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161. A Study to Determine the Safety and Sensitizing Potential of HAT1 Topical Products Using Skin Sensitivity Patch Tests

to keep their patches dry. Subjects were instructed to return to the test facility for patch removal and disposal by test facility personnel. Skin sites were gently wiped with water and patted dry to remove excess test substance immediately following patch removal. Skin sites were graded approximately 20-40 minutes following patch removal. Subjects were not allowed to replace any patches that fall off. Subjects were provided with instructions and a schedule of the study dates on the first day (...) A Study to Determine the Safety and Sensitizing Potential of HAT1 Topical Products Using Skin Sensitivity Patch Tests A Study to Determine the Safety and Sensitizing Potential of HAT1 Topical Products Using Skin Sensitivity Patch Tests - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

162. Defining the Skin and Blood Biomarkers of Ichthyosis

of Medicine at Mount Sinai Galderma Information provided by (Responsible Party): Amy Paller, Northwestern University Study Details Study Description Go to Brief Summary: Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this disease is required to develop better treatments. There are different (...) Defining the Skin and Blood Biomarkers of Ichthyosis Defining the Skin and Blood Biomarkers of Ichthyosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Defining the Skin and Blood Biomarkers of Ichthyosis

2018 Clinical Trials

163. LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. (PubMed)

barrier function and underlie skin diseases such as dry skin and atopic dermatitis. However, intrinsic factors that regulate FLG expression and their mechanisms of action remain unknown. Here, we show that lysophosphatidic acid induces FLG expression in human keratinocytes via the LPAR1 and LPAR5 receptors and the downstream RHO-ROCK-SRF pathway. Comprehensive gene profiling analysis further showed that lysophosphatidic acid not only induces FLG expression but also facilitates keratinocyte (...) LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. The skin barrier protects the body from water loss, allergens, and pathogens. Profilaggrin is produced by differentiated keratinocytes and is processed into filaggrin monomers. These monomers cross-link keratin filaments and are also decomposed to natural moisturizing factors in the stratum corneum for skin hydration and barrier function. Deficits in FLG expression impair skin

2018 Journal of Investigative Dermatology

164. Chitosan-carboxymethyl-5-fluorouracil-folate conjugate particles: Microwave modulated uptake by skin and melanoma cells. (PubMed)

-drying technique. The size, zeta potential, morphology, drug content, and drug release, as well as skin permeation and retention, pharmacokinetics, in vitro SKMEL-28 melanoma cell line cytotoxicity, and intracellular trafficking profiles of drug/particles, were examined as a function of skin/melanoma cell treatment by microwaves at 2,450 MHz for 5 + 5 minutes. The level of skin drug/particle retention in vitro and in vivo increased in skin treated by microwaves. This was facilitated by the drug (...) Chitosan-carboxymethyl-5-fluorouracil-folate conjugate particles: Microwave modulated uptake by skin and melanoma cells. 5-Fluorouracil delivery profiles in the form of chitosan-folate submicron particles through skin and melanoma cells in vitro were examined using microwaves as the penetration enhancer. The in vivo pharmacokinetic profile of 5-fluorouracil was also determined. Chitosan-carboxymethyl-5-fluorouracil-folate conjugate was synthesized and processed into submicron particles by spray

2018 Journal of Investigative Dermatology

165. Highly Adaptable and Biocompatible Octopus‐Like Adhesive Patches with Meniscus‐Controlled Unfoldable 3D Microtips for Underwater Surface and Hairy Skin (Full text)

Highly Adaptable and Biocompatible Octopus‐Like Adhesive Patches with Meniscus‐Controlled Unfoldable 3D Microtips for Underwater Surface and Hairy Skin Adhesion capabilities of various skin architectures found in nature can generate remarkable physical interactions with their engaged surfaces. Among them, octopus suckers have unique hierarchical structures for reversible adhesion in dry and wet conditions. Here, highly adaptable, biocompatible, and repeatable adhesive patches (...) on a Si wafer in both dry and underwater conditions (max. 11 N cm-2 in pull-off strength) as well as on a moist pigskin (max. 14.6 mJ peeling energy). Moreover, the geometry-controlled microsuckers exhibit high-repeatability (over 100 cycles) in a pull-off direction. The adhesive demonstrates stable attachments on a moist, hairy, and rough skin, without any observable chemical residues.

