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6361. Steroids and the Skin

Steroids and the Skin Steroids and the Skin. Information about Steroids and the skin. | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Topical Steroids for the Skin Authored by , Reviewed by | Last edited 22 Feb 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence (...) , UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Topical Steroids for the Skin In this article Topical corticosteroids have been used for over 60 years and their introduction was a milestone in dermatology. They are used to treat inflammatory skin conditions by suppressing the inflammatory reaction and relieving symptoms. However, they are not curative and attempts to increase potency have often been associated with more

2008 Mentor

6362. Skin Manifestations of Systemic Disease

nigricans and psoriasis. [ ] Skin creases in the head area are deeper than normal (cutis verticis gyrata or 'Klingon head'). [ ] Hypopituitarism [ ] In the skin is dry, scaly and puffy and the nails become brittle. The hair is coarse and sparse, especially in the axillae. Fine wrinkles around the eyes and mouth are typical. Hypothyroidism [ ] In the skin in myxoedema is cool to the touch, doughy, dry and puffy and there may be hair loss. Peri-orbital oedema may be accompanied by a yellowish colour (...) Skin Manifestations of Systemic Disease Skin Manifestations of Systemic Disease Information Page | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Skin Manifestations of Systemic Disease Authored by , Reviewed by | Last edited 25 Nov 2014 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based

2008 Mentor

6363. Viral Skin Infections

. Viral skin infections and sport Sport increases the risk of transmission of dermatological infections generally. A number of features may predispose to transmission: There may be direct skin-to-skin contact (as in rugby, wrestling on other contact sports). Profuse sweating may cause maceration of skin and provide a portal of entry. Sharing wet areas predisposes to transfer of infection from feet. These include showers and swimming pools. Bare but dry feet, as in judo, other oriental martial arts (...) Viral Skin Infections Viral Skin Infections. Types of viral skin infections, information | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Viral Skin Infections Authored by , Reviewed by | Last edited 30 Nov 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK

2008 Mentor

6364. Allowing wounds to be uncovered and wet in the first 48 hours after minor skin excision did not differ from standard dry management for wound infections

Allowing wounds to be uncovered and wet in the first 48 hours after minor skin excision did not differ from standard dry management for wound infections Allowing wounds to be uncovered and wet in the first 48 hours after minor skin excision did not differ from standard dry management for wound infections | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more (...) did not differ from standard dry management for wound infections Article Text Treatment Allowing wounds to be uncovered and wet in the first 48 hours after minor skin excision did not differ from standard dry management for wound infections Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission

2006 Evidence-Based Nursing

6365. Distribution and putative function of autonomic nerve fibres in the bill skin of the platypus (Ornithorhynchus anatinus). Full Text available with Trip Pro

Distribution and putative function of autonomic nerve fibres in the bill skin of the platypus (Ornithorhynchus anatinus). The electroreceptors located in the bill skin of the platypus are modified secretory glands. The electroreceptive nerve terminals form bare endings in close proximity to the duct of these glands. In this study, we describe the autonomic innervation of the glands and a separate specialized autonomic innervation of the epidermal portion of the glandular duct. A range (...) epidermis surrounding the pore of the gland. When the bill of the platypus is dry these pores were closed. However, when room temperature water was washed over the bill, the pores opened. It is proposed that this autonomic and sensory innervation, along with the actin sphincter, mediates the opening and closing of the pores. By doing this, the platypus prevents the desiccation of the bare electrosensory nerve terminals when it is out of the water, and it may also be a way to regulate the impedance

1998 Philosophical Transactions of the Royal Society B: Biological Sciences

6366. Pharmacological modulation by cetirizine and atropine of the histamine- and methacholine-induced wheals and flares in human skin. (Abstract)

-over, double-blind, placebo-controlled study designed to compare the effects of cetirizine and atropine. The intradermal injection of agonists elicited the appearance of wheal and flare reactions and, after histamine, the skinfold thickness was significantly increased. Skin capacitance and transepidermal water loss measurements reflected sweat gland activation after methacholine injection but were, respectively, not or less affected by histamine dry skin prick test or saline; hence, both methods (...) Pharmacological modulation by cetirizine and atropine of the histamine- and methacholine-induced wheals and flares in human skin. This study was planned to verify whether different methods for the measurement of skin reactivity, i.e. wheal and flare area, wheal thickness, skin capacitance and transepidermal water loss, were or were not able to discriminate between intradermally injected agonists (histamine and methacholine). For evaluating agonist/antagonist interactions, we adopted a cross

