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Dry Mouth

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181. Espranor (buprenorphine oral lyophilisate) 2mg and 8mg

for administration, the dissolution rate will be less than the solid dose form. 3 Administration issues The oral lyophilisate should be removed from the blister pack with dry fingers – any contact with moisture will result in disintegration of the wafer. The oral lyophilisate must be placed whole on the tongue until dispersed. This is different to current buprenorphine tablets which are placed under the tongue. Healthcare professionals need to be clear about this to advise patients and avoid administration (...) errors. Placing Espranor on the tongue makes supervision of dosing easier as it instantly begins to disintegrate making removal from the mouth for the purposes of diversion impossible. If the oral lyophilisate or saliva containing buprenorphine is swallowed, the buprenorphine will be metabolised, excreted and have minimal effect. [2] Swallowing should be avoided for 2 minutes. Food and drink should not be consumed for 5 minutes after administration. [2] This may require observation of people having

2017 Specialist Pharmacy Services

182. Foot-and-Mouth Disease Virus: Stability of Neutralizing Antibody After Freeze-drying and Air-drying Full Text available with Trip Pro

Foot-and-Mouth Disease Virus: Stability of Neutralizing Antibody After Freeze-drying and Air-drying It is possible to stabilize foot-and-mouth disease antiserum by either freeze-drying in bottles or air-drying on paper for periods of 7 months.

1969 Applied microbiology

183. Factors affecting institutionalized older peoples’ self-perceived dry mouth Full Text available with Trip Pro

results showed that the type of long-term care (LTC) facility, regular oral examinations, wearing dentures, and the ability to chew sticky foods affected self-perceived dry mouth. This study determined an association between the type of LTC facility where the participants lived and self-perceived dry mouth.The results indicated the importance of providing oral care in order to improve and prevent dry mouth among institutionalized older people living in SCWIs who do not undergo regular oral (...) Factors affecting institutionalized older peoples’ self-perceived dry mouth The purpose of this study was to determine the factors affecting institutionalized older peoples' self-perceived dry mouth.This cross-sectional study was conducted on elderly residents at 22 long-term care facilities. A total of 165 questionnaires were returned from 13 senior citizen welfare institutions (SCWIs) and nine nursing homes. Multiple logistic regression analysis was used to analyze the data obtained.The

2014 Quality of Life Research

184. Limited evidence for non-pharmacological interventions for the relief of dry mouth. (Abstract)

Limited evidence for non-pharmacological interventions for the relief of dry mouth. The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, AMED, CINAHL and CANCERLIT databases were searched. The metaRegister of Controlled Clinical Trials and ClinicalTrials.gov were also searched to identify ongoing and completed trials. Reference lists of included studies and relevant reviews were also searched. There were no restrictions (...) on the language of publication or publication status.Randomised controlled trials of non-pharmacological treatments for patients with dry mouth at baseline.Study assessment and data extraction were carried out independently by at least two reviewers. Mean difference (MD) and standardised mean differences (SMD) together with 95% CIs were calculated where appropriate.Nine studies (366 participants) were included in this review, eight were assessed at high risk of bias and one at unclear risk of bias. Five small

2014 Evidence Based Dentistry

185. Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome

Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02092207 Recruitment Status : Completed First Posted : March

2014 Clinical Trials

186. Managing the care of patients with Sjögren syndrome and dry mouth: Comorbidities, medication use and dental care considerations. (Abstract)

Managing the care of patients with Sjögren syndrome and dry mouth: Comorbidities, medication use and dental care considerations. As North Americans live longer, have more chronic conditions and take more medications, adverse oral events are likely to increase and aggravate the symptoms of Sjögren syndrome (SS).A total of 151 adults who self-reported having SS and who had a mean (standard deviation [SD]) age of 65.8 (11.5) years completed a survey that included questions about basic demographic (...) information, current medical conditions, medications used (prescription and over the counter [OTC]) and the use of oral products to manage SS symptoms. Owing to the self-reporting process in our survey, the term "SS" in our study population represented a mixture of people with SS and people with dry mouth symptoms.The mean (SD) number of daily medications recorded as prescription, OTC and oral care products were 4.9 (3.5), 4.5 (2.8) and 4.6 (1.4), respectively. Participants with four or more comorbid

