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Dry Skin

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181. Proteomic analysis identifies new biomarkers for postmenopausal and dry skin. (Abstract)

Proteomic analysis identifies new biomarkers for postmenopausal and dry skin. A proteomic analysis of stratum corneum (SC) samples of normal healthy skin revealed the presence of more than 70 proteins by 2D electrophoresis. The majority of these proteins to our knowledge have not yet been described in normal SC. We analysed by Western blot the levels of 25 proteins in the SC taken from postmenopausal and dry skin compared with young and normal skin, respectively. In postmenopausal skin (...) , there was a significantly increased amount of heat shock protein 27, plakoglobin and desmoglein 1, whereas transglutaminase 3, apolipoprotein D and acid ceramidase levels were significantly reduced compared with the SC of young skin. We confirmed corneodesmosin as a marker of dry skin. In addition, we showed for the first time that the levels of both phosphatidylethanolamine-binding protein 1 and annexin A2 were significantly increased in the SC of dry skin compared with the SC of normal skin. These results suggest

2012 Experimental Dermatology

182. Multifocal skin basal cell carcinomata 57 years after topical dry ice treatment. (Abstract)

Multifocal skin basal cell carcinomata 57 years after topical dry ice treatment. We report a rare case of simultaneous multiple basal cell carcinomata occurring on the back of a patient who had received dry ice treatment to this area almost 6 decades previously. This is also one of the longest recorded disease-free intervals between skin trauma and basal cell carcinoma development. We discuss the aetiopathology of multiple skin cancers in our patient and the propensity for destructive skin

2012 Australasian Journal of Dermatology

183. Experiments made with a Sarcoma-producing Mouse Carcinoma to ascertain whether the Tumour, when killed by drying, will incite a Sarcomatous Growth in the Host on being introduced beneath the Skin Full Text available with Trip Pro

Experiments made with a Sarcoma-producing Mouse Carcinoma to ascertain whether the Tumour, when killed by drying, will incite a Sarcomatous Growth in the Host on being introduced beneath the Skin 19976288 2010 06 24 2010 06 24 0035-9157 5 Pathol Sect 1912 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Experiments made with a Sarcoma-producing Mouse Carcinoma to ascertain whether the Tumour, when killed by drying, will incite a Sarcomatous Growth in the Host on being introduced (...) beneath the Skin. 35-8 Shattock S G SG Dudgeon L S LS eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1912 1 1 0 0 1912 1 1 0 1 ppublish 19976288 PMC2004974

1912 Proceedings of the Royal Society of Medicine

184. Urea creams in the treatment of dry skin and hand dermatitis. (Abstract)

Urea creams in the treatment of dry skin and hand dermatitis. Two randomized, double-blind comparison studies were conducted to evaluate the efforts of 2 emollient dry skin creams containing urea in the management of dry skin in atopic patients. Cream with 10% urea was shown to be effective in the management of dry skin and hand dermatitis. The cream with a pH of 6 caused less burning.

1975 International journal of dermatology Controlled trial quality: uncertain

185. Aqueous cream: may cause skin irritation

Aqueous cream: may cause skin irritation Aqueous cream: may cause skin irritation - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Aqueous cream: may cause skin irritation May cause skin irritation, particularly in children with eczema, possibly due to sodium lauryl sulfate content. Published 11 December 2014 From: Therapeutic area: Contents Article date: March 2013 Aqueous cream is a widely used product topically applied as an emollient for the symptomatic relief of dry skin (...) conditions such as atopic eczema, and as a soap-substitute for skin washing. Although aqueous cream is useful as a leave-on emollient in a substantial proportion of patients with eczema, it is known that in some patients, especially in children, it can cause skin reactions, such as stinging, burning, itching and redness. In light of new information from the published literature all data on the benefits and risks of aqueous cream, particularly when used in children with eczema, have been . Review outcome

