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Dry Mouth

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4681. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. (PubMed)

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. Polypharmacy is a common cause of salivary hypofunction, producing symptoms of dry mouth or xerostomia, especially among older populations. As the number of older people continues to increase, polypharmacy-induced salivary hypofunction is becoming an increasing problem. Many over-the-counter products are available for relieving symptoms (...) of dry mouth, but few have been tested in controlled clinical investigations. The purpose of this investigation was to evaluate the safety and efficacy of a group of topical dry mouth products (toothpaste, mouth rinse, mouth spray and gel) containing olive oil, betaine and xylitol. Forty adults were entered into this single-blinded, open-label, cross-over clinical study and 39 completed all the visits. Subjects were randomly assigned at baseline to using the novel topical dry mouth products daily

2007 Journal of oral rehabilitation

4682. Oral pilocarpine for symptomatic relief of dry mouth and dry eyes in patients with Sjögrens syndrome. (PubMed)

Oral pilocarpine for symptomatic relief of dry mouth and dry eyes in patients with Sjögrens syndrome. 9634997 1998 09 15 2016 11 09 0065-2598 438 1998 Advances in experimental medicine and biology Adv. Exp. Med. Biol. Oral pilocarpine for symptomatic relief of dry mouth and dry eyes in patients with Sjögrens syndrome. 973-8 Papas A S AS Tufts University School of Dental Medicine, Boston, Massachusetts, USA. Fernandez M M MM Castano R A RA Gallagher S C SC Trivedi M M Shrotriya R C RC eng (...) Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial United States Adv Exp Med Biol 0121103 0065-2598 0 Miotics 01MI4Q9DI3 Pilocarpine IM Administration, Oral Adult Aged Aged, 80 and over Double-Blind Method Dry Eye Syndromes drug therapy Electrocardiography drug effects Female Humans Male Middle Aged Miotics administration & dosage adverse effects therapeutic use Pilocarpine administration & dosage adverse effects therapeutic use Salivation drug effects Sjogren's Syndrome drug

1998 Advances in experimental medicine and biology

4683. Weak association between subjective symptoms of and objective testing for dry eyes and dry mouth: results from a population based study (PubMed)

Weak association between subjective symptoms of and objective testing for dry eyes and dry mouth: results from a population based study To determine associations between symptoms of dry eyes and dry mouth and objective evidence of lacrimal and salivary gland dysfunction in a population based sample. To determine associations between these elements and the presence of autoantibodies.A cross sectional population based survey. Subjects were interviewed and examined (Schirmer-1 test (...) and unstimulated salivary flow) for the presence of dry eyes and mouth. Antibodies (anti-Ro [SS-A], anti-La [SS-B], rheumatoid factor, antinuclear antibody) were measured.341 subjects were examined. Twenty four per cent had dry eye symptoms, 29% dry mouth symptoms, and 14% both. There was only a weak association between the presence of oral or ocular symptoms and their respective test results. Associations were strongest between dry mouth symptoms and positive test results, and in subjects under 55 years

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1998 Annals of the Rheumatic Diseases

4684. Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. (PubMed)

Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. Patients with Sjögren syndrome (SS) experience slowly progressive infiltration of lacrimal and salivary glands by mononuclear cells. This leads to diminished secretions, with resultant symptoms of xerostomia and xerophthalmia. Although pilocarpine hydrochloride tablets are currently indicated (...) for the treatment of radiation-induced xerostomia, their effects on dry mouth or dry eyes in patients with SS are unclear.To assess the safety and efficacy of pilocarpine (Salagen) tablets as symptomatic treatment for dry mouth and dry eyes caused by SS in a multicenter, doubleblind, placebo-controlled trial.After providing written informed consent, 373 patients with primary or secondary SS and clinically significant dry mouth and dry eyes were randomized to receive 2.5-mg pilocarpine, 5-mg pilocarpine

1999 Archives of internal medicine

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