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Dyspepsia in Pregnancy

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41. Gastrointestinal Disease and Pregnancy (Diagnosis)

smoking, alcoholism, stress, socioeconomic status, and a previous history of PUD or . Nonsteroidal medications are not a common risk factor for PUD in pregnancy unless in combination with colonization with H pylori . [ ] The clinical features of this condition in pregnant women are similar to those in the nonpregnant state. Symptoms include dyspepsia, epigastric pain, nausea, vomiting, and heartburn. [ ] Gastrointestinal bleeding and perforation are rare complications of PUD in pregnancy. PUD does (...) Gastrointestinal Disease and Pregnancy (Diagnosis) Gastrointestinal Disease and Pregnancy: Overview, Nausea and Vomiting, Hyperemesis Gravidarum Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg2MjI1LW92ZXJ2aWV3

2014 eMedicine.com

42. Gastrointestinal Disease and Pregnancy (Overview)

smoking, alcoholism, stress, socioeconomic status, and a previous history of PUD or . Nonsteroidal medications are not a common risk factor for PUD in pregnancy unless in combination with colonization with H pylori . [ ] The clinical features of this condition in pregnant women are similar to those in the nonpregnant state. Symptoms include dyspepsia, epigastric pain, nausea, vomiting, and heartburn. [ ] Gastrointestinal bleeding and perforation are rare complications of PUD in pregnancy. PUD does (...) Gastrointestinal Disease and Pregnancy (Overview) Gastrointestinal Disease and Pregnancy: Overview, Nausea and Vomiting, Hyperemesis Gravidarum Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg2MjI1LW92ZXJ2aWV3

2014 eMedicine.com

43. Gastrointestinal Disease and Pregnancy (Treatment)

smoking, alcoholism, stress, socioeconomic status, and a previous history of PUD or . Nonsteroidal medications are not a common risk factor for PUD in pregnancy unless in combination with colonization with H pylori . [ ] The clinical features of this condition in pregnant women are similar to those in the nonpregnant state. Symptoms include dyspepsia, epigastric pain, nausea, vomiting, and heartburn. [ ] Gastrointestinal bleeding and perforation are rare complications of PUD in pregnancy. PUD does (...) Gastrointestinal Disease and Pregnancy (Treatment) Gastrointestinal Disease and Pregnancy: Overview, Nausea and Vomiting, Hyperemesis Gravidarum Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg2MjI1LW92ZXJ2aWV3

2014 eMedicine.com

44. Gastrointestinal Disease and Pregnancy (Follow-up)

smoking, alcoholism, stress, socioeconomic status, and a previous history of PUD or . Nonsteroidal medications are not a common risk factor for PUD in pregnancy unless in combination with colonization with H pylori . [ ] The clinical features of this condition in pregnant women are similar to those in the nonpregnant state. Symptoms include dyspepsia, epigastric pain, nausea, vomiting, and heartburn. [ ] Gastrointestinal bleeding and perforation are rare complications of PUD in pregnancy. PUD does (...) Gastrointestinal Disease and Pregnancy (Follow-up) Gastrointestinal Disease and Pregnancy: Overview, Nausea and Vomiting, Hyperemesis Gravidarum Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTg2MjI1LW92ZXJ2aWV3

2014 eMedicine.com

45. Peptic ulceration in pregnancy: report of a case with perforation. (PubMed)

Peptic ulceration in pregnancy: report of a case with perforation. 5929536 1966 07 14 2018 11 13 0008-4409 94 16 1966 Apr 16 Canadian Medical Association journal Can Med Assoc J Peptic ulceration in pregnancy: report of a case with perforation. 861-2 Baird R M RM eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 AIM IM Adult Dyspepsia Female Gastrectomy Humans Peptic Ulcer Perforation Pregnancy Pregnancy Complications 1966 4 16 1966 4 16 0 1 1966 4 16 0 0 ppublish

Full Text available with Trip Pro

1966 Canadian Medical Association Journal

46. Obstetrics in General Practice: Minor Disorders of Pregnancy (PubMed)

Obstetrics in General Practice: Minor Disorders of Pregnancy 14102023 1996 12 01 2018 12 01 0007-1447 1 5385 1964 Mar 21 British medical journal Br Med J OBSTETRICS IN GENERAL PRACTICE. MINOR DISORDERS OF PREGNANCY. 749-52 PHILIPP E E EE eng Journal Article England Br Med J 0372673 0007-1447 OM Anemia Anxiety Back Pain Classification Constipation Dyspepsia Family Practice Female General Practice Heartburn Hemorrhoids Hernia, Diaphragmatic Humans Hypertension Migraine Disorders Muscle Cramp (...) Obstetrics Paresthesia Pre-Eclampsia Pregnancy Pregnancy Complications Sleep Wake Disorders Trichomonas Vaginitis Urinary Tract Infections Urination Disorders Varicose Veins Vomiting ANEMIA ANXIETY BACKACHE CLASSIFICATION CONSTIPATION DIAPHRAGMATIC HERNIA DYSPEPSIA GENERAL PRACTICE HEARTBURN HEMORRHOIDS HYPERTENSION MIGRAINE MUSCLE CRAMP PARESTHESIA PREGNANCY PREGNANCY COMPLICATIONS PREGNANCY TOXEMIAS SLEEP DISORDERS TRICHOMONAS VAGINITIS URINARY TRACT INFECTIONS URINATION DISORDERS VARICOSE VEINS

