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Dry Mouth

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41. "Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth

-over group, randomized, single center, study will evaluate the efficacy of HA formulation in alleviating dry mouth in type 2 diabetic patients. Condition or disease Intervention/treatment Phase Dry Mouth Xerostomia Type 2 Diabetics Device: HA formulation Oral Spray Device: Placebo Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 30 participants Allocation: Randomized Intervention Model: Crossover Assignment (...) and schedule of the study. Exclusion Criteria: Subjects with open mouth sores at study entry. Any pathology that, based on the judgement of the researcher, could negatively affect the oral mucosa and subsequent treatment for xerostomia. Subjects who are nursing, becoming pregnant or plan to become pregnant during the study period Subjects currently on medication or treatment for dry mouth/xerostomia Hypersensitivity to any of the following ingredients- HA ,xylitol and Sodium Benzoate. Subjects with soft

2017 Clinical Trials

42. Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms

Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms (TURMERIC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03265327 Recruitment Status : Completed First Posted : August 29, 2017 Last Update Posted : August 23, 2018 Sponsor: Nature's Way Canada Collaborator: Centre

2017 Clinical Trials

43. "Hyaluronan" Formulation for Dry Mouth in Sleep Apnea Patients

/treatment Phase Dry Mouth Xerostomia OSA Sleep Apnea Device: Test Oral Spray Device: Placebo Oral Spray Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 45 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: Clinical Evaluation of the Efficacy of "Hyaluronan" Formulation for Dry Mouth (...) the assigned mouth spray provided for the 4 week duration of the study. Device: Test Oral Spray HA formulation of FDA listed ingredients Placebo Comparator: Placebo Oral Spray Subjects will be instructed to mouth spray with 0.3 ml ( 2 sprays to the mouth) of their placebo mouth spray, 2 times daily (morning and evening), for the 4 week duration of the study. Device: Placebo Oral Spray Placebo formulation without the active ingredients Outcome Measures Go to Primary Outcome Measures : Relief from dry mouth

2017 Clinical Trials

44. Subjective Assessment of Enamelon® Preventive Treatment Gel in a Self-Reported Dry-Mouth Population. (Abstract)

Subjective Assessment of Enamelon® Preventive Treatment Gel in a Self-Reported Dry-Mouth Population. The efficacy of stannous fluoride toothpastes is well established for reducing caries, plaque, and gingivitis and relieving the discomfort of dentin hypersensitivity. Management of dry mouth may include relief remedies in addition to usual oral hygiene methods to maintain oral health and improve quality of life. This 6-week, single-blind, randomized, two-period crossover clinical study (...) was designed to evaluate the oral tolerance and potential of Enamelon® Preventive Treatment Gel (EPTG), with 0.4% stannous fluoride, to relieve subject-perceived dry-mouth symptoms in a self-reported dry-mouth population, after 14 days of use, compared to a marketed over-the-counter (OTC) artificial saliva gel product (Biotene® Oral Balance Gel [BOBG]).Following a 7-day washout period, 52 qualified subjects with self-reported dry-mouth symptoms received EPTG or BOBG for once-daily use for 14 days. All

2017 Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) Controlled trial quality: uncertain

45. The Null Effect of Chewing Gum During Hemodialysis on Dry Mouth. (Abstract)

The Null Effect of Chewing Gum During Hemodialysis on Dry Mouth. The study was conducted to determine the effect of chewing gum during hemodialysis on dry mouth and its symptoms.The imposition of fluid restriction and the use of medications that reduce saliva production may lead to dry mouth.This study is a randomized, controlled, single-blind, crossover experimental study.The subjects consisted of 61 hemodialysis patients recruited from 4 dialysis centers in southern Turkey. The data were (...) collected using a Patient Identification Form, a Form for Assessing the Symptoms of Dry Mouth, and a Patient Follow-up Form. Saliva samples were obtained for analysis of flow rates.The salivary flow rates of the patients increased during the first hour on the day when gum was chewed, and this increase was statistically significant. However, no significant difference was found between the salivary flow rates at the 0- and 4-hour time points on the day when gum was chewed (P > .05). In addition

