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Dry Mouth

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81. A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Patients and Patients With Average to Very Serious Psoriasis

: NCT03329885 Recruitment Status : Terminated (Adverse change in the risk/benefit) First Posted : November 6, 2017 Last Update Posted : July 23, 2018 Sponsor: Bristol-Myers Squibb Information provided by (Responsible Party): Bristol-Myers Squibb Study Details Study Description Go to Brief Summary: The purpose of this study is to investigate experimental medication BMS-986251 taken by mouth in healthy patients and patients with average to very serious Psoriasis (a condition characterized by itchy, dry skin (...) A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Patients and Patients With Average to Very Serious Psoriasis A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Patients and Patients With Average to Very Serious Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2017 Clinical Trials

82. Influence of Mouth Breathing on Periodontal Healing

provided by (Responsible Party): Postgraduate Institute of Dental Sciences Rohtak Study Details Study Description Go to Brief Summary: Studies reveal association between dry conditions and decreased healing in wounds or any treatment. From these studies, it can be hypothesized that healing in mouth breathers after scaling and root planing in terms of bleeding on probing, gingival index, plaque Index, clinical attachment level, probing depth may not show as much improvement as in case of nose breathers (...) Influence of Mouth Breathing on Periodontal Healing Influence of Mouth Breathing on Periodontal Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Influence of Mouth Breathing on Periodontal Healing

2017 Clinical Trials

83. Healing of extraction socket following local application of simvastatin: A split mouth prospective study (PubMed)

Healing of extraction socket following local application of simvastatin: A split mouth prospective study The role of simvastatin in lowering serum cholesterol level is well described. However, recent findings suggest they have a role in bone formation as well.The present prospective study was conducted to evaluate the efficacy of simvastatin on bone formation in extraction sockets.15 patients undergoing all four first premolar extraction were selected based on inclusion and exclusion criteria (...) . Extraction sockets of left premolars (24 and 34) were considered as cases and right premolars (14 and 44) as controls. Overall 30 extraction sites were assigned to each group. Atraumatic extraction was done in all cases following which simvastatin mixed with gelatin sponge was placed in extraction socket of 24 and 34 while only gelatin sponge was placed in 14 and 44. All sockets were then closed with 3-0 vicryl. The patients were kept on follow-up and complications such as dry socket, pain, and swelling

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2017 Journal of oral biology and craniofacial research

84. Patients with burning mouth sensations. A clinical investigation of causative factors in a group of “compete denture wearers” Jordanian population (PubMed)

associations were found between local factors (i.e., wearing complete dentures with unsatisfactory retention or jaw relationship, dry mouth or candidasis) and patients suffering from burning mouth sensation. The results also show that some systemic or psychological disorders were significantly more present among patients with burning mouth symptoms when compared to the control group (p < 0.05).Spontaneous symptoms of burning mouth without mucosal signs should be considered as a manifestation of undermind (...) Patients with burning mouth sensations. A clinical investigation of causative factors in a group of “compete denture wearers” Jordanian population To find out the prevalence of "true" burning mouth syndrome and study the association between patients' spontaneous complaints of burning mouth and systemic conditions in a group of middle age and elderly "denture wearers" patients in Jordan.A group of 129 patients (112 female and 17 male) of "complete denture wearers" subjects aged 40 years

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2017 The Saudi dental journal

85. Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials. (PubMed)

Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials. It is estimated that 39,000 Australians die from malignant disease yearly. Of these, 60% to 88% of advanced cancer patients suffer xerostomia, the subjective feeling of mouth dryness. Xerostomia has significant physical, social and psychological consequences which compromise function and quality of life. Pilocarpine is one treatment for xerostomia. Most studies have shown some (...) variation in individual response to pilocarpine, in terms of dose used, and timing and extent of response.We will determine a population estimate of the efficacy of pilocarpine drops (6 mg) three times daily compared to placebo in relieving dry mouth in palliative care (PC) patients. A secondary aim is to assess individual patients' response to pilocarpine and provide reports detailing individual response to patients and their treating clinician.Aggregated n-of-1 trials (3 cycle, double blind, placebo

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2013 BMC Palliative Care

86. Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome

Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Laser Therapy to Treat the Dry Mouth (...) feels dry when eating a meal I get up at night to drink My mouth feels dry I have difficulty in eating dry foods I suck sweets or cough lollies to relieve dry mouth I have difficulties swallowing certain foods The skin of my face feels dry My eyes feel dry My lips feel dry The inside of my nose feels dry __________________________________________________________ Score: Never' (1), Hardly ever' (2), Occasionally' (3), Fairly often' (4), Very often' (5) Secondary Outcome Measures : Salivary Biomarker

