontinence, anatomic abnormalities (hydronephrosis, VUR), recurrent urinary tract infection, dysuria (...) in children, and use of bedwetting alarms has shown the best long-term success. However, use of alarms is very time-intensive, often taking months before yielding results. Researchers in the division of pediatric urology are initiating a randomized controlled study comparing a standard bedwetting alarm with a newly developed technology, with the hope that the new alarm will result in better, more rapid, and easier treatment for bedwetting. Children between the ages of 5 to 15 years old who have issues

2018 Clinical Trials

143. Late Effects of Treatment for Childhood Cancer (PDQ®): Health Professional Version

for Childhood Cancer During the past five decades, dramatic progress has been made in the development of curative therapy for pediatric malignancies. Long-term survival into adulthood is the expectation for more than 80% of children with access to contemporary therapies for pediatric malignancies.[ , ] The therapy responsible for this survival can also produce adverse long-term health-related outcomes, referred to as late effects , which manifest months to years after completion of cancer treatment (...) to Support Survivor Care Risk-based screening The need for long-term follow-up for childhood cancer survivors is supported by the American Society of Pediatric Hematology/Oncology, the International Society of Pediatric Oncology, the American Academy of Pediatrics, the Children’s Oncology Group (COG), and the Institute of Medicine. A risk-based medical follow-up is recommended, which includes a systematic plan for lifelong screening, surveillance, and prevention that incorporates risk estimates based

2016 PDQ - NCI's Comprehensive Cancer Database

145. Guidance on adolescent sexual health

and Westminster Hospital NHS Foundation Trust, Imperial, London, Consultant GUM / HIV • Rita Browne – Haringey NHS Trust Consultant GUM / HIV. BASHH Adolescent Special Interest Group (ASIG) • Caroline Foster –Imperial College Healthcare NHS Trust, London Consultant Paediatrician HIV • Eva Jungmann – Archway Sexual Health, Camden Primary Care Trust, London, Consultant GUM / HIV • Elaine Pearson Scott – Positive Parenting Children (PPC) (Lambeth) • Maria Phelan – Children and Young people HIV Network (...) Coordinator, National Children’s Bureau 5 • Katia Prime – St George’s Hospital NHS Trust, London, Consultant GUM / HIV • Ella Sherlock – Clinical Psychologist HIV Child and Family Psychology Service CASCAID (Lewisham and Southwark), Paediatric HIV Psychology Group • Rebecca Wilkins – Community Matron, Diabetes Centre Newbury park Redbridge PCT 1.2 Competing Interests None declared 1.3 Stakeholder involvement HIV Young Persons’ Network (HYPNET) - Caroline Foster - Chair Children’s HIV Association (CHIVA

2011 The Children's HIV Association

146. Research and Reviews in the Fastlane 135

% of ED patients with headaches got opioids (which, incidentally, don’t work for headache). We need to do better. Recommended by: Seth Trueger Emergency Medicine Gágyor I, et al. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. BMJ (Clinical research ed.) . 2015. PMID: Despite being one of the greatest advances in modern medicine, antibiotics get a bad rap in EBM. Do they work in UTI? Probably, as this RCT shows lower rates of dysuria (...) and pericardial effusion in children: contemporary epidemiology and management. J Am Heart Assoc. 2014. PMID: Pediatric Chest Pain is common… and fortunately, often due to benign causes. Before you announce that this is merely costochondritis, be sure to contemplate Pericarditis. Recommended by: Sean Fox The R&R iconoclastic sneak peek icon key R&R Hall of famer You simply MUST READ this! R&R Hot stuff! Everyone’s going to be talking about this R&R Landmark paper A paper that made a difference R&R Game

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2016 Life in the Fast Lane Blog

147. Studying the Impact of Exercise on Hot Flashes

and children will not be included. Have current history of fever, cough, dysuria or diarrhea (i.e., signs of infection). Have >10% of hot flashes predictably related to certain food ingestion alcohol intake. Have a history of "easily blushing" and have >10% hot flashes associated with embarrassing events or migraines. Have an MI, stroke, functional decline within 1 month. Have a history of somatoform disorder. Have an estimated creatinine clearance < 60ml/min. Fail to record data in the diary for >3 days

2017 Clinical Trials

148. Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours

: January 14, 2019 See Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust Collaborator: AstraZeneca Information provided by (Responsible Party): Great Ormond Street Hospital for Children NHS Foundation Trust Study Details Study Description Go to Brief Summary: Phase I and II study of the MEK inhibitor Selumetinib given twice daily on 5 out of 7 days in children with NF1 and inoperable plexiform neurofibromas or progressive/relapsed optic pathway gliomas. This study will test (...) the early and late toxicities of selumetinib when it is given in this intermittent schedule (in 5 out of 7 days) and will also test the effectiveness of the drug in reducing the size of plexiform neurofibromas and optic pathway gliomas in children with NF1. It will also test the effectiveness of the drug in improving the participants function in day to day life. Condition or disease Intervention/treatment Phase Neurofibromatosis Type 1 Plexiform Neurofibroma Optic Nerve Glioma Drug: Selumetinib Phase 1

