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Dry Skin

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121. Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. (Abstract)

that in the placebo group. In conclusion, the intake of Acacia bark extract tablets reduced TEWL and improved dry and uncomfortable skin. (...) Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. This study investigated the effects of proanthocyanidins derived from Acacia (Acacia mearnsii) bark extract in healthy Japanese adult subjects experiencing uncomfortable skin symptoms. All subjects were randomly allocated into two groups (n = 33 each) using a computerized random-number generator. The subjects received either Acacia bark extract tablets or placebo for 8

2019 Bioscience, biotechnology, and biochemistry Controlled trial quality: uncertain

122. 3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress. Full Text available with Trip Pro

3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress. Skin sensitivity is a serious problem for many people, and it can be induced by various factors such as UV irradiation, physical and mental stresses, air pollution, dry air and so on. Skin dryness triggered by UV and dry air is one of the most important causes inducing the development of sensitive skin, and it has been reported that oxidative stress contributes to skin dryness (...) . In this study, we investigated whether treatment with 3-O-laurylglyceryl ascorbate (VC-3LG), which is an amphipathic ascorbic acid derivative, can suppress the development of sensitive skin. The results demonstrate that VC-3LG restores the expression levels of interleukin-1α, nerve growth factor and matrix metalloprotease-9 in the dry skin models of reconstructed human epidermal equivalents (RHEEs) and in H2 O2 -treated keratinocytes. In addition, VC-3LG suppresses the dendrite elongation of nerve cells

2019 Experimental Dermatology

123. Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice. (Abstract)

Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice. The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder.This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G. scabra, roots (...) and rhizomes.Thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) revealed the presence of gentiopicrin in the roots and rhizomes of G. scabra. We then investigated the effects of ethanol extract of G. scabra, roots and rhizomes (EEGS) on skin lesions and thickness, erythema and melanin index, histopathological abnormalities, and cytokine and chemokine production in mice with contact dermatitis (CD) induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). Moreover, the effects of EEGS

2019 Journal of Ethnopharmacology

124. Lactobacillus reuteri DSM 17938 - A comparative study on the effect of probiotics and lysates on human skin. (Abstract)

Lactobacillus reuteri DSM 17938 - A comparative study on the effect of probiotics and lysates on human skin. Human skin microbiota might play an important role in maintaining skin health and potentially prevent premature skin aging. The use of probiotics in therapeutic skin applications is an attractive idea, as it could offer an alternative option for certain inflammatory skin disorders and dry or sensitive skin. Here, we investigated for the first time, a comparative study of live (...) and the lysate products of probiotic strain Lactobacillus reuteri DSM 17938 in skin topical applications using ex vivo skin models focusing on anti-inflammatory and skin barrier function and in vitro assays for antimicrobial activity. Our results in ultraviolet-B radiation (UVB-R) induced inflammation model demonstrated, that both live bacteria and the lysate of L. reuteri DSM 17938 reduced proinflammatory IL-6 and IL-8, illustrated in both reconstructed human epidermis (RHE) and native skin models. Live L

2019 Experimental Dermatology

125. Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. (Abstract)

Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. Background: Established procedures for mass casualty decontamination involve the deployment of equipment for showering with water (such as the ladder pipe system [LPS] and technical decontamination [TD]). This necessarily introduces a short, but critical delay. The incorporation of dry decontamination to the incident response process offers the potential to establish (...) a more rapid and timely intervention. Objectives: To investigate the effectiveness of various dry (DD) and wet decontamination strategies for removing a chemical warfare simulant (methyl salicylate; MS) from the hair and skin of human volunteers. Methods: The simulant was applied to volunteers via whole body exposure to an aerosol. Three decontamination protocols (dry, LPS and technical decontamination) were applied, singly and in various combinations. The efficacy of the protocols was evaluated

