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Dry Mouth

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21. New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Full Text available with Trip Pro

New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Patients with Sjögren's syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LPA) solution with pilocarpine hydrochloride to inhibit systemic adverse effects by administering via the oral mucosa (...) . The purpose of this study was to assess its stability, safety, and efficacy.The pilocarpine concentration in an LPA liquid formulation was measured 3, 7, 14, and 28 days after preparation to assess its stability. A prospective clinical trial was undertaken to assess the efficacy and safety of the LPA solution as a symptomatic treatment for dry mouth in SS. Patients (n = 24) with clinically significant xerostomia were enrolled after providing written informed consent. Whole-mouth salivary flow rate

2018 Journal of pharmaceutical health care and sciences

22. Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. (Abstract)

Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, EBSCO (Cumulative Index to Nursing and Allied Health Literature, LILACS, BIREME, Virtual Health Library (Latin American and Caribbean Health Science Information database), Zetoc Conference Proceedings, the US National Institutes (...) , selenium, antiseptic mouthrinse, antimicrobial lozenge, polaprezinc, azulene rinse and Venalot Depot (coumarin plus troxerutin).ConclusionsThere is some low quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three-month post radiotherapy). However, it is less clear whether or not this effect is sustained to 12-month post radiotherapy

2018 Evidence Based Dentistry

23. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

26, 2018 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief Summary: This study assessed the efficacy of three dry mouth products (including an experimental Oralbalance gel, oral rinse, and moisturizing spray) to relieve the feeling of dry mouth compared to water, in dry mouth population over a period of 28 days. Condition or disease Intervention/treatment Phase Xerostomia Device: Experimental Oralbalance Moisturizing (...) Gel Device: Biotene Original Oral Rinse Device: Biotene Moisturizing Mouth Spray Other: Water Not Applicable Detailed Description: This was a multi-centered (two-sites), examiner-blinded, four treatment arms, stratified (by Modified Dry Mouth Inventory [DMI] score), randomized, parallel group study in participants with self-reported dry mouth symptoms as determined by participant responses to the DMI. Participants used their assigned dry mouth treatment at home for 28 days. Study Design Go

2018 Clinical Trials

24. Topical Management of Xerostomia With Dry Mouth Products

Speciality in Oral Medicine, Universidad Complutense de Madrid ClinicalTrials.gov Identifier: Other Study ID Numbers: 0001 First Posted: August 2, 2018 Last Update Posted: August 2, 2018 Last Verified: August 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Rosa María López-Pintor Muñoz, Universidad Complutense de Madrid: Xerostomia Sjögren's syndrome Topical dry mouth products Olive Oil Oral (...) Topical Management of Xerostomia With Dry Mouth Products Topical Management of Xerostomia With Dry Mouth Products - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Management of Xerostomia With Dry

2018 Clinical Trials

25. An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects. (Abstract)

An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects. This randomized, open-label, multiple-dose, two-period, crossover study compared the systemic bioavailability of mometasone furoate (MF) administered from a metered-dose inhaler containing MF and formoterol fumarate (F) (MF/F-MDI) versus MF administered from a single-ingredient dry-powder inhaler

2018 Clinical pharmacology in drug development Controlled trial quality: uncertain

26. Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib Full Text available with Trip Pro

Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib This study aims at developing and evaluating reconstitutable dry suspension (RDS) improved for dissolution rate, oral absorption, and convenience of use of poorly water-soluble celecoxib (CXB). Micro-sized CXB particle was used to manufacture nanosuspension by using bead milling and then RDS was made by spray-drying the nanosuspension with effective (...) ) and XRD analysis, it was identified that CXB has the CXB active pharmaceutical ingredient (API)'s original crystallinity after the bead milling and spray-drying process. In vitro dissolution of RDS was higher than that of CXB powder (93% versus 28% dissolution at 30 min). Furthermore, RDS formulation resulted in 5.7 and 6.3-fold higher area under the curve (AUC∞) and peak concentration (Cmax) of CXB compared to after oral administration of CXB powder in rats. Collectively, our results suggest

2018 Pharmaceutics

27. Dry mouth adverse effects from drugs used to manage pain, mental health illnesses, and urinary incontinence in adults: A Systematic Review and Meta-analysis