2014 Journal of the American Dental Association

187. A randomized clinical trial of an intervention to relieve thirst and dry mouth in intensive care unit patients. Full Text available with Trip Pro

cognitively intact patients reporting thirst intensity (TI) and/or thirst distress (TD) scores ≥3 on 0-10 numeric rating scales (NRS) were randomized to intervention or usual care groups. A research team nurse (RTN#1) obtained patients' pre-procedure TI and TD scores and reports of dry mouth. She then administered a thirst bundle to the intervention group: oral swab wipes, sterile ice-cold water sprays, and a lip moisturizer, or observed patients in the usual care group. RTN#2, blinded to group assignment (...) A randomized clinical trial of an intervention to relieve thirst and dry mouth in intensive care unit patients. To test an intervention bundle for thirst intensity, thirst distress, and dry mouth, which are among the most pervasive, intense, distressful, unrecognized, and undertreated symptoms in ICU patients, but for which data-based interventions are lacking.This was a single-blinded randomized clinical trial in three ICUs in a tertiary medical center in urban California. A total of 252

2014 Intensive Care Medicine Controlled trial quality: uncertain

188. Hyperhidrosis: oral glycopyrronium bromide

. Summary There is weak evidence from case series that oral glycopyrronium bromide tablets reduce sweating in people with hyperhidrosis. The most commonly reported adverse effects are antimuscarinic, particularly dry mouth. There is no randomised controlled trial evidence of the use of oral glycopyrronium bromide for hyperhidrosis. Regulatory status Regulatory status: unlicensed © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights (...) be an early symptom of incomplete intestinal obstruction. P Patient factors atient factors Glycopyrronium bromide tablets and oral solution or suspension are imported or prepared by 'specials' manufacturers. Dosage varies, ranging from 1 mg to a maximum 8 mg (in divided doses) daily in case series. Across case series 29–79% of participants experienced adverse effects, most frequently dry mouth (affecting 16–63%). In 3 case series, 26%, 20% and 3% of participants withdrew because of adverse effects. In 2

2013 National Institute for Health and Clinical Excellence - Advice

189. Hypersalivation: oral glycopyrronium bromide

dry mouth. There is no evidence of its long-term efficacy or safety in treating hypersalivation. Regulatory status: Regulatory status: unlicensed. © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 35Effectiv Effectiveness eness Oral glycopyrronium bromide significantly improved drooling in children and young people with neurological conditions compared with placebo (2 randomised controlled trials [RCTs], 8 (...) ) therapy and with concomitant oral potassium chloride. The most commonly reported adverse effects listed are dry mouth, vomiting, constipation, flushing and nasal congestion. P Patient factors atient factors Glycopyrronium bromide tablets and oral solution or suspension are imported or prepared by 'specials' manufacturers. Dosage varies: generally given 3 times daily, titrated and dependent on weight in children (Cuvposa labelling advises to give either 1 hour before, or 2 hours after, meals). Oral

2013 National Institute for Health and Clinical Excellence - Advice

190. Anticoagulation - oral

Anticoagulation - oral Anticoagulation - oral - NICE CKS Share Anticoagulation - oral: Summary There are five oral anticoagulants licensed for use in the UK: warfarin, apixaban, dabigatran, edoxaban and rivaroxaban. Apixaban, dabigatran, edoxaban and rivaroxaban are newer anticoagulants which may be prescribed instead of warfarin for people with non-valvular atrial fibrillation (NVAF): Apixaban, dabigatran, edoxaban and rivaroxaban have been approved by the National Institute for Health (...) in secondary care consists of stopping treatment and general haemostatic measures, such as mechanical compression and surgical haemostasis with bleeding control procedures, fluid replacement and haemodynamic support, blood products (packed red cells or fresh frozen plasma, depending on associated anaemia or coagulopathy), or platelets. People taking oral anticoagulants should be advised: To seek immediate medical advice if spontaneous bleeding occurs and does not stop, or recurs. This includes bruising

2019 NICE Clinical Knowledge Summaries

191. Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer

Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01748942 Recruitment Status : Completed First Posted : December 13, 2012 Results First Posted : September

