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Dry Skin

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41. Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice Full Text available with Trip Pro

Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice Dry skin pruritus is common in the elderly. Recent reports show that T-cell signal path is involved in dry skin pruritus. Zeta-chain-associated protein kinase 70 (ZAP70), as a T-cell receptor, may induce interleukin 2 (IL-2) secretion and promote nerve growth factor (NGF) secretion in skin. This study aimed to detect the alteration of ZAP70 in a mice model with dry skin pruritus. The C57BL mice with 5 months and 22 months were used (...) was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 and NGF may induce dry skin itch.

2016 BioMed research international

42. Effects of a Moisturizing Product on Dry Eye and Skin

Effects of a Moisturizing Product on Dry Eye and Skin Effects of a Moisturizing Product on Dry Eye and Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of a Moisturizing Product on Dry Eye (...) and Innovation Finnsusp Oy, Lieto, Finland Information provided by (Responsible Party): Petra Larmo, Aromtech Ltd. Study Details Study Description Go to Brief Summary: Dry eye is a common syndrome associated with symptoms of dryness, burning, itching and grittiness of eyes. The objective of this study is to investigate the effects of a moisturizing product in liquid formula on symptoms and signs of dry eye and on skin around the eyes. Condition or disease Intervention/treatment Phase Dry Eye Syndromes Device

2016 Clinical Trials

43. Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema

Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02691507 Recruitment Status : Completed First Posted : February 25, 2016

2016 Clinical Trials

44. To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin

To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02857062 Recruitment Status : Completed First Posted : August 5, 2016

2016 Clinical Trials

45. The effectiveness of using a bath oil to reduce signs of dry skin: A randomized controlled pragmatic study. (Abstract)

The effectiveness of using a bath oil to reduce signs of dry skin: A randomized controlled pragmatic study. Dry skin (xerosis cutis) is increasingly recognized as a relevant health problem in daily life and in health and nursing care. The use of bath additives such as oils is common to reduce dry skin, but empirical evidence supporting this practice is limited.The aim of this study was to investigate the effectiveness of using a bath oil additive in improving skin barrier function (...) and ameliorating dry skin in comparison to non-oil containing skin cleansers for bathing or showering.Single centre randomized observer blind pragmatic parallel group trial.Outpatient/community care.Volunteers showing clinically mild to moderate dry skin recruited from the city of Berlin.Healthy children and adults were randomly assigned to use either a commercially available bath oil or to continue using their regular non-oil containing skin cleansers every other day over a study period of 28days. Skin

2016 International journal of nursing studies Controlled trial quality: predicted high

46. Novel TRPM8 agonist Cooling Compound against chronic itch: Results from a randomized, double-blind, controlled, pilot study in dry skin. (Abstract)

Novel TRPM8 agonist Cooling Compound against chronic itch: Results from a randomized, double-blind, controlled, pilot study in dry skin. Patients suffering from chronic pruritus (CP) due to dry skin with are often applying emollients containing menthol. However, topical menthol may be irritating and of weak potency in severe pruritus. Two TRPM8 agonists, (1R,2S,5R)-N-(2-(2-pyridinyl)ethyl)-2-ispropyl-5-methylcyclohexancarboxamide and menthoxypropanediol, combined as cooling compound (CC) have (...) shown stronger activation of TRPM8 than menthol.Objective of this study was to evaluate the efficacy and safety of CC in alleviating pruritus in patients with dry itchy skin.In this vehicle-controlled, double-blind, randomized (1 : 1) study, 70 dry skin patients with pruritus intensity measured by Numerical Rating Scale (NRS) ≥3, were treated twice daily over 4 weeks, either with a lotion containing CC or with its vehicle.At treatment end, pruritus, assessed by a global score, improved significantly

2016 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

47. Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study). Full Text available with Trip Pro

Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study). Topical oils on baby skin may contribute to development of childhood atopic eczema. A pilot, assessor-blinded, randomized controlled trial assessed feasibility of a definitive trial investigating their impact in neonates. One-hundred and fifteen healthy, full-term neonates were randomly assigned to olive oil, sunflower oil or no oil (...) group. There were no significant differences in TEWL, pH or erythema/skin scores. The study was not powered for clinical significance, but until further research is conducted, caution should be exercised when recommending oils for neonatal skin.

