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Dry Mouth

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81. Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine. Full Text available with Trip Pro

Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine. We investigated the long-term relationships between dry mouth, fluid intake and overactive bladder symptoms in women undergoing treatment with fesoterodine. We hypothesized that women who experienced dry mouth would increase their fluid intake and worsen their urinary symptoms.We conducted a prospective ancillary study to a 9-month open-label trial of fesoterodine for women with urgency urinary (...) incontinence. Fluid intake was measured and compared according to reported dry mouth. Multivariable analysis was used to study the interaction between dry mouth, fluid intake and urinary symptoms.During the study 407 women without dry mouth significantly reduced their fluid intake (mean decrease 172.1 ml, median 118.3 ml, p = 0.02), while 91 women with dry mouth did not (mean decrease 95.8 ml, median 118.3 ml, p = 0.54). On univariable analysis a greater proportion of women who experienced dry mouth

2016 The Journal of urology Controlled trial quality: uncertain

82. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications.

Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. (LactoXeros) The safety and scientific validity of this study

2016 Clinical Trials

83. Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects

history or upon oral examination Participant reports having a feeling of a dry mouth according to the Dry Mouth Screening Questionnaire (DMSQ) (Subject must answer at least 2 out of the 4 questions with 'agree a little', 'agree' or 'strongly agree' at the Screening Visit (Visit 1). Participants with un-stimulated whole salivary flow rate of ≤0.1 ml/min at the Screening Visit (Visit 1). Participants with un-stimulated whole salivary flow rate of ≤0.1 ml/min ATH the Screening Visit (Visit 1 (...) in the study e.g. Alzheimer's Disease Participant with untreated oral mucosal disease which in the opinion of the investigator could interfere with the study (e.g. current oral ulceration) Evidence of gross intra-oral neglect or need for extensive dental therapy Denture wearer (complete dentures) Participant not on stable doses of prescription systemic parasympathetic medications (e.g. Pilocarpine), for the treatment of the feeling of dry mouth Known or suspected intolerance or hypersensitivity

2016 Clinical Trials

84. The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease

The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02802150 Recruitment Status : Completed First Posted : June 16, 2016 Last Update Posted : June 16, 2016 Sponsor: Chonbuk National University

2016 Clinical Trials

85. Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes. Full Text available with Trip Pro

Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes. To assess the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, matrix metalloproteinase-9 (MMP-9), tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), fluorescein corneal staining, Schirmer score, meibomian gland dysfunction (MGD) stage and omega-3 index in subjects with dry eyes and confirmed MGD.This was a multicenter, prospective, interventional, placebo-controlled, double-masked (...) control group (67.9% vs. 35.0%, P = 0.024) and OSDI scores decreased significantly in omega-3 (-17.0 ± 2.6) versus control group (-5.0 ± 2.7, P = 0.002).Oral consumption of re-esterified omega-3 fatty acids is associated with statistically significant improvement in tear osmolarity, omega-3 index levels, TBUT, MMP-9, and OSDI symptom scores.

2016 Cornea Controlled trial quality: uncertain

86. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. Full Text available with Trip Pro

A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES).A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus (...) ) with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer's test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS) in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance.Forty-three

2016 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

87. Dry socket – oral contraceptives may increase incidence

osteitis) is not fully understood and a number of factors have been implicated including surgical trauma, surgeons experience, perioperative patient stress factors and focal fibrinolytic activity. A number of additional risk factors including smoking, age, gender and oral contraceptive use, menstrual cycle and the use of antimicrobial drugs and mouth rinses have also been suggested. The aim of this review was to assess the association between oral contraceptive use and the development of dry socket (...) Dry socket – oral contraceptives may increase incidence Dry socket: oral contraceptives may increase incidence Search National Elf Service Search National Elf Service » » » » Dry socket – oral contraceptives may increase incidence Jul 16 2015 Posted by Dry Socket is a complication that can follow tooth extraction occurring in 1%- 5% of routine extractions. It is more common following the extraction of third molars with rates of between 1% – 37% reported. The aetiology of dry socket (alveolar

