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Dry Mouth

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1. A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. (Abstract)

A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. This study examined ratings of two subjective aspects (moisturization and dry mouth relief) that may be changed following the use of dry mouth relief products (an oral gel, an oral rinse, or a mouth spray), in comparison to water over a period of four hours following a single supervised use on two separate occasions.This was a single-center, two site, randomized (...) , examiner blind, four treatment arm, stratified (by dry mouth screening score at baseline), parallel group study in healthy subjects with a self-reported feeling of dry mouth. Prior to product use, subjects rated their current subjective perception of moisturization and dry mouth on an 11-point scale. Subjects then rated the two questions immediately after product use and 30, 60, 90, 120, and 240 minutes later. At the 240-minute time point, subjects also rated global efficacy questions regarding

2018 The Journal of clinical dentistry Controlled trial quality: uncertain

2. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Full Text available with Trip Pro

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Salivary gland dysfunction is an 'umbrella' term for the presence of either xerostomia (subjective sensation of dryness), or salivary gland hypofunction (reduction in saliva production). It is a predictable side effect of radiotherapy to the head and neck region, and is associated with a significant impairment of quality of life. A wide range of pharmacological interventions (...) , antiseptic mouthrinse, antimicrobial lozenge, polaprezinc, azulene rinse, and Venalot Depot (coumarin plus troxerutin).There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy). However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy. The benefits of amifostine

2017 Cochrane

3. Pilocarpine improves dry mouth caused by radiotherapy

Pilocarpine improves dry mouth caused by radiotherapy Pilocarpine improves dry mouth caused by radiotherapy Discover Portal Discover Portal Pilocarpine improves dry mouth caused by radiotherapy Published on 7 November 2017 doi: Out of several treatments tested, the drug pilocarpine gave the most significant improvement in dry mouth following radiotherapy for head and neck cancer. Less dry mouth and increased salivary flow were twice as likely after taking pilocarpine than after a dummy pill (...) . Dry mouth from radiotherapy impairs quality of life. Although people can try simple measures at home, such as sucking ice cubes, they may wish to discuss pilocarpine treatment with their GP. Side effects from this medication are usually short-lived but if they are troublesome other options are available, though not supported by such good evidence as pilocarpine. Share your views on the research. Why was this study needed? Every day in the UK, 31 people are diagnosed with a type of head and neck

2019 NIHR Dissemination Centre

4. Pilocarpine improves dry mouth caused by radiotherapy

Pilocarpine improves dry mouth caused by radiotherapy Pilocarpine improves dry mouth caused by radiotherapy Discover Portal Discover Portal Pilocarpine improves dry mouth caused by radiotherapy Published on 7 November 2017 doi: Out of several treatments tested, the drug pilocarpine gave the most significant improvement in dry mouth following radiotherapy for head and neck cancer. Less dry mouth and increased salivary flow were twice as likely after taking pilocarpine than after a dummy pill (...) . Dry mouth from radiotherapy impairs quality of life. Although people can try simple measures at home, such as sucking ice cubes, they may wish to discuss pilocarpine treatment with their GP. Side effects from this medication are usually short-lived but if they are troublesome other options are available, though not supported by such good evidence as pilocarpine. Share your views on the research. Why was this study needed? Every day in the UK, 31 people are diagnosed with a type of head and neck

2018 NIHR Dissemination Centre

5. Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients. Full Text available with Trip Pro

Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by reduced lacrimal and salivary secretion. Sicca symptoms together with fatigue and musculoskeletal pain can significantly reduce the patients' quality of life. Furthermore, low salivary secretion may disrupt the oral microbial homeostasis. The aim of this study was to compare the salivary microbiota from pSS patients with patients

2019 PLoS ONE

6. Interventions for the management of dry mouth: non-pharmacological interventions. Full Text available with Trip Pro

Interventions for the management of dry mouth: non-pharmacological interventions. Xerostomia is the subjective sensation of dry mouth. Common causes of xerostomia include adverse effects of many commonly prescribed medications, disease (e.g. Sjogren's Syndrome) and radiotherapy treatment for head and neck cancers. Non-pharmacological techniques such as acupuncture or mild electrostimulation may be used to improve symptoms.To assess the effects of non-pharmacological interventions administered (...) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrials.gov) were also searched to identify ongoing and completed trials. References lists of included studies and relevant reviews were also searched. There were no restrictions on the language of publication or publication status.We included parallel group randomised controlled trials of non-pharmacological interventions to treat dry mouth, where participants had dry mouth symptoms at baseline.At least two review authors assessed each

