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Dry Mouth

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4681. Effects of placebo versus guanabenz on hypertensive out-patients. (PubMed)

-treated patients (p < 0.01). Mean daily guanabenz dose was 24 mg. Drug-related biochemical or electrocardiographic abnormalities were absent. Side-effects of sedation and dry mouth were recorded two and three times more frequently, respectively, in guanabenz as compared to placebo patients. Side-effects usually occurred within Week 1 and diminished in incidence thereafter. Consequently, in these patients it appeared that: (1) guanabenz was an effective, well-tolerated drug, (2) placebo effects (...) on efficacy were significant, occurred early and remained stable, and (3) placebo and guanabenz side-effects were mainly sedation and dry mouth.

1980 The Journal of international medical research

4682. Treatment of hypertensive out-patients with a sustained-release dosage form of clonidine: a comparison with standard tablet therapy and long-term follow-up study. (PubMed)

occasionally occurred at the start of the study, in particular dry mouth and a slight sensation of dizziness, subsided in the course of therapy. Laboratory investigations and clinical findings gave no indication of any chronic toxic changes.

1980 Current medical research and opinion

4683. A controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patients. (PubMed)

of amitriptyline and 20 the course of flupenthixol. All variables improved over time, but there were no significant differences between the two drugs. The Newcastle scores pre-treatment were not related to drug response suggesting that both drugs were similarly effective across a wide spectrum of depressive disorders. Patients on amitriptyline tended to complain of dry mouth; those on flupenthixol had a higher incidence of extrapyramidal signs, the majority receiving anti-parkinsonian drugs at some time during

1982 British Journal of Psychiatry

4684. Lormetazepam and amobarbital sodium in the outpatient treatment of insomnia: a controlled trial. (PubMed)

fewer adverse effects (eg, hangover in the morning, sedation in the morning and during the day, and dry mouth) in patients receiving lormetazepam than in patients receiving amobarbital.

1983 Clinical therapeutics

4685. Treatment of severe hypertension with labetalol compared with methyldopa and furosemide. Results of a long-term, double-blind, multicenter trial. (PubMed)

reductions in heart rate; in contrast, resting tachycardia was observed in methyldopa-treated patients. Side effect profiles of the two treatments were different, with nausea being the most commonly reported side effect during labetalol therapy, and asthenia, somnolence, and dry mouth during methyldopa therapy. Overall, 33 of 65 (53 percent) labetalol-treated and 28 of 60 (47 percent) methyldopa-treated patients had at least a good response (that is, standing diastolic blood pressure 90 to 94 mm Hg

1983 The American journal of medicine

4686. Evaluation of intramuscular levonantradol and placebo in acute postoperative pain. (PubMed)

) on levonantradol reported one or more side effect. Drowsiness was most frequent. Dry mouth, dizziness, "weird dreams," mild hallucinations, nervousness, apprehension and confusion occurred less frequently. Changes in resting heart rate and blood pressure were minor and general acceptability was good.

1982 Journal of clinical pharmacology

4687. Spiramycin and erythromycin in the treatment of acute tonsillo-pharyngitis: a comparative study. (PubMed)

, significantly fewer patients on erythromycin had complete disappearance of all the signs and symptoms at the end of the treatment period. These findings were supported by the results of the bacteriological cultures. Both treatments reduced leucocyte levels in those patients with high counts initially, but there was no apparent effect on haemoglobin or erythrocyte sedimentation rate. Two patients on spiramycin complained of dry mouth. In the erythromycin group, 2 patients reported dizziness and 5 nausea.

1984 Current medical research and opinion

4688. Trazodone--a comparison of single night-time and divided daily dosage regimens. (PubMed)

complaints of side-effects, particularly dry mouth, headache and drowsiness which led to more of these patients requiring modification of dosage. Thus trazodone appears to have clinically useful sedative properties. It has relatively few side-effects and these are generally reduced by giving a single dose at night.

1984 Psychopharmacology

4689. [Analysis of controlled studies comparing mianserin and clomipramine (author's transl)]. (PubMed)

as to efficacy was a more precocious onset of action for mianserin in the group of the endogenous depressions (de Buck). Mianserin causes significantly less side effects, above all as to hypotension, dry mouth, tremor and blurred vision.

1981 L'Encéphale

4690. Comparative antihypertensive effects of guanabenz and methyldopa. (PubMed)

-treated patients who completed six months of treatment. Clinically significant individual SDBP decreases occurred in 76% of the guanabenz-treated patients and in 63% of the methyldopa-treated patients (P less thn 0.05). Blood pressure remained unchanged during the second six months, with response of 82% and 60%, respectively, for guanabenz and methyldopa (P less than 0.05). Although drowsiness and dry mouth occurred more frequently with guanabenz, evidence of fluid retention, such as weight gain

1981 Clinical therapeutics

4691. A double-blind crossover study of diazepam rectal suppositories, 5 mg and 10 mg, for sedation in patients with advanced malignant disease. (PubMed)

period in between. Sleep was rated daily as 'well', 'same' or 'badly' by the night nurse and by the patient. The majority of patients slept well while taking diazepam, with no apparent difference between the two doses. The most common side-effects reported were day-time drowsiness (58% of patients), dry mouth (29%) and amnesia (21%). No adverse reaction necessitated premature withdrawal from the study. Results indicated that diazepam suppositories were well tolerated and appeared to provide effective

1982 Pharmatherapeutica

4692. A double-blind comparison of zimelidine and amitriptyline in depressive out-patients. (PubMed)

) was 22.2 for zimelidine and 21.9 for amitriptyline. During the treatment period of 6 weeks, zimelidine and amitriptyline appeared to be equally effective as antidepressants in HRS and Global Ratings. The zimelidine group showed significantly less somnolence and dry mouth. No clinically important changes were seen in the laboratory parameters during the study.