Dry mouth adverse effects from drugs used to manage pain, mental health illnesses, and urinary incontinence in adults: A Systematic Review and Meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

28. Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics

Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics UTCAT2668, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics Clinical Question In patients with Type I or Type II diabetes, is there an increased incidence of xerostomia, compared to non-diabetics (...) and measures needed to treat diabetic patients who may not only suffer from decreased salivary flow, but also other symptoms that can emanate from xerostomia, such as dysesthesia, periodontitis and increased risk for caries. In particular, the article by Moore/2001 addresses the possibility that xerostomia in diabetics may be due to correlative issues relating to consumption of prescription drugs as opposed to diabetes being a direct cause of dry mouth symptoms. Applicability Because of the high prevalence

2014 UTHSCSA Dental School CAT Library

29. Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch?

September 10, 2018 Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch? Clinical Question: Does oral omega-3 supplementation improve symptoms of dry eye disease? Bottom Line: The evidence for omega-3 is inconsistent. The best quality randomized control trial (RCT) found that omega-3 supplementation does not improve dry eye symptoms or function. Smaller RCTs suggest statistically significant benefits in symptom scores that are not always clinically relevant. At best, omega-3 will improve (...) Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca

2018 Tools for Practice

30. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

31. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

32. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms.

No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. No evidence-based recommendation for topical interventions that effectively relieve dry mouth symptoms. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage (...) -based recommendation for topical interventions that effectively relieve dry mouth symptoms. Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion There is no strong evidence that any topical therapy is effective to relieve the symptoms of dry mouth. Critical Summary Assessment This good of limited evidence suggests no clear evidence-based recommendation can be made regarding the effective topical management of dry mouth symptoms. Evidence Quality Rating

2012 ADA Center for Evidence-Based Dentistry

33. Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. (Abstract)

Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse (...) model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Expression of nerve growth factor (NGF) levels in the epidermis was significantly decreased by oral administration of MPLs, whereas expression of semaphorin (Sema)3A, a nerve repulsion factor, was increased in the MPL group. These results suggest that dietary MPLs attenuate the penetration of nerve fibres into the epidermis by reducing epidermal NGF levels

2017 Clinical & Experimental Dermatology

34. Effects of A Novel Disc Formulation on Dry Mouth Symptoms and Enamel Remineralization in Patients With Hyposalivation: An In Vivo Study Full Text available with Trip Pro

Effects of A Novel Disc Formulation on Dry Mouth Symptoms and Enamel Remineralization in Patients With Hyposalivation: An In Vivo Study The goal of this study was to identify the in vivo effects in patients with hyposalivation of a novel slowly dissolving adhering test disc upon on enamel remineralization, oral biofilm, salivary production, pH and buffering, gingival health, and on self-evaluation of oral well-being.Five subjects with xerostomia wore custom made retainers carrying 5 (...) >0.05). The discs favorably impacted eating problems and dental sensitivity. Subjects were positive about disc flavor and mouth feel.Using established in vivo techniques, the effects of a novel product in xerostomic patients were evaluated and quantified. The adhering disc facilitated eating, reduced dental sensitivity, improved saliva production and buffering capacity, reduced plaque, and alleviated xerostomia symptoms.Xerostomia management is challenging. A novel dry mouth disc was effective

2017 Dentistry (Sunnyvale, Calif.) Controlled trial quality: uncertain

35. Whey protein mouth drying influenced by thermal denaturation Full Text available with Trip Pro

Whey protein mouth drying influenced by thermal denaturation Whey proteins are becoming an increasingly popular functional food ingredient. There are, however, sensory properties associated with whey protein beverages that may hinder the consumption of quantities sufficient to gain the desired nutritional benefits. One such property is mouth drying. The influence of protein structure on the mouthfeel properties of milk proteins has been previously reported. This paper investigates the effect (...) increased with longer heating times. As the pH of all samples was close to neutral, this implies that neither the precipitation of whey proteins at low pH, nor their acidity, as reported in previous literature, can be the drying mechanisms in this case. The increase in mouth drying with increased heating time suggests that protein denaturation is a contributing factor and a possible mucoadhesive mechanism is discussed.

