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121. Skin biopsy: punch method

the child with their favourite toy or book ( ). Consider moving and handling risks. Preparation of the skin biopsy site Perform a handwash ( available to GOSH staff internally on the GOSHweb intranet site). Put on the appropriate protective clothing. Remove the local anaesthetic cream and wipe dry with a tissue or gauze. Confirm with the child, if appropriate, that the cream has caused numbness of the skin effectively. The biopsy area should be cleaned for 30 seconds with an alcohol-based cleansing (...) or until bleeding stops ( ). For immunocompromised children, once bleeding has stopped apply some Fucidin® ointment to the site. Dressing the skin biopsy site Apply wound closure strips, eg Steri-strips® in a ‘star’ pattern ( ). Once haemostasis has been achieved apply either: a dry dressing, eg Cutiplast® or Op-site® or a low-adherent dressing, eg Mepitel®, if the surrounding skin is fragile ( ) Dispose of used equipment and sharps according to the Trust Waste Management Policy. Remove protective

2014 Publication 1593

122. Dressings and Care of Skin Graft Sites

Dressings and Care of Skin Graft Sites TITLE: Dressings and Care of Skin Graft Sites: A Review of Clinical Evidence and Guidelines DATE: 19 December 2013 CONTEXT AND POLICY ISSUES A skin graft is sheet of skin harvested from a donor site; it may include the epidermis and part of the dermis (split thickness skin graft) or both the epidermis and dermis (full thickness graft) to cover skin lost due to surgery or trauma. 1 Dressings are used to cover the donor site or the grafted skin; this is done (...) to enhance healing, improve patients’ comfort and reduce the pain. Skin dressings can be broadly classified into medicated and non-medicated dressings. 2 Medicated dressings include hydrocolloid dressings, hydrogel dressings. alginate dressings, fibrous absorbent dressings, dressings that contribute to odour management, antimicrobial dressings, and Manuka Honey dressings. 2 The non-medicated dressings include vapour permeable dressings, foam dressings, low adherent dressings, non-adherent wound contact

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

123. Association of sensitive skin with sensitive corneas and sensitive eyelids. (Abstract)

. Notably, 52.2% declared sensitive eyes, which was more frequent in women than in men. The subjects who reported sensitive eyes were more numerous according to the severity of skin sensitivity, the severity of sleep disorders and the presence of bright eyes. More than half of the subjects with sensitive eyes thought that they were sensitive to sun exposure, dust, computer or touch pads or dry air. The presence of sensitive eyelids was reported by 18.65% (more frequent in women) and was associated (...) Association of sensitive skin with sensitive corneas and sensitive eyelids. Sensitive scalp or irritable bowel syndrome has been previously shown to be associated with sensitive skin. We wondered whether sensitive eyelids and sensitive eyes could also be associated with sensitive skin.A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method, using a questionnaire.A total of 2048 subjects were included in the present study

2019 Journal of the European Academy of Dermatology and Venereology

124. Infant skin care: updates and recommendations. (Abstract)

Infant skin care: updates and recommendations. Neonatal skin acclimates rapidly to dry, aerobic conditions at birth and skin function gradually matures throughout infancy. Gentle skin care practices support the ongoing development and function of newborn skin. This article reviews research updates and current skin care recommendations for full-term infants, premature infants, and infants born with severe cutaneous manifestations of genetic skin disorders.Although safe early bathing of full-term (...) infants with environmental controls is possible, delaying the first newborn bath for 12-24 h of life offers benefits of increased parental bonding and breastfeeding success. Swaddled bathing every 4 days is an effective bathing strategy for premature neonates. Among infants with a family history of atopic dermatitis, regular application of bland skin moisturizers reduces their risk of developing the disease. For newborns with erosive or blistering genetic skin conditions, use of specialized wound

2019 Current Opinion in Pediatrics

125. Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Full Text available with Trip Pro

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch-scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strategies (...) are utilised to overcome dry skin and itch, primarily in the form of emollients. Recent advances in our understanding of the mechanisms underlying itch have enabled the development of new topical therapies, which may be incorporated into existing treatment regimes. Ultimately, treatment of dry skin and itch must be highly tailored to the individual according to their needs.

