How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

4,262 results for

Dystonia

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

4241. Inheritance of idiopathic torsion dystonia among Jews. (PubMed)

Inheritance of idiopathic torsion dystonia among Jews. Idiopathic torsion dystonia (ITD) has long been considered to be genetically determined, but the pattern of inheritance has been unclear. It has been suggested that inheritance may differ in Jews and non-Jews. In the present study, data gathered in a nationwide survey of ITD in Israel were analysed. Between 1969 and 1980, 47 patients were collected, of whom 40 were of European origin. In these European Jews, the ITD frequency was about 1:23

Full Text available with Trip Pro

1984 Journal of Medical Genetics

4242. Torsion dystonia genes in two populations confined to a small region on chromosome 9q32-34. (PubMed)

Torsion dystonia genes in two populations confined to a small region on chromosome 9q32-34. Idiopathic torsion dystonia (ITD) is characterized by sustained, involuntary muscle contractions, frequently causing twisting and repetitive movements or abnormal postures. Most familial forms of ITD display autosomal dominant inheritance with reduced penetrance. Linkage analysis has been previously used to localize a dystonia gene to the 9q32-34 region in a large non-Jewish family and in a group (...) of Ashkenazi Jewish families. Utilizing GT repeat polymorphisms from this region, here we demonstrate that the gene causing dystonia in Ashkenazi Jews can be localized to the 11-cM interval between AK1 and D9S10. Linkage analysis in the non-Jewish family is also consistent with occurrence of the gene in this region, although positive lod scores extend over a greater than 20-cM interval in that family. These results set the stage for positional cloning of the dystonia gene. Currently there are no known

Full Text available with Trip Pro

1991 American Journal of Human Genetics

4243. Tic or dystonia? (PubMed)

Tic or dystonia? 1615672 1992 07 30 2018 11 13 0093-0415 156 6 1992 Jun The Western journal of medicine West. J. Med. Tic or dystonia? 667 Wasserstein P H PH Honig L S LS eng Letter United States West J Med 0410504 0093-0415 J6292F8L3D Haloperidol AIM IM Adult Diagnosis, Differential Dystonia diagnosis Haloperidol adverse effects Humans Tic Disorders diagnosis Torticollis diagnosis 1992 6 1 1992 6 1 0 1 1992 6 1 0 0 ppublish 1615672 PMC1003371 West J Med. 1992 Feb;156(2):198-9 1536082

Full Text available with Trip Pro

1992 Western Journal of Medicine

4244. Strong allelic association between the torsion dystonia gene (DYT1) and loci on chromosome 9q34 in Ashkenazi Jews (PubMed)

Strong allelic association between the torsion dystonia gene (DYT1) and loci on chromosome 9q34 in Ashkenazi Jews The DYT1 gene responsible for early-onset, idiopathic torsion dystonia (ITD) in the Ashkenazi Jewish population, as well as in one large non-Jewish family, has been mapped to chromosome 9q32-34. Using (GT)n and RFLP markers in this region, we have identified obligate recombination events in some of these Jewish families, which further delineate the area containing the DYT1 gene (...) predicts that these three genes lie within 1-2 cM of each other; on the basis of obligate recombination events, the DYT1 gene is centromeric to ASS. Furthermore, this allelic association supports the idea that a single mutation event is responsible for most hereditary cases of dystonia in the Jewish population. Of the 53 definitely affected typed, 13 appear to be sporadic, with no family history of dystonia. However, the proportion of sporadic cases which potentially carry the A12 haplotype at ASS (8

Full Text available with Trip Pro

1992 American Journal of Human Genetics

4245. Dystonia-parkinsonism syndrome (XDP) locus: flanking markers in Xq12-q21.1. (PubMed)

Dystonia-parkinsonism syndrome (XDP) locus: flanking markers in Xq12-q21.1. The study of rare genetic forms of dystonia and parkinsonism permits positional cloning of genes potentially involved in more common, multifactorial forms of these diseases. One movement disorder amenable to molecular genetic analysis is the X-linked dystonia-parkinsonism syndrome (XDP). This disease is endemic to the Philippines where it originated by a genetic founder effect. Linkage analysis was performed with DNA

