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Dyspepsia in Pregnancy

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81. Public health service provision by community pharmacies: a systematic map of evidence

services, including enhancing pharmacy’s contribution via initiatives aimed at: • smoking cessation; • teenage pregnancy rate reduction via contraceptive advice and support and sexual health advice; • increased access to emergency hormonal contraception (EHC); • minor ailments; • chlamydia testing and treatment; • growing Healthy Living Pharmacy centres; • checking and testing at risk people; • monitoring and health checks for conditions such as raised blood pressure, diabetes and asthma (DH 2008

2019 EPPI Centre

83. Finasteride

. Two patients stopped treatment for economic reasons and one stopped due to dyspepsia. No sexual or other adverse effects were observed. Patients were given periodic physical and analytical examinations by endocrinologists without any significant finding. Mean follow-up of patients was 16.2 2017 20. Aphalangia possibly linked to unintended use of finasteride during early pregnancy 19318745 2009 03 25 2009 08 20 2014 12 10 0256-4947 29 2 2009 Mar-Apr Annals of Saudi medicine Ann Saudi Med Aphalangia (...) possibly linked to unintended use of finasteride during early pregnancy. 155-6 Sallout Bahauddin I BI Al Wadi Khalid A KA eng Case Reports Letter Saudi Arabia Ann Saudi Med 8507355 0256-4947 0 Enzyme Inhibitors 57GNO57U7G Finasteride IM J Ultrasound Med. 1985 Nov;4(11):595-601 3908707 Teratology (...) . 1997 Feb;55(2):119-31 9143092 Teratology. 1990 Jul;42(1):91-100 2168096 Abnormalities, Multiple chemically induced Adult Enzyme Inhibitors adverse effects Female Finasteride adverse effects Fingers

2018 Trip Latest and Greatest

85. Ranitidine

) 50 mg (once daily) versus ranitidine 150 mg (twice daily) in the maintenance 2009 5. Ranitidine USE OF H2 RECEPTOR ANTAGONISTS IN PREGNANCY 0344 892 0909 USE OF H2 RECEPTOR ANTAGONISTS IN PREGNANCY (Date of issue: January 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient (...) information leaflet on is available at . Summary Histamine H2 (H 2 ) receptor antagonists (...) (cimetidine, famotidine, nizatidine and ranitidine ) reduce gastric acid output and thus gastric acidity. H 2 receptor antagonists are used in the symptomatic relief of chronic episodic dyspepsia and gastro-oesophageal reflux disease, in the prevention and treatment of gastric or duodenal ulceration, and prior to general anaesthesia in patients at risk of acid aspiration. The BNF suggests ranitidine

2018 Trip Latest and Greatest

87. Budesonide (Jorveza) - to treat adults with eosinophilic oesophagitis

of these studies resemble those which are already known from other glucocorticoids (e.g. foetal deaths, intrauterine growth retardation, and skeletal abnormalities). Budesonide for oral use has already been licensed in Europe for other gastrointestinal indications with daily doses above the maximum recommended dose for Jorveza (9 mg versus 2 mg). Therefore no unknown risk will be associated with a lower daily dose in pregnant women. The information provided in section 4.6 of the SmPC is in line

2018 European Medicines Agency - EPARs

88. Semaglutide (Ozempic) - Diabetes Mellitus

contraception, and cease with semaglutide treatment prior to planned pregnancy as well as during pregnancy and lactation. 2.3.7. Conclusion on non-clinical aspects The pharmacology, safety pharmacology, pharmacokinetics and toxicology programs are considered sufficient. There are no major objections from a non-clinical point of view. 2.4. Clinical aspects 2.4.1. Introduction GCP The clinical trials were performed in accordance with GCP as claimed by the applicant. The applicant has provided a statement

2018 European Medicines Agency - EPARs

89. Rucaparib camsylate - Ovarian Neoplasms

in pregnant SD rats. Absorption The absolute oral bioavailability of rucaparib was 17%, 22%, and 74-75% in mice, rats, and dogs respectively. Rucaparib showed moderate plasma protein binding and a high distribution volume with V ss of 6.14, 6.5, and 15.2 L/kg in mouse, rat and dog, respectively. This is consistent with the preferential rucaparib distribution in RBCs with RBC-to-plasma ratios of 2 to 5.21 in animal species and wide tissue distribution in rats. The terminal elimination half-life (T 1/2

2018 European Medicines Agency - EPARs

90. Dolutegravir sodium rilpivirine hydrochloride (Juluca) - HIV Infections

of pregnant rats and was excreted into rat milk. Protein binding of rilpivirine was > 99% in human, monkey, dog, rat, rabbit and mouse. The highest levels of drug-related material were found at 4 h after dosing in the uveal tract, liver and adrenal gland. Rilpivirine-related material crosses the blood-brain barrier and was found to be binding to melanin. Rilpivirine-related material crossed the placenta barrier in rats. Concentrations of rilpivirine were quantifiable in blood samples from rat pups

2018 European Medicines Agency - EPARs

92. Diagnosis and management of gonorrhoea and syphilis

literature search: Treatment of gonorrhoea in women and men, including young people 93 4 Diagnosis and management of gonorrhoea and syphilis KCE Report 310 Recommendation for treatment of gonorrhoea in women and men including young people 99 Treatment of gonorrhea: Good practice statements 99 3.8 TREATMENT OF GONORRHOEA: TREATMENT CHOICE IN PREGNANT WOMEN 100 Recommendations from international guidelines 100 Recommendations from national guides 101 Additional literature search: Treatment of gonorrhoea (...) in pregnant women 101 Recommendation for treatment of gonorrhoea in pregnant women 104 Treatment of gonorrhoea in pregnant women: Good practice statements 104 3.9 TREATMENT OF GONORRHOEA: TREATMENT CHOICE IN PEOPLE WITH AN ALLERGY TO CEPHALOSPORIN 105 Background cephalosporin allergy 105 Recommendations from international guidelines 105 Recommendations from national guides 106 Additional literature search: Treatment of gonorrhoea in people with an allergy to cephalosporin 106 Treatment of gonorrhoea

