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Dry Skin

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161. LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. (Abstract)

barrier function and underlie skin diseases such as dry skin and atopic dermatitis. However, intrinsic factors that regulate FLG expression and their mechanisms of action remain unknown. Here, we show that lysophosphatidic acid induces FLG expression in human keratinocytes via the LPAR1 and LPAR5 receptors and the downstream RHO-ROCK-SRF pathway. Comprehensive gene profiling analysis further showed that lysophosphatidic acid not only induces FLG expression but also facilitates keratinocyte (...) LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. The skin barrier protects the body from water loss, allergens, and pathogens. Profilaggrin is produced by differentiated keratinocytes and is processed into filaggrin monomers. These monomers cross-link keratin filaments and are also decomposed to natural moisturizing factors in the stratum corneum for skin hydration and barrier function. Deficits in FLG expression impair skin

2018 Journal of Investigative Dermatology

162. Evaluation of fast-acting bactericidal activity and substantivity of an antiseptic agent, olanexidine gluconate, using an ex vivo skin model. Full Text available with Trip Pro

Evaluation of fast-acting bactericidal activity and substantivity of an antiseptic agent, olanexidine gluconate, using an ex vivo skin model. We assessed the fast-acting bactericidal activity and substantivity of olanexidine gluconate (OLG) to investigate its remaining bactericidal activity on the skin after rinsing and drying by using an ex vivo Yucatan micropig (YMP) skin model.The fast-acting bactericidal activity was evaluated in pigskin models inoculated with methicillin-resistant (...) Staphylococcus aureus (MRSA), Staphylococcus epidermidis, vancomycin-resistant Enterococcus faecalis (VRE), Acinetobacter baumannii, Corynebacterium minutissimum and Cutibacterium acnes. To evaluate substantivity, the YMP skin piece first had 1.5 % OLG, chlorhexidine gluconate (CHG) formulations or 10 % povidone-iodine (PVP-I) applied to it, and was then rinsed with distilled water, incubated for 4, 6, 8 or 12 h and inoculated with the test bacteria (MRSA, S. epidermidis and VRE). The viable bacteria

2018 Journal of Medical Microbiology

163. Evaluation of Fenofibrate on Radiation-induced Skin Injury

proliferating and maturing cells. Ionizing radiation promotes reactive nitrogen and oxygen species (RNS/ROS) production due to radiolysis of water and direct ionization of target molecules, which result in oxidative damage and skin injuries. It is considered that ~95 % of cancer patients receiving radiation therapy will develop some form of radiodermatitis, including erythema, dry desquamation, and moist desquamation. Radiation-induced skin injury negatively affects the process of radiotherapy (...) Evaluation of Fenofibrate on Radiation-induced Skin Injury Evaluation of Fenofibrate on Radiation-induced Skin Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of Fenofibrate on Radiation

2018 Clinical Trials

164. Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment

is the first-line medication to treat coccidioidomycosis. Through the investigator's clinical observations at the Valley Fever Center for Excellence, nearly all patients who have been placed on systemic azole treatment show some extent of cosmetic changes in their skin and hair, such as dry skin, chapped lips, hair loss, and change in hair characteristics. The goals of the study are to 1) understand the cosmetic changes in the skin and hair in patients initiating and discontinuing long-term oral (...) Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

165. The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin Full Text available with Trip Pro

The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well (...) as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Recent genomic approaches have revealed the physiological importance of zinc transporters in skin formation and clarified their functional impairment in cutaneous pathogenesis. In this review, we provide an overview of the relationships between zinc deficiency and skin disorders, focusing on the roles of zinc transporters in the skin. We also discuss therapeutic outlooks and advantages of controlling zinc levels via

2018 Nutrients

166. Determinants of hand dermatitis, urticaria and loss of skin barrier function in professional cleaners in New Zealand Full Text available with Trip Pro

Determinants of hand dermatitis, urticaria and loss of skin barrier function in professional cleaners in New Zealand This study assessed the risk of dermatitis, urticaria and loss of skin barrier function in 425 cleaners and 281 reference workers (retail workers and bus drivers). Symptoms, atopy and skin barrier function were assessed by questionnaire, skin prick tests, and measurement of transepidermal water loss. Cleaners had an increased risk of current (past 3 months) hand/arm dermatitis (...) (14.8% vs. 10.0%; OR = 1.9, p < 0.05) and urticaria (11% vs. 5.3%; OR = 2.4, p < 0.05) and were more likely to have dermatitis as adults (17.6% vs. 11.4%; OR = 1.8, p < 0.05). The risk of atopy was not increased, but associations with symptoms were more pronounced in atopics. Transepidermal water loss was significantly higher in cleaners. Wet-work was a significant risk factor for dermatitis and hand washing and drying significantly reduced the risk of urticaria. In conclusion, cleaners have

2018 International journal of occupational and environmental health

167. In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products Full Text available with Trip Pro

In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method (...) to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals. Our raster-scan imaging showed that the skin condition for in vivo spectroscopic glucose monitoring

