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Dry Mouth

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181. Cannabis-based medicinal products

outdated antiemetic regimens that do not reflect current practice. Nabilone was also associated with more adverse events (drowsiness, dizziness and dry mouth), particularly in children. The committee noted that although use of cannabis-based medicinal products for intractable chemotherapy-induced nausea and vomiting would be short term, there was a lack of evidence on longer term adverse events, such as dependence and the development of psychological disorders. They identified this as a concern

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

182. Urinary incontinence and pelvic organ prolapse in women: management

incontinence or overactive bladder. [2006] [2006] Medicines for o Medicines for ov ver eractiv active bladder e bladder 1.4.25 Before starting treatment with a medicine for overactive bladder, explain to the woman: the likelihood of the medicine being successful the common adverse effects associated with the medicine that some adverse effects of anticholinergic medicines, such as dry mouth and constipation, may indicate that the medicine is starting to have an effect that she may not see substantial

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

183. Cough (acute): antimicrobial prescribing

Safety Update, April 2009). Cough medicines containing codeine have restricted use in children (Drug Safety Update, April 2015). Ov Over-the-counter antihistamines and decongestants er-the-counter antihistamines and decongestants Loratadine in combination with pseudoephedrine for 4 days was no more effective than placebo in reducing a composite cough symptom score in 1 RCT of adults with a common cold (very low quality evidence). Adverse effects (including dry mouth, headache and insomnia) were (...) (pseudoephedrine) had no benefit on cough symptoms, and increased adverse effects (including drowsiness and dry mouth). Over-the-counter cough medicines containing the antihistamines diphenhydramine and promethazine are subject to MHRA advice on how to use cough and cold medicines safely for children under 12 years. Bronchodilators Beta-2 agonists Beta-2 agonists Beta-2 agonists (salbutamol syrup) did not significantly reduce the presence of cough at 7 days, or mean cough score at days 1 to 7, compared

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

184. Doxylamine/pyridoxine (Xonvea) for treating nausea and vomiting of pregnancy

profile of doxylamine/pyridoxine is relatively well established. The most common adverse reactions (incidence at least 1 in 100) are somnolence, dizziness, dry mouth and fatigue (summary of product characteristics). In the study by Koren et al. (2010), there were no statistically significant differences between doxylamine/pyridoxine and placebo in the rates of any adverse events. Adverse events also appeared to be similar between the groups in the DESI study reported by Zhang et al. (2017), although

2019 National Institute for Health and Clinical Excellence - Advice

185. Sore throat (acute): antimicrobial prescribing

al. 2001, Blagden et al. 2001, Chrubasik et al. 2012, McNally et al. 2012 and Schachtel et al. 2014). However, the absolute improvements in pain score were small. Few adverse events were reported in the RCTs with benzocaine lozenges or hexylresorcinol lozenges. Adverse events occurred in 30% to 50% of people using flurbiprofen lozenges, including taste disturbances, numbness, dry mouth and nausea. Throat spr Throat spra ays ys Chlorhexidine plus benzydamine combination throat spray (not available (...) ) or an Sore throat (acute): antimicrobial prescribing (NG84) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 24antiseptic. However, they may only help to reduce pain by a small amount. 1.2.4 Be aware that no evidence was found on non-medicated lozenges, mouthwashes, or local anaesthetic mouth spray used on its own. See the evidence and committee discussion on self-care. 1.3 Choice of antibiotic 1.3.1 When prescribing

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

186. Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoea

rate, global impression of change scale and DSFS to quality of life were uncertain. The committee considered unstimulated salivary flow rate to be unsuitable because the ability of a treatment to reduce saliva is not an entirely appropriate way of estimating clinical effectiveness. For example, dry mouth is a common adverse event of anticholinergic treatments, so it is inappropriate to assume that a reduction in salivary flow translates to improved clinical outcomes. The committee instead preferred (...) their marketing authorisations. Therefore, there is a lack of data on their effectiveness and safety in the population with chronic sialorrhoea. The company assumed that all anticholinergic treatments were 75% as effective as Xeomin based on an assumption in NICE's guideline on cerebral palsy in under 25s. The committee considered that this may not be the case because a common adverse event of anticholinergics is dry mouth, so the drying effect would be dose related and would depend on whether the patient

