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Dry Mouth

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21. A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. Full Text available with Trip Pro

Performance and Attributes Questionnaire 3-Question 1 ("Relieves the discomfort of dry mouth"; the predefined primary efficacy variable) in favor of mouthwash versus water (0.63 [95% confidence interval 0.17-1.10]; P = .0084). Subgroup analysis found a significant difference that favored mouthwash in participants without Sjögren syndrome (0.67 [0.11,1.23]; P = .0203) but not with Sjögren syndrome (0.52 [-0.35,1.38; P = .2272). Eight, non-serious, oral treatment-related adverse events were reported (...) A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. The aim of this study was to evaluate the efficacy and tolerability of an experimental moisturizing mouthwash versus water only in participants experiencing dry mouth symptoms, including those with Sjögren syndrome (n = 28).Participants were randomized to the experimental mouthwash group (n = 53) or the water-only group (n = 47). For 8 days, the mouthwash

2018 Oral surgery, oral medicine, oral pathology and oral radiology Controlled trial quality: uncertain

22. Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

will be applied to the interior of the mouth by means of a mouthwash. This research poses the first potential curative treatment for dry mouth - all other current dry mouth treatments are either symptomatic or lifestyle-based. Autologous blood has been shown to be effective in treating the epithelial surface of dry eyes. This has been attributed to the analogous growth factors in the blood to that of tears - and potentially in this case, saliva - in healing the oral epithelial surface (Herbst et al., 2004 (...) and differentiation of the oral epithelial cells (Klenkler et al., 2007). Therefore, as severe dry mouth disease (and a subsequent lack of saliva and growth factors) causes damage to the epithelial surface lining the mouth, a growth factor rich saliva substitute like FAB, should be an effective treatment for dry mouth. There is currently no study which details FAB for use in dry mouth. Whole or parts of the three major salivary glands have been surgically transplanted or redirected to provide a replacement tear

2018 Clinical Trials

23. Duration of Effect of Biotene Spray in Patients With Dry Mouth

Duration of Effect of Biotene Spray in Patients With Dry Mouth Duration of Effect of Biotene Spray in Patients With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duration of Effect of Biotene (...) Spray in Patients With Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03663231 Recruitment Status : Recruiting First Posted : September 10, 2018 Last Update Posted : January 4, 2019 See Sponsor: University

2018 Clinical Trials

24. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome.

Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03723798 Recruitment Status : Active, not recruiting First

2018 Clinical Trials

25. New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Full Text available with Trip Pro

New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Patients with Sjögren's syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LPA) solution with pilocarpine hydrochloride to inhibit systemic adverse effects by administering via the oral mucosa (...) . The purpose of this study was to assess its stability, safety, and efficacy.The pilocarpine concentration in an LPA liquid formulation was measured 3, 7, 14, and 28 days after preparation to assess its stability. A prospective clinical trial was undertaken to assess the efficacy and safety of the LPA solution as a symptomatic treatment for dry mouth in SS. Patients (n = 24) with clinically significant xerostomia were enrolled after providing written informed consent. Whole-mouth salivary flow rate

2018 Journal of pharmaceutical health care and sciences

26. Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. (Abstract)

Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, EBSCO (Cumulative Index to Nursing and Allied Health Literature, LILACS, BIREME, Virtual Health Library (Latin American and Caribbean Health Science Information database), Zetoc Conference Proceedings, the US National Institutes (...) , selenium, antiseptic mouthrinse, antimicrobial lozenge, polaprezinc, azulene rinse and Venalot Depot (coumarin plus troxerutin).ConclusionsThere is some low quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three-month post radiotherapy). However, it is less clear whether or not this effect is sustained to 12-month post radiotherapy