1982 The Journal of international medical research

4693. Lofexidine and clonidine in moderate essential hypertension. (PubMed)

doses of lofexidine and clonidine in combination with hydrochlorothiazide had equivalent antihypertensive effects, but when the effects of lofexidine and clonidine were compared at each dose level, larger doses of lofexidine patients in either the supine or erect position during the titration phase but heart rate fell in the clonidine patients (P less than 0.05) over the same period. Dry mouth and drowsiness were reported in both groups but were both less frequent and less severe in the lofexidine

1981 Clinical pharmacology and therapeutics

4694. Mianserin and clomipramine in the treatment of depression. (PubMed)

reaching significance in the 5th week. Side-effects, especially tremor, tachycardia, dystonia, dizziness, excitement, nasal congestion and dry mouth, were significantly more common in the group using clomipramine. This study confirms reports that mianserin is an effective antidepressant which is better tolerated and produces fewer side-effects (especially anticholinergic) than comparable tricyclic antidepressants such as clomipramine.

1982 South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

4695. A double-blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders. (PubMed)

in the placebo group at week 4, and among the imipramine group at weeks 4, 6 and last available assessment. The Clinical Global Impression (CGI) scales and the 56-item Hopkins Symptom Check-list (HSCL-56) self-rating inventory both showed significantly more improvement in the zimeldine patients than in the placebo or the imipramine patients. Fewer zimeldine patients reported adverse experiences than imipramine patients. Dry mouth was the most frequently reported adverse experience, occurring significantly (...) more often in the imipramine group than the zimeldine or the placebo groups; significantly more zimeldine than placebo patients reported dry mouth. Headache was the only other adverse experience which occurred more often in the zimeldine than in the placebo group. The imipramine group had consistently higher mean pulse rates than the other two groups, and postural hypotension was also more common in the imipramine group.

1983 Acta psychiatrica Scandinavica. Supplementum

4696. [Randomized comparative trial of a new anti-emetic: nabilone, in cancer patients treated with cisplatin]. (PubMed)

was administered at a dose of 12.5 mg given IM, 15 minutes before the start of cis-platinum. Nabilone, in comparison with chlorpromazine did not significantly reduce the number of vomiting. Ten patients preferred nabilone, 5 preferred chlorpromazine and 3 were undecided. Predominant side effects noted by patients were similar for both agents and included somnolence, dry mouth and orthostatic hypotension. No other intervention besides reassurance of the patient was necessary to treat these adverse reactions.

1983 Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie

4697. Metkephamid and meperidine analgesia after episiotomy. (PubMed)

min and peaked at 1 to 2 hr; with 140 mg metkephamid, maximum analgesia was sustained 6 hr, i.e., 2 hr longer than with meperidine. Metkephamid, 70 mg, could not be distinguished from placebo throughout its entire time course. Although dizziness was experienced with meperidine, the two metkephamid doses induced other side effects, including sensation of heavy limbs, dry mouth, eye redness, and nasal stuffiness. None were distressing. Our results suggest that 140 mg metkephamid compares favorably

1983 Clinical pharmacology and therapeutics

4698. Crossover comparison of moxonidine and clonidine in mild to moderate hypertension. (PubMed)

. In the mean daily dose of 0.3 mg both drugs showed the same antihypertensive activity, but on CLON a higher incidence of side effects (p = 0.003) was noted, and after discontinuation of therapy a more rapid rise in BP (systolic BP p less than 0.01, diastolic BP p less than 0.02) was found. 17 patients on CLON complained of side effects, especially tiredness and dry mouth, whilst only 6 patients on MOX were affected (p = 0.003).

1984 European journal of clinical pharmacology

4699. Comparison of guanabenz and clonidine in hypertensive patients. (PubMed)

) reduction in systolic and diastolic blood pressures in the standing and supine positions. They also reduced significantly the standing and supine pulse rates. Normal orthostatic responses were maintained with both regimens. All but 1 patient in each group reported side-effects during active treatment, the most frequent being dry mouth and sedation with each drug. No laboratory or ECG abnormalities related to treatment were observed.

1980 Current medical research and opinion

4700. Preliminary clinical trial with a new hypotensive, guanabenz, in a group of hypertensive patients. (PubMed)

blood pressure normalized or side effects intervened. The 16 patients accumulated 97 months of guanabenz treatment. The 6 unsuccessful cases included only 2 outright therapeutic failures; the other 4 patients discontinued treatment for various reasons: dry mouth and nausea (with good blood pressure reduction); aggravation of existing depression; or generalized urticaria. The fourth patient discontinued for reasons unknown.

1980 Acta cardiologica

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