2019 Prehospital emergency care

126. Factors related to skin health in hairdressing apprentices from two Croatian regions. (Abstract)

>20 times per day more frequently (28% vs 10%, respectively, P = 0.004), and consequently more frequently having dry hands (37% vs 16%, respectively, P = 0.002), and significantly higher TEWL values on the hand and forearm, which was confirmed by the results obtained with multiple linear regression models.A higher extent of exposure to skin hazards was related to poorer skin barrier function, which confirms the need for improvement of appropriate safety practices in hairdressing schools.© 2019 (...) Factors related to skin health in hairdressing apprentices from two Croatian regions. Hairdressing apprentices are at high risk for developing occupational contact dermatitis.The objective of this study was to analyse whether there are differences in skin health, skin protection and health-related quality of life between apprentices from two Croatian regions (Zagreb and Dalmatia).Final-year hairdressing apprentices from Zagreb (n = 101) and Dalmatia (n = 77) were enrolled in the study. Clinical

2019 Contact Dermatitis

127. Saline irrigation for the management of skin extravasation injury in neonates. (Abstract)

Saline irrigation for the management of skin extravasation injury in neonates. Extravasation injury is a common complication of neonatal intensive care and can result in scarring with cosmetic and functional sequelae. A wide variety of treatments are used in practice including subcutaneous irrigation with saline (with or without hyaluronidase), liposuction, use of specific antidotes, different topical applications and normal wound care with dry or wet dressings. All such treatments aim

2012 Cochrane

128. Medication Causes of Dry Mouth

Medication Causes of Dry Mouth Medication Causes of Dry Mouth Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes of Dry (...) Mouth Medication Causes of Dry Mouth Aka: Medication Causes of Dry Mouth , Medication Causes of Dry Eyes From Related Chapters II. Causes: Psychiatric medications s s ( ) ( ) s s ( s) ADHD s III. Causes: Upper Respiratory Medications s (e.g. ) s s IV. Causes: Antihypertensives s (e.g. ) (e.g. ) s (e.g. ) s V. Causes: Miscellaneous medications and drugs Muscle relaxants and antispasmodics s Cannabinoids s Antiparkinsonian agents s (e.g. ) VI. References Images: Related links to external sites (from

2018 FP Notebook

129. Dry Eye

Dry Eye Dry Eye Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Eye Dry Eye Aka: Dry Eye , Xerophthalmia From Related Chapters II (...) . Epidemiology As many as 30% of over age 50 years old complain of dry, irritated eyes III. Causes Decreased blinking with prolonged reading or driving Chronic exposure to dry, dusty conditions See (e.g. s, s, ) IV. Management ral measures Room humidifiers Take computer breaks Protect eyes from fan Avoid drying, s ( s, s, s) Artificial tears or ointments Preservative-free solutions are preferred (e.g. Refresh Plus), esp. if used more than 4x/day users may try rewetting drops (e.g. Renu rewetting, Blink

2018 FP Notebook

130. Dry-On Suffocation-based Pediculicide

Dry-On Suffocation-based Pediculicide Dry-On Suffocation-based Pediculicide Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry (...) -On Suffocation-based Pediculicide Dry-On Suffocation-based Pediculicide Aka: Dry-On Suffocation-based Pediculicide , DSP , Nuvo Lotion , Cetaphil for Head Lice From Related Chapters II. Indications Resistant Parental refusal to use standard topical anti-parasitic agents (e.g. ) III. Mechanism Suffocates IV. Preparations is Cetaphil (OTC) V. Technique Cetaphil applied to hair and hair blow-dried Nit removal not required May be repeated weekly VI. Efficacy Highly effective with low rate of recurrence VII