2018 Advanced Science PubMed

166. Association of psychological stress with skin symptoms among medical students (Full text)

students suffered from more oily, waxy patches or flakes on scalp (p≤0.0001), dry/sore rash (p≤0.0001), warts (p≤0.0001), pimples (p≤0.0001), itchy skin (p≤0.0001), hands itchy rash (p≤0.0001), hair loss (p≤0.0001), pull-out own hair (p=0.008), scaly skin (p=0.012), troublesome sweating (p=0.016), nails biting (p=0.028), and other rashes on face (p= 0.028).  Conclusion: Various common skin conditions could appear in context of psychological stress among medical students. (...) Association of psychological stress with skin symptoms among medical students To evaluate the association between psychological stress and skin symptoms among medical students.  Methods: A cross-sectional study was carried out between January and June 2015. Electronic survey consists of Perceived Stress Questionnaire (PSQ) and Self-Reported Skin Complaints Questionnaire were distributed to all 1435 undergraduate students at College of Medicine, King Saud University (KSU), Riyadh, Saudi Arabia

2018 Saudi medical journal PubMed

167. Skin Disorders and Primary Tumor Location as Prognostic Factors in Patients with Metastatic Colorectal Cancer Treated with Cetuximab and Chemotherapy (Full text)

patient. The OS and PFS in relation to the location of the primary tumors and presence or absence of skin disorder were also compared. Results: Total frequency of each skin disorder as rash acneiform, paronychia, and dry skin in patients with left- and right-sided mCRC was 70%, 70%, and 43% and 27%, 36%, and 27%, respectively. The median OS was 8.9 months for mCRC on the left-sided without skin disorder and 56.3 months for mCRC on the left-sided with skin disorder. In comparison, the median OS (...) Skin Disorders and Primary Tumor Location as Prognostic Factors in Patients with Metastatic Colorectal Cancer Treated with Cetuximab and Chemotherapy Background: Cetuximab-induced skin disorder is common in colorectal cancer (CRC), and is known to affect prolonged overall survival (OS). Patients with left-sided CRC survive longer than those with right-sided CRC, among those treated with combination cetuximab and chemotherapy. However, no study has evaluated patient prognosis in terms of OS

2018 Asian Pacific journal of cancer prevention : APJCP PubMed

168. Non-Invasive Electromagnetic Skin Patch Sensor to Measure Intracranial Fluid–Volume Shifts (Full text)

Non-Invasive Electromagnetic Skin Patch Sensor to Measure Intracranial Fluid–Volume Shifts Elevated intracranial fluid volume can drive intracranial pressure increases, which can potentially result in numerous neurological complications or death. This study's focus was to develop a passive skin patch sensor for the head that would non-invasively measure cranial fluid volume shifts. The sensor consists of a single baseline component configured into a rectangular planar spiral with a self (...) -resonant frequency response when impinged upon by external radio frequency sweeps. Fluid volume changes (10 mL increments) were detected through cranial bone using the sensor on a dry human skull model. Preliminary human tests utilized two sensors to determine feasibility of detecting fluid volume shifts in the complex environment of the human body. The correlation between fluid volume changes and shifts in the first resonance frequency using the dry human skull was classified as a second order

2018 Sensors (Basel, Switzerland) PubMed

169. Tactile Sliding Behavior of R2R Mass-Produced PLLA Nanosheet towards Biomedical Device in Skin Applications (Full text)

Tactile Sliding Behavior of R2R Mass-Produced PLLA Nanosheet towards Biomedical Device in Skin Applications In this research, sliding friction was measured between the fingertip and nanosheet on a silicon substrate under two conditions: dry and wet. By using a force transducer, the tactile friction force and applied load were measured. According to the experimental results, the relationship of friction force and applied load exhibits a positive correlation under both dry and wet conditions (...) . In addition, the nanosheets are able to reduce the friction force and coefficient of friction (COF) compared to the reference sample, especially under the wet condition. Under the assumption of a full contact condition, the estimated contact area increases with larger applied loads. Furthermore, based on the wear observation, the skin sliding performance caused slight abrasions to the surface of the nanosheet samples with a mild wear track along the sliding direction. Overall, the sliding behavior between