1989 Skin pharmacology : the official journal of the Skin Pharmacology Society

6367. Clinical efficacy of a chlorous acid preoperative skin antiseptic. (Abstract)

log reductions were achieved, and activity persisted as long as 6 hours. Compared with chlorhexidine, the chlorous acid product has the practical advantages of a shorter scrub time, less foam, air drying (instead of wiping), and no perceivable residue.An activated chlorous acid product statistically matched the performance of chlorhexidine gluconate in reducing populations of resident flora on treated skin sites. With an easier and shorter application procedure and strong, long-term antimicrobial (...) Clinical efficacy of a chlorous acid preoperative skin antiseptic. Among the ways to reduce the incidence of iatrogenic infectious disease is the use of efficacious preoperative antiseptics. Iodophors and chlorhexidines, the chief presurgical disinfectants today, have various problems with practicality. A new preoperative skin antiseptic has been developed (Alcide Corporation, Redmond, Wash) that involves the mixture of a 0.1% sodium chlorite formulation and an activating preparation of 0.5

1998 American journal of infection control Controlled trial quality: uncertain

6368. Radiation recall skin toxicity with bleomycin in a patient with Kaposi sarcoma related to acquired immune deficiency syndrome. (Abstract)

regimens for KS. Each lesion was randomized to one of three possible radiation fractionation schemes. All lesions were photographed and measured before treatment with radiation.Two skin sites developed erythema and dry desquamation 18 days after completion of radiation therapy to a dose of 40 Gy in 20 fractions. These reactions took place after the second dose of bleomycin administered intravenously on a weekly basis. The reactions were exacerbated by oral etoposide therapy, which was started 4 days (...) Radiation recall skin toxicity with bleomycin in a patient with Kaposi sarcoma related to acquired immune deficiency syndrome. Radiation recall is a recurrence of acute toxicity within a previously quiescent radiation field that occurs with subsequent administration of chemotherapy.A patient with acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma (KS) who had radiation recall is reported. The patient was participating in a randomized prospective trial of radiation treatment

1993 Cancer Controlled trial quality: uncertain

6369. Effect of polyethylene occlusive skin wrapping on heat loss in very low birth weight infants at delivery: a randomized trial. (Abstract)

Effect of polyethylene occlusive skin wrapping on heat loss in very low birth weight infants at delivery: a randomized trial. Significant evaporative heat loss in the very low birth weight infant can occur in the delivery room. We investigated the effect of polyethylene wrap applied immediately at birth (without drying) on rectal temperature measured at nursery admission.Sixty-two consecutive infants delivered at <32 weeks' gestation were stratified by gestational age and randomly allocated

1999 The Journal of pediatrics Controlled trial quality: uncertain

6370. Effects of softened and unsoftened fabrics on sensitive skin. (Abstract)

Effects of softened and unsoftened fabrics on sensitive skin. The effects of softened fabrics on the skin were evaluated by a forearm wet and dry test, under conditions simulating real-life skin contact with fabrics. 15 volunteers with sensitive skin according to dermatological assessment and their own recognition entered a double-blind 12 day, 3 sessions per day, forearm wetting and drying test, using cotton fabrics washed with a powder detergent and softened or not with a liquid fabric (...) conditioner. To simulate conditions of skin damage, a dilute solution of sodium lauryl sulfate was applied under patch to the forearm before the start of the study. Skin effects were evaluated by visual grading (redness, dryness and smoothness), by noninvasive skin stripping and measuring of Chroma C* (squamometry), and by instrumental measurements (capacitance, transepidermal water loss, and colorimetry). Both the unsoftened and softened fabrics induced no deleterious effects on control or previously

1994 Contact dermatitis Controlled trial quality: uncertain

6371. Clinical study: assessing the performance and skin environments of two reusable underpads. (Abstract)

facilities) and completed by 107 patients. The majority of the patients had a Braden score near 13, were 70 to 80 years of age, and weighed 130 to 138 lbs. The Test Group underpad ranked more favorably overall and in all eight categories of daily assessment. These differences were statistically significant (p < 0.05) in the Total Score and in four of the eight individual categories: Keeping Skin Dry, Keeping Clothing Dry, No Pooling of Fluid, and Patient Comfort. The Test Group underpad also ranked more (...) favorably with statistical significance (p < 0.05) in three of the assessment categories at the conclusion of the study: Pad Absorbency, Pad's Ability to Wick Moisture, and Pad's Ability to Keep Skin Dry. Investigators also noted that 57 patients (53%) exhibited some measure of improvement by the end of the study. Of these, 45 (79%) had been assigned to the Test Group. The Test Group underpad demonstrated better absorbency, kept patients' skin, clothing and bed linens drier, exhibited less pooling