2018 FP Notebook

131. Dry Mouth

Dry Mouth Dry Mouth Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Mouth Dry Mouth Aka: Dry Mouth , Xerostomia , Salivary (...) % Fluoride gel daily Fluoride toothpaste Fluoride rinses Scrupulous dental care is essential See Dentist regularly stimulation Sugar-free chewing gum (esp. Xylitol containing gums) Lemon lozenges Consider s in severe refractory Xerostomia of ( ) ( ) VI. References Daniels in Goldman (2000) Cecil Medicine, p. 2245 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Dry Mouth." Click on the image (or right click) to open the source website

2018 FP Notebook

132. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model. (Abstract)

Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model. Epidermal hyperinnervation is considered one cause of sensitization to itch, and is thought to regulated by keratinocyte-derived axonal guidance molecules, including nerve growth factor (NGF) and semaphorin (Sema)3A. Neurotropin (NTP) shows antipruritic effects in allergic disease and is also used for pain relief. Using cultured rat dorsal root ganglion neurones, we previously found

2013 Clinical & Experimental Dermatology

133. Freeze-drying as a preserving preparation technique for in vitro testing of human skin. Full Text available with Trip Pro

Freeze-drying as a preserving preparation technique for in vitro testing of human skin. In vitro testing of drugs with excised human skin is a valuable prerequisite for clinical studies. However, the analysis of excised human skin presents several obstacles. Ongoing drug diffusion, microbial growth and changes in hydration state influence the results of drug penetration studies. In this work, we evaluate freeze-drying as a preserving preparation method for skin samples to overcome (...) these obstacles. We analyse excised human skin before and after freeze-drying and compare these results with human skin in vivo. Based on comprehensive thermal and spectroscopic analysis, we demonstrate comparability to in vivo conditions and exclude significant changes within the skin samples due to freeze-drying. Furthermore, we show that freeze-drying after skin incubation with drugs prevents growth of drug crystals on the skin surface due to drying effects. In conclusion, we introduce freeze-drying

2013 Experimental Dermatology

134. The efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial- study protocol. Full Text available with Trip Pro

The efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial- study protocol. Moisturisers prevent and treat dry skin. They can also protect sensitive skin, improve skin tone and texture, and mask imperfections. Herbal medicines or their extracts have been available as topical formulations and cosmetics. Arctium lappa L. (Asteraceae) has been used to treat inflammatory disorders and various skin problems (...) . It could be a candidate herbal medicine for treating dry skin condition.This study aims to establish the efficacy and safety of a proposed herbal moisturising cream containing Arctium lappa L. seed extract, which has been approved by the Korean Ministry of Food and Drug Safety for use in cosmetics.This study is a randomised, double-blind, placebo-controlled study with two parallel groups (proposed herbal moisturising cream vs. placebo cream). We will recruit 66 healthy male and female participants

2013 BMC Complementary and Alternative Medicine Controlled trial quality: predicted high

135. Candida - skin

it be? Differential diagnoses of candidal skin infection include: Atopic eczema — a chronic, relapsing, itchy skin condition thought to be caused by a genetic predisposition, skin barrier dysfunction, environmental factors (such as exposure to pets, house-dust mites, and pollen), and/or immune system dysfunction. See the CKS topic on for more information. Bacterial skin infections, such as impetigo and cellulitis — see the CKS topics on and for more information. Dermatophyte infections — usually more dry (...) Candida - skin Candida - skin - NICE CKS Share Candida - skin: Summary Candida is a yeast-like fungus which is part of the normal commensal flora of the human gastrointestinal tract and the vagina. It is not part of the normal skin flora, but there may be transient colonization of fingers or body folds. Colonization with Candida is usually asymptomatic. However, if mucosal barriers are disrupted or defences lowered, it can cause infections ranging from non-life threatening superficial

2017 NICE Clinical Knowledge Summaries

136. A prospective randomised comparison of 2 skin closure techniques in primary total hip arthroplasty surgery. (Abstract)

