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Dry Mouth

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61. Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis. Full Text available with Trip Pro

the efficacy of an inhaled dry powder combination, referred to as Pyrazinoic acid/ester Dry Powder (PDP), which is comprised of pyrazinoic acid (POA), the active moiety of PZA, and pyrazinoic acid ester (PAE), which is a PZA analog. Both POA and PAE have the advantage of being able to act on PZA-resistant Mycobacterium tuberculosis. When used in combination with oral rifampicin (R), inhaled PDP had striking effects on tissue pathology. Effects were observed in lungs, the site of delivery, but also (...) Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis. New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a critical component of current first-line TB therapy. However, the rise in PZA-resistant TB cases jeopardizes the future utility of PZA. To address this problem, we used the guinea pig model of TB and tested

2018 PLoS ONE

62. Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide. Full Text available with Trip Pro

Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide. Prothionamide (PTH), a second line antitubercular drug is used to administer in conventional oral route. However, its unpredictable absorption and frequent administration limit its use. An alternate approach was thought of administering PTH through pulmonary route in a form of nanoparticles, which can sustain the release for several hours in lungs. Chitosan, a bio-degradable polymer (...) was used to coat PTH and further freeze dried to prepare dry powder inhaler (DPI) with aerodynamic particle size of 1.76μm. In vitro release study showed initial burst release followed by sustained release up to 96.91% in 24h. In vitro release further correlated with in vivo study. Prepared DPI maintained the PTH concentration above MIC for more than 12h after single dose administration and increased the PTH residency in the lungs tissue more than 24h. Animal study also revealed the reduction of dose

2018 PLoS ONE

63. Severe sialorrhoea (drooling) in children and young people with chronic neurological disorders: oral glycopyrronium bromide

neurological disorders: oral glycopyrronium bromide (ES5) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 34Safety Safety The SPC states that adverse effects are common with glycopyrronium bromide due to its anticholinergic action. The most common adverse reactions include dry mouth, constipation, diarrhoea, vomiting, urinary retention, flushing and nasal congestion. The SPC advises that anticholinergic adverse (...) %) Patients reporting any adverse event 20/20 (23%) 15/18 (83%) Not reported Severe sialorrhoea (drooling) in children and young people with chronic neurological disorders: oral glycopyrronium bromide (ES5) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 26 of 34Patients reporting an adverse event considered to be treatment-related 15/20 (75%) 7/18 (39%) Dry mouth 8/20 (40%) 2/18 (11%) Constipation 6/20 (30%) 4/18 (22

2017 National Institute for Health and Clinical Excellence - Advice

64. Restoration Materials in Dry Mouth Patients

Restoration Materials in Dry Mouth Patients UTCAT789, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Restoration Materials In Dry Mouth Patients Clinical Question For a patient with dry mouth, which restorative material, amalgam or resin composite, has the lowest incidence of recurrent caries? Clinical Bottom Line Glass ionomer has the lowest incidence of recurrent caries when compared to amalgam. (See Comments (...) the success of resin restorations are compared to amalgam restorations in xerostomic patients. No potential harm to the patient. Patient benefit is the placement of the most successful restorative material. Specialty/Discipline (General Dentistry) (Restorative Dentistry) Keywords Dry mouth, xerostomia, amalgam, resin composite, caries ID# 789 Date of submission: 04/14/2011 E-mail garciam30@livemail.uthscsa.edu Author Meagan D. Garcia Co-author(s) Co-author(s) e-mail Faculty mentor/Co-author Vidya Sankar

2011 UTHSCSA Dental School CAT Library

65. The impact of poor oral health on the oral health-related quality of life (OHRQoL) in older adults: the oral health status through a latent class analysis. Full Text available with Trip Pro

(GOHAI). Clinical evaluation of their oral health: painful chewing, use of dentures, dry mouth, xerostomia, plaque, calculus, coronal and root caries, tooth loss and gingival bleeding. Finally, we determined the oral health of participants through Latent Class Analysis (LCA), excluding totally edentulous. The strength of association was determined (Odds Ratio [OR] and 95% confidence interval [95% CI]) through logical regression between the oral health categories (latent classes) and OHRoL in older (...) The impact of poor oral health on the oral health-related quality of life (OHRQoL) in older adults: the oral health status through a latent class analysis. Determine the impact of poor oral health on the oral health-related quality of life (OHRQoL) in community-dwelling older adults.Cross-sectional study of community-dwelling older adults in Mexico City. Sociodemographic characteristics were obtained and assessed their OHRQoL according to the Geriatric/General Oral Health Assessment Index