2019 National Institute for Health and Clinical Excellence - Technology Appraisals

187. Solriamfetol (Sunosi) - Narcolepsy

in 10 people, is headache. Common side effects, which may affect up to 1 in 10 people, are decreased appetite, anxiety, insomnia (difficulty sleeping), irritability, bruxism (teeth grinding), dizziness, palpitations (a forceful heartbeat that may be rapid or irregular), cough, nausea (feeling sick), diarrhoea, dry mouth, abdominal pain (belly ache), constipation, vomiting, hyperhidrosis (excessive sweating), feeling jittery, chest discomfort and increased blood pressure. Sunosi must not be used

2020 European Medicines Agency - EPARs

188. Chronic obstructive pulmonary disease: beclometasone, formoterol and glycopyrronium (Trimbow)

the active ingredients have been used for many years, alone and in combination. From the studies, there was no evidence that the safety of this triple therapy is worse than that of any of the comparators used in the 3 studies. The most frequently reported adverse effects included oral candidiasis, muscle spasms and dry mouth. Beclometasone/formoterol/glycopyrronium may be an option for some people with moderate-to- severe COPD who have found triple therapy beneficial using more than 1 inhaler and can use

2018 National Institute for Health and Clinical Excellence - Advice

189. Effect of omega-3 and vitamin E supplementation on dry mouth in patients with Sjögren's syndrome. (Abstract)

Effect of omega-3 and vitamin E supplementation on dry mouth in patients with Sjögren's syndrome. To determine whether omega-3 (n-3) increases saliva production in patients with Sjögren's syndrome, 61 patients with Sjögren's received either wheat germ oil (n = 23) or n-3 supplement (TheraTears Nutrition®) (n = 38) in a prospective, randomized, double-masked trial. The outcomes assessed were salivary secretion and markers for oral inflammation. The differences between the n-3 group and wheat

2010 Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry Controlled trial quality: uncertain

190. Use of a mucoadhesive disk for relief of dry mouth: a randomized, double-masked, controlled crossover study. (Abstract)

Use of a mucoadhesive disk for relief of dry mouth: a randomized, double-masked, controlled crossover study. Dry mouth is a frequent complaint of adults worldwide. In those who experience dry mouth, therapeutic options include the use of salivary substitutes and sialogogues.The authors compared the efficacy and safety of mucoadhesive disks (OraMoist, Axiomedic, Zurich; distributed by Quantum Health, Eugene, Ore.) applied three times daily with those of placebo mucoadhesive disks in a double (...) -masked, randomized, controlled crossover study. The primary end point of interest was within-participant differences in subjective (visual analog scale) ratings of dry mouth according to the New York University Bluestone Mouthfeel Questionnaire. The secondary end point was within-participant differences in salivary flow rates.Twenty-seven participants completed the single-site study. The results showed no significant difference between the two types of mucoadhesive disks, both of which were

2010 Journal of the American Dental Association Controlled trial quality: uncertain

191. Acupuncture in Treating Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer

Acupuncture in Treating Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) Study Completion Date : February 2021 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Standard Oral Hygiene All patients will receive standard oral hygiene patient teaching information that includes instructions regarding mouth rinses, use of lip balms, use of mild fluoride toothpaste, the importance of adequate oral hydration, and other standard advice. Each participating site

2010 Clinical Trials

192. Canadian guidelines on opioid use disorder among older adults

are detrimental, including nausea and vomiting, constipation, sedation, mood changes, myocardial infarction, immunosuppression, and trauma, the latter of which includes falls, fractures, and motor vehicle accidents . Other harmful effects of opioids include hormone suppression leading to sexual dysfunction and osteoporosis, dry mouth leading to tooth decay, respiratory depression leading to sleep apnea and/or overdose (sometimes fatal), and addiction (Baldini et al ., 2012) . Most clinicians are aware

2019 CPG Infobase

194. Adjuvant therapy with antidepressants for the management of inflammatory bowel disease. (Abstract)

evidence).The effect of antidepressants on AEs is uncertain. Fifty-seven per cent (8/14) of antidepressant participants group reported AEs versus 25% (3/12) of placebo participants (RR 2.29, 95% CI 0.78 to 6.73, low certainty evidence). Commonly reported AEs include nausea, headache, dizziness, drowsiness, sexual problems, insomnia, fatigue, low mood/anxiety, dry mouth, muscle spasms and hot flushes. None of the included studies reported any serious AEs. None of the included studies reported