2013 MHRA Drug Safety Update

186. Dry Eye

Dry Eye Dry Eye Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dry Eye Dry Eye Aka: Dry Eye , Xerophthalmia From Related Chapters II (...) . Epidemiology As many as 30% of over age 50 years old complain of dry, irritated eyes III. Causes Decreased blinking with prolonged reading or driving Chronic exposure to dry, dusty conditions See (e.g. s, s, ) IV. Management ral measures Room humidifiers Take computer breaks Protect eyes from fan Avoid drying, s ( s, s, s) Artificial tears or ointments Preservative-free solutions are preferred (e.g. Refresh Plus), esp. if used more than 4x/day users may try rewetting drops (e.g. Renu rewetting, Blink

2017 FP Notebook

187. Operating Room Fires and Surgical Skin Preparation. (Abstract)

-based preparations caused flash flames at 0 minutes in 22% (13 of 60) and at 3 minutes in 10% (6 of 60) of tests. When examining pooling of alcohol-based preparations, fires occurred in 38% (23 of 60) at 0 minutes and 27% (16 of 60) at 3 minutes.Alcohol-based skin preparations fuel operating room fires in common clinical scenarios. Following manufacturer guidelines and allowing 3 minutes for drying, surgical fires were still created in 1 in 10 cases without pooling and more than one-quarter of cases (...) Operating Room Fires and Surgical Skin Preparation. Operating room fires are "never events" that remain an under-reported source of devastating complications. One common set-up that promotes fires is the use of surgical skin preparations combined with electrosurgery and oxygen. Limited data exist examining the incidence of fires and surgical skin preparations.A standardized, ex vivo model was created with a 15 × 15 cm section of clipped porcine skin. An electrosurgical "Bovie" pencil

2017 Journal of the American College of Surgeons

188. Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity. (Abstract)

Colloidal Oatmeal (Avena Sativa) Improves Skin Barrier Through Multi-Therapy Activity. Oats (Avena sativa) are a centuries-old topical treatment for a variety of skin barrier conditions, including dry skin, skin rashes, and eczema; however, few studies have investigated the actual mechanism of action for the skin barrier strengthening activity of colloidal oatmeal. Four extracts of colloidal oatmeal were prepared with various solvents and tested in vitro for skin barrier related gene (...) moderate to severe dry skin on their lower legs. Subjects were treated with a colloidal oatmeal skin protectant lotion. Clinically, the colloidal oatmeal lotion showed significant clinical improvements in skin dryness, moisturization, and barrier. Taken together, these results demonstrate that colloidal oatmeal can provide clinically effective benefits for dry and compromised skin by strengthening skin barrier.

J Drugs Dermatol. 2016;15(6):684-690.

2017 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

189. Radio Frequency Microneedling for Suprapatellar Skin

of elastin. Additionally, as humans age, skin tends to appear more dry due to its poor hydration and turgor capacity. The use of minimally invasive aesthetic treatments in reducing signs of aging has been gaining in popularity over surgical treatments in recent years. Several energy types including, laser, radiofrequency, infrared, and ultrasound, have been developed for facial rejuvenation. These treatments induce controlled thermal damage into the dermis and cause collagen contraction (...) Radio Frequency Microneedling for Suprapatellar Skin Radio Frequency Microneedling for Suprapatellar Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Radio Frequency Microneedling for Suprapatellar Skin

2017 Clinical Trials

190. A large and distinct skin impression on the cast of a sauropod dinosaur footprint from Early Cretaceous floodplain deposits, Korea Full Text available with Trip Pro

by sheetflood processes. The large impression is preserved in silty mudstone with microbial lenses and wisps overlying a planar- to cross-laminated and fine-grained sandstone to siltstone bed. The paleoenvironment of the skin impression-bearing deposits is interpreted as a saline sandflat to mudflat where microbial mats can form around lakes or ponds under semi-arid paleoclimatic conditions with alternating wetting and drying intervals. These paleoenvironmental conditions would have permitted the distinct (...) A large and distinct skin impression on the cast of a sauropod dinosaur footprint from Early Cretaceous floodplain deposits, Korea The occurrence and features of skin impressions in a sauropod footprint, the largest (>50 cm in diameter) reported to date for this taxon, from the Lower Cretaceous Haman Formation (Albian) in Korea are described, and its preservation and paleoenvironmental implications are interpreted. The skin impression-bearing deposits are floodplain sediments formed

