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Dry Mouth

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4821. Dry mouth (PubMed)

Dry mouth 17347241 2007 03 26 2012 03 06 1756-1833 334 7592 2007 Mar 10 BMJ (Clinical research ed.) BMJ Dry mouth. 534 Taubert Mark M Holme Tower Marie Curie Centre, Penarth CF64 3YR. mtaubert@hotmail.com Davies Eleanor M R EM Back Ian I eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM BMJ. 2007 Mar 24;334(7594):600 17379870 Humans Medical History Taking Physical Examination methods Xerostomia diagnosis therapy 0 2007 3 10 9 0 2007 3 27 9 0 2007 3 10 9 0 ppublish 17347241 334

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2007 BMJ : British Medical Journal

4822. Effects of a betaine-containing toothpaste on subjective symptoms of dry mouth: a randomized clinical trial. (PubMed)

Effects of a betaine-containing toothpaste on subjective symptoms of dry mouth: a randomized clinical trial. Our aim was to study the effects of mildly flavoured sodium lauryl sulphate (SLS)-containing and detergent-free toothpastes with and without betaine (BET) on subjective symptoms of dry mouth in a randomised clinical trial. BET is an osmoprotectant that reacts with molecules to supply the surface with a water coating that protects cells from surfactants. Twenty-seven xerostomic patients (...) and 18 healthy controls took part in the randomised, double-blind clinical trial with a crossover design. Three mildly flavoured toothpastes: (1) 4% BET, (2) 1% SLS and 4% BET, and (3) 1% SLS were used for six weeks each. The reference or washout paste contained neither SLS nor BET. The subjects' dental appointments were at the beginning of the trial and before and after the use of each toothpaste. At each appointment, the subjects were interviewed about subjective sensations of dry mouth (Visual

2003 The journal of contemporary dental practice Controlled trial quality: uncertain

4823. [Efficacy of oral balance gel for dry mouth in preoperative patients]. (PubMed)

[Efficacy of oral balance gel for dry mouth in preoperative patients]. Following anticholinergic premedication and preoperative fasting, preoperative patients with a potential xerostomia have complaints associated with oral dryness. Xerostomia may lead to risk of mucosal burning and secondary infection. The purpose of this prospective study was to assess the effect of oral balance gel on dryness of the mouth in preoperative patients.Thirty nine patients scheduled for elective surgery were (...) randomly assigned to either of the group with or without using the oral balance gel. Severity of the dry mouth was assesed using a 4-point scale (0=none, 1=mild, 2=moderate, 3=severe) and diadochokinesis test was performed on the day before surgery and on arrival at the OR.Comparing results of the two stages, we found that patients with no treatment had significantly deteriorated state of dry mouth, but patients who had received the oral balance gel had no significantly worse dry mouth compared

2004 Masui. The Japanese journal of anesthesiology Controlled trial quality: uncertain

4824. Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients. (PubMed)

Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients. To establish whether an intra-oral lubricating device for dry mouth alters the oral environment.A single-blind randomized cross-over study.Twenty-nine dentate subjects from the Sjogren's syndrome clinic attended on five occasions at 4-week intervals. They were randomized, having the device fitted on either the second or the fourth visit for the experimental period, whilst using their preferred method (...) of lubrication throughout the rest of the study. The preferred methods of lubrication were either water (group 1, n = 10) or saliva substitute (group 2, n = 9) or sugar-free chewing gum (group 3, n = 10). At each visit microbiological, unstimulated and stimulated saliva samples were collected. Dry mouth score, speech test and periodontal indices were recorded.The water lubrication group (1) had a resting salivary flow greater than lubrication groups (2 and 3) by post-ANOVA contrasts (P < 0.001

2006 Oral diseases Controlled trial quality: uncertain

4825. A double-blind randomized dose-response study comparing daily doses of 5, 10 and 15 mg controlled-release oxybutynin: balancing efficacy with severity of dry mouth. (PubMed)