2019 Belgian Health Care Knowledge Centre

94. Robot-assisted surgery in thoracic and visceral indications

Organ Prolapse/Urinary Incontinence Sexual Questionnaire PSQ Photograph series questionnaire QLQ-LC-13 Lung-cancer-specific questionnaire Module QOL Quality of Life QOLRAD Quality of Life in Reflux and Dyspepsia R Range RATS Robot-assisted thoracospic Surgery RCT randomised controlled trial RR Relative risk SCLC Small cell lung cancer SD standard deviation SF-12 Short Form 12 SIRC Single-incision robotic cholecystectomy TM Trade Mark VAS Visual Analogue Scale VATS Video-assisted thoracospic Surgery

2019 EUnetHTA

95. Management of Atopic Eczema

) Diarrhoea, dyspepsia, vomiting, abnormal liver function test, acne, leukopenia, sepsis, certain infections Avoid use of concomitant live vaccines Pregnancy and women of childbearing age Screen for Hepatitis B (...) ). Prevalence of schizophrenia and affective disorders are also higher in AE compared with control (1.2% vs 0.5% and 7.7% vs 4.5% respectively). 23, level II-2 Prevalence of AE is increased with exposure to active and passive smoking. However, it is not associated with maternal smoking during pregnancy. 24, level II-2 • Co-morbidities e.g. skin infection, atopic disease, food allergy, cardiovascular disease, psychological and psychosocial dysfunction may co-exist in AE.7 Management of Atopic Eczema 5

2019 Ministry of Health, Malaysia

97. Surgery to Reduce the Risk of Ovarian Cancer Information for Women at Increased Risk

chance of getting ovarian cancer: • Pregnancy and oral contraceptive pill use • Having tubes tied (tubal ligation) • Risk reducing surgery: the best way to reduce the chance of ovarian cancer is to remove the ovaries and fallopian tubes. This type of surgery is called Risk Reducing Salpingo-Oophorectomy (RRSO). In Australia, 1 in 81 women will develop ovarian cancer by age 85 16 SYMPTOMS The symptoms for ovarian cancer are often vague or similar to other common medical problems. Doctors sometimes do (...) not recognise them as ovarian cancer. Symptoms may include: Unexplained fatigue Abdominal bloating or increased abdominal size Abdominal or pelvic pain Appetite loss, feeling full quickly or indigestion Urinary changes, such as increased frequency or urgency Changes in bowel habit, such as constipation Unexplained weight loss or weight gain If you develop persistent symptoms like these, please see your doctor. 7 DIAGNOSIS AND SCREENING If a woman has signs of ovarian cancer, the following tests may be used

2019 European Society of Endocrinology

98. Gynaecological Cancers: a Handbook for Aboriginal and Torres Strait Islander Health Workers and Health Practitioners

include vaginal cancer, vulval cancer, and placenta cancer (a pregnancy-related cancer). 1 This handbook contains information about the three most common types of gynaecological cancer. 4 GYNAECOLOGICAL CANCERS • A HANDBOOK FOR HEALTH WORKERS Figure 1.1 The female reproductive system How cancer spreads When cells grow in an uncontrolled way, they form a tumour. Not all tumours are cancer. Benign tumours do not spread to other parts of the body. Most benign tumours do not develop into cancer. However (...) ongoing monitoring/treatment • giving birth to five or more children: may slightly increase the risk of cervical cancer • previous use of diethylstilbestrol (DES): prescribed to pregnant women in the 1940s to 1970s to prevent miscarriage. Reducing the risk of cervical cancer National HPV Vaccination Program 8,9 The HPV vaccine protects against the types of the HPV virus that are known to cause cervical cancer. The HPV vaccine is provided free in school to all girls and boys aged 12-13 years under

2018 Cancer Australia

99. Chronic Pelvic Pain

of the story. Hum Reprod Update, 2009. 15: 177. 330. Vercellini, P., et al. Medical treatment for rectovaginal endometriosis: what is the evidence? Hum Reprod, 2009. 24: 2504. 331. Walters, C., et al. Pelvic girdle pain in pregnancy. Aust J Gen Pract, 2018. 47: 439. 332a. Khan, K.S., et al. MRI versus laparoscopy to diagnose the main causes of chronic pelvic pain in women: a test-accuracy study and economic evaluation. Health Technol Assess, 2018. 22: 1. 332b. Kaminski, P., et al. The usefulness

2019 European Association of Urology

100. Paediatric Urology

of erythropoietin during testicular torsion of the rats. World J Urol, 2007. 25: 531. 185. Lian, B.S., et al. Factors Predicting Testicular Atrophy after Testicular Salvage following Torsion. Eur J Pediatr Surg, 2016. 26: 17. 186. Philip, J., et al. Mumps orchitis in the non-immune postpubertal male: a resurgent threat to male fertility? BJU Int, 2006. 97: 138. 187. Gielchinsky, I., et al. Pregnancy Rates after Testicular Torsion. J Urol, 2016. 196: 852. 188. Bergman, J.E., et al. Epidemiology of hypospadias

2019 European Association of Urology

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