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Dry Mouth

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181. Cough (acute): antimicrobial prescribing

Safety Update, April 2009). Cough medicines containing codeine have restricted use in children (Drug Safety Update, April 2015). Ov Over-the-counter antihistamines and decongestants er-the-counter antihistamines and decongestants Loratadine in combination with pseudoephedrine for 4 days was no more effective than placebo in reducing a composite cough symptom score in 1 RCT of adults with a common cold (very low quality evidence). Adverse effects (including dry mouth, headache and insomnia) were (...) (pseudoephedrine) had no benefit on cough symptoms, and increased adverse effects (including drowsiness and dry mouth). Over-the-counter cough medicines containing the antihistamines diphenhydramine and promethazine are subject to MHRA advice on how to use cough and cold medicines safely for children under 12 years. Bronchodilators Beta-2 agonists Beta-2 agonists Beta-2 agonists (salbutamol syrup) did not significantly reduce the presence of cough at 7 days, or mean cough score at days 1 to 7, compared

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

182. Urinary incontinence and pelvic organ prolapse in women: management

incontinence or overactive bladder. [2006] [2006] Medicines for o Medicines for ov ver eractiv active bladder e bladder 1.4.25 Before starting treatment with a medicine for overactive bladder, explain to the woman: the likelihood of the medicine being successful the common adverse effects associated with the medicine that some adverse effects of anticholinergic medicines, such as dry mouth and constipation, may indicate that the medicine is starting to have an effect that she may not see substantial

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

183. Sore throat (acute): antimicrobial prescribing

al. 2001, Blagden et al. 2001, Chrubasik et al. 2012, McNally et al. 2012 and Schachtel et al. 2014). However, the absolute improvements in pain score were small. Few adverse events were reported in the RCTs with benzocaine lozenges or hexylresorcinol lozenges. Adverse events occurred in 30% to 50% of people using flurbiprofen lozenges, including taste disturbances, numbness, dry mouth and nausea. Throat spr Throat spra ays ys Chlorhexidine plus benzydamine combination throat spray (not available (...) ) or an Sore throat (acute): antimicrobial prescribing (NG84) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 24antiseptic. However, they may only help to reduce pain by a small amount. 1.2.4 Be aware that no evidence was found on non-medicated lozenges, mouthwashes, or local anaesthetic mouth spray used on its own. See the evidence and committee discussion on self-care. 1.3 Choice of antibiotic 1.3.1 When prescribing

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

184. Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted. (PubMed)

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted. Traumatic dental injuries are common. One of the most severe injuries is when a permanent tooth is knocked completely out of the mouth (avulsed). In most circumstances the tooth should be replanted as quickly as possible. There is uncertainty on which interventions will maximise the survival and repair of the replanted tooth. This is an update of a Cochrane Review first published in 2010 (...) teeth.A third study at high risk of bias with 19 participants compared extra- or intra-oral endodontics for avulsed teeth which were stored dry for longer than 60 minutes before replantation. There was insufficient evidence of a difference in periodontal healing.The fourth study at high risk of bias with 73 participants compared a 10-minute soak in either thymosin alpha 1 or saline before replantation followed by daily gingival injections with these same medicaments for the first 7 days

2019 Cochrane

185. Adjuvant therapy with antidepressants for the management of inflammatory bowel disease. (PubMed)

evidence).The effect of antidepressants on AEs is uncertain. Fifty-seven per cent (8/14) of antidepressant participants group reported AEs versus 25% (3/12) of placebo participants (RR 2.29, 95% CI 0.78 to 6.73, low certainty evidence). Commonly reported AEs include nausea, headache, dizziness, drowsiness, sexual problems, insomnia, fatigue, low mood/anxiety, dry mouth, muscle spasms and hot flushes. None of the included studies reported any serious AEs. None of the included studies reported