2019 Acta Dermato-Venereologica

126. Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. (Abstract)

that in the placebo group. In conclusion, the intake of Acacia bark extract tablets reduced TEWL and improved dry and uncomfortable skin. (...) Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. This study investigated the effects of proanthocyanidins derived from Acacia (Acacia mearnsii) bark extract in healthy Japanese adult subjects experiencing uncomfortable skin symptoms. All subjects were randomly allocated into two groups (n = 33 each) using a computerized random-number generator. The subjects received either Acacia bark extract tablets or placebo for 8

2019 Bioscience, biotechnology, and biochemistry Controlled trial quality: uncertain

127. 3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress. Full Text available with Trip Pro

3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress. Skin sensitivity is a serious problem for many people, and it can be induced by various factors such as UV irradiation, physical and mental stresses, air pollution, dry air and so on. Skin dryness triggered by UV and dry air is one of the most important causes inducing the development of sensitive skin, and it has been reported that oxidative stress contributes to skin dryness (...) . In this study, we investigated whether treatment with 3-O-laurylglyceryl ascorbate (VC-3LG), which is an amphipathic ascorbic acid derivative, can suppress the development of sensitive skin. The results demonstrate that VC-3LG restores the expression levels of interleukin-1α, nerve growth factor and matrix metalloprotease-9 in the dry skin models of reconstructed human epidermal equivalents (RHEEs) and in H2 O2 -treated keratinocytes. In addition, VC-3LG suppresses the dendrite elongation of nerve cells

2019 Experimental Dermatology

128. Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice. (Abstract)

Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice. The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder.This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G. scabra, roots (...) and rhizomes.Thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) revealed the presence of gentiopicrin in the roots and rhizomes of G. scabra. We then investigated the effects of ethanol extract of G. scabra, roots and rhizomes (EEGS) on skin lesions and thickness, erythema and melanin index, histopathological abnormalities, and cytokine and chemokine production in mice with contact dermatitis (CD) induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). Moreover, the effects of EEGS

2019 Journal of Ethnopharmacology

129. Lactobacillus reuteri DSM 17938 - A comparative study on the effect of probiotics and lysates on human skin. (Abstract)

Lactobacillus reuteri DSM 17938 - A comparative study on the effect of probiotics and lysates on human skin. Human skin microbiota might play an important role in maintaining skin health and potentially prevent premature skin aging. The use of probiotics in therapeutic skin applications is an attractive idea, as it could offer an alternative option for certain inflammatory skin disorders and dry or sensitive skin. Here, we investigated for the first time, a comparative study of live (...) and the lysate products of probiotic strain Lactobacillus reuteri DSM 17938 in skin topical applications using ex vivo skin models focusing on anti-inflammatory and skin barrier function and in vitro assays for antimicrobial activity. Our results in ultraviolet-B radiation (UVB-R) induced inflammation model demonstrated, that both live bacteria and the lysate of L. reuteri DSM 17938 reduced proinflammatory IL-6 and IL-8, illustrated in both reconstructed human epidermis (RHE) and native skin models. Live L

2019 Experimental Dermatology

130. Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. (Abstract)

Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. Background: Established procedures for mass casualty decontamination involve the deployment of equipment for showering with water (such as the ladder pipe system [LPS] and technical decontamination [TD]). This necessarily introduces a short, but critical delay. The incorporation of dry decontamination to the incident response process offers the potential to establish (...) a more rapid and timely intervention. Objectives: To investigate the effectiveness of various dry (DD) and wet decontamination strategies for removing a chemical warfare simulant (methyl salicylate; MS) from the hair and skin of human volunteers. Methods: The simulant was applied to volunteers via whole body exposure to an aerosol. Three decontamination protocols (dry, LPS and technical decontamination) were applied, singly and in various combinations. The efficacy of the protocols was evaluated