2019 Cochrane

195. Dacomitinib (non-small cell lung cancer) - Benefit assessment according to §35a Social Code Book V

of Life Questionnaire-Lung Cancer 13 (QLQ-LC13). In each case, the time until the single confirmed deterioration (deterioration versus baseline on at least 2 consecutive visits by = 10 points) is considered. Pain, appetite loss, diarrhoea, sore mouth, dysphagia, peripheral neuropathy, alopecia, other pain A statistically significant difference to the disadvantage of dacomitinib was shown for the scales of pain, appetite loss, diarrhoea, sore mouth, dysphagia, peripheral neuropathy, alopecia and other (...) pain. This effect was no more than marginal for the outcomes “pain” and “other pain”, however. This resulted in no hint of an added benefit of dacomitinib in comparison with gefitinib; an added benefit is therefore not proven for these 2 outcomes. There was a hint of lesser benefit of dacomitinib in comparison with gefitinib for the following outcomes: appetite loss, diarrhoea, sore mouth, dysphagia, peripheral neuropathy and alopecia. Fatigue, nausea/vomiting, dyspnoea, insomnia, constipation

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

196. Pembrolizumab (melanoma) - Benefit assessment according to §35a Social Code Book V

disorders (SOC)”, “dry mouth (preferred term [PT])”, “dyspepsia (PT)”, “decreased appetite (PT)”, “musculoskeletal pain (PT)” and “dyspnoea (PT)” There is a statistically significant difference to the disadvantage of pembrolizumab in comparison with placebo between the treatment groups for the outcomes “infections and infestations (SOC)”, “skin and subcutaneous tissue disorders (SOC)”, “dry mouth (PT)”, “dyspepsia (PT)”, “decreased appetite (PT)”, “musculoskeletal pain (PT)” and “dyspnoea (PT

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

198. Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted. Full Text available with Trip Pro

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted. Traumatic dental injuries are common. One of the most severe injuries is when a permanent tooth is knocked completely out of the mouth (avulsed). In most circumstances the tooth should be replanted as quickly as possible. There is uncertainty on which interventions will maximise the survival and repair of the replanted tooth. This is an update of a Cochrane Review first published in 2010 (...) teeth.A third study at high risk of bias with 19 participants compared extra- or intra-oral endodontics for avulsed teeth which were stored dry for longer than 60 minutes before replantation. There was insufficient evidence of a difference in periodontal healing.The fourth study at high risk of bias with 73 participants compared a 10-minute soak in either thymosin alpha 1 or saline before replantation followed by daily gingival injections with these same medicaments for the first 7 days

2019 Cochrane

199. Hypoglossal nerve stimulation for moderate to severe obstructive sleep apnoea

reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 85.7 Infection was reported in 1 patient in a prospective case series of 22 patients from the systematic review and meta-analysis of 200 patients; the device was removed. 5.8 Dry mouth was reported in 13% (16/126) of patients in the prospective case series of 126 patients within 3 years of the procedure. 5.9 Discomfort due to electrical stimulation was reported in 58% (73/126) of patients

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

200. Pre-school vaccinations: guide to vaccinations from 2 to 5 years

worse than a heavy cold. In children, it causes fever, stuffy nose, dry cough, sore throat, aching muscles and joints, and extreme tiredness that can last several days. Flu can lead to painful ear infection, bronchitis and pneumonia – these may be severe. What causes flu and how do you catch it? Flu is caused by influenza viruses that infect the windpipe and lungs. When an infected person coughs or sneezes, they spread the flu virus in tiny drops of saliva over a wide area. These droplets can (...) . If you can’t get in touch with your doctor, or are still worried after getting advice, trust your instincts and take your child to the nearest hospital with an emergency department. The ‘glass’ test Press the side of a drinking glass firmly against the rash so you can see if the rash fades and loses colour under pressure. If it doesn’t change colour, contact your doctor immediately. Watch out for meningitis and septicaemia * On dark skin, check inside the eyelids or roof of the mouth where the spots

2019 Public Health England

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