1994 Ostomy/wound management Controlled trial quality: uncertain

6372. Split-thickness skin graft donor site management. A randomized prospective trial comparing a hydrophilic polyurethane absorbent foam dressing with a petrolatum gauze dressing. (Abstract)

Split-thickness skin graft donor site management. A randomized prospective trial comparing a hydrophilic polyurethane absorbent foam dressing with a petrolatum gauze dressing. Traditionally, skin graft donor sites have been covered with fine-mesh gauze dressings, and a dry eschar has been allowed to form. Newer dressings that can provide a moist wound environment may facilitate reepithelialization. We compared a hydrophilic semipermeable absorbent polyurethane foam dressing that provides (...) a moist wound environment with a petrolatum gauze dressing for donor sites.Prospective randomized trial; follow-up at 14 days.Department of head and neck surgery in a tertiary care center.Sixty-eight eligible patients received one of the two dressings. Harvested skin grafts were 0.375-mm (0.015-in) thick; donor site surface areas were recorded. At postoperative day 14, the dressings were removed, and wound epithelialization was scored: 1, none; 2, scattered or spotty; and 3, complete. Donor site

1995 Archives of otolaryngology--head & neck surgery Controlled trial quality: uncertain

6373. Comparative trial of octyl-cyanoacrylate and silver sulfadiazine for the treatment of full-thickness skin wounds. (Abstract)

Comparative trial of octyl-cyanoacrylate and silver sulfadiazine for the treatment of full-thickness skin wounds. A prospective, randomized, blinded, controlled experimental trial was performed in pigs to compare the rates of reepithelialization of 126 full-thickness cutaneous 4-mm punches treated with an octyl-cyanoacrylate spray, silver sulfadiazine, or a dry gauze (controls). Full thickness biopsies were taken 7, 14, or 30 days later for histopathological evaluation of hematoxylin and eosin

1999 Wound Repair and Regeneration

6374. Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants. (Abstract)

have an acid pH optimum. The dissolution of fat from the skin surface may influence the hydration status leading to a dry and squamous skin. (...) Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants. In adults the influence of cleansing preparations on the pH, fat content and hydration of the skin is well documented. Studies in newborn and small infants have not been reported.Our study aimed at examining whether similar effects can be ascertained in infants.Infants without skin disease, aged 2 weeks to 16 months, entered an open, controlled and randomized study. Ten infants each had skin

1997 Dermatology (Basel, Switzerland) Controlled trial quality: uncertain

6375. Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. (Abstract)

Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Moisturizers are used daily by many people to alleviate symptoms of clinically and subjectively dry skin. Recent studies suggest that certain ingredients in creams may accelerate the recovery of a disrupted barrier and decrease the skin susceptibility to irritant stimuli. In the present single-blind study, a moisturizing cream was tested for its influence both on barrier recovery in surfactant-damaged (...) skin and on the susceptibility of normal skin to exposure to the irritant sodium lauryl sulphate (SLS). Parameters measured were transepidermal water loss (TEWL) and skin corneometer values, indicating degree of hydration. Treatment of surfactant-damaged skin with the test cream for 14 days promoted barrier recovery, as observed as a decrease in TEWL. Skin corneometer values also normalized more rapidly during the treatment. In normal skin, use of the test cream significantly reduced TEWL after 14

1997 Contact dermatitis Controlled trial quality: uncertain

6376. An evaluation of five protocols for surgical handwashing in relation to skin condition and microbial counts. (Abstract)