2015 Acta Dermato-Venereologica Controlled trial quality: uncertain

48. Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin

Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02404493 Recruitment Status : Terminated (Lack of subject enrollment and the eczema season has completed) First Posted : March 31

2015 Clinical Trials

49. Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model. (Abstract)

Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model. Pruritus and discomfort are often present in patients with xerosis and atopic dermatitis. Several studies suggest an important role of diet in skin pathophysiology.This study evaluated the effect of dietary fatty acids in the skin physiology via an itch-related animal model with and without supplementation with fish oil (FO), a source of polyunsaturated fatty acids (PUFA), especially omega (...) 3 (n-3).Male Wistar rats were divided into two groups-non-supplemented (control) and supplemented with FO (3g/kg/day) by gavage for 90 days. Every 30 days, scratching and skin parameters (transepidermal water loss (TEWL), hydration, and local blood flow) were evaluated before and after dorsal skin exposure to acetone to induce the itch-related dry skin. At the end of the study, animals were sacrificed, and skin samples collected for fatty acids composition analysis by GC-FID.FO supplementation

2015 Journal of dermatological science

50. Scabies PCR with standardized dry swab sampling Easy tool for cluster diagnosis of human scabies. (Abstract)

Scabies PCR with standardized dry swab sampling Easy tool for cluster diagnosis of human scabies. Expert visualization of Sarcoptes scabiei remains essential for diagnosing human scabies but access to experts can be difficult. PCR is a very specific tool for the detection and confirmation of Sarcoptes scabiei but this test has a poor sensitivity because of the requirement of previous expertise when collecting appropriate samples to gain a positive result.Evaluate PCR as a diagnostic method (...) for scabies using non expert-dependent standardized sampling.The dry swab was systematically rubbed across the front of both wrists, the eight interdigital spaces and on any suspected scabies lesions in all patients referred for scabies. A new PCR-based diagnostic test was run on the samples. All patients underwent clinical and dermoscopic examination. Scabies diagnosis was confirmed when dermoscopic examination was positive or the patient had typical clinical signs of scabies.Of 183 suspected scabies

2019 British Journal of Dermatology

51. Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial. (Abstract)

with the interventions were identified. Reported skin symptoms and signs (including itching, oedema, exanthema, dry skin, and urticaria) were no more frequent in the skin, food, and combined intervention groups than in the no intervention group.Neither early skin emollients nor early complementary feeding reduced development of atopic dermatitis by age 12 months. Our study does not support the use of these interventions to prevent atopic dermatitis by 12 months of age in infants.The study was funded by several (...) Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial. Skin emollients applied during early infancy could prevent atopic dermatitis, and early complementary food introduction might reduce food allergy in high-risk infants. The study aimed to determine if either regular skin emollients applied from 2 weeks of age, or early complementary feeding introduced between 12 and 16 weeks of age, reduced

2020 Lancet

52. Tinea Cruris Skin Infection - Guidelines for Prescribing Topical Antifungals

treatment for tinea infections: Skin should be kept dry to help stop infection from spreading. Avoid rubbing or scratching lesions. Use a hair dryer on cool setting to dry the affected area. Wear loose fitting, cotton clothing or moisture absorbing synthetics. Launder items used by infected person separately and often. Use of non-medicated powders may help absorb moisture. Do not use cornstarch or powders that contain cornstarch as these may provide nourishment for the tinea organisms. The main cause (...) of tinea cruris is transfer of the microorganism from the patient's feet. This can occur while changing after exercise, swimming or bathing. Instruct patient to fully dry feet and put on socks before undergarments, especially after using a public change room. 2. Over-the-counter drug options for treating tinea infections of the skin OTC anti-fungal agents are available in a variety of dosage forms; creams, lotions, gels, solutions, sprays and powders. Generally creams and solutions are most effective