A double-blind randomized dose-response study comparing daily doses of 5, 10 and 15 mg controlled-release oxybutynin: balancing efficacy with severity of dry mouth. To assess the efficacy, incidence of dry mouth and overall satisfaction with initial doses of 5, 10 and 15 mg of a new, once-daily, controlled-release (CR) form of oxybutynin for treating urge urinary incontinence (UUI).Patients who reported urinary incontinence (UI) (one or more episodes/diary) and voiding frequency (eight or more (...) voids/day) or urgency (one or more episodes/diary) during a 2-week baseline were randomized to once-daily 5, 10 or 15 mg CR oxybutynin for 4 weeks. Daily episodes of UI, voids, urgency, adverse events, dry mouth and satisfaction were recorded in a 3-day diary at baseline and after 4 weeks of treatment. In all, 237 patients were randomized and evaluated.Episodes of UI, voids and urgency were significantly reduced over the study period at all doses. Daily UI episodes were significantly lower with 15

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2006 BJU international Controlled trial quality: uncertain

4826. Comparison of dry mouth in women treated with extended-release formulations of oxybutynin or tolterodine for overactive bladder. (PubMed)

Comparison of dry mouth in women treated with extended-release formulations of oxybutynin or tolterodine for overactive bladder. The incidence, severity and tolerability of dry mouth was compared in 790 women with overactive bladder who were treated with extended-release oxybutynin chloride 10 mg/day or extended-release tolterodine tartrate 4 mg/day for 12 weeks in a multicenter, double-blind, parallel-group study. Dry mouth was the most common adverse event associated with treatment (...) , with an incidence rate of 28.1% in the oxybutynin group and 21.6% in the tolterodine group (P = 0.039). The majority of dry mouth events were mild in both treatment groups. Severe dry mouth occurred in 1.5% and 0.5% of patients in the oxybutynin and tolterodine groups, respectively (P = 0.173). Seven patients on extended-release oxybutynin and 4 patients on extended-release tolterodine discontinued treatment due to dry mouth (P = 0.380). The results of this analysis showed that dry mouth was common with both

2005 International urology and nephrology Controlled trial quality: uncertain

4827. Subjective assessment of a new moisturizing mouthwash for the symptomatic management of dry mouth. (PubMed)

Subjective assessment of a new moisturizing mouthwash for the symptomatic management of dry mouth. A randomized clinical trial and consumer usage test were conducted to evaluate the acceptability and benefits of OASIS Moisturizing Mouthwash in subjects experiencing symptoms of dry mouth.Study 1: A randomized, double blind, two-period crossover clinical trial was conducted in 49 subjects to evaluate OASIS Moisturizing Mouthwash and an experimental mouthwash formulation. Following a three-day (...) products three times per day. OASIS Moisturizing Mouthwash was found to be beneficial in managing dry mouth, and was well-liked by the study population, as evidenced by a statistically significant improvement over subjects' normal remedies for managing dry mouth for strength of flavor, taste, freshening breath, immediate and long lasting lubrication, and moisturization. Both products were well-tolerated. Study 2: Three-hundred and twenty-three subjects completed a one- to two-week consumer home usage

2006 The Journal of clinical dentistry Controlled trial quality: uncertain

4828. Successful Treatment of Dry Mouth and Dry Eye Symptoms in Sjögren's Syndrome Patients With Oral Pilocarpine: A Randomized, Placebo-Controlled, Dose-Adjustment Study. (PubMed)

Successful Treatment of Dry Mouth and Dry Eye Symptoms in Sjögren's Syndrome Patients With Oral Pilocarpine: A Randomized, Placebo-Controlled, Dose-Adjustment Study. : Sjögren's syndrome is characterized by the presence of xerostomia and/or xerophthalmia. Pilocarpine, a muscarinic cholinergic agonist, has been proven to be efficacious in treating radiation-induced xerostomia (up to 30 mg/day) and symptoms of dry mouth in Sjögren's patients (up to 20 mg/day).: To compare the safety and efficacy (...) of oral pilocarpine (dose-adjusted) versus placebo in the treatment of dry eye and dry mouth symptoms in Sjögren's syndrome at 6 and 12 weeks.: In this 11-center, 256-patient placebo-controlled study, the safety and efficacy of oral pilocarpine (20 mg to 30 mg daily) for relief of Sjögren's-related dry mouth and dry eye symptoms was assessed. Changes in symptoms and salivary flow were measured over 12 weeks.: Compared with placebo, salivary flow was significantly increased in the pilocarpine group (P