Full Text available with Trip Pro

1964 British medical journal

47. Mirtazapine Versus Placebo in Functional Dyspepsia

Mirtazapine Versus Placebo in Functional Dyspepsia Mirtazapine Versus Placebo in Functional Dyspepsia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Mirtazapine Versus Placebo in Functional Dyspepsia (...) Information provided by: Universitaire Ziekenhuizen Leuven Study Details Study Description Go to Brief Summary: Double-blind randomized controlled trials of 8 weeks mirtazapine 15 mg daily or placebo, followed by 8 weeks of open-label mirtazapine 15 mg daily Condition or disease Intervention/treatment Phase Functional Dyspepsia Drug: Mirtazapine Phase 4 Detailed Description: Double-blind randomized controlled trials of 8 weeks mirtazapine 15 mg or placebo, followed by 8 weeks of open-label mirtazapine Two

2010 Clinical Trials

48. Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition

) with defined functional dyspepsia per the ROME III criteria with a negative EGD who are on proton pump inhibitor therapy yet still have a sense of inadequate symptom control. Exclusion Criteria: Patients excluded will be women of childbearing age who refuse to have a baseline pregnancy test and/or who refuse to prevent pregnancy during the trial period. Exclusion criteria will also include anyone with a history of adverse effect or allergy to gabapentin. Finally, any patient undergoing hemodialysis (...) Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Gabapentin

2010 Clinical Trials

49. Cerebral palsy in under 25s: assessment and management

://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 461 Optimising nutritional status in children with cerebral palsy 44 2 Managing communication difficulties in children with cerebral palsy 44 3 Recognition and early management of pain in children and young people with cerebral palsy 45 4 Association between treating infections in pregnancy and rates of cerebral palsy 45 5 Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy 46 Cerebral palsy in under (...) of pain, discomfort and distress identified in children and young people with cerebral palsy, treat the cause as appropriate using targeted interventions in line with the following NICE guidelines: spasticity in under 19s constipation in children and young people gastro-oesophageal reflux disease in children and young people and gastro- oesophageal reflux disease and dyspepsia in adults headaches in over 12s low back pain and sciatica in over 16s urinary incontinence in neurological disease urinary

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

50. Istradefylline (Nourianz) - Parkinson's disease

, 2017 for all NDAs and BLAs Reference ID: 4482736 Reference ID: 4484018 3 Clinical Review Natalie Branagan, MD NDA 022075 Nourianz/istradefylline 8.7. Specific Safety Studies/Clinical Trials 80 8.8. Additional Safety Explorations 80 8.8.1. Human Carcinogenicity or Tumor Development 80 8.8.2. Human Reproduction and Pregnancy 83 8.8.3. Pediatrics and Assessment of Effects on Growth 84 8.8.4. Overdose, Drug Abuse Potential, Withdrawal, and Rebound 84 8.9. Safety in the Postmarket Setting 86 8.9.1 (...) belonging to narrow SMQs with incidence of at least 1% greater than placebo for Pool 1. The only TEAEs related to laboratory analysis belonged narrow SMQ with incidence of at least 1% greater than placebo was Hyperglycaemia/New Onset Diabetes Mellitus. The following table shows the incidence by dose. Overall, the maximum difference from placebo was low at = 65 13.7 7.4 Fall, dizziness, balance disorder = 65 8.2 9.8 Dyspepsia, N, V, indigestion, epigastric pain, gastritis, duodenitis = 65 5.4 5.6

2019 FDA - Drug Approval Package

51. Iron Deficiency – Diagnosis and Management

history, symptom review and physical examination. Directed history should include: nutrition and physical activity history pregnancy status and number of pregnancies history of blood loss, including GI bleeding, hematuria, menorrhagia, and blood donation GI symptoms including changes in bowel habits, abdominal pain, dyspepsia, and unexplained weight loss family history including colorectal cancer Menorrhagia is the most frequent cause of iron deficiency among pre-menopausal women. Consider referral (...) athletes, regular blood donors, disordered eating Pre-menopausal women: especially those with menorrhagia, vegetarian diet All adults age >65 All ages: low socioeconomic status, lack of balanced diet, inadequate nutritional intake Table 1: Common causes of and risk factors for iron deficiency and IDA in adults Note: Please refer to and for causes and risk factors in children, pregnancy and the perinatal period. Increased Requirements Decreased Intake Pregnancy (2 nd /3 rd trimester) Lactation Rapid