2019 BMC Oral Health

66. Mouth Care

complications. Key principles Assess every patient Plan regular effective mouth care Confidence to refer Identify urgent referrals. Assessment All patients are at risk of oral problems and will benefit from planned regular mouth care, particularly patients receiving chemotherapy or radiotherapy who will need careful monitoring both pre- and post-treatment. Drug history is significant as numerous medications can affect the oral environment: opioids, diuretics and anticholinergics increase dry mouth steroids (...) increase the risk of candidosis bisphosphonates increase the risk of osteonecrosis of the jaw. Ill-fitting dentures and surgical intervention including tooth extraction increase this risk, highlighting the need for preventative oral hygiene therapy. Ask patients on a daily basis if they are having problems Ensure privacy Remove dentures before examining the mouth or performing routine mouth care Use a torch to thoroughly examine the mouth Check the lining of the mouth is clean. If not, refer to dry

2018 Scottish Palliative Care Guidelines

67. Prospective Assessment of Patient-Reported Dry Eye Syndrome After Whole Brain Radiation. (Abstract)

Prospective Assessment of Patient-Reported Dry Eye Syndrome After Whole Brain Radiation. Dry eye is not typically considered a toxicity of whole brain radiation therapy (WBRT). We analyzed dry eye syndrome as part of a prospective study of patient-reported outcomes after WBRT.Patients receiving WBRT to 25 to 40 Gy were enrolled on a study with dry mouth as the primary endpoint and dry eye syndrome as a secondary endpoint. Patients received 3-dimensional WBRT using opposed lateral fields. Per (...) standard practice, lacrimal glands were not prospectively delineated. Patients completed the Subjective Evaluation of Symptom of Dryness (SESoD, scored 0-4, with higher scores representing worse dry eye symptoms) at baseline, immediately after WBRT (EndRT), and at 1 month (1M), 3 months, and 6 months. Patients with baseline SESoD ≥3 (moderate dry eye) were excluded. The endpoints analyzed were ≥1-point and ≥2-point increase in SESoD score at 1M. Lacrimal glands were retrospectively delineated

2019 Biology and Physics

68. The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial. (Abstract)

. The mean pain severity dropped significantly in Group A. Fennel seed infusion plus a dry cupping uses a safe and effective therapeutic intervention in the management of oligomenorrhoea. IMPACT STATEMENT What is already known on this subject? Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. Some common clinical manifestations of this syndrome include menstrual disorders such as oligomenorrhoea and amenorrhoea. The recommended therapeutic interventions include oral intervention (...) The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial. Oligomenorrhoea treatment with hormone therapy and Metformin is not usually well tolerated and is associated with a broad range of side effects. In Persian medicine, the management of oligomenorrhoea can be done with fennel and dry cupping. A clinical trial was conducted on 61 patients with oligomenorrhoea. The patients

2019 Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Controlled trial quality: uncertain

69. Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA. Full Text available with Trip Pro

Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA. Mixed inhaler device use for asthma is associated with worse inhaler technique and outcomes. Given that relievers are commonly prescribed as pressurized metred-dose inhalers (pMDI), changing preventers from dry powder inhalers (DPI) to pMDI may improve asthma outcomes. This study aimed to assess the persistence and effectiveness (...) respiratory diagnosis or acute course of oral corticosteroids) and overall asthma control (OAC; RDAC and ≤ 200 μg salbutamol/≤500 μg terbutaline average daily dose) comparing 1 year after and before the switch.Within 85 patients who switched from DPI to pMDI and persisted for a year, higher proportion were free from asthma exacerbation after the switch (mean difference in proportion = 0.129, 95% CI: 0.038-0.220). Switching to pMDI was also associated with better RDAC (75.3% vs 57.7%, P = 0.001) and OAC

2019 Respirology

70. Meibomian Gland Dysfunction and Dry Eye are Similar, but Different based on a Population-Based Study (Hirado-Takushima Study) in Japan. Full Text available with Trip Pro