2019 Cochrane

188. Pre-school vaccinations: guide to vaccinations from 2 to 5 years

worse than a heavy cold. In children, it causes fever, stuffy nose, dry cough, sore throat, aching muscles and joints, and extreme tiredness that can last several days. Flu can lead to painful ear infection, bronchitis and pneumonia – these may be severe. What causes flu and how do you catch it? Flu is caused by influenza viruses that infect the windpipe and lungs. When an infected person coughs or sneezes, they spread the flu virus in tiny drops of saliva over a wide area. These droplets can (...) . If you can’t get in touch with your doctor, or are still worried after getting advice, trust your instincts and take your child to the nearest hospital with an emergency department. The ‘glass’ test Press the side of a drinking glass firmly against the rash so you can see if the rash fades and loses colour under pressure. If it doesn’t change colour, contact your doctor immediately. Watch out for meningitis and septicaemia * On dark skin, check inside the eyelids or roof of the mouth where the spots

2019 Public Health England

189. A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome

A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00852839 Recruitment Status : Completed First Posted : February 27, 2009 Last Update Posted : September 18

2009 Clinical Trials

190. Effect of Korean Red Ginseng (KRG) on Dry Mouth

Effect of Korean Red Ginseng (KRG) on Dry Mouth Effect of Korean Red Ginseng (KRG) on Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Korean Red Ginseng (KRG) on Dry Mouth The safety (...) to Brief Summary: The purpose of this study is to determine the effect of KRG (Korean Red Ginseng) on Dry Mouth (Xerostomia). Condition or disease Intervention/treatment Phase Xerostomia Dietary Supplement: Korean Red Ginseng Powder Capsule Dietary Supplement: Corn-starch powder with ginseng flavor Phase 4 Detailed Description: Korean Red Ginseng Worldwide use A main herb of old oriental prescriptions for dry mouth Need for correct information by RCT Study Design Go to Layout table for study

2009 Clinical Trials

191. Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjögren's syndrome: a double-blind placebo-controlled multicenter trial. (PubMed)

Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjögren's syndrome: a double-blind placebo-controlled multicenter trial. The effects of rebamipide on dry mouth and salivary secretion in Sjögren's syndrome patients were investigated in a double-blind placebo-controlled study. Rebamipide (100 mg TID) or placebo was administered for eight weeks and patient-assessed improvement of dry mouth and increase in salivary secretion measured by the Saxon test (...) were evaluated. At two, four, and eight weeks, dry mouth improvement rates were, respectively, 26.0, 44.0, and 46.9% for rebamipide and 20.0, 27.1, and 39.1% for placebo, and mean increases in salivary secretion were, respectively, 0.14, 0.24, and 0.35 g for rebamipide and 0.03, 0.09, and 0.17 g for placebo, indicating higher values in the rebamipide group for both parameters at all timepoints but no significant differences between the two groups. Analysis by baseline characteristics suggested

2009 Modern rheumatology / the Japan Rheumatism Association

192. The cholinesterase inhibitor physostigmine for the local treatment of dry mouth: a randomized study. (PubMed)

The cholinesterase inhibitor physostigmine for the local treatment of dry mouth: a randomized study. Application of physostigmine to the oromucosal surface with the aim of stimulating underlying mucin-producing glands while reducing cholinergic systemic effects might be a strategy for treating dry mouth. Subjects suffering from dry mouth and with hyposalivation participated in a crossover, double-blind, randomized study. A gel containing physostigmine (0.9, 1.8, 3.6, and 7.2 mg) or placebo (...) modality for dry-mouth treatment.

2009 European journal of oral sciences

193. Increased Prevalence of Antibodies to Thyroid Peroxidase in Dry Eyes and Mouth Syndrome or Sicca Asthenia Polyalgia Syndrome. (PubMed)

Increased Prevalence of Antibodies to Thyroid Peroxidase in Dry Eyes and Mouth Syndrome or Sicca Asthenia Polyalgia Syndrome. A subset of patients presenting with sicca features suggestive of primary Sjögren's syndrome (pSS) do not fulfill diagnostic or histopathological criteria. This presentation was previously designated as dry eyes and mouth syndrome (DEMS) or sicca asthenia polyalgia syndrome (SAPS). We sought to define the underlying clinical, laboratory, and histological features