2018 Scientific reports

168. Defining the Skin and Blood Biomarkers of Ichthyosis

of Medicine at Mount Sinai Galderma Information provided by (Responsible Party): Amy Paller, Northwestern University Study Details Study Description Go to Brief Summary: Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this disease is required to develop better treatments. There are different (...) Defining the Skin and Blood Biomarkers of Ichthyosis Defining the Skin and Blood Biomarkers of Ichthyosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Defining the Skin and Blood Biomarkers of Ichthyosis

2018 Clinical Trials

169. Evaluation of the Benefits of FloraGLOâ„¢ Lutein on Skin Health

: 1. Skin Hydration 2. Skin texture/smoothness 2. Reduction of facial fine lines and wrinkles 3. Skin elasticity and firmness 4. Sagging skin, dry skin, skin tone, appearance from expert clinical grading and subjective questionnaire responses. 6. Skin hydration 7. Skin collagen 8. Skin lipid content. 9. Skin Carotenoids Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model (...) Questionnaire Visual Analog Scale Objective Sagging skin, dry skin, skin tone, and overall appearance [ Time Frame: ANOVA including weeks 6 and 12 ] Expert clinical grading Subjective Sagging skin, dry skin, skin tone, and overall appearance [ Time Frame: ANOVA including weeks 6 and 12 ] Subjective Questionnaire Visual Analog Scale Objective Skin elasticity [ Time Frame: ANOVA including weeks 6 and 12 ] Expert clinical grading Subjective Skin elasticity [ Time Frame: ANOVA including weeks 6 and 12

2018 Clinical Trials

170. Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation Full Text available with Trip Pro

Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation Skin hydration is a common problem both in elderly and young people as dry skin may cause irritation, dermatological disorders, and wrinkles. While both genetic and environmental factors seem to influence skin hydration, thorough genetic studies on skin hydration have not yet been conducted.We used a genome-wide association study (GWAS) to explore the genetic elements underlying skin (...) hydration by regulating epidermal differentiation and skin barrier function.A GWAS was conducted to investigate the genetic factors influencing skin hydration in 100 Korean females along with molecular studies of genes in human epidermal keratinocytes for functional study in vitro.Among several single nucleotide polymorphisms identified in GWAS, we focused on Single Stranded DNA Binding Protein 3 (SSBP3) which is associated with DNA replication and DNA damage repair. To better understand the role

2018 Annals of dermatology

171. Topical oils for the prevention or treatment of dry skin in term infants [Cochrane Protocol]

Topical oils for the prevention or treatment of dry skin in term infants [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2015 PROSPERO

172. Dry Skin Management

Dry Skin Management Dry Skin Management Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Skin Management Dry Skin Management Aka (...) : Dry Skin Management From Related Chapters II. Management: General Measures Avoid Provocative Factors Excessive bathing (see below) Rough clothing (see ) Excessive sweating Wear comfortable clothing See Skin barrier protection ( s) See bathing below Apply immediately after patting dry from bathing lotions (e.g. Lubriderm) Apply lotion frequently throughout the day Avoid lotions with (drying) creams or oils (Eucerin or Vaseline) Bedtime application Severe cases III. Management: "Do not bath, Soak

2015 FP Notebook

173. Dry Skin

Dry Skin Dry Skin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Skin Dry Skin Aka: Dry Skin , Xerotic Eczema , Dyshidrotic (...) : Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Dry Skin." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Vesicular eczema of hands and/or feet (C0032633) Definition (SCTSPA) Erupción autolimitada de palmas y plantas Definition (SNOMEDCT_US) Self-limited vesicular eruption of palms and soles Definition (SNOMEDCT_US) Self -limited vesicular eruption

2015 FP Notebook

174. Vascular device insertion and lumbar puncture: skin preparation

that the skin should be disinfected for 30 seconds and be allowed to dry ( , ). The Trust recommends that this is for a minimum of 30 seconds ( ). Critically ill children are susceptible to blood stream infections ( ). Therefore it is essential that a consistent and best practice approach in dealing with the pre-insertion insertion and maintenance of all vascular devices is established ( ). The use of Chloraprep® alone, will not reduce infection rates, a package of standardised care is required (...) pinching the wings of the Frepp® applicator breaking the glass ampoule inside. Gently press the gauze or sponge part of the applicator onto the patients skin, applying the solution in a dabbing motion for 30 seconds. Allow the covered area to dry naturally; this will take approximately 30 seconds. Carry out procedure. Should you need to re-palpate the skin, repeat the above procedure ( )( ). Once procedure is completed, including the application of the dressing, any exposed skin previously cleaned