2012 Clinical Trials

192. Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients

or disease Intervention/treatment Phase Cancer of Head Neck Radiation-Induced Xerostomia Dry Mouth Dietary Supplement: Oral moisturizing jelly Other: Artificial saliva Not Applicable Detailed Description: Oral moisturizing jelly is a novel edible, gel-based artificial saliva. It has been proven effective in reducing dry mouth sign and symptoms in elderly patients with xerostomia. This randomized control trial intends to determine if continuous use of oral moisturizing jelly may be effective in reduction (...) jelly 5 times/day for two months Dietary Supplement: Oral moisturizing jelly Gel-based artificial saliva is an edible non-nutritious gel intended to relieve dry mouth Active Comparator: Artificial saliva Daily use of non-edible oral lubricating gel 5 times/day for two months Other: Artificial saliva A non-edible oral lubricating gel for dry mouth patients Other Name: Dry mouth gel Outcome Measures Go to Primary Outcome Measures : Changes in subjective dry mouth score compared to baseline [ Time

2017 Clinical Trials

193. How to treat dry eyes

. - Topical omega-3 fatty acids - Oral antioxidants - Vitamin A – Systemic vitamin A deficiency is associated with severe ocular surface dryness with keratinization of the conjunctiva (Bitot spots) and night blindness. Topical vitamin A eye drops can improve dry eye symptoms. - Punctal occlusion – Either temporary or permanent occlusion of the openings of the tear drainage system. - Scleral contact lenses – large-diameter contact lenses can be used to help retain a tear reservoir over the ocular surface (...) How to treat dry eyes CasesBlog - Medical and Health Blog: How to treat dry eyes Health News Updated Daily by Internist and Allergist at Cleveland Clinic Florida Pages How to treat dry eyes How common are dye eyes? The prevalence of dry eyes has been estimated to be 5-30% percent in persons aged 50 years and older, 7% of US adult population has been diagnosed with dry eye disease. The prevalence increases with age (2.7% in those 18 to 34 years old vs. 19% in those aged 75 years and older

2018 CasesBlog - Medical and Health Blog

194. Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth

of dry mouth is called xerostomia and can be found in people with normal salivary gland function. The normal range of salivary production ranges from 0.5 to 1.5 litres per day. The aim of this Cochrane review was to assess the effects of non-pharmacological interventions administered to stimulate saliva production for the relief of dry mouth. Searches were conducted in the Cochrane Oral Health Group’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, AMED (...) Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth Search National Elf Service Search National Elf Service » » » » Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth Sep 3 2013 Posted by It has been estimated that between 10-26% of men and 10-33% of women experience dry mouth. The subjective sensation

2013 The Dental Elf

195. Oral Health Care for the Pregnant Adolescent

enamel softening by acids and control pulpal sensitivity may be prescribed. 97 A palliative approach to alle- viate dry mouth may include increased water consumption or chewing sugarless gum to increase salivation. 44 Common invasive dental procedures may require certain precautions during pregnancy, particularly during the first trimester. Elective restorative and periodontal therapies should be performed during the second trimester. Dental treatment for a pregnant patient who is experiencing pain (...) of delivery and other maternal factors influ- ence the acquisition of Streptococcus mutans in infants. J Dent Res 2005;84(9):806-11. 76. Ge Y, Caufield PW, Fisch GS, Li Y. Streptococcus mutans and Streptococcus sanguis colonization correlated with caries experience in children. Caries Res 2008;42(6): 444-8. 77. Berkowitz RJ, Jordan HV, White G. The early establish- ment of Streptococcus mutans in the mouths of infants. Arch Oral Biol 1975;20(3):171-4. 78. Stiles HM, Meyers R, Brunnelle JA, Wittig AB

2016 American Academy of Pediatric Dentistry

196. Lip and Oral Cavity Cancer Treatment (Adult) (PDQ®): Health Professional Version

of tongue and floor of mouth. Am J Clin Oncol 9 (1): 50-7, 1986. [ ] Takagi M, Kayano T, Yamamoto H, et al.: Causes of oral tongue cancer treatment failures. Analysis of autopsy cases. Cancer 69 (5): 1081-7, 1992. [ ] Cellular Classification of Lip and Oral Cavity Cancer Most head and neck cancers are of the squamous cell variety and may be preceded by various precancerous lesions. Minor salivary gland tumors are not uncommon in these sites. Specimens removed from the lesions may show the carcinomas (...) Lip and Oral Cavity Cancer Treatment (Adult) (PDQ®): Health Professional Version Lip and Oral Cavity Cancer Treatment (Adult) (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information