2017 Clinical nurse specialist CNS Controlled trial quality: uncertain

46. Effectiveness of an Intervention Bundle on Thirst Intensity and Dry Mouth Among Patients in ICUs

information Ages Eligible for Study: 18 Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 18 or above 18 years of age. Having thirst score ≥ 5 and dry mouth score ≥ 1 Willing to participate in the study. Able to report verbally or non verbally about thirst intensity. Admitted in ICCU,Respiratory ICU, Neurosurgical ICU and step Up ICU Exclusion Criteria: On mechanical ventilation. Not able to follow the commands. Having any oral (...) Effectiveness of an Intervention Bundle on Thirst Intensity and Dry Mouth Among Patients in ICUs Effectiveness of an Intervention Bundle on Thirst Intensity and Dry Mouth Among Patients in ICUs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

47. Oral Omega-3 Fatty Acid Supplementation for Laser In Situ Keratomileusis-Associated Dry Eye. (Abstract)

Oral Omega-3 Fatty Acid Supplementation for Laser In Situ Keratomileusis-Associated Dry Eye. To determine the effect of oral omega-3 fatty acid (ω3FA) supplementation in laser in situ keratomileusis (LASIK)-associated dry eye.In this prospective, open-label study, patients undergoing LASIK were randomized to receive either 1.2 g/d of a triglyceride formulation of oral ω3FA (treatment group) or 400 mg/d vitamin E (control group) for 1 week before and continued for 12 weeks after surgery. Ocular

2017 Cornea Controlled trial quality: uncertain

48. Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study. Full Text available with Trip Pro

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study. Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and intestinal tumor growth amongst others. Our previous investigations have suggested that oral intake of heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88™) suppresses dermatitis (...) frequency of taking lactic fermentation products was less than once per week, the levels of corneal hydration at the neck (in the 50 mg/day group) and lower eye region (in the 25 mg/day group) were significantly increased at week 12 (P<0.05). In conclusion, the results of the present investigation suggest that oral intake of heat-killed L. brevis SBC8803 is effective at improving skin hydration conditions in populations with low habitual frequency of taking lactic fermentation products.

2017 Experimental and therapeutic medicine Controlled trial quality: uncertain

49. A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water. (Abstract)

A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water. This multicenter, randomized, parallel group study analyzed the effectiveness of an experimental oral gel, a commercially available oral rinse and a commercially available mouth spray versus water alone at relieving self-reported symptoms of dry mouth over a 28-day home use treatment period. The effects of the study treatments (...) on dry mouth-related quality of life (QoL) were also investigated.Eligible subjects were stratified by dry mouth severity (mild, moderate or severe) and randomized to receive one of the study treatments. Prior to first use they completed a questionnaire designed to assess their baseline dry mouth-related QoL. Following first use and on Day 8 (2 hours post-treatment only) and Day 29, subjects completed the modified Product Performance and Attributes Questionnaire (PPAQ) I at 0.5, 1, 2 and 4 hours post

2016 American journal of dentistry Controlled trial quality: uncertain

50. Medication Causes of Dry Mouth

Medication Causes of Dry Mouth Medication Causes of Dry Mouth Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes of Dry (...) Mouth Medication Causes of Dry Mouth Aka: Medication Causes of Dry Mouth , Medication Causes of Dry Eyes From Related Chapters II. Causes: Psychiatric medications s s ( ) ( ) s s ( s) ADHD s III. Causes: Upper Respiratory Medications s (e.g. ) s s IV. Causes: Antihypertensives s (e.g. ) (e.g. ) s (e.g. ) s V. Causes: Miscellaneous medications and drugs Muscle relaxants and antispasmodics s Cannabinoids s Antiparkinsonian agents s (e.g. ) VI. References Images: Related links to external sites (from

2018 FP Notebook

51. Dry Mouth

and Craniofacial Disorders Definition (NCI_NCI-GLOSS) Dry mouth. It occurs when the body is not able to make enough saliva. Definition (NCI_CTCAE) A disorder characterized by reduced salivary flow in the oral cavity. Definition (NCI) An oral condition in which salivary flow is reduced. Definition (CSP) dryness of the mouth due to salivary gland secretion dysfunction. Definition (MSH) Decreased salivary flow. Concepts Sign or Symptom ( T184 ) MSH ICD10 SnomedCT 162014002 , 196513007 , 249425009 , 139281004 (...) , 266425004 , 87715008 , 56893005 LNC MTHU013517 English Asialia , Asialias , Hyposalivation , Hyposalivations , Mouth Dryness , Xerostomia , Xerostomias , APTYALISM , Dryness, Mouth , MOUTH DRY , ORAL DRYNESS , SALIVA DECREASED , XEROSTOMIA , dry mouth , mouth dryness (symptom) , mouth dryness (xerostomia) , mouth dryness , xerostomia (physical finding) , xerostomia , salivary secretion disturbance: xerostomia , xerostomia (diagnosis) , xerostomia was observed , Mouth became dry , Saliva decreased