2013 Publication 1593

175. Capecitabine: risk of severe skin reactions - discontinue treatment

Capecitabine is a first-line, adjuvant, or combination treatment for colon cancer, and for metastatic colorectal cancer, gastric cancer, or breast cancer. Full prescribing information is provided in the . Skin reactions associated with the use of capecitabine include palmar-plantar erythrodysaesthesia (hand-foot syndrome) and dermatitis, which occur very commonly (ie, >10% of patients). Rash, alopecia, erythema, and dry skin are common reactions. Furthermore, pruritus, localised exfoliation, skin (...) Capecitabine: risk of severe skin reactions - discontinue treatment Capecitabine: risk of severe skin reactions - discontinue treatment - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Capecitabine: risk of severe skin reactions - discontinue treatment Severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported during treatment with capecitabine. Published 11 December 2014 From: Therapeutic area: Article date: January 2014

2014 MHRA Drug Safety Update

176. The effect of an amphiphilic self-assembled lipid lamellar phase on the relief of dry skin. (Abstract)

The effect of an amphiphilic self-assembled lipid lamellar phase on the relief of dry skin. Humectant and occlusive technologies have traditionally been used for the treatment of dry skin. Originally, non-lamellar-forming ingredients were used such as petrolatum but recent research has shown the advantage of using lamellar-forming ingredients such as ceramides, pseudoceramides and phospholipids in the relief of dry skin. Nevertheless, the importance of using lipid-phase transition inducers (...) technology option for the treatment of dry skin.© 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

2012 International journal of cosmetic science Controlled trial quality: uncertain

177. Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. (Abstract)

Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. Irritant contact dermatitis (ICD) is an inflammatory skin disease triggered by exposure to a chemical that is toxic or irritating to the skin. A major characteristic of chronic ICD is an inflammatory dry-skin condition with associated itching. Although glucosylceramide (GlcCer) is known to improve the skin barrier function, its mechanism (...) of action is unknown.Using a mouse model of oxazolone-induced chronic ICD, this study investigated the effects of oral administration of GlcCer on inflammatory dry skin.Chronic ICD was induced by repeated application of oxazolone in mice. GlcCer was orally administered once daily throughout the elicitation phase. The beneficial efficacy of GlcCer on cutaneous inflammation was evaluated by assessing ear thickness, lymph node weight, histological findings, and mRNA expression of pro-inflammatory cytokines

2012 Journal of dermatological science

178. Evaluation of the efficacy of orange roughy (Hoplostetbus atlanticus) oil in subjects with dry skin. (Abstract)

Evaluation of the efficacy of orange roughy (Hoplostetbus atlanticus) oil in subjects with dry skin. Moisturizers have beneficial effects in treating dry skin. The objective of this study was to evaluate the effect of orange roughy (Hoplostethus atlanticus) oil, a marine-derived wax ester, on skin dryness in comparison with a reference commercially available petrolatum-based moisturizer (Vaseline) and untreated control. Subjects (n = 24) with moderate to severe skin dryness at the lower limb (...) microscopy. In Study 1, the dryness score of skin applied with orange roughy oil improved significantly (P < 0.01) in 6 weeks. The skin looked smooth with no or little dry scaly skin. Orange roughy oil was evaluated with a 60% efficacy in treating skin dryness by the expert, which comparable to that of petrolatum (68%). No significant change in TEWL was found either in orange roughy oil or petrolatum treatment, although the values showed a tendency to improve in both cases. Similarly, the results

2012 International journal of cosmetic science Controlled trial quality: uncertain

179. Profilaggrin, dry skin, and atopic dermatitis risk: size matters. Full Text available with Trip Pro

Profilaggrin, dry skin, and atopic dermatitis risk: size matters. Mutations in the FLG gene, which encodes profilaggrin, are known to be a major risk factor for atopic dermatitis as well as other atopic diseases and systemic allergies. New research, however, shows that intragenic copy number variation within FLG also represents an independent risk factor for atopic dermatitis. The new findings indicate that upregulating FLG protein levels by 5-10% may have clinical utility in improving (...) the management of many patients with dry skin and atopy.

2012 Journal of Investigative Dermatology

180. Proteomic analysis identifies new biomarkers for postmenopausal and dry skin. (Abstract)

Proteomic analysis identifies new biomarkers for postmenopausal and dry skin. A proteomic analysis of stratum corneum (SC) samples of normal healthy skin revealed the presence of more than 70 proteins by 2D electrophoresis. The majority of these proteins to our knowledge have not yet been described in normal SC. We analysed by Western blot the levels of 25 proteins in the SC taken from postmenopausal and dry skin compared with young and normal skin, respectively. In postmenopausal skin (...) , there was a significantly increased amount of heat shock protein 27, plakoglobin and desmoglein 1, whereas transglutaminase 3, apolipoprotein D and acid ceramidase levels were significantly reduced compared with the SC of young skin. We confirmed corneodesmosin as a marker of dry skin. In addition, we showed for the first time that the levels of both phosphatidylethanolamine-binding protein 1 and annexin A2 were significantly increased in the SC of dry skin compared with the SC of normal skin. These results suggest

2012 Experimental Dermatology

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