Full Text available with Trip Pro

1992 American Journal of Human Genetics

4246. Sleep disorders. Consider nocturnal paroxysmal dystonia. (PubMed)

Sleep disorders. Consider nocturnal paroxysmal dystonia. 8518657 1993 07 29 2018 11 13 0959-8138 306 6890 1993 May 29 BMJ (Clinical research ed.) BMJ Sleep disorders. Consider nocturnal paroxysmal dystonia. 1476-7 Borrow S S Tattersall M L ML Hartman D D Oakey M M Sedgwick P P Crisp A H AH eng Case Reports Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1993 Apr 3;306(6882):921-4 8490425 Dystonia complications Humans Male Sleep Wake Disorders etiology 1993 5 29 1993 5 29 0 1 1993 5 29

Full Text available with Trip Pro

1993 BMJ : British Medical Journal

4247. Unawareness of dystonia. (PubMed)

Unawareness of dystonia. 1392906 1992 11 16 2008 11 20 0959-8138 305 6849 1992 Aug 08 BMJ (Clinical research ed.) BMJ Unawareness of dystonia. 368 Martin A A eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1990 Jan 20;300(6718):139-44 2105790 Awareness Dystonia Family Practice Health Education Humans 1992 8 8 1992 8 8 0 1 1992 8 8 0 0 ppublish 1392906 PMC1883027

Full Text available with Trip Pro

1992 BMJ : British Medical Journal

4248. Acute upper airway obstruction due to supraglottic dystonia induced by a neuroleptic. (PubMed)

Acute upper airway obstruction due to supraglottic dystonia induced by a neuroleptic. 3142568 1989 01 09 2018 11 13 0959-8138 297 6654 1988 Oct 15 BMJ (Clinical research ed.) BMJ Acute upper airway obstruction due to supraglottic dystonia induced by a neuroleptic. 964-5 Newton-John H H Fairfield Hospital, Victoria, Australia. eng Case Reports Journal Article England BMJ 8900488 0959-8138 1NHL2J4X8K Benztropine L4YEB44I46 Metoclopramide YHP6YLT61T Prochlorperazine AIM IM Adolescent Adult Airway (...) Obstruction chemically induced drug therapy Benztropine analogs & derivatives therapeutic use Dystonia chemically induced diagnostic imaging drug therapy Epiglottis diagnostic imaging Humans Male Metoclopramide adverse effects Prochlorperazine adverse effects Radiography 1988 10 15 1988 10 15 0 1 1988 10 15 0 0 ppublish 3142568 PMC1834652 Psychopharmacology (Berl). 1986;88(4):403-19 2871578 Am J Psychiatry. 1975 May;132(5):532-4 1119613

Full Text available with Trip Pro

1988 BMJ : British Medical Journal

4249. Cranial dystonia, blepharospasm and hemifacial spasm: clinical features and treatment, including the use of botulinum toxin. (PubMed)

Cranial dystonia, blepharospasm and hemifacial spasm: clinical features and treatment, including the use of botulinum toxin. Blepharospasm, the most frequent feature of cranial dystonia, and hemifacial spasm are two involuntary movement disorders that affect facial muscles. The cause of blepharospasm and other forms of cranial dystonia is not known. Hemifacial spasm is usually due to compression of the seventh cranial nerve at its exit from the brain stem. Cranial dystonia may result in severe (...) dystonia and hemifacial spasm.

Full Text available with Trip Pro

1988 CMAJ: Canadian Medical Association Journal

4250. Acute upper airway obstruction due to supraglottic dystonia. (PubMed)

Acute upper airway obstruction due to supraglottic dystonia. 3147023 1989 03 28 2018 11 13 0959-8138 297 6661 1988 Dec 03 BMJ (Clinical research ed.) BMJ Acute upper airway obstruction due to supraglottic dystonia. 1469-70 Thompson A C AC McClymont L G LG eng Letter England BMJ 8900488 0959-8138 AIM IM Acute Disease Airway Obstruction etiology Dystonia complications Epiglottis Humans 1988 12 3 1988 12 3 0 1 1988 12 3 0 0 ppublish 3147023 PMC1835146 N Engl J Med. 1986 May 1;314(18):1133-9