2017 Scientific reports

191. The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study Full Text available with Trip Pro

subjects with anticancer therapy, 136 (36.27%) and 114 (30.40%) were treated for breast cancer and colorectal cancer, respectively. We found that women, breast cancer, targeted agent use, and longer duration of anticancer therapy were associated with higher dermatology-specific quality of life distraction. In addition, itching, dry skin, easy bruising, pigmentation, papulopustules on face, periungual inflammation, nail changes, and palmoplantar lesions were associated with significantly higher DLQI (...) The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life.In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review.Of 375 evaluated

2017 Cancer research and treatment : official journal of Korean Cancer Association

192. Skin flap vaginal augmentation helps prevent and cure post obstetric fistula repair urine leakage: a critical anatomical analysis. Full Text available with Trip Pro

'tethered, forcibly opening the urethra when give the signal to close'. Skin graft restores elasticity and closure. Used prophylactically with Goh type 4 fistula (n = 45), 46% were dry against an expected 19%. In patients with successful fistula closure, still with severe leakage (n = 24), 71% were dry against an expected 26%.Singapore skin flap restores elasticity and prevents and treats incontinence in patients with successful obstetric fistula repair.© 2017 Royal College of Obstetricians (...) Skin flap vaginal augmentation helps prevent and cure post obstetric fistula repair urine leakage: a critical anatomical analysis. Our aim was to describe a new surgical method for prophylaxis/cure of post obstetric fistula repair leakage based on restoring vaginal elasticity with Singapore skin flap. The rationale for this operation was based on the integral theory: scarring removes elasticity required for independent function of oppositely acting urethral closure forces so they become

2017 BJOG

193. Removal of Bacterial Spores in Adults on Skin

and disinfect the skin Active Comparator: HUBS with Hibiclens Dry cloths to be used with water and disinfectant Combination Product: HUBS with Hibiclens A dry cloth to be used in combination with water and antimicrobial soap to cleanse and disinfect the skin Outcome Measures Go to Primary Outcome Measures : Removal of Clostridium difficile and the associated organic soil load will be used as an indicator of potential removal efficacy for difficult-to-remove microorganisms and associated organic matter from (...) Removal of Bacterial Spores in Adults on Skin Removal of Bacterial Spores in Adults on Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Removal of Bacterial Spores in Adults on Skin The safety

2017 Clinical Trials

194. Significantly Accelerated Wound Healing of Full-Thickness Skin Using a Novel Composite Gel of Porcine Acellular Dermal Matrix and Human Peripheral Blood Cells Full Text available with Trip Pro

Significantly Accelerated Wound Healing of Full-Thickness Skin Using a Novel Composite Gel of Porcine Acellular Dermal Matrix and Human Peripheral Blood Cells Here we report the fabrication of a novel composite gel from decellularized gal-gal-knockout porcine skin and human peripheral blood mononuclear cells (hPBMCs) for full-thickness skin wound healing. Decellularized skin extracellular matrix (ECM) powder was prepared via chemical treatment, freeze drying, and homogenization. The powder (...) was mixed with culture medium containing hyaluronic acid to generate a pig skin gel (PSG). The effect of the gel in regeneration of full-thickness wounds was studied in nude mice. We found significantly accelerated wound closure already on day 15 in animals treated with PSG only or PSG + hPBMCs compared to untreated and hyaluronic acid-treated controls (p < 0.05). Addition of the hPBMCs to the gel resulted in marked increase of host blood vessels as well as the presence of human blood vessels. At day 25

2017 Cell transplantation

195. Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma Full Text available with Trip Pro

Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma.Case report and review of the literature.A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Four months after (...) initiation of treatment, the patient developed red eyelids and conjunctivae, with painful gritty eyes, limiting his capacity to read. Following a diagnosis of severe ocular rosacea and dry eyes, treatment including corticosteroids, antimicrobial agents, and eyelid hygiene was started, and within 3 months, the ocular complaints resolved.Treatment with checkpoint inhibitor immunotherapy for metastatic melanoma may trigger several ocular immune-related adverse events. This case describes severe ocular

