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Dry Mouth

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81. Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis. (Abstract)

Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis. Enhancing chloride (Cl- ) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl- secretion in sinonasal cultures in vitro and murine epithelium in vivo. The objective of this study is to evaluate whether the BNO 1011 improves MCC and clinical (...) parameters in a rabbit model of CRS.After the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl- secretion (sinus potential difference [PD] assay), airway surface liquid (ASL) depth using micro-optical coherence tomography

2019 International forum of allergy & rhinology

82. Parasympathomimetic drugs for dry mouth due to radiotherapy. (Abstract)

Parasympathomimetic drugs for dry mouth due to radiotherapy. Data sourcesCochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase and CINAHL databases. Reference lists of identified articles were checked and experts in the field and relevant pharmaceutical companies were contacted.Study selectionRandomised controlled trials, including parallel and crossover, carried out in any setting on any patient population with radiation-induced salivary

2016 Evidence Based Dentistry

83. Parasympathomimetic drugs for dry mouth after radiotherapy

Parasympathomimetic drugs for dry mouth after radiotherapy Parasympathomimetic drugs for dry mouth after radiotherapy Search National Elf Service Search National Elf Service » » » » Parasympathomimetic drugs for dry mouth after radiotherapy Oct 9 2015 Posted by Over 90% of patients experience xerostomia during head and neck radiotherapy and for three quarters of patients this can last from one month to 2 years. Xerostomia causes a variety of oral problems including discomfort chewing problems (...) - indications. However, many fail to respond and side effects are common. Another Cochrane review by Furness et al (see Dental Elf 3 rd Sept 2013) looked at non-pharmacological approaches for dry mouth although not specifically related to those patients with radiation-induced xerostomia. They included 9 studies involving acupuncture, electrostimulation devices and powered toothbrushes but the quality of evidence was low or very low. Links Davies AN, Thompson J. Cochrane Database of Systematic Reviews 2015

2015 The Dental Elf

84. Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study Full Text available with Trip Pro

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were (...) instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec(®) 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme.At 12 weeks, each dry eye symptom improved significantly (P<0.001), and the use of artificial tears decreased significantly from 3.77 (standard deviation [SD] =2.08

2016 Clinical interventions in aging

85. A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer

Information provided by (Responsible Party): University College, London Study Details Study Description Go to Brief Summary: This trial is looking at using an intra-oral electrostimulating device for the management of radiotherapy-induced dry mouth. Condition or disease Intervention/treatment Phase Xerostomia Head and Neck Neoplasms Device: Active Electrostimulator device Device: Sham Electrostimulator device Phase 3 Detailed Description: Dry mouth is a common complaint of radiotherapy for cancer (...) of the head and neck region. It is a distressing often persistent condition which can lead to longlasting oral discomfort, dental infections, diminished quality of life, social isolation and loneliness. Unfortunately, current therapies of dry mouth are often unsatisfactory, expensive and may result in adverse effects. A novel intraoral electronic device has recently been developed to treat dry mouth. The device, acting as a "salivary pacemaker", harmlessly stimulates nerves of the salivary glands and does

2016 Clinical Trials

86. A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy

A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study (...) of Patients With Dry Mouth and Sticky Saliva During Radiotherapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02687087 Recruitment Status : Completed First Posted : February 22, 2016 Last Update Posted : February 20, 2017 Sponsor: NHS Greater Glasgow and Clyde Collaborators: Lamellar Biomedical Ltd

2016 Clinical Trials

87. Comparison of levocetirizine pharmacokinetics after single doses of levocetirizine oral solution and cetirizine dry syrup in healthy Japanese male subjects. Full Text available with Trip Pro

Comparison of levocetirizine pharmacokinetics after single doses of levocetirizine oral solution and cetirizine dry syrup in healthy Japanese male subjects. Levocetirizine, the R-enantiomer of cetirizine, is classified as a second generation antihistamine used for the treatment of allergic disorders. This study aimed to compare exposure to levocetirizine when given as levocetirizine oral solution (OS) 5 mg to that when given as cetirizine dry syrup (DS) 10 mg, which contains equal proportions

2016 Journal of drug assessment Controlled trial quality: uncertain

88. Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine. Full Text available with Trip Pro

Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine. We investigated the long-term relationships between dry mouth, fluid intake and overactive bladder symptoms in women undergoing treatment with fesoterodine. We hypothesized that women who experienced dry mouth would increase their fluid intake and worsen their urinary symptoms.We conducted a prospective ancillary study to a 9-month open-label trial of fesoterodine for women with urgency urinary (...) incontinence. Fluid intake was measured and compared according to reported dry mouth. Multivariable analysis was used to study the interaction between dry mouth, fluid intake and urinary symptoms.During the study 407 women without dry mouth significantly reduced their fluid intake (mean decrease 172.1 ml, median 118.3 ml, p = 0.02), while 91 women with dry mouth did not (mean decrease 95.8 ml, median 118.3 ml, p = 0.54). On univariable analysis a greater proportion of women who experienced dry mouth

2016 The Journal of urology Controlled trial quality: uncertain

89. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications.

Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. (LactoXeros) The safety and scientific validity of this study

2016 Clinical Trials

90. Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects

history or upon oral examination Participant reports having a feeling of a dry mouth according to the Dry Mouth Screening Questionnaire (DMSQ) (Subject must answer at least 2 out of the 4 questions with 'agree a little', 'agree' or 'strongly agree' at the Screening Visit (Visit 1). Participants with un-stimulated whole salivary flow rate of ≤0.1 ml/min at the Screening Visit (Visit 1). Participants with un-stimulated whole salivary flow rate of ≤0.1 ml/min ATH the Screening Visit (Visit 1 (...) in the study e.g. Alzheimer's Disease Participant with untreated oral mucosal disease which in the opinion of the investigator could interfere with the study (e.g. current oral ulceration) Evidence of gross intra-oral neglect or need for extensive dental therapy Denture wearer (complete dentures) Participant not on stable doses of prescription systemic parasympathetic medications (e.g. Pilocarpine), for the treatment of the feeling of dry mouth Known or suspected intolerance or hypersensitivity

2016 Clinical Trials

91. The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease

The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02802150 Recruitment Status : Completed First Posted : June 16, 2016 Last Update Posted : June 16, 2016 Sponsor: Chonbuk National University

2016 Clinical Trials

92. Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes. Full Text available with Trip Pro

Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes. To assess the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, matrix metalloproteinase-9 (MMP-9), tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), fluorescein corneal staining, Schirmer score, meibomian gland dysfunction (MGD) stage and omega-3 index in subjects with dry eyes and confirmed MGD.This was a multicenter, prospective, interventional, placebo-controlled, double-masked (...) control group (67.9% vs. 35.0%, P = 0.024) and OSDI scores decreased significantly in omega-3 (-17.0 ± 2.6) versus control group (-5.0 ± 2.7, P = 0.002).Oral consumption of re-esterified omega-3 fatty acids is associated with statistically significant improvement in tear osmolarity, omega-3 index levels, TBUT, MMP-9, and OSDI symptom scores.

2016 Cornea Controlled trial quality: uncertain

93. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. Full Text available with Trip Pro

A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES).A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus (...) ) with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer's test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS) in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance.Forty-three

2016 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

94. Dry socket – oral contraceptives may increase incidence

osteitis) is not fully understood and a number of factors have been implicated including surgical trauma, surgeons experience, perioperative patient stress factors and focal fibrinolytic activity. A number of additional risk factors including smoking, age, gender and oral contraceptive use, menstrual cycle and the use of antimicrobial drugs and mouth rinses have also been suggested. The aim of this review was to assess the association between oral contraceptive use and the development of dry socket (...) Dry socket – oral contraceptives may increase incidence Dry socket: oral contraceptives may increase incidence Search National Elf Service Search National Elf Service » » » » Dry socket – oral contraceptives may increase incidence Jul 16 2015 Posted by Dry Socket is a complication that can follow tooth extraction occurring in 1%- 5% of routine extractions. It is more common following the extraction of third molars with rates of between 1% – 37% reported. The aetiology of dry socket (alveolar

2015 The Dental Elf

95. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Full Text available with Trip Pro

weeks in four studies (415 participants in total), with a range of estimates between 26% and 51% in individual studies.Adverse event and withdrawal reporting was inconsistent. Two serious adverse events were reported with NSAIDs, and 22 deaths, but these were not clearly related to any pain treatment. Common adverse events were thirst/dry mouth (15%), loss of appetite (14%), somnolence (11%), and dyspepsia (11%). Withdrawals were common, mostly because of lack of efficacy (24%) or adverse events (5 (...) Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Pain is a common symptom with cancer, and 30% to 50% of all people with cancer will experience moderate to severe pain that can have a major negative impact on their quality of life. Non-opioid drugs are commonly used to treat cancer pain, and are recommended for this purpose in the World Health Organization (WHO) cancer pain treatment ladder, either alone or in combination with opioids.A previous Cochrane review