2015 The Dental Elf

88. Dry eye syndrome

information, see the CKS topic on . Past medical history of conditions associated with dry eye such as rosacea, psoriasis, atopy, Sjögren's syndrome, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, menopause, lymphoma, chronic viral infections (for example HIV and hepatitis C), orbital radiation and neurological conditions (for example Parkinson disease or Bell’s palsy). Associated features indicative of an undiagnosed underlying condition such as dry mouth, dental cavities, oral ulcers (...) , fatigue, joint or muscle pain. Systemic medications associated with dry eye such as retinoids, oral contraception, hormone replacement therapy, beta-blockers, anticholinergics, diuretics, antihistamines, antidepressants, and isotretinoin. Trauma to the eye area. Social history including smoking, alcohol, and occupation. Examine the person, checking: Visual acuity – visual acuity should not be severely impaired with dry eye syndrome. For of dry eye syndrome such as mild conjunctival redness – in many

2017 NICE Clinical Knowledge Summaries

89. The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review. (Abstract)

The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review. Primary Sjögren's syndrome (pSS) is a frequent autoimmune systemic disease, clinically characterized by eyes and mouth dryness in all patients, salivary gland swelling or extraglandular systemic manifestations in half of the patients, and development of lymphoma in 5 to 10 % of the patients. However, patients presenting with sicca symptoms or salivary gland swelling may have a variety of conditions (...) that may require very different investigations, treatments, or follow-up. Eye and/or mouth dryness is a frequent complaint in clinical setting, and its frequency increases with age. When evaluating a patient with suspected pSS, the first step is to rule out its differential diagnoses, before looking for positive arguments for the disease. Knowledge of normal and abnormal lachrymal and salivary gland physiology allows the clinician to prescribe the most adapted procedures for evaluating their function

2014 Clinical Reviews in Allergy & Immunology

90. Effect of Oral Lactoferrin on Cataract Surgery Induced Dry Eye: A Randomised Controlled Trial. Full Text available with Trip Pro

Effect of Oral Lactoferrin on Cataract Surgery Induced Dry Eye: A Randomised Controlled Trial. Cataract surgery is one of the most frequently performed intra-ocular surgeries, of these manual Small Incision Cataract Surgery (SICS) is a time tested technique of cataract removal. Any corneal incisional surgery, including cataract surgery, can induce dry eye postoperatively. Various factors have been implicated, of which oneis the inflammation induced by the surgery. Lactoferrin, a glycoprotein (...) present in tears is said to have anti-inflammatory effects, and promotes cell growth. It has been used orally in patients of immune mediated dry eye to alleviate symptoms.This study was aimed to evaluate the dry eyes induced by manual Small Incision Cataract Surgery, and the effect if any, of oral lactoferrin on the dry eyes.A single centre, prospective randomised controlled trial with a concurrent parallel design. The study was carried out on patients presenting in the OPD of Rohilkhand Medical

2015 Journal of clinical and diagnostic research : JCDR Controlled trial quality: uncertain

91. Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. (Abstract)

Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. Saliva is vital for the maintenance of normal oral physiology and mucosal health. The loss of salivary function can have far-reaching consequences, as observed with dry mouth, which is associated with increased orodental disease, speech impairment, dysphagia, and a significant negative effect on quality of life. The timely diagnosis of oral dryness is vital for the management of orodental disease and any associated (...) often-undiagnosed systemic disease (e.g., Sjögren syndrome). Our aim was to investigate differences in mucin glycoproteins and saliva rheological properties between sufferers and nonsufferers of dry mouth in order to understand the relationship between saliva composition, rheological properties, and dryness perception and provide additional potential diagnostic markers. All patients exhibited objective and subjective oral dryness, irrespective of etiology. Over half of the patients (n = 20, 58.8