2017 Food quality and preference

36. The Cause of Dry Mouth During CPAP Application Full Text available with Trip Pro

The Cause of Dry Mouth During CPAP Application 28162149 2018 12 28 1550-9397 13 4 2017 04 15 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine J Clin Sleep Med The Cause of Dry Mouth During CPAP Application. 647 10.5664/jcsm.6568 Bortolotti Mauro M Department of Gastroenterology and Internal Medicine, S.Orsola-Malpighi Polyclinic, University of Bologna, Italy. eng Letter 2017 04 15 United States J Clin Sleep Med 101231977 1550-9389 2016

2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

37. Evaluation of a novel dry eye model induced by oral administration of finasteride Full Text available with Trip Pro

Evaluation of a novel dry eye model induced by oral administration of finasteride Dry eye is a common eye disease, and suitable animal models are indispensable for investigating the pathogenesis and developing treatments for dry eye. The present study was conducted to develop an androgen deficiency dry eye model induced by finasteride, and to evaluate ocular surface status and inflammatory cytokine gene expression in the lacrimal gland using a cytokine antibody array system. The results (...) revealed that the antiandrogenic drug finasteride induced significant tear deficiency, and the histopathology results revealed significant inflammatory cell infiltration in the lacrimal gland. The cytokine antibody array system identified increased B7‑2 (also known as cluster of differentiation 86), interleukin (IL)‑1β, IL‑4, IL‑6, IL‑10, matrix metalloproteinase‑8, Fas ligand, tumor necrosis factor (TNF)‑α and metalloproteinase inhibitor 1 levels in the lacrimal gland of the dry eye model

2017 Molecular medicine reports

38. Aloe vera for Dry Mouth Denture Patients – Palliative Therapy Full Text available with Trip Pro

Aloe vera for Dry Mouth Denture Patients – Palliative Therapy Xerostomia (dry mouth) is dryness of the mouth which is due to reduced salivary flow. Lack of adequate saliva causes discomfort in denture wearing patients and decreases retention of dentures. The ability of saliva to wet the tissue surface is one of the most important properties for oral comfort and retention of complete denture in dry mouth patients.This study was conducted to evaluate and compare the wetting ability

2017 Journal of clinical and diagnostic research : JCDR

39. Evaluation of wetting ability of five new saliva substitutes on heat-polymerized acrylic resin for retention of complete dentures in dry mouth patients: a comparative study Full Text available with Trip Pro

Evaluation of wetting ability of five new saliva substitutes on heat-polymerized acrylic resin for retention of complete dentures in dry mouth patients: a comparative study The aim of this study was to evaluate & compare the wetting ability of five saliva substitutes & distilled water on heat-polymerized acrylic resin. Contact angle of the saliva substitute on denture base can be taken as an indicator of wettability. Good wetting of heat-polymerized acrylic resin is critical for optimum (...) ), and Moi-Stir (Group VI).The contact angles of five saliva substitutes and distilled water were measured and compared. Group II (AQWET) has the lowest advancing and receding contact angle values and the highest angle of hysteresis on heat-polymerized acrylic resin. Based on contact angle values, Group II (AQWET) has the best wetting ability on heat-cured acrylic resins. The ability of saliva to wet the denture surface is one of the most important properties for complete denture retention in dry mouth

2017 The Pan African medical journal

40. Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid Full Text available with Trip Pro

Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid Sea buckthorn (Hippophae rhamnoides)-derived products have traditionally been used as food and medicinal ingredients in Eastern countries. The purpose of this study was to investigate the effect of oral intake of sea buckthorn oil products on tear secretion using a murine dry eye model. Orally administered sea buckthorn pulp oil (not seed oil) restored aqueous tear secretion to its normal value (...) under a dry eye condition. Palmitoleate (C16:1), a fatty acid present in sea buckthorn pulp oil, preserved tear secretion and suppressed inflammatory cytokines in the lacrimal gland to the same extent as that by pulp oil. These results suggest that an oral intake of sea buckthorn pulp oil has a potency to preserve tear secretion capacity in the dry eye state and palmitoleate, its main constituent fatty acid, is an active component of the oil. This effect may enable a potent diet-based treatment

2017 Nutrients

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