Meibomian Gland Dysfunction and Dry Eye are Similar, but Different based on a Population-Based Study (Hirado-Takushima Study) in Japan. To evaluate the prevalence and risk factors of and the relation between meibomian gland dysfunction (MGD) and dry eye (DE) in Japan.A population-based cross-sectional study.Participants filled in questionnaires regarding ocular symptoms, systemic diseases, and lifestyle factors. Meibomian gland-related parameters and tear film-related parameters were evaluated (...) was 32.9% and 33.4%, respectively, with a coexistence rate of 12.9%. The prevalence of MGD was associated with male sex (odds ratio [OR], 2.42), age (OR per decade increment,1.53), and oral intake of lipid-lowering agents (OR, 3.22). The prevalence of DE was associated with female sex (OR, 3.36), contact lens wear (OR, 2.84), conjunctivochalasis (OR, 2.57) and lid margin abnormalities (OR, 3.16). The age-specific prevalence of MGD and DE differed, and factor analysis for 16 parameters showed that MGD

2019 American Journal of Ophthalmology

71. Comparison of the Efficacies of Dry Needling and Botox Methods in the Treatment of Myofascial Pain Syndrome Affecting the Temporomandibular Joint. (Abstract)

Comparison of the Efficacies of Dry Needling and Botox Methods in the Treatment of Myofascial Pain Syndrome Affecting the Temporomandibular Joint. To compare the efficacies of botulinum toxin-A injection and dry needling methods in the treatment of patients with myofascial pain syndrome (MPS) in the temporomandibular joint (TMJ).In this prospective study, 40 MPS patients (29 women, 11 men) were randomly assigned to abobotulinum toxin-A injection (Group 1, n = 20) or dry needling (Group 2, n (...)  = 20) groups. Pain, crepitation, functional limitation, maximum mouth opening, jaw strength were evaluated at baseline and 6 weeks, and the results in both groups were compared.The average age of the authors' patients was 33.8±8.1. There was a remarkable difference between 2 groups regarding visual analog scale for TMJ pain at rest (P = 0.048). The pain at rest was relieved more effectively in Group 2 at the end of 6 weeks. Improvement in jaw protrusion angles on the right (P = 0.009) and left (P

2019 The Journal of craniofacial surgery Controlled trial quality: uncertain

72. Preliminary Report on the Role of Dry Needling Versus Corticosteroid Injection, an Effective Treatment Method for Plantar Fasciitis: A Randomized Controlled Trial. (Abstract)

Preliminary Report on the Role of Dry Needling Versus Corticosteroid Injection, an Effective Treatment Method for Plantar Fasciitis: A Randomized Controlled Trial. Plantar fasciopathy (PF) is a common disorder for which there is no consensus regarding an optimal treatment strategy. We hypothesized that dry needling would be as effective as the use of corticosteroid injections for treating PF while avoiding the potential adverse effects of corticosteroids. After approval was received from (...) the institutional review board, patients diagnosed with PF were prescribed a 3-week nonoperative treatment regimen. In addition to using oral and topical antiinflammatory drugs, patients engaged in plantar fascia and gastrocnemius stretching exercises. A study population of 98 patients was planned. An appointment was made in the third week of first-line treatment. Patients whose pain did not abate and who required further treatment were included in the study. One week later, we randomly divided patients into 2

2019 The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons Controlled trial quality: uncertain

73. Pregabalin Failed to Prevent Dry Eye Symptoms after Laser-Assisted in Situ Keratomileusis (LASIK) in a Randomized Pilot Study. Full Text available with Trip Pro

after laser-assisted in situ keratomileusis (LASIK).Prospective, masked, randomized single-center pilot study. Patients were treated with either pregabalin (oral solution of pregabalin 150 mg twice daily, first dose prior to surgery, continued for a total of 28 doses over 14 days) or placebo solution. The primary outcome was dry eye symptoms as measured by the Dry Eye Questionnaire 5 (DEQ-5). Secondary outcome measures included pain-related eye symptoms.In total, 43 individuals were enrolled (...) Pregabalin Failed to Prevent Dry Eye Symptoms after Laser-Assisted in Situ Keratomileusis (LASIK) in a Randomized Pilot Study. Perioperative pregabalin administration has been found to reduce the risk of persistent pain after a variety of surgical procedures. However, this approach has not been tested in relation to eye surgery. As such, the purpose of this study was to evaluate whether perioperative pregabalin can reduce the presence of dry eye (DE) symptoms, including eye pain, six months