2015 Journal of Dental Research

92. Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. (Abstract)

Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. Reports on post-surgical pain are a few, controversial and flawed (by statistics and analgesic consumption). Besides, it is not known if chlorhexidine can reduce post-extraction pain adjusting for its effect on prevention of infection and dry socket (DS). We assessed these. A total of 90 impacted (...) mandibular third molars of 45 patients were extracted. Intra-alveolar 0·2% chlorhexidine gel was applied in a split-mouth randomised design to one-half of the sockets. None of the included patients took antibiotics or analgesics afterwards. In the first and third post-operative days, DS formation and pain levels were recorded. Predictive roles of the risk factors were analysed using fixed-effects (classic) and multilevel (mixed-model) multiple linear regressions (α = 0·05, β≤0·1). In the first day, pain

2015 Journal of oral rehabilitation Controlled trial quality: uncertain

93. Oral contraceptives use may increase incidence of dry sockets. (Abstract)

Oral contraceptives use may increase incidence of dry sockets. 26492809 2016 05 24 2018 12 02 1476-5446 16 3 2015 Sep Evidence-based dentistry Evid Based Dent Oral contraceptives use may increase incidence of dry sockets. 92 10.1038/sj.ebd.6401122 Spivakovsky Silvia S NYU College of Dentistry, New York, USA. Spivakovsky Yael Y NYU College of Dentistry, New York, USA. eng Journal Article Comment England Evid Based Dent 100883603 1462-0049 0 Contraceptives, Oral D IM Int J Oral Maxillofac Surg (...) . 2015 Sep;44(9):1160-5 26116066 Contraceptives, Oral adverse effects Dry Socket chemically induced Female Humans Mandible surgery Molar, Third surgery Tooth Extraction Tooth, Impacted surgery 2015 10 24 6 0 2015 10 24 6 0 2016 5 25 6 0 ppublish 26492809 6401122 10.1038/sj.ebd.6401122

2015 Evidence Based Dentistry

94. Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms

nowadays; Q44:Dry mouth is a quality of life issue; Q45:My dry mouth stops me enjoying things; Q46:How would you rate your oral health overall?, and Think back over last week about things you have done to relieve your symptoms. How much do you agree or disagree that those things have made following symptoms more manageable? M1: Uncomfortable; M2: Bad taste; M3:Loss of Taste; M4: Lips sticking to roof of mouth; M5: Tongue sticking to roof of mouth; M6: Throat dry; M7: No moisture M8:Devoid of any (...) that symptoms were manageable (M). Q40:It's a big issue for me; Q41:My dry mouth makes me feel different to other people; Q42:My mouth is deteriorating, Dry mouth can also affect your quality of life. Q43:Dry mouth is part of my life nowadays; Q44:Dry mouth is a quality of life issue; Q45:My dry mouth stops me enjoying things; Q46:How would you rate your oral health overall?, and Think back over last week about things you have done to relieve your symptoms. How much do you agree or disagree that those

2015 Clinical Trials

95. Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye. (Abstract)

Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye. To assess the efficacy of dietary consumption of omega-3 fatty acids (O3FAs) on dry eye symptoms, Schirmer test, tear film break up time (TBUT) and conjunctival impression cytology (CIC) in patients with computer vision syndrome.Interventional, randomized, double blind, multi-centric study.Four hundred and seventy eight symptomatic patients using computers for more than 3h per day for minimum 1 year were randomized (...) dietary intervention, the mean symptom score, Schirmer, TBUT and CIC scores were 7.5±2, 19.9±4.7mm, 11.5±2s and 1±0.9 respectively, and 3 months later were 6.8±2.2, 20.5±4.7mm, 12±2.2s and 0.9±0.9 respectively. In the O3FA group, these values were 8.0±2.6, 20.1±4.2mm, 11.7±1.6s and 1.2±0.8 before dietary intervention and 3.9±2.2, 21.4±4mm, 15±1.7s, 0.5±0.6 after 3 months of intervention, respectively.This study demonstrates the beneficial effect of orally administered O3FAs in alleviating dry eye