Full Text available with Trip Pro

1988 BMJ : British Medical Journal

4251. Fluctuating dystonia responsive to levodopa. (PubMed)

Fluctuating dystonia responsive to levodopa. Four cases of hereditary progressive dystonia with diurnal fluctuation were studied. All were sporadic; three of them mimicked spastic diplegia; and the fourth showed some similarity to torsion dystonia. Emotional or cognitive disturbance, or both, was seen in three. The correct diagnosis was suggested by fluctuating signs and symptoms, which worsened towards evening, but this was reached only after many years of handicap, hospital admissions (...) , and invasive diagnostic procedures. Typically there was a prompt, pronounced, and sustained response to moderate doses of levodopa. Sleep recordings were obtained in three patients and showed increased body movements during rapid eye movement sleep. Several close relatives had periods of increased leg movements during sleep. It is suggested that hereditary dystonia responsive to levodopa should be considered as the diagnosis in children with fluctuating signs of motor disability syndromes, simulating

Full Text available with Trip Pro

1987 Archives of Disease in Childhood

4252. Dopa responsive dystonia: a treatable condition misdiagnosed as cerebral palsy. (PubMed)

Dopa responsive dystonia: a treatable condition misdiagnosed as cerebral palsy. 2499372 1989 07 20 2018 11 13 0959-8138 298 6679 1989 Apr 15 BMJ (Clinical research ed.) BMJ Dopa responsive dystonia: a treatable condition misdiagnosed as cerebral palsy. 1019-20 Boyd K K Department of Neurology, Royal Victoria Hospital, Belfast. Patterson V V eng Case Reports Journal Article England BMJ 8900488 0959-8138 46627O600J Levodopa AIM IM Adult Cerebral Palsy diagnosis Diagnosis, Differential Dystonia

Full Text available with Trip Pro

1989 BMJ : British Medical Journal

4253. Dopa responsive dystonia. (PubMed)

Dopa responsive dystonia. 2502235 1989 08 31 2018 11 13 0959-8138 298 6682 1989 May 06 BMJ (Clinical research ed.) BMJ Dopa responsive dystonia. 1250 eng Case Reports Letter England BMJ 8900488 0959-8138 46627O600J Levodopa AIM IM Adult Dystonia drug therapy Female Humans Levodopa therapeutic use 1989 5 6 1989 5 6 0 1 1989 5 6 0 0 ppublish 2502235 PMC1836277 BMJ. 1989 Apr 15;298(6679):1019-20 2499372 Dev Med Child Neurol. 1970 Jun;12(3):309-14 5433148 J Neurol Neurosurg Psychiatry. 1980 Sep;43

Full Text available with Trip Pro

1989 BMJ : British Medical Journal

4254. A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. (PubMed)

A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. To review the literature on primary dystonia and dystonia plus and to provide evidence-based recommendations. Primary dystonia and dystonia plus are chronic and often disabling conditions with a widespread spectrum mainly in young people. Computerized MEDLINE and EMBASE literature reviews (1966-1967 February 2005) were conducted. The Cochrane (...) Library was searched for relevant citations. Diagnosis and classification of dystonia are highly relevant for providing appropriate management and prognostic information, and genetic counselling. Expert observation is suggested. DYT-1 gene testing in conjunction with genetic counselling is recommended for patients with primary dystonia with onset before age 30 years and in those with an affected relative with early onset. Positive genetic testing for dystonia (e.g. DYT-1) is not sufficient to make

Full Text available with Trip Pro

2006 European journal of neurology : the official journal of the European Federation of Neurological Societies

4255. Predominant dystonia with marked cerebellar atrophy: a rare phenotype in familial dystonia. (PubMed)

Predominant dystonia with marked cerebellar atrophy: a rare phenotype in familial dystonia. Dystonia syndromes constitute a heterogeneous group of phenotypes that may be caused by different heredodegenerative, metabolic, or genetic diseases.To describe the characteristics of an unusual dystonia-plus phenotype associated with cerebellar atrophy.We selected patients with predominant dystonia and cerebellar atrophy among the 861 families referred to us for genetic testing from 1992 to 2003 (...) . The main secondary heredodegenerative causes and the major genes responsible for hereditary dystonias and autosomal dominant or recessive ataxias were excluded.We identified 12 patients in 8 families with an unusual dystonia-plus phenotype characterized by dystonia and cerebellar atrophy on brain MRI. The mean age at onset was 27.3 +/- 11.5 years (range: 9 to 42 years) and the mean disease duration 14.7 +/- 7.7 years (range: 4 to 30). At onset, dystonia was focal or multifocal, mainly affecting vocal