2013 Clinical Trials

87. Xylitol Disk Use in Adults With Dry Mouth

Xylitol Disk Use in Adults With Dry Mouth Xylitol Disk Use in Adults With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Xylitol Disk Use in Adults With Dry Mouth The safety and scientific (...) : The purpose of this study is to demonstrate whether decay causing bacteria are reduced when adhesive xylitol disks are used intraorally three times a day for two weeks in adults with dry mouth. Condition or disease Intervention/treatment Phase Mutans Streptococci Xerostomia Other: Xylitol disk Not Applicable Detailed Description: Xylitol,an FDA approved sugar substitute, has been shown to reduce tooth decay. Patients who experience dry mouth may be more susceptible to dental decay because they lack

2013 Clinical Trials

88. Information for Physicians and Pharmacists About Drugs That Might Cause Dry Mouth: A Study of Monographs and Published Literature. (PubMed)

Information for Physicians and Pharmacists About Drugs That Might Cause Dry Mouth: A Study of Monographs and Published Literature. Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health.The objectives of this study were to (1) identify warnings in the literature about dry mouth associated with the most (...) journals.The CPS provided monographs for 43% of the medications, and requests to manufacturers produced the remaining monographs. Mentions of dry mouth were identified in 61% of the products (43% amongst CPS monographs; an additional 43% amongst manufacturers' monographs; 7% in the DailyMed database and 7% from biomedical journals); five medications had contradictory reports in different monographs.Nearly two-thirds (61%) of the most commonly prescribed medications can cause dry mouth, yet warnings about

2013 Drugs & Aging

89. Effects of Intra-alveolar Placement of 0.2% Chlorhexidine Bioadhesive Gel on Dry Socket Incidence and Postsurgical Pain: A Double-Blind Split-Mouth Randomized Controlled Clinical Trial. (PubMed)

Effects of Intra-alveolar Placement of 0.2% Chlorhexidine Bioadhesive Gel on Dry Socket Incidence and Postsurgical Pain: A Double-Blind Split-Mouth Randomized Controlled Clinical Trial. To assess the effects of intra-alveolar application of chlorhexidine gel on the incidence of alveolar osteitis (dry socket) and the severity of postsurgical pain.A total of 160 impacted mandibular third molars were extracted in 80 patients enrolled in this trial. In each subject, a socket was randomly selected (...) and packed to the crest of the alveolar ridge with a gelatin sponge dressing saturated in 0.2% chlorhexidine gel. The contralateral socket was packed with a dry dressing as the placebo. None of the included patients took antibiotics or analgesics. The occurrence of dry socket and patients' pain levels were assessed at the first and third postoperative days. The data were analyzed using Spearman correlation coefficient, McNemar, Wilcoxon, and chi-square tests.Chlorhexidine gel significantly reduced dry

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2013 Journal of orofacial pain

90. The efficacy of a topical sialogogue spray containing 1% malic Acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. (PubMed)

The efficacy of a topical sialogogue spray containing 1% malic Acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. One of the most important antidepressants side effects is dry mouth. The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by dry mouth caused by antidepressants drug.This research took the form of a double-blind, randomized clinical trial at Faculty (...) of Dentistry of University of Granada (Spain). Seventy participants with antidepressant-induced dry mouth were divided into two groups: for the first "intervention group" (35 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second "control group" (35 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The dry mouth questionnaire (DMQ) was used to evaluate dry mouth symptoms before and after product/placebo application

2013 Depression and anxiety

91. Drowning in a sea of misinformation: Dry drowning and secondary drowning

is why we encourage people to seek care immediately when they have warning signs like chest pain. The warning signs for drowning are submersion or immersion followed by difficulty breathing, excessive coughing, foam in the mouth, and not acting normally. Subsequent death or complication from drowning is no more a secondary or delayed drowning than subsequent death or complication from heart attack is a secondary or delayed heart attack. 4. The bottom line. Near, dry, wet, delayed, and secondary (...) Drowning in a sea of misinformation: Dry drowning and secondary drowning Drowning in a sea of misinformation: Dry drowning and secondary drowning Drowning in a sea of misinformation: Dry drowning and secondary drowning | | July 6, 2017 203 Shares Recently, a young child died following days of vomiting. He had been in shallow water in a Texas dike about a week before his death. The story was picked up as an alleged case of a rare condition called . The media accounts went viral, spreading

2017 KevinMD blog

92. Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome. (PubMed)

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome. Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Fluoromethalone eye drops over 8 weeks were more effective (...) than topical cyclosporine in the treatment of dry eye symptoms and signs; similarly, indomethacin eye drops over 1 month were more efficacious than diclofenac eye drops. Oral pilocarpine 5 mg twice daily over 3 months was superior to use of lubricants or punctal plugs for treating dry eye, but 5% of participants had gastrointestinal adverse effects from pilocarpine, though none discontinued treatment. In contrast, etanercept, a TNF-alpha blocking antibody, administered as subcutaneous injections

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2017 Journal of inflammation (London, England)