2015 Contact lens & anterior eye : the journal of the British Contact Lens Association Controlled trial quality: predicted high

96. Oral omega-3 Fatty Acid treatment for dry eye in contact lens wearers. Full Text available with Trip Pro

Oral omega-3 Fatty Acid treatment for dry eye in contact lens wearers. The aim of this study was to evaluate the effect of dietary omega-3 fatty acid (O3FA) supplementation on dry eye symptoms, tear film tests, and conjunctival impression cytology in patients with contact lens wear-associated dry eye.In this randomized, double-blind, multicentric trial, contact lens wearers (n = 496) were randomized to receive either O3FAs or placebo capsules (corn oil) twice daily for 6 months. Subjects (...) )] was relatively small (P = 0.08).The results of this study point toward benefits of orally administered O3FAs in alleviating dry eye symptoms, improving lens wear comfort, and cytological changes in contact lens wearers.

2015 Cornea Controlled trial quality: predicted high

97. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. Full Text available with Trip Pro

Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. Dry mouth is a common complication of radiotherapy for head and neck cancers. This study compared the efficacy of an herbal compound containing Malva sylvestris and Alcea digitata (Boiss) with artificial saliva (Hypozalix) for improving the symptoms of dry mouth in head and neck cancer patients. The study examined a total of 62 subjects assigned to 2 groups. The herbal (...) compound and Hypozalix were administered for 4 weeks. Efficacy was assessed using the visual analog scale and by grading the degree of dry mouth. Both groups showed a significant difference between visual analog scale before and following intervention. There was also a significant difference in visual analog scale between groups at 4 weeks after onset of intervention. The herbal group showed a significant difference between the grade of dry mouth before and after intervention, but no change

2015 Journal of evidence-based complementary & alternative medicine Controlled trial quality: uncertain

98. Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model. (Abstract)

Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model. Pruritus and discomfort are often present in patients with xerosis and atopic dermatitis. Several studies suggest an important role of diet in skin pathophysiology.This study evaluated the effect of dietary fatty acids in the skin physiology via an itch-related animal model with and without supplementation with fish oil (FO), a source of polyunsaturated fatty acids (PUFA), especially omega (...) 3 (n-3).Male Wistar rats were divided into two groups-non-supplemented (control) and supplemented with FO (3g/kg/day) by gavage for 90 days. Every 30 days, scratching and skin parameters (transepidermal water loss (TEWL), hydration, and local blood flow) were evaluated before and after dorsal skin exposure to acetone to induce the itch-related dry skin. At the end of the study, animals were sacrificed, and skin samples collected for fatty acids composition analysis by GC-FID.FO supplementation

2015 Journal of dermatological science

99. A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids Full Text available with Trip Pro

A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids We used nuclear magnetic resonance spectroscopy of hydrogen-1 nuclei ((1)H NMR S) to analyze the metabolic profile of reflex tears from patients with dry eye disorders.We performed a prospective case-control study involving 90 participants: 55 patients diagnosed with dry eye syndrome (DESG) and 35 healthy subjects (control group, CG). From the DESG, two subgroups were formed: mild (...) DES (n=22) and moderate DES (n=33). Participants were prescribed an oral nutraceutic supplementation containing antioxidants and essential polyunsaturated fatty acids to be taken as three capsules per day for 3 months. Reflex tears (20-30 µl) were collected from the tear meniscus of both eyes of each subject with a microglass pipette. Nuclear magnetic resonance (NMR) spectra were acquired with a standard one-dimensional pulse sequence with water suppression; 256 free induction decays were

2015 Molecular vision

100. Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics. (Abstract)

Dry Eye Assessment and Management (DREAM©) Study: Study design and baseline characteristics. Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study.Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED).RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline

2018 Contemporary clinical trials Controlled trial quality: uncertain

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