2009 Journal of Rheumatology

194. Deprescribing benzodiazepine receptor agonists

guideline for details. Alternate drugs or consult psychiatrist if considering deprescribing Continue AP Good practice recommendation Stop AP • APs associated with increased risk of: • Metabolic disturbances, weight gain, dry mouth, dizziness • Somnolence, drowsiness, injury or falls, hip fractures, EPS, abnormal gait, urinary tract infections, cardiovascular adverse events, death • Risk factors: higher dose, older age, Parkinsons’, Lewy Body Dementia Bjerre LM, Farrell B, Hogel M, Graham L, Lemay G

2018 CPG Infobase

195. Antidepressants for depression in adults with HIV infection. (PubMed)

%; very low quality evidence). Based on this, we were unable to determine if there was a difference in the proportion of participants experiencing adverse events in the antidepressant versus placebo arms. However, sexual dysfunction was reported commonly in people receiving selective serotonin reuptake inhibitors (SSRIs). People receiving tricyclic antidepressants (TCAs) frequently reported anticholinergic adverse effects such as dry mouth and constipation. There were no reported grade 3 or 4 adverse

2018 Cochrane

196. Pharmacological therapies for management of opium withdrawal. (PubMed)

) and in the comparison of methadone versus methadone plus gabapentin (MD -2.20, 95% CI -6.72 to 2.32; 1 study, 40 participants).Comparing clonidine versus buprenorphine in an outpatient setting, more adverse effects were reported in the clonidine group (1 study, 76 participants). Higher numbers of participants in the clonidine group experienced hypotension at days 5 to 8, headache at days 1 to 8, sedation at days 5 to 8, dizziness and dry mouth at days 1 to 10, and nausea at days 1 to 9. Sweating was reported

2018 Cochrane

197. Antidepressants for treating depression in dementia. (PubMed)

(antidepressant: 49.2%, placebo: 38.4%; OR 1.55, 95% CI 1.21 to 1.98, 1073 participants; 3 studies), as did the analyses for participants suffering one event of dry mouth (antidepressant: 19.6%, placebo: 13.3%; OR 1.80, 95% CI 1.23 to 2.63, 1044 participants; 5 studies), and one event of dizziness (antidepressant: 19.2%, placebo: 12.5%; OR 2.00, 95% CI 1.34 to 2.98, 1044 participants; 5 studies). Heterogeneity in the way adverse events were reported in studies presented a major difficulty for meta-analysis

2018 Cochrane

198. Eszopiclone for insomnia. (PubMed)

difference (RD) 0.18, 95% CI 0.14 to 0.21; 9 studies, 3787 participants), dry mouth (RD 0.04, 95% CI 0.02 to 0.06; 6 studies, 2802 participants), somnolence (RD 0.04, 95% CI 0.02 to 0.06; 8 studies, 3532 participants) and dizziness (RD 0.03, 95% CI 0.01 to 0.05; 7 studies, 2933 participants). According to the GRADE criteria, evidence was rated as being of moderate quality for sleep efficacy outcomes and adverse events and of low quality for rebound effects and next-day functioning.Eszopiclone appears

2018 Cochrane

199. Primary biliary cholangitis

hx of autoimmune disease FHx of autoimmune disease hx of hypercholesterolaemia itch fatigue dry eyes and dry mouth sleep disturbance postural dizziness/blackouts hepatomegaly FHx of primary biliary cholangitis weight loss and other metabolic features of malabsorption memory and concentration problems jaundice ascites splenomegaly skin pigmentation xanthelasmata female sex age between 45 and 60 years FHx of PBC/autoimmune disease smoking urinary tract infection Diagnostic investigations alkaline

2018 BMJ Best Practice

200. Obstructive sleep apnoea in adults

erectile dysfunction morning headaches heartburn/dyspepsia dry mouth nocturnal sweating obesity male sex post-menopause (women) large neck circumference maxillomandibular anomalies (e.g., narrowing, retrognathia, and high, arched palate) increased volume of soft tissues (includes tonsils, adenoids, and tongue) FHx of OSA chronic snoring nasal obstruction polycystic ovary syndrome levels of sex hormones hypothyroidism Down's syndrome mucopolysaccharidoses alcohol use increasing age black, Hispanic

2018 BMJ Best Practice

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