2017 medSask

53. CRACKCast E137 – Skin Infections

CRACKCast E137 – Skin Infections CRACKCast E137 - Skin Infections - CanadiEM CRACKCast E137 – Skin Infections In , , by Adam Thomas December 21, 2017 This episode of CRACKCast covers Rosen’s Chapter 129, Skin Infections. These are common and rarely life threatening, but careful consideration should be given for those who may benefit from admission over outpatient treatment. This is a big episode covering the bugs, presentations, and useful tips when treating these infections in the ED (...) . Shownotes – Key Concepts Skin infections are common and are rarely life – threatening . Deadly necrotizing skin and soft tissue infections are rare , and there is insufficient evidence to motivate screening by laboratory tests . Necrotizing infection is suggested by pain out of proportion to physical findings , crepitance , gas seen on imaging studies , or clinical instability . Suspected necrotizing infection is managed aggressively, with broad-spectrum antibiotics, critical care resuscitation

2017 CandiEM

54. Reducing Facial Wrinkle Size and Increasing Skin Firmness Using Skin Care Polymers. (Abstract)

Reducing Facial Wrinkle Size and Increasing Skin Firmness Using Skin Care Polymers. Many cosmetic polymers shrink on drying, producing a tensile force if coated on a substrate. This tensile force can be used to smoothen wrinkles and pores in facial skin. In this study, we evaluated two polymers, a polyvinylpyrrolidone (PVP) and a polyacrylate, for skin tightening properties. We conducted a double-blinded, placebo-controlled and randomized clinical study with 32 female volunteers aged 35-65 (...) years who perceived themselves to have a loss of skin elasticity. Both polymers were formulated in a model cosmetic emulsion with hydrogenated polyisobutene as the oil phase. We measured skin firmness and tightening parameters at baseline and after each product application. Also, facial images were recorded with a fringe projection instrument. The firming measurements indicated that both polymers instantly tightened facial skin, whereas the placebo product offered no significant tightening benefit

2018 Journal of cosmetic science Controlled trial quality: uncertain

55. Ingestion of Coffee Polyphenols Improves a Scaly Skin Surface and the Recovery Rate of Skin Temperature after Cold Stress: A Randomized, Controlled Trial. Full Text available with Trip Pro

Ingestion of Coffee Polyphenols Improves a Scaly Skin Surface and the Recovery Rate of Skin Temperature after Cold Stress: A Randomized, Controlled Trial. Coffee polyphenols (CPPs) derived from coffee beans have beneficial effects on blood pressure and vascular endothelial function. In addition, CPPs suppress ultraviolet light induced erythema. However, the effects of CPPs on dry skin and cutaneous vascular function have not been clarified. We investigated the effects of CPPs on dry skin (...) and the recovery rate (RR) of skin temperature after a cold-stress test as a measure of vascular function in subjects with visible scaliness in a double-blind, placebo-controlled, randomized study. The subjects were divided into two groups, the CPP group and the Placebo group. In the CPP group, the subjects ingested a beverage containing 297.8 mg CPPs every day for 4 wk. The degree of skin dryness was assessed quantitatively using a Visioscan to evaluate skin scaliness and smoothness. A subjective evaluation

2018 Journal of nutritional science and vitaminology Controlled trial quality: uncertain

56. Sensitive skin in france: a study on prevalence, relationship with age and skin type and impact on quality of life. (Abstract)

skin is higher for people with dry skin (OR = 6.18 compared with normal skin), but sensitive skin can occur in other skin types (OR = 2.45 for mixed skin and OR = 2.16 for greasy skin). Quality of life was clearly altered in patients with sensitive skin, as assessed by SF-12 and DLQI.This large study demonstrates that sensitive skin can alter quality of life and is more common in young people and in women as well as patients with dry skin or fair skin or an atopic predisposition. It also suggests (...) Sensitive skin in france: a study on prevalence, relationship with age and skin type and impact on quality of life. Many epidemiological studies have been performed, but a potential increase in the prevalence of sensitive skin, its relationship with age and skin type and the impact of sensitive skin on quality of life are still debated.To answer these unresolved questions.An opinion poll was conducted on a representative French 5000 person sample.Fifty-nine per cent of the people declared very