2018 Evidence Based Dentistry

27. Meta-analysis: Risk of dry mouth with second generation antidepressants. (Abstract)

Meta-analysis: Risk of dry mouth with second generation antidepressants. The goal of this meta-analysis was to quantify the risk of dry mouth associated with commonly prescribed antidepressant agents and examine the potential implications of medication class, dose, and pharmacodynamics and dose on risk of treatment-induced dry mouth.A PubMed search was conducted to identify double-blind, randomized, placebo-controlled trials examining the efficacy and tolerability of second generation (...) antidepressant medications for adults with depressive disorders, anxiety disorders, and OCD.A random-effects meta-analysis was used to quantify the pooled risk ratio of treatment-emergent dry mouth with second generation antidepressants compared to placebo. Stratified subgroup analysis and meta-regression was utilized to further examine the effects antidepressant agent, class, dosage, indication, and receptor affinity profile on the measured risk of dry mouth.99 trials involving 20,868 adults. SNRIs

2018 Progress in neuro-psychopharmacology & biological psychiatry

28. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

26, 2018 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief Summary: This study assessed the efficacy of three dry mouth products (including an experimental Oralbalance gel, oral rinse, and moisturizing spray) to relieve the feeling of dry mouth compared to water, in dry mouth population over a period of 28 days. Condition or disease Intervention/treatment Phase Xerostomia Device: Experimental Oralbalance Moisturizing (...) Gel Device: Biotene Original Oral Rinse Device: Biotene Moisturizing Mouth Spray Other: Water Not Applicable Detailed Description: This was a multi-centered (two-sites), examiner-blinded, four treatment arms, stratified (by Modified Dry Mouth Inventory [DMI] score), randomized, parallel group study in participants with self-reported dry mouth symptoms as determined by participant responses to the DMI. Participants used their assigned dry mouth treatment at home for 28 days. Study Design Go

2018 Clinical Trials

29. Topical Management of Xerostomia With Dry Mouth Products

Speciality in Oral Medicine, Universidad Complutense de Madrid ClinicalTrials.gov Identifier: Other Study ID Numbers: 0001 First Posted: August 2, 2018 Last Update Posted: August 2, 2018 Last Verified: August 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Rosa María López-Pintor Muñoz, Universidad Complutense de Madrid: Xerostomia Sjögren's syndrome Topical dry mouth products Olive Oil Oral (...) Topical Management of Xerostomia With Dry Mouth Products Topical Management of Xerostomia With Dry Mouth Products - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Management of Xerostomia With Dry

2018 Clinical Trials

30. An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects. (Abstract)

An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects. This randomized, open-label, multiple-dose, two-period, crossover study compared the systemic bioavailability of mometasone furoate (MF) administered from a metered-dose inhaler containing MF and formoterol fumarate (F) (MF/F-MDI) versus MF administered from a single-ingredient dry-powder inhaler

2018 Clinical pharmacology in drug development Controlled trial quality: uncertain

31. Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib Full Text available with Trip Pro

Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib This study aims at developing and evaluating reconstitutable dry suspension (RDS) improved for dissolution rate, oral absorption, and convenience of use of poorly water-soluble celecoxib (CXB). Micro-sized CXB particle was used to manufacture nanosuspension by using bead milling and then RDS was made by spray-drying the nanosuspension with effective (...) ) and XRD analysis, it was identified that CXB has the CXB active pharmaceutical ingredient (API)'s original crystallinity after the bead milling and spray-drying process. In vitro dissolution of RDS was higher than that of CXB powder (93% versus 28% dissolution at 30 min). Furthermore, RDS formulation resulted in 5.7 and 6.3-fold higher area under the curve (AUC∞) and peak concentration (Cmax) of CXB compared to after oral administration of CXB powder in rats. Collectively, our results suggest