2019 Journal of clinical medicine Controlled trial quality: uncertain

74. Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis. (Abstract)

Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis. Enhancing chloride (Cl- ) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl- secretion in sinonasal cultures in vitro and murine epithelium in vivo. The objective of this study is to evaluate whether the BNO 1011 improves MCC and clinical (...) parameters in a rabbit model of CRS.After the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl- secretion (sinus potential difference [PD] assay), airway surface liquid (ASL) depth using micro-optical coherence tomography

2019 International forum of allergy & rhinology

75. Parasympathomimetic drugs for dry mouth due to radiotherapy. (Abstract)

Parasympathomimetic drugs for dry mouth due to radiotherapy. Data sourcesCochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase and CINAHL databases. Reference lists of identified articles were checked and experts in the field and relevant pharmaceutical companies were contacted.Study selectionRandomised controlled trials, including parallel and crossover, carried out in any setting on any patient population with radiation-induced salivary

2016 Evidence Based Dentistry

76. Parasympathomimetic drugs for dry mouth after radiotherapy

Parasympathomimetic drugs for dry mouth after radiotherapy Parasympathomimetic drugs for dry mouth after radiotherapy Search National Elf Service Search National Elf Service » » » » Parasympathomimetic drugs for dry mouth after radiotherapy Oct 9 2015 Posted by Over 90% of patients experience xerostomia during head and neck radiotherapy and for three quarters of patients this can last from one month to 2 years. Xerostomia causes a variety of oral problems including discomfort chewing problems (...) - indications. However, many fail to respond and side effects are common. Another Cochrane review by Furness et al (see Dental Elf 3 rd Sept 2013) looked at non-pharmacological approaches for dry mouth although not specifically related to those patients with radiation-induced xerostomia. They included 9 studies involving acupuncture, electrostimulation devices and powered toothbrushes but the quality of evidence was low or very low. Links Davies AN, Thompson J. Cochrane Database of Systematic Reviews 2015

2015 The Dental Elf

77. Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study Full Text available with Trip Pro

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were (...) instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec(®) 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme.At 12 weeks, each dry eye symptom improved significantly (P<0.001), and the use of artificial tears decreased significantly from 3.77 (standard deviation [SD] =2.08

2016 Clinical interventions in aging

78. A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer

Information provided by (Responsible Party): University College, London Study Details Study Description Go to Brief Summary: This trial is looking at using an intra-oral electrostimulating device for the management of radiotherapy-induced dry mouth. Condition or disease Intervention/treatment Phase Xerostomia Head and Neck Neoplasms Device: Active Electrostimulator device Device: Sham Electrostimulator device Phase 3 Detailed Description: Dry mouth is a common complaint of radiotherapy for cancer (...) of the head and neck region. It is a distressing often persistent condition which can lead to longlasting oral discomfort, dental infections, diminished quality of life, social isolation and loneliness. Unfortunately, current therapies of dry mouth are often unsatisfactory, expensive and may result in adverse effects. A novel intraoral electronic device has recently been developed to treat dry mouth. The device, acting as a "salivary pacemaker", harmlessly stimulates nerves of the salivary glands and does

2016 Clinical Trials

79. A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy

A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study (...) of Patients With Dry Mouth and Sticky Saliva During Radiotherapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02687087 Recruitment Status : Completed First Posted : February 22, 2016 Last Update Posted : February 20, 2017 Sponsor: NHS Greater Glasgow and Clyde Collaborators: Lamellar Biomedical Ltd

2016 Clinical Trials

80. Comparison of levocetirizine pharmacokinetics after single doses of levocetirizine oral solution and cetirizine dry syrup in healthy Japanese male subjects. Full Text available with Trip Pro

Comparison of levocetirizine pharmacokinetics after single doses of levocetirizine oral solution and cetirizine dry syrup in healthy Japanese male subjects. Levocetirizine, the R-enantiomer of cetirizine, is classified as a second generation antihistamine used for the treatment of allergic disorders. This study aimed to compare exposure to levocetirizine when given as levocetirizine oral solution (OS) 5 mg to that when given as cetirizine dry syrup (DS) 10 mg, which contains equal proportions

2016 Journal of drug assessment Controlled trial quality: uncertain

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