2017 Ocular oncology and pathology

196. Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model Full Text available with Trip Pro

Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress (...) treatments (hot-wet and cold-dry) reduced the expression of genes encoding collagens, laminin, and proteoglycans, suggesting a profound remodeling of the extracellular matrix. Strong induction of the entire family of late cornified envelope genes after cold-dry exposure, confirmed at protein level, was also observed. These changes correlated with an increase in epidermal differentiation markers such as corneodesmosin and a thickening of the stratum corneum, indicating possible implementation of defense

2017 Clinical, cosmetic and investigational dermatology

197. Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury Full Text available with Trip Pro

Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury Accidental high-dose radiation exposures can lead to multi-organ injuries, including radiation dermatitis. The types of cellular damage leading to radiation dermatitis are not completely understood. To identify the cellular mechanisms that underlie radiation-induced skin injury in vivo, we evaluated the time-course of cellular effects of radiation (14, 16 or 17 Gy X-rays; 0.5 Gy/min) in the skin of C57BL/6 (...) mice. Irradiation of 14 Gy induced mild inflammation, observed histologically, but no visible hair loss or erythema. However, 16 or 17 Gy radiation induced dry desquamation, erythema and mild ulceration, detectable within 14 days post-irradiation. Histological evaluation revealed inflammation with mast cell infiltration within 14 days. Fibrosis occurred 80 days following 17 Gy irradiation, with collagen deposition, admixed with neutrophilic dermatitis, and necrotic debris. We found that in cultures

2017 Journal of radiation research

198. Beneficial effects of a novel shark-skin collagen dressing for the promotion of seawater immersion wound healing Full Text available with Trip Pro

which should be suitable to prevent the wound from seawater immersion and to promote the wound healing.Shark skin collagen (SSC) was purified via ethanol de-sugaring and de-pigmentation and adjusted for pH. A shark skin collagen sponge (SSCS) was prepared by freeze-drying. SSCS was attached to an anti-seawater immersion polyurethane (PU) film (SSCS + PU) to compose a new dressing. The biochemical properties of SSC and physicochemical properties of SSCS were assessed by standard methods. The effects (...) Beneficial effects of a novel shark-skin collagen dressing for the promotion of seawater immersion wound healing Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing

2017 Military Medical Research

199. Temporal and spatial distribution of lumpy skin disease outbreaks in Ethiopia in the period 2000 to 2015 Full Text available with Trip Pro

Temporal and spatial distribution of lumpy skin disease outbreaks in Ethiopia in the period 2000 to 2015 Lumpy skin disease (LSD) is an infectious viral disease of cattle caused by a virus of the genus Capripoxvirus. LSD was reported for the first time in Ethiopia in 1981 and subsequently became endemic. This time series study was undertaken with the aims of identifying the spatial and temporal distribution of LSD outbreaks and to forecast the future pattern of LSD outbreaks in Ethiopia.A total (...) of 3811 LSD outbreaks were reported in Ethiopia between 2000 and 2015. In this period, LSD was reported at least once in 82% of the districts (n = 683), 88% of the administrative zones (n = 77), and all of the regional states or city administrations (n = 9 and n = 2) in the country. The average incidence of LSD outbreaks at district level was 5.58 per 16 years (0.35 year-1). The incidence differed between areas, being the lowest in hot dry lowlands and highest in warm moist highland. The occurrence

2017 BMC veterinary research

200. GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model Full Text available with Trip Pro

were characterized by transmission electron microscopy, Western blot and size distribution analysis. The chitosan/silk-based hydrogel sponge was prepared using the freeze-drying method and then structural and physical properties were characterized. Then, the exosomes were added to the hydrogel and tested in a diabetic rat skin defect model. The effects were evaluated by wound area measurement, histological, immunohistochemical and immunofluorescence analysis. Results: We have successfully isolated (...) GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model Background: Delayed wound healing in diabetic patients is one of the most challenging complications in clinical medicine, as it poses a greater risk of gangrene, amputation and even death. Therefore, a novel method to promote diabetic wound healing is of considerable interest at present. Previous studies showed that injection of MSC-derived exosomes has beneficial

2017 Frontiers in physiology

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