2017 Cochrane

96. Dry eye syndrome

information, see the CKS topic on . Past medical history of conditions associated with dry eye such as rosacea, psoriasis, atopy, Sjögren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, menopause, lymphoma, chronic viral infections (for example HIV and hepatitis C), orbital radiation and neurological conditions (for example Parkinson disease or Bell’s palsy). Associated features indicative of an undiagnosed underlying condition such as dry mouth, dental cavities, oral ulcers (...) , fatigue, joint or muscle pain. Systemic medications associated with dry eye such as retinoids, oral contraception, hormone replacement therapy, beta-blockers, anticholinergics, diuretics, antihistamines, antidepressants, and isotretinoin. Trauma to the eye area. Social history including smoking, alcohol, and occupation. Examine the person, checking: Visual acuity – visual acuity should not be severely impaired with dry eye syndrome. For of dry eye syndrome such as mild conjunctival redness – in many

2017 NICE Clinical Knowledge Summaries

97. The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review. (Abstract)

The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review. Primary Sjögren's syndrome (pSS) is a frequent autoimmune systemic disease, clinically characterized by eyes and mouth dryness in all patients, salivary gland swelling or extraglandular systemic manifestations in half of the patients, and development of lymphoma in 5 to 10 % of the patients. However, patients presenting with sicca symptoms or salivary gland swelling may have a variety of conditions (...) that may require very different investigations, treatments, or follow-up. Eye and/or mouth dryness is a frequent complaint in clinical setting, and its frequency increases with age. When evaluating a patient with suspected pSS, the first step is to rule out its differential diagnoses, before looking for positive arguments for the disease. Knowledge of normal and abnormal lachrymal and salivary gland physiology allows the clinician to prescribe the most adapted procedures for evaluating their function

2014 Clinical Reviews in Allergy & Immunology

98. Effect of Oral Lactoferrin on Cataract Surgery Induced Dry Eye: A Randomised Controlled Trial. Full Text available with Trip Pro

Effect of Oral Lactoferrin on Cataract Surgery Induced Dry Eye: A Randomised Controlled Trial. Cataract surgery is one of the most frequently performed intra-ocular surgeries, of these manual Small Incision Cataract Surgery (SICS) is a time tested technique of cataract removal. Any corneal incisional surgery, including cataract surgery, can induce dry eye postoperatively. Various factors have been implicated, of which oneis the inflammation induced by the surgery. Lactoferrin, a glycoprotein (...) present in tears is said to have anti-inflammatory effects, and promotes cell growth. It has been used orally in patients of immune mediated dry eye to alleviate symptoms.This study was aimed to evaluate the dry eyes induced by manual Small Incision Cataract Surgery, and the effect if any, of oral lactoferrin on the dry eyes.A single centre, prospective randomised controlled trial with a concurrent parallel design. The study was carried out on patients presenting in the OPD of Rohilkhand Medical

2015 Journal of clinical and diagnostic research : JCDR Controlled trial quality: uncertain

99. Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. (Abstract)

Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. Saliva is vital for the maintenance of normal oral physiology and mucosal health. The loss of salivary function can have far-reaching consequences, as observed with dry mouth, which is associated with increased orodental disease, speech impairment, dysphagia, and a significant negative effect on quality of life. The timely diagnosis of oral dryness is vital for the management of orodental disease and any associated (...) often-undiagnosed systemic disease (e.g., Sjögren syndrome). Our aim was to investigate differences in mucin glycoproteins and saliva rheological properties between sufferers and nonsufferers of dry mouth in order to understand the relationship between saliva composition, rheological properties, and dryness perception and provide additional potential diagnostic markers. All patients exhibited objective and subjective oral dryness, irrespective of etiology. Over half of the patients (n = 20, 58.8

2015 Journal of Dental Research

100. Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. (Abstract)

Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. Reports on post-surgical pain are a few, controversial and flawed (by statistics and analgesic consumption). Besides, it is not known if chlorhexidine can reduce post-extraction pain adjusting for its effect on prevention of infection and dry socket (DS). We assessed these. A total of 90 impacted (...) mandibular third molars of 45 patients were extracted. Intra-alveolar 0·2% chlorhexidine gel was applied in a split-mouth randomised design to one-half of the sockets. None of the included patients took antibiotics or analgesics afterwards. In the first and third post-operative days, DS formation and pain levels were recorded. Predictive roles of the risk factors were analysed using fixed-effects (classic) and multilevel (mixed-model) multiple linear regressions (α = 0·05, β≤0·1). In the first day, pain

2015 Journal of oral rehabilitation Controlled trial quality: uncertain

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