2018 Pharmaceutics

32. Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics

Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics UTCAT2668, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics Clinical Question In patients with Type I or Type II diabetes, is there an increased incidence of xerostomia, compared to non-diabetics (...) and measures needed to treat diabetic patients who may not only suffer from decreased salivary flow, but also other symptoms that can emanate from xerostomia, such as dysesthesia, periodontitis and increased risk for caries. In particular, the article by Moore/2001 addresses the possibility that xerostomia in diabetics may be due to correlative issues relating to consumption of prescription drugs as opposed to diabetes being a direct cause of dry mouth symptoms. Applicability Because of the high prevalence

2014 UTHSCSA Dental School CAT Library

33. Punctal occlusion for dry eye syndrome. Full Text available with Trip Pro

Punctal occlusion for dry eye syndrome. Dry eye syndrome is a disorder of the tear film that is associated with symptoms of ocular discomfort. Punctal occlusion is a mechanical treatment that blocks the tear drainage system in order to aid in the preservation of natural tears on the ocular surface.To assess the effects of punctal plugs versus no punctal plugs, different types of punctal plugs, and other interventions for managing dry eye.We searched the Cochrane Central Register of Controlled (...) in symptomatic participants diagnosed with aqueous tear deficiency or dry eye syndrome.Two review authors independently assessed trial quality and extracted data. We contacted study investigators for additional information when needed.We included 18 trials (711 participants, 1249 eyes) from Austria, Canada, China, Greece, Japan, Mexico, Netherlands, Turkey, the UK, and the USA in this review. We also identified one ongoing trial. Overall we judged these trials to be at unclear risk of bias because they were

2017 Cochrane

34. Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions. Full Text available with Trip Pro

Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions. Individuals on continuous treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) are at increased risk of bleeding complications during and after oral or dental procedures. Anticoagulant treatment is preferably continued at the same dose, since dose reduction or discontinuation of treatment is associated with an increased risk (...) of thromboembolism. The use of haemostatic measures during or after the procedure (or both) could enable continuation of the oral anticoagulant treatment.We aimed to assess the efficacy of antifibrinolytic agents for preventing bleeding complications in people on oral anticoagulants undergoing minor oral surgery or dental extractions.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Coagulopathies Trials Register, compiled from electronic database searches and handsearching of journals

2018 Cochrane

35. Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch?

September 10, 2018 Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch? Clinical Question: Does oral omega-3 supplementation improve symptoms of dry eye disease? Bottom Line: The evidence for omega-3 is inconsistent. The best quality randomized control trial (RCT) found that omega-3 supplementation does not improve dry eye symptoms or function. Smaller RCTs suggest statistically significant benefits in symptom scores that are not always clinically relevant. At best, omega-3 will improve (...) Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca

2018 Tools for Practice

36. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

37. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

38. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

39. Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. (Abstract)

Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse (...) model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Expression of nerve growth factor (NGF) levels in the epidermis was significantly decreased by oral administration of MPLs, whereas expression of semaphorin (Sema)3A, a nerve repulsion factor, was increased in the MPL group. These results suggest that dietary MPLs attenuate the penetration of nerve fibres into the epidermis by reducing epidermal NGF levels

2017 Clinical & Experimental Dermatology

40. Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis. Full Text available with Trip Pro

Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis. To assess and quantify the risk of drug-induced dry mouth as a side effect in older people.Systematic review and metaanalysis.A search of the literature was undertaken using Medline, Embase, Cochrane, Web of Science, and PubMed from 1990 to 2016.Older people (aged ≥60) who participated in intervention or observational studies investigating drug use as an exposure and xerostomia (...) in metaanalyses. The majority of studies were of moderate methodological quality. In the intervention studies, urological medications (odds ratio (OR) = 5.91, 95% confidence interval (CI) = 4.04-8.63; I2  = 62%), antidepressants (OR = 4.74, 95% CI = 2.69-8.32, I2  = 21%), and psycholeptics (OR = 2.59, 95% CI = 1.79-3.95, I2  = 0%) were significantly associated with dry mouth. In the observational studies, numbers of medications and several medication classes were significantly associated with xerostomia

2017 Journal of the American Geriatrics Society

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