2004 Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Controlled trial quality: uncertain

4829. Subjective assessment of a new moisturizing mouth spray for the symptomatic relief of dry mouth. (PubMed)

Subjective assessment of a new moisturizing mouth spray for the symptomatic relief of dry mouth. A randomized clinical trial (Study 1) and consumer usage test (Study 2) were conducted to evaluate the acceptability and efficacy of OASIS Mouth Moisturizing Spray in subjects experiencing dry mouth.Study 1: A randomized, single-blind, four-arm crossover clinical trial was conducted in 24 subjects, ranging from 50-84 years of age, to evaluate OASIS Mouth Moisturizing Spray and two experimental mouth (...) of life attributes of the product.Study 1: On average, subjects used the four test products 2-3 times per day. OASIS Mouth Moisturizing Spray was found to be effective in relieving dry mouth in the study population, as evidenced by a statistically significant feeling of coating the mouth (p < 0.05), and statistically significantly longer dry mouth relief (p < 0.005) than the commercial control. The OASIS Mouth Moisturizing Spray was statistically significantly (p < 0.05) better and preferred over

2006 The Journal of clinical dentistry Controlled trial quality: uncertain

4830. A proposed new method for the treatment of dry mouth. (PubMed)

A proposed new method for the treatment of dry mouth. 6859785 1983 07 08 2018 11 30 0035-8843 65 3 1983 May Annals of the Royal College of Surgeons of England Ann R Coll Surg Engl A proposed new method for the treatment of dry mouth. 191-3 Marks N J NJ Roberts B J BJ eng Journal Article England Ann R Coll Surg Engl 7506860 0035-8843 0 Tablets 3WJQ0SDW1A Polyethylene Glycols IM Elasticity Humans Polyethylene Glycols therapeutic use Rheology Saliva physiology Tablets Viscosity Xerostomia drug

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1983 Annals of the Royal College of Surgeons of England

4831. Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer

Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00017511 Recruitment Status : Completed First Posted : January 27, 2003 Last Update Posted : May 16, 2012

2001 Clinical Trials

4832. Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer

Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00003139 Recruitment Status : Completed First Posted

1999 Clinical Trials

4833. Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids

Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pilocarpine in Treating (...) Patients With Dry Mouth Caused by Opioids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00003686 Recruitment Status : Terminated (Terminated due to poor accrual.) First Posted : August 17, 2004 Last Update Posted : June 3, 2013 Sponsor: NCIC Clinical Trials Group Information provided by (Responsible

1999 Clinical Trials

4834. Study of Oral Bacteria in Patients With Dry Mouth

Study of Oral Bacteria in Patients With Dry Mouth Study of Oral Bacteria in Patients With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of Oral Bacteria in Patients With Dry Mouth (...) ) Study Details Study Description Go to Brief Summary: This study will examine the types of bacteria present in the dental plaque of patients with persistent dry mouth. Saliva is essential for digestion and swallowing and for maintaining the normal mineralization of teeth. People who suffer from dry mouth usually have a significant increase in tooth decay (caries). This study will determine if this increase is due solely to reduced salivary flow or also to an increase in certain types of bacteria

2002 Clinical Trials

4835. Comparison of peripheral anticholinergic effects of antidepressants: dry mouth. (PubMed)

Comparison of peripheral anticholinergic effects of antidepressants: dry mouth. Twenty-one healthy volunteers were given single doses of placebo or antidepressants corresponding to average daily doses of patient medications. Spontaneous whole mouth and parotid salivation was measured two, six, and ten hours after drug administration in session 1; in session 2 after ten hours. The results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect

1981 Acta psychiatrica Scandinavica. Supplementum

4836. A third study on the use of orally administered anhydrous crystalline maltose for relief of dry mouth in primary Sjogren's syndrome. (PubMed)

A third study on the use of orally administered anhydrous crystalline maltose for relief of dry mouth in primary Sjogren's syndrome. To examine the safety and efficacy of anhydrous crystalline maltose for treatment of dry mouth and other symptoms of dryness in patients with primary Sjögren's syndrome.Anhydrous crystalline maltose was delivered orally as a 200-mg lozenge given three times daily over a 24-week period to a total of 100 subjects. All participants had prominent complaints (...) of persistent dry mouth associated with primary Sjögren's syndrome. Patients were examined at baseline and every 6 weeks of treatment.Patients were seen in outpatient clinics at a total of 27 sites within the United States.Unstimulated whole saliva output, a measure of basal salivary gland function, was determined at each visit. Symptoms associated with oral and ocular dryness were assessed at the same time with the use of 100-mm visual analogue scales. Safety was assessed by physical examination

2002 Journal of Alternative and Complementary Medicine

4837. Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study. (PubMed)

Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study. Five saliva stimulants (Salivin, V6, Mucidan, Ascoxal-T and Nicotinamide) and three saliva substitutes (Saliment, Salisynt and an ex témpore solution) were evaluated in 106 patients with a low salivay flow rate and a long history of dry mouth. The study was carried out as a multi-centre study in collaboration with ten different hospital dental clinics (...) . The participants were interviewed about their complaints related to dry mouth. Each patient was then asked to use the eight saliva stimulants and substitutes for 14 days in a randomized order with one week intervals. After the 14-day-periods, the patients were interviewed about the effect of the various products by a dentist using a standardized questionnaire. Paraffin-stimulated whole saliva samples were collected after each test period. The most serious complaints among the patients were, besides dryness

1990 Swedish dental journal Controlled trial quality: uncertain

4838. Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). (PubMed)

Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). We studied the effects of pilocarpine hydrochloride, a para-sympathomimetic agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions

1991 Archives of internal medicine Controlled trial quality: uncertain

4839. The effect of a chewing gum on salivary secretion, oral mucosal friction, and the feeling of dry mouth in xerostomic patients. (PubMed)

The effect of a chewing gum on salivary secretion, oral mucosal friction, and the feeling of dry mouth in xerostomic patients. A new chewing gum (PTC) with the ability to release flavoring substances for a rather long time was tested for its ability to stimulate saliva secretion. The chewing gum is mildly flavored and contains non-cariogenic sweeteners (xylitol and sorbitol). Measurements of saliva secretion rate and oral mucosal sliding friction and subjective evaluations on visual analog

1991 Acta odontologica Scandinavica Controlled trial quality: uncertain

4840. Oral mucosal friction and subjective perception of dry mouth in relation to salivary secretion. (PubMed)

Oral mucosal friction and subjective perception of dry mouth in relation to salivary secretion. Assessment of oral mucosal friction and subjective perception of dry mouth was performed during treatment with thiazide diuretic bendroflumethiazide (2.5 mg o.d.) or placebo in a randomized, double-blind, cross-over study (2 x 2 wk) in 34 healthy volunteers. Treatment with bendroflumethiazide was associated with a 10% reduction in the stimulated whole saliva secretion rate and a 15% reduction (...) in the salivary sodium concentration, as compared with placebo. Oral mucosal friction was concomitantly measured on the buccal mucosa and on the mucosa of the lower lip by means of a newly developed sliding friction device. In addition, a questionnaire was used to evaluate how the treatment was subjectively perceived with regard to symptoms of dry mouth. Mucosal friction of the lower lip increased significantly during treatment with bendroflumethiazide, as compared with placebo. When the test subjects

1993 Scandinavian journal of dental research Controlled trial quality: uncertain

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