2018 PDQ - NCI's Comprehensive Cancer Database

197. Palliative care - oral

Palliative care - oral Palliative care - oral - NICE CKS Share Palliative care - oral: Summary Common oral problems in palliative care include dry mouth, painful mouth, halitosis, alteration of taste, and excessive salivation. They may result from poor oral intake, drug treatments, local irradiation, oral tumours, or chemotherapy. Oral symptoms may significantly affect the person's quality of life, causing eating, drinking, and communication problems, and oral discomfort and pain. When (...) assessing a person with oral symptoms in palliative care: Ask about dry mouth, oral pain, halitosis, alteration in taste, excessive salivation, bad breath, difficulty chewing, difficulty speaking, dysphagia, and bleeding. Examine the oral cavity for signs of dehydration, level of oral hygiene, ulceration and vesicles, erythema or white patches, local tumour, bleeding, and infection. The cause of most oral problems can be diagnosed on the basis of clinical features alone, and investigations are rarely

2018 NICE Clinical Knowledge Summaries

198. The Production of a Stable Infliximab Powder: The Evaluation of Spray and Freeze-Drying for Production. Full Text available with Trip Pro

The Production of a Stable Infliximab Powder: The Evaluation of Spray and Freeze-Drying for Production. In prospect of developing an oral dosage form of Infliximab, for treatment of Crohn's disease and rheumatoid arthritis, freeze-drying (vial vs Lyoguard trays) and spray-drying were investigated as production method for stable powders. Dextran and inulin were used in combination with sucrose as stabilizing excipients. The drying processes did not affect Infliximab in these formulations, i.e (...) formulation, both spray-drying and freeze-drying may be useful for (bulk) powder production of Infliximab.

2016 PLoS ONE

199. The Use of Xylitol Products in Patients With Xerostomia May Relieve Symptoms of Oral Dryness and Discomfort

before bedtime. All study participants reported an increase in morning oral wetness (P #3) Ship/2007 40 adults with polypharmacy induced xerostomia Crossover study Key results The 40 patients in this study were all on medications causing salivary hypo function. The patients were divided randomly into two groups – one group was told to continue with their normal dry mouth regimen for seven days (N=20), and the other half of the group received topical products for their dry mouth, which contained olive (...) Search PubMed search “Xylitol”[Mesh] and “Xerostomia”[Mesh] Comments on The Evidence Morales-Bozo/2012 was a randomized double blind clinical trial showing improvement in oral dryness symptoms in patients with xerostomia after the use of mouth rinses with xylitol. The evidence was valid. The patients were divided into two different groups and each group used slightly different mouth rinses, both containing xylitol, and both groups reported improvements in their dry mouth condition. Burgess/2012

2016 UTHSCSA Dental School CAT Library

200. Does poor oral health status increase the risk of falls?: The JAGES Project Longitudinal Study. Full Text available with Trip Pro

Does poor oral health status increase the risk of falls?: The JAGES Project Longitudinal Study. We sought to examine if self-reported oral health conditions regarding difficulty eating tough foods, dry mouth, choking, number of teeth and denture use are associated with incident falls. Our study was based on panel data from the Japan Gerontological Evaluation Study conducted in 2010 and 2013 using self-administered questionnaires. Data from 19,995 male and 20,858 female community-dwelling older (...) , depression, self-rated health, instrumental activities of daily living, body mass index, present illness related to falls, social participation, walking in min/day, alcohol drinking status, and municipality population density, dry mouth in males (odds ratio [OR] = 1.41; 95% confidence interval [CI]: 1.12-1.77) and choking in females (OR = 1.64; 95% CI: 1.27-2.11) were significantly associated with incident falls. Difficulty eating tough foods in both sexes and choking in males were marginally associated

2018 PLoS ONE

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