2018 Journal of the European Academy of Dermatology and Venereology

57. The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. (Abstract)

in 2015. We performed skin type (moist, dry, and oily)-matched comparisons within six burn patients (43 pairs of swabs) and with 13 skin-healthy, control patients (22 pairs of samples) using 16S ribosomal RNA gene sequencing results. Results of comparative microbiome analysis showed that, there were no substantial variations in the microbial abundance (all p > 0.05) or composition (all p > 0.01, adjusted for multiple comparisons) between samples obtained from wound scars and those from unaffected (...) The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Although studies on skin microbiome of acute and chronic wounds abound, evidence on newly built microbial communities of subacute wounds remains scant. To characterize the skin microbiome of recently healed (scarred) burn wounds in relation to unaffected skin surfaces, we collected weekly swabs from patients with moderate to severe burns in the 3rd postburn month for 4 weeks

2018 Wound Repair and Regeneration

58. The Role of Skin Care Regimen in Skin Health

): Johns Hopkins University Study Details Study Description Go to Brief Summary: This research is being done to evaluate the role of a regular skin care regimen comprising of a mild soap and moisturizer in improving dry skin and overall skin health. In this study, the investigators hope to learn the importance of regular skin care regimen in improving dry skin and overall skin health. Condition or disease Intervention/treatment Phase Itching Xerosis Other: skin care regimen Not Applicable Detailed (...) Description: Dry skin is a common phenomenon and can dramatically decrease a person's quality of life as well as contribute to a wide variety of skin diseases. Skin care products hydrate the skin and breaks the dry skin cycle. While there is extensive evidence of benefits of using mild cleansers and moisturizers, much of the previous studies are limited to the effects of single cleanser or moisturizer. In this study, the investigators are going to enroll up to 100 people over the age of 18 with dry, itchy

2018 Clinical Trials

59. The Effect of Early Skin-to-skin Contact on Initiation of Breastfeeding, Newborn Temperature and Duration of Third Stage of Labor

covered with a pre-warmed blanket. To prevent heat loss, the infant's head was covered with a dry cap that was replaced when it became damp. Dressing and measuring of the infant were postponed to an hour after the delivery by registered midwife. Other: Skin to skin contact By assistance of the researcher, intervention infants were placed undressed in a prone position against their mothers' bare chest between breasts immediately after birth and before placental delivery and suturing of tears (...) The Effect of Early Skin-to-skin Contact on Initiation of Breastfeeding, Newborn Temperature and Duration of Third Stage of Labor The Effect of Early Skin-to-skin Contact on Initiation of Breastfeeding, Newborn Temperature and Duration of Third Stage of Labor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2018 Clinical Trials

60. Medical compression stockings on the skin moisture in patients with chronic venous disease. (Abstract)

decreased (p = 0.021) and the skin roughness increased significantly (p = 0.001), whereas in patients wearing the MCS-SC skin moisture and skin roughness changed only slightly (n.s.). These protective effects of MCS-SC compared to MCS were most common in patients with CVI at stage 3 (p = 0.046), in male patients (p = 0.013) and patients with initial dry skin (p = 0.034). Both MCS reduced lower leg volume, MCS by 80 ml (p < 0.001) and MCS-SC by 60 ml (p < 0.001), both MCS improved quality of life: leg (...) Medical compression stockings on the skin moisture in patients with chronic venous disease. Background: Because of side effects like skin dryness and consecutive symptoms like itching the therapy of chronic venous insufficiency (CVI) with medical compression stockings (MCS) can lead to a diminished wear comfort and restricted compliance. Compression stockings with integrated skin care may have a positive influence on the skin hydration and moreover a positive effect on patients compliance

2019 VASA. Zeitschrift fur Gefasskrankheiten Controlled trial quality: uncertain

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