2019 Clinical Practice Guidelines and Protocols in British Columbia

53. Trastuzumab (Ogivri) - breast cancer or stomach cancer

. Pharmacokinetic data from Study H4613g/GO01305 suggested that carboplatin had no impact on the PK of trastuzumab. The administration of concomitant anastrozole did not appear to influence the pharmacokinetics of trastuzumab. 4.6 Fertility, pregnancy and lactation Women of childbearing potential Women of childbearing potential should be advised to use effective contraception during treatment with trastuzumab and for 7 months after treatment has concluded (see section 5.2). Pregnancy Reproduction studies have (...) predictive of human response, trastuzumab should be avoided during pregnancy unless the potential benefit for the mother outweighs the potential risk to the foetus. In the post-marketing setting, cases of foetal renal growth and/or function impairment in association with oligohydramnios, some associated with fatal pulmonary hypoplasia of the foetus, have been reported in pregnant women receiving trastuzumab. Women who become pregnant should be advised of the possibility of harm to the foetus

2019 European Medicines Agency - EPARs

54. Public health service provision by community pharmacies: a systematic map of evidence

services, including enhancing pharmacy’s contribution via initiatives aimed at: • smoking cessation; • teenage pregnancy rate reduction via contraceptive advice and support and sexual health advice; • increased access to emergency hormonal contraception (EHC); • minor ailments; • chlamydia testing and treatment; • growing Healthy Living Pharmacy centres; • checking and testing at risk people; • monitoring and health checks for conditions such as raised blood pressure, diabetes and asthma (DH 2008

2019 EPPI Centre

55. Assessment of nausea and vomiting, adults

dysrhythmias Gastroparesis Bacterial peritonitis Anorexia nervosa Bulimia nervosa Pregnancy Drug-induced Nephrolithiasis Uraemia Idiopathic functional dyspepsia or post-prandial distress syndrome Acute coronary syndrome Postural orthostatic tachycardia syndrome (POTS) Meniere's disease Acoustic neuroma Traumatic brain injury Meningitis Brain abscess Complex partial seizures CNS tumours Primary adrenal insufficiency (acute or chronic) Hyperthyroidism Hypopituitarism Heat stroke Acute pancreatitis Bariatric

2018 BMJ Best Practice

56. Diagnosis and management of gonorrhoea and syphilis

384 1101 6.7 21.1 Source: Vanden Berghe et al. 2018 5 To reduce transmission, timely and effective treatment is necessary by shortening the duration of infection and decreasing the risk of serious health sequelae, including pelvic in?ammatory disease, infertility, and ectopic pregnancy. 1 Unfortunately, N. gonorrhoea has progressively developed resistance to the antimicrobials that are recommended as ?rst-line treatment regimens, and current treatment options are severely limited. 1 Pharyngeal (...) are nonexistent. 1.1.1.2 Syphilis Syphilis is a systemic human disease due to infection with the spirochete bacterium Treponema pallidum subspecies pallidum (T. pallidum) and either acquired by direct contact with an infectious lesion, usually sexual contact, or by vertical transmission at any stage during pregnancy (highest in early pregnancy). Approximately one third of sexual contacts of infectious syphilis will develop the disease. 6 Extra-genital transmission is common in MSM (ano-rectal, oral) through

2019 Belgian Health Care Knowledge Centre

59. Ranitidine

) 50 mg (once daily) versus ranitidine 150 mg (twice daily) in the maintenance 2009 5. Ranitidine USE OF H2 RECEPTOR ANTAGONISTS IN PREGNANCY 0344 892 0909 USE OF H2 RECEPTOR ANTAGONISTS IN PREGNANCY (Date of issue: January 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient (...) information leaflet on is available at . Summary Histamine H2 (H 2 ) receptor antagonists (...) (cimetidine, famotidine, nizatidine and ranitidine ) reduce gastric acid output and thus gastric acidity. H 2 receptor antagonists are used in the symptomatic relief of chronic episodic dyspepsia and gastro-oesophageal reflux disease, in the prevention and treatment of gastric or duodenal ulceration, and prior to general anaesthesia in patients at risk of acid aspiration. The BNF suggests ranitidine

2018 Trip Latest and Greatest

60. Finasteride

. Two patients stopped treatment for economic reasons and one stopped due to dyspepsia. No sexual or other adverse effects were observed. Patients were given periodic physical and analytical examinations by endocrinologists without any significant finding. Mean follow-up of patients was 16.2 2017 20. Aphalangia possibly linked to unintended use of finasteride during early pregnancy 19318745 2009 03 25 2009 08 20 2014 12 10 0256-4947 29 2 2009 Mar-Apr Annals of Saudi medicine Ann Saudi Med Aphalangia (...) possibly linked to unintended use of finasteride during early pregnancy. 155-6 Sallout Bahauddin I BI Al Wadi Khalid A KA eng Case Reports Letter Saudi Arabia Ann Saudi Med 8507355 0256-4947 0 Enzyme Inhibitors 57GNO57U7G Finasteride IM J Ultrasound Med. 1985 Nov;4(11):595-601 3908707 Teratology (...) . 1997 Feb;55(2):119-31 9143092 Teratology. 1990 Jul;42(1):91-100 2168096 Abnormalities, Multiple chemically induced Adult Enzyme Inhibitors adverse effects Female Finasteride adverse effects Fingers

2018 Trip Latest and Greatest

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