2018 Nanomaterials PubMed

170. Determinants of hand dermatitis, urticaria and loss of skin barrier function in professional cleaners in New Zealand (Full text)

Determinants of hand dermatitis, urticaria and loss of skin barrier function in professional cleaners in New Zealand This study assessed the risk of dermatitis, urticaria and loss of skin barrier function in 425 cleaners and 281 reference workers (retail workers and bus drivers). Symptoms, atopy and skin barrier function were assessed by questionnaire, skin prick tests, and measurement of transepidermal water loss. Cleaners had an increased risk of current (past 3 months) hand/arm dermatitis (...) (14.8% vs. 10.0%; OR = 1.9, p < 0.05) and urticaria (11% vs. 5.3%; OR = 2.4, p < 0.05) and were more likely to have dermatitis as adults (17.6% vs. 11.4%; OR = 1.8, p < 0.05). The risk of atopy was not increased, but associations with symptoms were more pronounced in atopics. Transepidermal water loss was significantly higher in cleaners. Wet-work was a significant risk factor for dermatitis and hand washing and drying significantly reduced the risk of urticaria. In conclusion, cleaners have

2018 International journal of occupational and environmental health PubMed

171. In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products (Full text)

In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method (...) to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals. Our raster-scan imaging showed that the skin condition for in vivo spectroscopic glucose monitoring

2018 Scientific reports PubMed

172. Prediction of Steam Burns Severity using Raman Spectroscopy on ex vivo Porcine Skin (Full text)

Prediction of Steam Burns Severity using Raman Spectroscopy on ex vivo Porcine Skin Skin burns due to accidental exposure to hot steam have often been reported to be more severe than the ones occurring from dry heat. While skin burns due to flames or radiant heat have been thoroughly characterized, the mechanisms leading to steam burns are not well understood and a conundrum still exists: can second degree burns occur without destruction of the epidermis, i.e. even before first degree burns (...) are detected? Skin permeability is dependent both on temperature and on the kinetic energy of incoming water molecules. To investigate the mechanism underlying the injuries related to steam exposure, we used porcine skin as an ex vivo model. This model was exposed to either steam or dry heat before measuring the skin hydration via confocal Raman microspectroscopy. The results show that during the first minute of exposure to steam, the water content in both the epidermis and dermis increases. By analyzing

2018 Scientific reports PubMed

173. Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment

is the first-line medication to treat coccidioidomycosis. Through the investigator's clinical observations at the Valley Fever Center for Excellence, nearly all patients who have been placed on systemic azole treatment show some extent of cosmetic changes in their skin and hair, such as dry skin, chapped lips, hair loss, and change in hair characteristics. The goals of the study are to 1) understand the cosmetic changes in the skin and hair in patients initiating and discontinuing long-term oral (...) Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

174. Clinical Trial to Assess the Effects of Topical Lotions on Changes in the Skin Microbiome and Associations With Itch

) drug monographed ingredient for treatment of eczema. The other group was supplied with a cosmetic test product which is a standard dry skin daily moisturizer. Both groups were also provided with a cosmetic test cleanser to use in place of their normal cleanser. Subjects used the products for 14 days, followed by a 7-day regression period (no product use). Subjects were assessed at Baseline and at Day 1, Day 3, Day 7, and Day 14 of product use. They were assessed again 7 days after stopping product (...) an OTC drug monographed ingredient for treatment of eczema and the other group was supplied with a cosmetic test product which is a standard dry skin daily moisturizer. Both groups were also provided with a cosmetic test cleanser to use in place of their normal cleanser. There was a 7-day regression period following the 14 days of product use. Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Basic Science Official Title: A Multi-Center, Controlled Clinical Trial