An evaluation of five protocols for surgical handwashing in relation to skin condition and microbial counts. Five protocols for surgical handwashing (scrubbing) were evaluated for their efficiency of removal of micro-organisms and their drying effect on the skin. The scrubbing protocols tested were: (1) an initial scrub of 5 min and consecutive scrubs of 3.5 min with chlorhexidine gluconate 4% (CHG-5); (2) an initial scrub of 3 min and consecutive scrubs of 2.5 min with chlorhexidine gluconate (...) and the alcohol-based antiseptics was found at the beginning of the test week, but after exclusive use of the respective protocols for a week, the alcohol-based antiseptics were associated with significantly lower cfu numbers in two out of the three post-scrub samples (P = 0.003, P = 0.035). Although virtually no statistically significant differences in skin condition were found, many subjects reported the alcohol-based antiseptic protocols to be less drying on the skin. The findings of this study support

1997 The Journal of hospital infection Controlled trial quality: uncertain

6377. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. (Abstract)

An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. A number of genetic, intrinsic, and extrinsic factors can cause conditions of problem dry skin, marked by unusual dryness, rough texture, and extreme flaking and scaling, that are generally not controlled by conventional moisturizers. A study was undertaken to evaluate the safety and efficacy of two novel alpha (...) hydroxy acid (AHA)-containing creams in reducing the appearance and symptoms of problem dry skin on subjects with a range of dry skin conditions, including xerosis, epidermolytic hyperkeratosis, and ichthyosis. Twenty subjects completed a course of treatment with either regular or extra strength AHA-blend cream on a test site, compared with a currently marketed, non-AHA moisturizing lotion on a control site. Subjects were treated for 4 weeks, with clinical evaluations performed at weeks 0, 2, and 4

1998 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

6378. Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model. (Abstract)

Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model. 2 acute irritants and 1 allergen were selected: sodium lauryl sulfate (SLS) representative of irritant household and occupational contact dermatitis, the combination of ammonium hydroxide (NH4OH) and urea to simulate diaper dermatitis, and Rhus to evaluate the effect of model protective materials. The putative protective materials and vehicle were applied to both ventral forearms (...) of 10 subjects in each group, according to a randomized code. Test materials were spread over a marked 2.0 cm2 area, massaged in, allowed to dry for 30 min, and reapplied with another 30 min drying period. The model irritants and allergen were then applied (0.025 ml) to an Al-test occlusive patch, which in turn was placed for 24 h over each of the 8 designated sites. Inflammation was scored according to a clinical scale 72 h post-application. Paraffin wax plus Acetulan in cetyl alcohol, and beeswax

1998 Contact dermatitis Controlled trial quality: uncertain

6379. Adapalene 0.1% gel for the treatment of acne vulgaris: its superiority compared to tretinoin 0.025% cream in skin tolerance and patient preference. (Abstract)

% gel over tretinoin 0.025% cream (P = 0.003). An overall assessment showed adapalene 0.1% gel was significantly less irritating to the skin in terms of producing erythema, dryness, desquamation and burning/stinging, at Visits 2, 3 and 4 (P < 0.02). Thirty-two patients experienced mild to moderately severe adverse events; three had adverse events considered to be drug related (two with skin discomfort; one with skin dryness). One patient stopped using the study drugs because of dry skin. This study (...) Adapalene 0.1% gel for the treatment of acne vulgaris: its superiority compared to tretinoin 0.025% cream in skin tolerance and patient preference. One hundred patients with acne vulgaris applied adapalene (Differin) 0.1% gel to one side of their face and tretinoin 0.025% cream to the other once a day for 4 weeks; the side of application was determined by randomization code. Patient tolerance (assessed as the side of the face least irritated by drug application) was recorded weekly and patient

1998 The British journal of dermatology Controlled trial quality: uncertain

6380. Do urea and sodium chloride together increase the efficacy of moisturisers for atopic dermatitis Skin? A comparative, double-blind and randomised study. (Abstract)

Do urea and sodium chloride together increase the efficacy of moisturisers for atopic dermatitis Skin? A comparative, double-blind and randomised study. Urea has long been used to treat dry skin. In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis. Following a 2-week wash-out period, their clinically non-eczematous, rough or normal-appearing skin (...) on the forearms was treated twice daily in a double-blind and randomised manner. We examined the treated areas by measuring transepidermal water loss, capacitance and electrical impedance. Our findings suggest that a moisturiser containing both urea and sodium chloride seems somewhat more effective than the same moisturiser without sodium chloride, at least concerning the ability to reverse impedance indices of atopic skin towards normal, an effect ascribed mainly to changes in hydration of the stratum

2001 Skin pharmacology and applied skin physiology Controlled trial quality: uncertain

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