2018 FP Notebook

52. Effects of combination oral care on oral health, dry mouth and salivary pH of intubated patients: A randomized controlled trial. (Abstract)

Effects of combination oral care on oral health, dry mouth and salivary pH of intubated patients: A randomized controlled trial. Intubated patients are at risk of oral health problems. Although a variety of oral care regimens for intubated patients have been studied, there is a lack of research on the effects of combination oral care that includes tooth brushing, chlorhexidine and cold water. This open-labelled, randomized, controlled trial aimed to evaluate the effects of combination oral care (...) in the control group. The intervention group had better oral health (effect size = 1.56), less dry mouth and higher salivary pH than the control group. Any additional burden of providing combination oral care to patients who are mechanically ventilated is worthwhile in terms of clinical outcomes.© 2016 John Wiley & Sons Australia, Ltd.

2016 International journal of nursing practice Controlled trial quality: uncertain

53. Oral Thrush - Guidelines for Prescribing Oral Nystatin

of age unless related to antibiotic use, immunosuppression or steroid inhaler use without post-use mouth rinsing. Risk factors: Medical conditions: Immunosuppression Malignancy Sjogren's disease Diabetes Cushings disease Medications: Inhaled corticosteroids (if not rinsing mouth properly) Recent broad-spectrum antibiotic use Chemotherapy or radiation therapy Age (newborns, or over 65) Pregnancy Dentures Poor oral hygiene Chronic dry mouth For photos and more information go to : Three types of oral (...) Oral Thrush - Guidelines for Prescribing Oral Nystatin Oral Thrush - Guidelines for Prescribing Oral Nystatin - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Oral Thrush - Guidelines for Prescribing Oral Nystatin Oral thrush is a fungal infection of the oral mucosa caused by Candida species. It is the most common human fungal infection. Oral thrush may refer to candidiasis in the mouths of babies, or if occurring in the mouth

2017 medSask

54. Oral mucosal manifestations in primary and secondary Sjögren syndrome and dry mouth syndrome Full Text available with Trip Pro

Oral mucosal manifestations in primary and secondary Sjögren syndrome and dry mouth syndrome One of the most important symptoms of Sjögren syndrome is xerostomia. The oral cavity deprived of saliva and its natural lubricative, protective and antibacterial properties is prone to a number of unfavourable consequences.To present the most important lesions on the oral mucosa in primary and secondary Sjögren syndrome and in dry mouth syndrome.The study group comprised 55 patients including 52 women (...) and 3 men aged 20-72 years (average: 28.25 years).Basing on the accepted criteria, primary Sjögren syndrome was diagnosed in 22 (40%) patients, secondary Sjögren syndrome in 18 (32.7%) patients, and dry mouth syndrome in 15 (27.27%) patients. The physical examination and the examination of the mouth were performed and history was elicited from every patient.The most common pathologies appearing on the oral mucosa in primary and secondary Sjögren syndrome are angular cheilitis, cheilitis, increased

2016 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

55. n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease. Full Text available with Trip Pro

n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease. Dry eye disease is a common chronic condition that is characterized by ocular discomfort and visual disturbances that decrease quality of life. Many clinicians recommend the use of supplements of n-3 fatty acids (often called omega-3 fatty acids) to relieve symptoms.In a multicenter, double-blind clinical trial, we randomly assigned patients with moderate-to-severe dry eye disease to receive a daily oral dose of 3000 mg (...) in the conjunctival staining score (mean difference in change, 0.0 points; 95% CI, -0.2 to 0.1), corneal staining score (0.1 point; 95% CI, -0.2 to 0.4), tear break-up time (0.2 seconds; 95% CI, -0.1 to 0.5), and result on Schirmer's test (0.0 mm; 95% CI, -0.8 to 0.9). At 12 months, the rate of adherence to treatment in the active supplement group was 85.2%, according to the level of n-3 fatty acids in red cells. Rates of adverse events were similar in the two trial groups.Among patients with dry eye disease