2006 Neurology

4256. Abnormal low frequency drive in myoclonus-dystonia patients correlates with presence of dystonia. (PubMed)

Abnormal low frequency drive in myoclonus-dystonia patients correlates with presence of dystonia. The pathophysiology of Myoclonus-Dystonia (M-D), an autosomal dominantly inherited movement disorder is largely unknown. In different forms of dystonia abnormal intermuscular coherence is present. The objective of this study was to investigate whether the myoclonic and dystonic features are the result of an abnormal common drive to the muscles in M-D. Coherence analysis was performed in 20 DYT11 (...) mutation carriers (MC) and 13 healthy controls during resting condition and during weak isometric contraction of the arm and neck. The EMG-EMG coherence analysis showed significantly increased intermuscular 3 to 10 Hz coherence in 4 DYT11 MC with clinical pronounced (mobile and static) dystonia. This coherence was not present in DYT11 MC with mild (static) dystonia and/or predominating myoclonus. The EEG-EMG analysis showed significant 15 to 30 Hz coherence during weak isometric contraction of the arm

2007 Movement Disorders

4257. Blepharospasm and limb dystonia caused by Mohr-Tranebjaerg syndrome with a novel splice-site mutation in the deafness/dystonia peptide gene. (PubMed)

Blepharospasm and limb dystonia caused by Mohr-Tranebjaerg syndrome with a novel splice-site mutation in the deafness/dystonia peptide gene. Mohr-Tranebjaerg syndrome (MTS) is an X-linked disorder characterized by childhood-onset progressive deafness, dystonia, spasticity, mental deterioration, and blindness. It is due to mutations in the deafness/dystonia peptide (DDP1) gene. We describe a sporadic 42-year-old man with MTS presenting with postlingual deafness, adult-onset progressive dystonia

2007 Movement Disorders

4258. Smothering dystonia in a patient with oromandibular dystonia. (PubMed)

Smothering dystonia in a patient with oromandibular dystonia. A case report is presented of a patient with pathologically confirmed striatonigral degeneration who experienced episodic syncope as a result of oromandibular dystonia obstructing inhalation through her mouth and nose.

2004 Movement Disorders

4259. Capturing the true burden of dystonia on patients: the Cervical Dystonia Impact Profile (CDIP-58). (PubMed)

Capturing the true burden of dystonia on patients: the Cervical Dystonia Impact Profile (CDIP-58). To develop a new rating scale for measuring the health impact of cervical dystonia (CD) that includes patients' perceptions and complements existing observer dependent clinician rating scales.Scale development was in three stages. In Stage 1, a large pool of items was generated from patient interviews (n = 25), expert opinion, and literature review. In Stage 2, these items were administered

2004 Neurology

4260. Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm. (PubMed)

Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm. In the past five years, 477 patients with various focal dystonias and hemifacial spasm received 3,806 injections of botulinum A toxin for relief of involuntary spasms. A definite improvement with a global rating greater than or equal to 2 on a 0-4 scale, was obtained in all 13 patients with spasmodic dysphonia, 94% of 70 patients with blepharospasm, 92% of 13 patients (...) with hemifacial spasm, 90% of 195 patients with cervical dystonia, 77% of 22 patients with hand dystonia, 73% of 45 patients with oromandibular dystonia, and in 90% of 21 patients with other focal dystonia who had adequate follow up. While the average duration of maximum improvement lasted about 11 weeks after an injection (range seven weeks in patients with hand dystonia to 15 weeks in patients with hemifacial spasm), some patients benefited for over a year. Only 16% of the 941 treatment visits with follow

Full Text available with Trip Pro

1990 Journal of neurology, neurosurgery, and psychiatry

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>