93. Lacripep™ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome

Keratoconjunctivitis Sicca Dry Eye Syndromes Sjogren's Syndrome Disease Pathologic Processes Keratoconjunctivitis Conjunctivitis Conjunctival Diseases Eye Diseases Keratitis Corneal Diseases Lacrimal Apparatus Diseases Arthritis, Rheumatoid Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Xerostomia Salivary Gland Diseases Mouth Diseases Stomatognathic Diseases Connective Tissue Diseases Autoimmune Diseases Immune System Diseases Pharmaceutical Solutions Ophthalmic Solutions (...) Lacripepâ„¢ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome Lacripep™ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

94. A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain

A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03236779 Recruitment Status : Recruiting First Posted : August 2, 2017 Last Update Posted : November 21

2017 Clinical Trials

95. Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome

Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2017 Clinical Trials

96. The Effects of Dietary Supplementation With a Combination of Flaxseed Oil, Borage Oil and Fish Oil Omega-3 Fatty Acids on Ocular Comfort Including Symptoms of Dry Eye

The Effects of Dietary Supplementation With a Combination of Flaxseed Oil, Borage Oil and Fish Oil Omega-3 Fatty Acids on Ocular Comfort Including Symptoms of Dry Eye The Effects of Dietary Supplementation With a Combination of Flaxseed Oil, Borage Oil and Fish Oil Omega-3 Fatty Acids on Ocular Comfort Including Symptoms of Dry Eye - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms (...) x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Dietary Supplementation With a Combination of Flaxseed Oil, Borage Oil and Fish Oil Omega-3 Fatty Acids on Ocular Comfort Including Symptoms of Dry Eye The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2017 Clinical Trials

97. LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients

terms: Layout table for MeSH terms Syndrome Keratoconjunctivitis Sicca Dry Eye Syndromes Sjogren's Syndrome Disease Pathologic Processes Keratoconjunctivitis Conjunctivitis Conjunctival Diseases Eye Diseases Keratitis Corneal Diseases Lacrimal Apparatus Diseases Arthritis, Rheumatoid Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Xerostomia Salivary Gland Diseases Mouth Diseases Stomatognathic Diseases Connective Tissue Diseases Autoimmune Diseases Immune System Diseases (...) LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. LAMELLEYE for the Treatment

2017 Clinical Trials

98. Fracture Toughness of Nanohybrid and Hybrid Composites Stored Wet and Dry up to 60 Days (PubMed)

) The effect of time on fracture toughness was material dependent.Wet storage adversely affected the fracture toughness of almost all materials. Keeping the restoration dry in the mouth may increase their fracture toughness. Therefore, using a coating agent on the surface of restoration may protect them from early water uptake and increase their strength during a time period. (...) Fracture Toughness of Nanohybrid and Hybrid Composites Stored Wet and Dry up to 60 Days Patients' demand for tooth-colored restoratives in the posterior region is increasing. Clinicians use universal nanohybrid resin composites for both anterior and posterior regions. There are few published reports comparing fracture toughness of nonohybrids and that of hybrid composite stored wet and dry.To investigate the fracture toughness of three nanohybrids compared to that of a hybrid resin composite

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2017 Journal of Dental Biomaterials

99. In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy (PubMed)

In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy Combining in vitro mouth-throat deposition measurements, cascade impactor data and computational fluid dynamics (CFD) simulations, four different inhalers were compared which are indicated for chronic obstructive pulmonary disease (COPD) treatment.The Respimat inhaler, the Breezhaler, the Genuair, and the Ellipta were coupled to the idealized Alberta throat model. The modeled dose to the lung (...) %) and 41% (SD 2%), respectively for the two breathing patterns. Based on the throat output and average flows of the different inhalers, CFD simulations were performed. Laminar and turbulent steady flow calculations indicated that deposition occurs mainly in the small airways. In summary, Respimat showed the lowest amount of particles depositing in the mouth-throat model and the highest amount reaching all regions of the simulation lung model.

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2017 International journal of chronic obstructive pulmonary disease

100. Rapid Induction of Therapeutic Hypothermia Using Transnasal High Flow Dry Air (PubMed)

Rapid Induction of Therapeutic Hypothermia Using Transnasal High Flow Dry Air Early induction of therapeutic hypothermia (TH) is recommended in out-of-hospital cardiac arrest (CA); however, currently no reliable methods exist to initiate cooling. We investigated the effect of high flow transnasal dry air on brain and body temperatures in adult porcine animals. Adult porcine animals (n = 23) under general anesthesia were subject to high flow of transnasal dry air. Mouth was kept open to create (...) a unidirectional airflow, in through the nostrils and out through the mouth. Brain, internal jugular, and aortic temperatures were recorded. The effect of varying airflow rate and the air humidity (0% or 100%) on the temperature profiles were recorded. The degree of brain cooling was measured as the differential temperature from baseline. A 10-minute exposure of high flow dry air caused rapid cooling of brain and gradual cooling of the jugular and the aortic temperatures in all animals. The degree of brain

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2017 Therapeutic hypothermia and temperature management

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