2019 Prehospital emergency care

131. Factors related to skin health in hairdressing apprentices from two Croatian regions. (Abstract)

>20 times per day more frequently (28% vs 10%, respectively, P = 0.004), and consequently more frequently having dry hands (37% vs 16%, respectively, P = 0.002), and significantly higher TEWL values on the hand and forearm, which was confirmed by the results obtained with multiple linear regression models.A higher extent of exposure to skin hazards was related to poorer skin barrier function, which confirms the need for improvement of appropriate safety practices in hairdressing schools.© 2019 (...) Factors related to skin health in hairdressing apprentices from two Croatian regions. Hairdressing apprentices are at high risk for developing occupational contact dermatitis.The objective of this study was to analyse whether there are differences in skin health, skin protection and health-related quality of life between apprentices from two Croatian regions (Zagreb and Dalmatia).Final-year hairdressing apprentices from Zagreb (n = 101) and Dalmatia (n = 77) were enrolled in the study. Clinical

2019 Contact Dermatitis

132. Saline irrigation for the management of skin extravasation injury in neonates. (Abstract)

Saline irrigation for the management of skin extravasation injury in neonates. Extravasation injury is a common complication of neonatal intensive care and can result in scarring with cosmetic and functional sequelae. A wide variety of treatments are used in practice including subcutaneous irrigation with saline (with or without hyaluronidase), liposuction, use of specific antidotes, different topical applications and normal wound care with dry or wet dressings. All such treatments aim

2012 Cochrane

133. Medication Causes of Dry Mouth

Medication Causes of Dry Mouth Medication Causes of Dry Mouth Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes of Dry (...) Mouth Medication Causes of Dry Mouth Aka: Medication Causes of Dry Mouth , Medication Causes of Dry Eyes From Related Chapters II. Causes: Psychiatric medications s s ( ) ( ) s s ( s) ADHD s III. Causes: Upper Respiratory Medications s (e.g. ) s s IV. Causes: Antihypertensives s (e.g. ) (e.g. ) s (e.g. ) s V. Causes: Miscellaneous medications and drugs Muscle relaxants and antispasmodics s Cannabinoids s Antiparkinsonian agents s (e.g. ) VI. References Images: Related links to external sites (from

2018 FP Notebook

134. Dry Eye

Dry Eye Dry Eye Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Eye Dry Eye Aka: Dry Eye , Xerophthalmia From Related Chapters II (...) . Epidemiology As many as 30% of over age 50 years old complain of dry, irritated eyes III. Causes Decreased blinking with prolonged reading or driving Chronic exposure to dry, dusty conditions See (e.g. s, s, ) IV. Management ral measures Room humidifiers Take computer breaks Protect eyes from fan Avoid drying, s ( s, s, s) Artificial tears or ointments Preservative-free solutions are preferred (e.g. Refresh Plus), esp. if used more than 4x/day users may try rewetting drops (e.g. Renu rewetting, Blink

2018 FP Notebook

135. Dry-On Suffocation-based Pediculicide

Dry-On Suffocation-based Pediculicide Dry-On Suffocation-based Pediculicide Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry (...) -On Suffocation-based Pediculicide Dry-On Suffocation-based Pediculicide Aka: Dry-On Suffocation-based Pediculicide , DSP , Nuvo Lotion , Cetaphil for Head Lice From Related Chapters II. Indications Resistant Parental refusal to use standard topical anti-parasitic agents (e.g. ) III. Mechanism Suffocates IV. Preparations is Cetaphil (OTC) V. Technique Cetaphil applied to hair and hair blow-dried Nit removal not required May be repeated weekly VI. Efficacy Highly effective with low rate of recurrence VII