2018 Clinical Trials

175. Evaluation of Fenofibrate on Radiation-induced Skin Injury

proliferating and maturing cells. Ionizing radiation promotes reactive nitrogen and oxygen species (RNS/ROS) production due to radiolysis of water and direct ionization of target molecules, which result in oxidative damage and skin injuries. It is considered that ~95 % of cancer patients receiving radiation therapy will develop some form of radiodermatitis, including erythema, dry desquamation, and moist desquamation. Radiation-induced skin injury negatively affects the process of radiotherapy (...) Evaluation of Fenofibrate on Radiation-induced Skin Injury Evaluation of Fenofibrate on Radiation-induced Skin Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of Fenofibrate on Radiation

2018 Clinical Trials

176. A Community-based Assessment of Skin Care, Allergies, and Eczema

. These emollients include (1) CeraVe Healing Ointment, (2) Vaseline, (3) Cetaphil cream, (4) CeraVe cream, and (5) Vanicream. Other: Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream Lipid-rich emollient serving as skin barrier No Intervention: Natural Skin Parents assigned to the control arm will receive educational materials promoting general infant skin care guidelines only and will be asked to refrain from emollient use unless dry (...) A Community-based Assessment of Skin Care, Allergies, and Eczema A Community-based Assessment of Skin Care, Allergies, and Eczema - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Community-based Assessment

2018 Clinical Trials

177. Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. (Full text)

Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with bilateral itching. Two emollients, containing lactic acid and refined almond oil (...) with/without polidocanol were administered on left versus right body sides. Itching severity, skin moisture, lipid content, and pH were assessed on Day 1, within 30-120 min after first administration, and on Days 7 and 14, and compared with baseline assessments. Severity of itching decreased 30 min after first administration of both emollients compared with baseline (p < .0001) and reached a maximum reduction of 63% (p < .0001) and 69% (p < .0001) on Day 14. Skin moisture and lipid content increased after

2018 Dermatologic therapy PubMed

178. Assessing the accumulated stickiness magnitude from fabric–skin friction: effect of wetness level of various fabrics (Full text)

fabric offered throughout the drying period, was developed. Thin cotton fabrics (fabric W01 and W03), having higher saturation level after contacting with wetted skin surface, arouse stronger stickiness feeling and their ASM is remarkably higher. The difference in stickiness estimates is due to the difference in chemical composition and surface geometry. This study suggests us the way to predict perceived stickiness in fabrics with different wetness levels which is useful for applications like (...) Assessing the accumulated stickiness magnitude from fabric–skin friction: effect of wetness level of various fabrics Increasing skin wetness tends to increase fabric-skin adhesion and friction, resulting in wear discomfort or skin injuries. Here, the magnitude estimation approach was used to assess the stickiness sensation perceived in fabrics. Seven fabric types were wetted by putting onto wet 'skin' surface and dried for different durations to achieve different wetness levels, simulating

2018 Royal Society Open Science PubMed

179. Optimization of Antioxidant and Skin-Whitening Compounds Extraction Condition from Tenebrio molitor Larvae (Mealworm) (Full text)

Optimization of Antioxidant and Skin-Whitening Compounds Extraction Condition from Tenebrio molitor Larvae (Mealworm) Skin-whitening ingredients are a very important part of the development of functional cosmetics and a wide variety of raw materials are used. Tyrosinase is a key enzyme in the animal melanogenic pathway that is the rate-limiting step for the production of melanin. Several synthetic and naturally occurring tyrosinase inhibitors have been studied for skin-whitening (...) , and ethanol concentration were optimized using response surface methodology (RSM). The results showed that optimum extraction temperature of 88.1 °C, extraction time of 43.7 min, and ethanol concentration of 72.0 v/v%, provided the predicted maximum levels of total phenolic compounds (TPC) of 5.41 mg GAE/g dry weight (DW) and tyrosinase inhibition activity (TIA) of 82.4%. From the validation experiment, 5.61 ± 0.2 mg GAE/g dry weight (DW), tyrosinase inhibition of 79.6 ± 3.3%, and radical scavenging

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry PubMed

180. Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems (Full text)

Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin (...) function which may make it suitable for use on dry skin.

2018 Clinical, cosmetic and investigational dermatology PubMed

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