A prospective randomised comparison of 2 skin closure techniques in primary total hip arthroplasty surgery. As an essential step of total hip arthroplasty (THA), an effective and secure skin closure technique after primary THA is important. Metallic staples closure and subcuticular suture are the 2 common techniques for skin closure. However, which closure technique is the optimal skin-closure method remains unclear. The purpose of this prospective randomised clinical study was to compare (...) the clinical outcomes and costs between staples and subcuticular suture techniques.In this clinical study, 165 patients who underwent primary unilateral THA through a posterolateral approach from August 2014 to May 2015 were included. According to skin closure technique, the patients were randomised into staples group (interrupted suture with staples, 83 cases) and sutures group (running 4-0 absorbable subcuticular suture, 82 cases). The same operative and perioperative care were provided to all patients

2018 Hip international : the journal of clinical and experimental research on hip pathology and therapy Controlled trial quality: uncertain

137. Effect of Passion Fruit Seed Extract Rich in Piceatannol on the Skin of Women: A Randomized, Placebo-Controlled, Double-Blind Trial. Full Text available with Trip Pro

passion fruit seed extract on the skin of healthy Japanese women (age, 35-54 y). Thirty-two women with dry skin received either passion fruit seed extract (5 mg piceatannol) or a placebo (dextrin) for 8 wk. Skin hydration and other parameters on the face were assessed at 0, 4, and 8 wk by using specialized equipment. Furthermore, questionnaire interviews were conducted regarding the physical condition of subjects at 0, 4, and 8 wk. The results showed that consumption of passion fruit seed extract led (...) " and "fatigue" in the passion fruit seed extract group as compared with the placebo group. These results indicate that oral intake of passion fruit seed extract that is rich in piceatannol could improve the moisture of dry skin and reduce fatigue.

2018 Journal of nutritional science and vitaminology Controlled trial quality: uncertain

138. Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatchâ„¢). Full Text available with Trip Pro

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatchâ„¢). Injection using needle and syringe (N&S) is the most widely used method for vaccination, but requires trained healthcare workers. Fear of needles, risk of needle-stick injury, and the need to reconstitute lyophilised vaccines, are also drawbacks. The Nanopatch (NP) is a microarray skin patch comprised of a high-density array (...) of microprojections dry-coated with vaccine that is being developed to address these shortcomings. Here we report a randomised, partly-blinded, placebo-controlled trial that represents the first use in humans of the NP to deliver a vaccine.Healthy volunteers were vaccinated once with one of the following: (1) NPs coated with split inactivated influenza virus (A/California/07/2009 [H1N1], 15 µg haemagglutinin (HA) per dose), applied to the volar forearm (NP-HA/FA), n = 15; (2) NPs coated with split inactivated

2018 Vaccine Controlled trial quality: predicted high

139. Comparison of skin hydration in combination and single use of common moisturizers (cream, toner, and spray water). (Abstract)

). The hydration rate of C-S differed slightly from T-T, followed by those four mentioned above, with T being the last. For dry skin (hydration value at baseline <35 a.u.), no statistical significance could be detected between C-T zone and C+T, T+C, and C zones ( p > 0.05), the other results were identical. When cream and toner were applied successively, the application order has little effect on skin hydration. The application of cream only was an effective and brief way to achieve favorable moisturization (...) especially for dry skin. As a complement, repeated application of toner rather than spray water is efficacious for skin hydration.

2018 Journal of cosmetic science Controlled trial quality: uncertain

140. Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. Full Text available with Trip Pro

Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with bilateral itching. Two emollients, containing lactic acid and refined almond oil (...) with/without polidocanol were administered on left versus right body sides. Itching severity, skin moisture, lipid content, and pH were assessed on Day 1, within 30-120 min after first administration, and on Days 7 and 14, and compared with baseline assessments. Severity of itching decreased 30 min after first administration of both emollients compared with baseline (p < .0001) and reached a maximum reduction of 63% (p < .0001) and 69% (p < .0001) on Day 14. Skin moisture and lipid content increased after

2018 Dermatologic therapy Controlled trial quality: uncertain

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