2017 Clinical Trials

149. UTI: More than you ever wanted to know

on diagnosis of UTI is very difficult to interpret. Because, what is the definition of a UTI? It’s not consistent across studies. There is no clear gold standard. It is often defined based on a culture, although a positive culture has many different definitions as well. Unfortunately, we know that people, especially children and the elderly, can have positive urine cultures without having UTIs. UTIs also occur without a positive culture. So culture both over and under calls UTI and can’t be used as a true (...) . History and Physical Self diagnosis is pretty accurate. If a woman has had a previous UTI and now has similar symptoms, that has a positive LR of 4.0 and is about 90% accurate for UTI. (Lane 2011; Bent 2002) A women telling you that she has a UTI is just as accurate as a positive dipstick (both with positive likelihood ratios of 4). (Aubin 2007) It’s not clear if these two pieces of information are additive, but there is reason to think they wouldn’t be: women without typical symptoms such as dysuria

2017 First10EM

150. Zavicefta (ceftazidime / avibactam) - infections

and efficacy in children and adolescents below 18 years of age have not yet been established. No data are available. Method of administration Zavicefta is administered by intravenous infusion over 120 minutes in an infusion volume of 100 mL (see section 6.6). For instructions on reconstitution and dilution of the medicinal product before administration (see section 6.6). Class D OXA ß-lactamases are also increasingly reported in Enterobacteriaceae. Amongst these, OXA- 48 is of particular concern due to its

2016 European Medicines Agency - EPARs

151. Adjuvant and Salvage Radiation Therapy After Prostatectomy Guideline

frequency was rare (0.4%). Grade 1 and 2 dysuria occurred in 37.9% and 10.3% of patients, respectively, with only 1.1% reporting grade 3 dysuria and no reports of grade 4. Hematuria was uncommon, with 3.7% of patients exhibiting grade 1, 0.9% exhibiting grade 2 and no patients exhibiting the higher grades. With regard to acute GI effects, Goenka 99 reported that 3D-CRT patients had higher levels of grade 2 or greater toxicities (13.2%) compared to IMRT patients (7.6%). Alongi 174 divided toxicities

2013 American Society for Radiation Oncology

152. Guideline for consultations requiring sexual history taking

sexual contact (LSC) and number of partners in the last three months Gender of partner(s), anatomic sites of exposure, condom use and any suspected infection, infection risk or symptoms in partners Previous STIs For women: last menstrual period (LMP), contraceptive and cervical cytology history. Blood borne virus risk assessment and vaccination history for those at risk Agree the method of giving results Establish competency, safeguarding children/vulnerable adults Recommend/consider Recognition (...) , contraceptive and cervical cytology history Pregnancy and gynaecological history Blood borne virus risk assessment and vaccination history for those at risk Past medical and surgical history Medication history and history of drug allergies Agree the method of giving results Establish competency, safeguarding children/vulnerable adults Recommend/consider Recognition of gender-based violence/intimate partner violence 1 Alcohol and recreational drug history 2 1 This is a requirement in Scotland

2013 British Association for Sexual Health and HIV

153. Macroscopic haematuria - a urological approach

in Table 1. Risk factors for haematuria Risk factors can help in determining which patients are at higher risk of urinary tract and bladder cancer. Risk factors include: 2,6 • age >40 years • a history of smoking • history of gross haematuria • history of chronic cystitis or irritative lower urinary tract symptoms (eg. frequency, urgency, dysuria, nocturia, hesitancy, sensation of incomplete emptying) • pelvic irradiation Macroscopic haematuria – a urological approach clinical 124 Reprinted from (...) Results are operator dependant. ultrasound has a 40% sensitivity for identifying renal tumours, but this can range from 0–57% depending on the size of the lesion. 8 ultrasound can also be useful in the investigation of haematuria in pregnant women, children and low risk patients, and does not have the risk of radiation or contrast reaction. ultrasound has a lower diagnostic yield and is less sensitive for ureteric and bladder tumours compared to ct . therefore it is the second investigative modality

2013 Clinical Practice Guidelines Portal

154. Adult Urodynamics: AUA/SUFU Guideline

is present. ( Option ; Evidence Quality: Grade C ) 19. Clinicians may perform videourodynamics in properly selected patients to localize the level of obstruction, particularly for the diagnosis of primary bladder neck obstruction. (Expert Opinion) Purpose Lower urinary tract symptoms (LUTS), which include urinary incontinence, are a common and significant source of impaired quality of life and comorbidity in large numbers of adults and children. Commonly, patients presenting with LUTS have overlapping

2012 American Urological Association

155. Monitoring of Nonsteroidal Immunosuppressive Drugs in Patients With Lung Disease and Lung Transplant Recipients

: 10.1378/chest.12-1044 Downloaded From: http://journal.publications.chestnet.org/ by David Kinnison on 11/09/2012journal.publications.chestnet.org CHEST / 142 / 5 / NOVEMBER 2012 e3S in addition to normal intake in adults; additional volume given to children needs to be calculated on the basis of body weight) on the days of therapy is recommended (Grade 1C) . 3.5e. For patients who undergo or have under- gone cyclophosphamide therapy and develop hematuria, further evaluation is recommended (Grade 1B (...) was assigned one primary and one secondary author. In addi- tion, a pediatric expert provided input to sections that were relevant to children’s health care. A ? nal meeting was con- vened with the committee members to review and approve the recommendations. 1.2 Con? ict of Interest From the outset, each member completed a con? ict of interest (COI) form to be kept on ? le with ACCP. In addition, panel members updated COI forms at the face- to-face meeting and verbally related any changes in con- ? ict