2018 FP Notebook

136. Dry Mouth

Dry Mouth Dry Mouth Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Mouth Dry Mouth Aka: Dry Mouth , Xerostomia , Salivary (...) % Fluoride gel daily Fluoride toothpaste Fluoride rinses Scrupulous dental care is essential See Dentist regularly stimulation Sugar-free chewing gum (esp. Xylitol containing gums) Lemon lozenges Consider s in severe refractory Xerostomia of ( ) ( ) VI. References Daniels in Goldman (2000) Cecil Medicine, p. 2245 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Dry Mouth." Click on the image (or right click) to open the source website

2018 FP Notebook

137. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model. (Abstract)

Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model. Epidermal hyperinnervation is considered one cause of sensitization to itch, and is thought to regulated by keratinocyte-derived axonal guidance molecules, including nerve growth factor (NGF) and semaphorin (Sema)3A. Neurotropin (NTP) shows antipruritic effects in allergic disease and is also used for pain relief. Using cultured rat dorsal root ganglion neurones, we previously found

2013 Clinical & Experimental Dermatology

138. Freeze-drying as a preserving preparation technique for in vitro testing of human skin. Full Text available with Trip Pro

Freeze-drying as a preserving preparation technique for in vitro testing of human skin. In vitro testing of drugs with excised human skin is a valuable prerequisite for clinical studies. However, the analysis of excised human skin presents several obstacles. Ongoing drug diffusion, microbial growth and changes in hydration state influence the results of drug penetration studies. In this work, we evaluate freeze-drying as a preserving preparation method for skin samples to overcome (...) these obstacles. We analyse excised human skin before and after freeze-drying and compare these results with human skin in vivo. Based on comprehensive thermal and spectroscopic analysis, we demonstrate comparability to in vivo conditions and exclude significant changes within the skin samples due to freeze-drying. Furthermore, we show that freeze-drying after skin incubation with drugs prevents growth of drug crystals on the skin surface due to drying effects. In conclusion, we introduce freeze-drying

2013 Experimental Dermatology

139. The efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial- study protocol. Full Text available with Trip Pro

The efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial- study protocol. Moisturisers prevent and treat dry skin. They can also protect sensitive skin, improve skin tone and texture, and mask imperfections. Herbal medicines or their extracts have been available as topical formulations and cosmetics. Arctium lappa L. (Asteraceae) has been used to treat inflammatory disorders and various skin problems (...) . It could be a candidate herbal medicine for treating dry skin condition.This study aims to establish the efficacy and safety of a proposed herbal moisturising cream containing Arctium lappa L. seed extract, which has been approved by the Korean Ministry of Food and Drug Safety for use in cosmetics.This study is a randomised, double-blind, placebo-controlled study with two parallel groups (proposed herbal moisturising cream vs. placebo cream). We will recruit 66 healthy male and female participants

2013 BMC Complementary and Alternative Medicine Controlled trial quality: predicted high

140. Candida - skin

it be? Differential diagnoses of candidal skin infection include: Atopic eczema — a chronic, relapsing, itchy skin condition thought to be caused by a genetic predisposition, skin barrier dysfunction, environmental factors (such as exposure to pets, house-dust mites, and pollen), and/or immune system dysfunction. See the CKS topic on for more information. Bacterial skin infections, such as impetigo and cellulitis — see the CKS topics on and for more information. Dermatophyte infections — usually more dry (...) Candida - skin Candida - skin - NICE CKS Share Candida - skin: Summary Candida is a yeast-like fungus which is part of the normal commensal flora of the human gastrointestinal tract and the vagina. It is not part of the normal skin flora, but there may be transient colonization of fingers or body folds. Colonization with Candida is usually asymptomatic. However, if mucosal barriers are disrupted or defences lowered, it can cause infections ranging from non-life threatening superficial

2017 NICE Clinical Knowledge Summaries

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