2018 NEJM Controlled trial quality: predicted high

56. 5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming. (Abstract)

5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming. Epigenetic therapy through demethylation of 5-methylcytosine has been largely ineffective in treating lung cancer, most likely due to poor tissue distribution with oral or subcutaneous delivery of drugs such as 5-azacytidine (5AZA). An inhalable, stable dry powder formulation of 5AZA was developed.Pharmacokinetics of inhaled dry powder and aqueous (...) formulations of 5AZA were compared to an injected formulation. Efficacy studies and effect of therapy on the epigenome were conducted in an orthotopic rat lung cancer model for inhaled formulations.Inhaled dry powder 5AZA showed superior pharmacokinetic properties in lung, liver, brain and blood compared to the injected formulation and for all tissues except lung compared to an inhaled aqueous formulation. Only dry powder 5AZA was detected in brain (~4-h half-life). Inhaled dry powder was superior

2020 British Journal of Cancer

57. Dry Eye: The Effect of Chi-Ju-Di-Huang-Wan Plus Si Wu Tang and the Underlying Mechanism. (Abstract)

Dry Eye: The Effect of Chi-Ju-Di-Huang-Wan Plus Si Wu Tang and the Underlying Mechanism. Objectives: In this pilot study, the effect of 970 mg Chi-Ju-Di-Huang-Wan (CJDHW) plus 30 mg four-substance decoction (Si Wu Tang; CJDHWSWT) was evaluated, in terms of its ability to alleviate dry eye symptoms and its therapeutic mechanism. Methods: This double-masked prospective investigation has recruited dry eye patients who have been randomly selected into two groups, namely treatment (n = 15) versus (...) nontreatment (n = 15). In the treatment group, a daily oral intake of CJDHWSWT plus eye drops systane ultra was given for 90 consecutive days. In the nontreatment group, only defined eye drops were prescribed. The examinations included Schirmer's test, fluorescein-stained superficial punctate keratitis (SPK), artificial tear consumption, tear vascular endothelium growth factor (VEGF) level, and ocular surface disease index. The drug safety tests included liver and kidney functions, and complete blood

2020 Journal of Alternative and Complementary Medicine

58. To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults.

To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults. To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults. - Full Text View (...) - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets

2015 Clinical Trials

59. Relative Bioavailability Study in Healthy Subjects Comparing 2 Dry Powder Oral Suspensions of Rivaroxaban Under Fasting and 20 mg of an Oral Suspension of Rivaroxaban Under Fed Conditions to 10 mg of an Immediate Release Tablet Under Fasting Conditions

Relative Bioavailability Study in Healthy Subjects Comparing 2 Dry Powder Oral Suspensions of Rivaroxaban Under Fasting and 20 mg of an Oral Suspension of Rivaroxaban Under Fed Conditions to 10 mg of an Immediate Release Tablet Under Fasting Conditions Relative Bioavailability Study in Healthy Subjects Comparing 2 Dry Powder Oral Suspensions of Rivaroxaban Under Fasting and 20 mg of an Oral Suspension of Rivaroxaban Under Fed Conditions to 10 mg of an Immediate Release Tablet Under Fasting (...) Conditions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Relative Bioavailability Study in Healthy Subjects Comparing 2 Dry Powder Oral Suspensions of Rivaroxaban Under Fasting and 20 mg of an Oral Suspension

2015 Clinical Trials

60. Prevention of Dry Socket After Tooth Extraction With Warm Saline Rinses

Prevention of Dry Socket After Tooth Extraction With Warm Saline Rinses UTCAT2996, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Prevention of Dry Socket After Tooth Extraction With Warm Saline Rinses Clinical Question Is warm saline rinse beneficial in preventing alveolar osteitis after dental extraction? Clinical Bottom Line Warm saline mouth rinses 24 hours after dental extraction is helpful in reducing (...) for post extraction complication. Applicability Rinsing with warm salt water after 24 hours is helpful in preventing post extraction complication such as alveolar osteitis. Warm saline rinsing twice a day is easy to follow by the patient and is a low cost rinse. It appears that rinsing two times a day is as beneficial as rinsing six times a day in the prevention of alveolar osteitis. Specialty/Discipline (General Dentistry) (Oral Surgery) Keywords Dental extraction complications, Dry socket, alveolar

2016 UTHSCSA Dental School CAT Library

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