2012 American College of Chest Physicians

156. Adult Urodynamics: AUA/SUFU Guideline

and significant source of impaired quality of life and comorbidity in large numbers of adults and children. Commonly, patients presenting with LUTS have overlapping symptoms and conditions, making an isolated or homogeneous source of symptoms rare. Clinicians evaluating these disorders collectively utilize history, physical examination, questionnaires and pad testing data in the evaluation of symptoms. Urodynamics (UDS) is the dynamic study of the transport, storage and evacuation of urine. UDS

2012 Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction

157. Orthostatic hypotension due to autonomic dysfunction: midodrine

mg 3 times daily increased standing blood pressure statistically significantly more than placebo, 1 hour after the dose was taken. Improvements in patient- and investigator-rated symptoms were seen with midodrine compared with placebo in both RCTs. However, the symptom measurement scales were not reported to have been validated. Safety Safety According to the summary of product characteristics, the most common adverse effects of midodrine are piloerection, pruritus of the scalp and dysuria (...) of the scalp and dysuria, which lead to discontinuation of treatment in some people. Patients should be monitored for supine hypertension, which occurs in between 1 in 10 and 1 in 100 people. Reducing the dose of midodrine may resolve supine hypertension but, if it does not, treatment must be stopped. See the summary of product characteristics for more information. The main limitation of the 2 RCTs is the focus on disease-oriented outcomes (changes in standing blood pressure), as opposed to patient

2015 National Institute for Health and Clinical Excellence - Advice

158. Clinical Applications of Contrast-Enhanced Ultrasonography in Pediatric Population

years. No adverse events were reported at 1 hour after exam. Follow-up phone interviews revealed no adverse events in the majority (973 of 1,010). The remaining 37 children experienced mild symptoms including dysuria (n=26) and urinary retention (n=2) which may have been related to catheterization rather than the contrast agent. A recent European survey at 29 centers evaluating the use of ultrasound contrast agent in 4,131 children for pediatric reflux diagnosis reported no adverse events (Riccabona (...) Last Update Posted : January 25, 2018 Sponsor: Johns Hopkins University Information provided by (Responsible Party): Johns Hopkins University Study Details Study Description Go to Brief Summary: In children, specifically the intravesicle administration to study vesicoureteral reflux in children already catheterized and scheduled for voiding cystourethrogram (VCUG). Contrast-enhanced ultrasonography is a tremendous advancement from conventional B-mode and color Doppler ultrasonography, as it permits

2016 Clinical Trials

159. Surgical Complications Following Early Genitourinary Reconstructive Surgery for Congenital Adrenal Hyperplasia- Interim Analysis at 6 Years. (PubMed)

patients from April 2003 to April 2015 who underwent genitourinary reconstructive surgeries. Demographic data and surgical postoperative complications (per Unplanned Postoperative Morbidity in Children [UPMC] and Clavien-Dindo classification) were evaluated.The average age at the time primary surgery was done at our institute was 17 ± 20 (5-87) months; the average length of follow-up was 72.56 ± 36.95 (4.5-142) months. The average length of the common urogenital sinus was 4.5 ± 1.9 (2.5-6.4) cm, and 15 (...) out of 22 (68%) patients had high confluence. A total of 7 complications were observed in 7 (27%) patients, 3 patients had Clavien grade I and UPMC 0 (dysuria, stitch dehiscence, wound separation), and 2 had Clavien grade II and UPMC 1 (urinary tract infection). Two (7.6%) patients required revision surgery, and both of them had Clavien grade IIIB. One patient had UPMC score 5 (suprapubic tube insertion for urinary retention secondary to cicatrization of the surgical site).Genitourinary

2016 Urology

160. How to create a modern superhero

How to create a modern superhero How to create a modern superhero How to create a modern superhero | | September 23, 2016 168 Shares You start out by working in a busy emergency department. You see patients with all sorts of complaints: abdominal pain, headaches, and chest pain. Vomiting, diarrhea, and dysuria. Ankle sprains, bug bites, and allergic reactions. Domestic violence, rape, and child abuse. You don’t ever let the stress of the job take away your humanity. You treat your patients (...) editor, and then publish it. You dedicate it to the courageous men, women, and children who have survived sexual, psychological, or physical assault and who are soldering on. Alberto Hazan is an emergency physician and author of and series. Image credit: … … 168 Shares Tagged as: Subscribe to KevinMD and never miss a story! Get free updates delivered free to your inbox. Subscribe Hire KevinMD to keynote your next event "Kevin's keynote presentation was perfect. Extremely rich in content

2016 KevinMD blog

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