2013 Cochrane

7. Interventions for the management of dry mouth: non-pharmacological interventions. (Abstract)

Interventions for the management of dry mouth: non-pharmacological interventions. Xerostomia is the subjective sensation of dry mouth. Common causes of xerostomia include adverse effects of many commonly prescribed medications, disease (e.g. Sjogren's Syndrome) and radiotherapy treatment for head and neck cancers. Non-pharmacological techniques such as acupuncture or mild electrostimulation may be used to improve symptoms.To assess the effects of non-pharmacological interventions administered (...) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrials.gov) were also searched to identify ongoing and completed trials. References lists of included studies and relevant reviews were also searched. There were no restrictions on the language of publication or publication status.We included parallel group randomised controlled trials of non-pharmacological interventions to treat dry mouth, where participants had dry mouth symptoms at baseline.At least two review authors assessed each

2013 Cochrane

8. Perceived Stress, Social Support, and Dry Mouth Among US Older Chinese Adults. Full Text available with Trip Pro

Perceived Stress, Social Support, and Dry Mouth Among US Older Chinese Adults. Dry mouth is a common condition among older adults that negatively influences oral health, general health, and quality of life. The role of psychosocial factors in oral health conditions and diseases remains largely unknown. We conducted a study to examine the relationship between perceived stress and dry mouth among US older Chinese adults and further investigated the potential moderating role of social support (...) -point scale, ranging from 0 ("never") to 4 ("very often"). Dry mouth was a binary self-reported outcome variable (1 = "dry mouth"). Social support was measured by the Health and Retirement Study's social support and strain scale from sources including spouse, other family members, and friends with a 3-point response set, ranging from 0 ("hardly ever") to 2 ("often"). Sociodemographics and disease processes were assessed as covariates. We conducted stepwise logistic regressions with interaction

2019 Journal of the American Geriatrics Society

9. Improvement of salivary flow and oral wetness by a lip trainer device and sonic toothbrush in older Japanese men and women with dry mouth. Full Text available with Trip Pro

Improvement of salivary flow and oral wetness by a lip trainer device and sonic toothbrush in older Japanese men and women with dry mouth. Dry mouth, caused by decreased salivary gland function and/or weak salivary stimulation, can severely affect oral health in older individuals. Therefore, the aim of this study is to evaluate whether a lip trainer device and sonic toothbrush can improve salivary flow and oral wetness in older patients complaining of dry mouth. Overall, 39 subjects aged ≥60 (...) significantly increased in group P (P < 0.01) compared with the level at baseline. However, no significant difference was observed over time in group S. Oral wetness of the tongue and buccal mucosa in group P had significantly improved at 1 and 6 months (P < 0.05). Dry mouth in older individuals may be improved by using a lip trainer device or a sonic toothbrush.

2019 Journal of oral science Controlled trial quality: uncertain

10. The combined effect of individually tailored xerostomia and nutritional interventions on dry mouth among nutritionally compromised old home care clients. (Abstract)

The combined effect of individually tailored xerostomia and nutritional interventions on dry mouth among nutritionally compromised old home care clients. To examine the effectiveness of tailored xerostomia and nutritional 6-month interventions on xerostomia among home care clients aged 75 years or over who were malnourished or at risk of malnutrition.A subjective feeling of dry mouth (xerostomia) is common among older adults and affects their quality of life, nutrition and oral health. Medical (...) conditions, polypharmacy, dehydration and malnutrition are often underlying causes of xerostomia.The data are based on the NutOrMed study with a dietary intervention group of 119 patients and control group of 97 patients. In-home interviews were carried out by home care nurses, nutritionists, dental hygienists and pharmacists and tailored interventions by nutritionist and dental hygienists. Xerostomia intervention included individual counselling on dry mouth care and was applied to all those suffering

2019 Gerodontology Controlled trial quality: uncertain

11. Evaluate five different diagnostic tests for dry mouth assessment in geriatric residents in long-term institutions in Taiwan. Full Text available with Trip Pro

Evaluate five different diagnostic tests for dry mouth assessment in geriatric residents in long-term institutions in Taiwan. Residents in long-term care (LTC) institutions require care plans to effectively resolve dry mouth. Simple and easily comprehensible dry mouth indices must be developed to assist care professionals in determining dry mouth among residents. Therefore, this study aim of the study was to evaluate five different diagnostic tests for dry mouth assessment.A total of 568 (...) residents were recruited from several LTC institutions in central Taiwan. The research instruments and tools comprised of the characteristics of the residents, state of oral health care, self-perceived ability to chew food, Taiwanese short-form of the Oral Health Impact Profile (OHIP-7 T), self-perceived levels of dry mouth, oral moisture checking, and a repetitive saliva swallowing test (RSST). The data collected were analyzed through demographic analysis, Correlation coefficient and chi-squared

2019 BMC Oral Health

12. Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. Full Text available with Trip Pro

Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. The aim of the present study was to prospectively evaluate the effect of aclatonium on dry mouth in patients with overactive bladder (OAB) after treatment with solifenacin.A multicenter randomized double-blind controlled trial was conducted. The study subjects were men and women who had been diagnosed with OAB for ≥3 months and presented with a total Overactive Bladder Symptom Score (OABSS (...) ) ≥3. Eligible subjects were randomized to receive 5 mg solifenacin with placebo or 5 mg solifenacin with 150 mg aclatonium once daily for 8 weeks. Subjects rated dry mouth using a visual analog scale (VAS) and completed the OAB-questionnaire (OAB-q) short form (SF) and OABSS questionnaires at baseline and after 8 weeks treatment. Dry mouth was defined as a VAS score >30 points (range 0-100).Overall, 92 patients (49 and 43 in the placebo and aclatonium groups, respectively) completed the 8-week

2019 Lower urinary tract symptoms Controlled trial quality: predicted high

13. Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients. (Abstract)

Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients. Thirst is a common, intense symptom reported by hospitalized patients. No studies indicate frequency of use of ice water and lip moisturizer with menthol to ameliorate thirst and dry mouth. In an audit of 30 intensive care unit patients at a 580-bed community teaching hospital, 66% reported dry mouth with higher thirst distress and intensity scores than in published studies.To evaluate the effectiveness (...) of scheduled use of ice water oral swabs and lip moisturizer with menthol compared with unscheduled use in relieving thirst and dry mouth for intensive care unit patients.In a quasi-experimental design, adult patients admitted to 2 intensive care units at a community hospital were provided with ice water oral swabs and lip moisturizer with menthol upon request. The intervention was unscheduled in 1 unit and scheduled in the other unit. The scheduled intervention was provided hourly during a 7-hour period

2019 American Journal of Critical Care Controlled trial quality: uncertain

14. Sjögren’s syndrome: treatments for dry mouth and hyposalivation

Sjögren’s syndrome: treatments for dry mouth and hyposalivation Sjögren's syndrome: treatments for dry mouth and hyposalivation - National Elf Service Search National Elf Service Search National Elf Service » » » » Sjögren’s syndrome: treatments for dry mouth and hyposalivation Oct 24 2018 Posted by One of Sjögren’s syndrome (SS) commonest features is persistent salivary gland hypofunction which typically leads to chronic dry mouth (xerostomia) intra‐oral discomfort, difficulty with speaking (...) cevimeline versus placebo and systemic pilocarpine versus placebo. Patients using pilocarpine were significantly more likely to have a 25 mm or higher reduction (probably short‐term) in xerostomia VAS score compared to placebo; OR= 3.79 (95%CI; 2.63–5.47) [ 3 studies,517 patients] Use of cevimeline was associated with a higher short‐term reduction in dry mouth symptoms than placebo; MD = 9.85 (95%CI; 1.76–17.94) [ 2 studies,180 patients]. In relation to the secondary outcome of salivary function increase

2018 The Dental Elf

15. Duration of Effect of Biotene Spray in Patients With Dry Mouth

Duration of Effect of Biotene Spray in Patients With Dry Mouth Duration of Effect of Biotene Spray in Patients With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duration of Effect of Biotene (...) Spray in Patients With Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03663231 Recruitment Status : Recruiting First Posted : September 10, 2018 Last Update Posted : January 4, 2019 See Sponsor: University

2018 Clinical Trials

16. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03494985 Recruitment Status : Completed First Posted : April 11, 2018 Results First Posted : July 18, 2018 Last Update Posted : September

2018 Clinical Trials

17. Topical Management of Xerostomia With Dry Mouth Products

Topical Management of Xerostomia With Dry Mouth Products Topical Management of Xerostomia With Dry Mouth Products - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Management of Xerostomia With Dry (...) Complutense de Madrid Study Details Study Description Go to Brief Summary: Objectives: To assess the effects of topical dry mouth products (toothpaste and mouthwash) containing olive oil, parsley oil, provitamin B5, allantoin, betaine and xylitol in Primary Sjögren's syndrome patients with xerostomia. Subjects and Methods: A double-blinded, placebo-controlled, randomized design where participants were randomly assigned at baseline test or placebo products. Participants used the products 3 times/day/28

2018 Clinical Trials

18. Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth Finger-prick Autologous Blood (FAB) for Use in Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Finger-prick Autologous Blood (FAB) for Use (...) in Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03530735 Recruitment Status : Not yet recruiting First Posted : May 21, 2018 Last Update Posted : July 27, 2018 See Sponsor: Bedford Hospital NHS Trust

2018 Clinical Trials

19. A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. Full Text available with Trip Pro

A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. The aim of this study was to evaluate the efficacy and tolerability of an experimental moisturizing mouthwash versus water only in participants experiencing dry mouth symptoms, including those with Sjögren syndrome (n = 28).Participants were randomized to the experimental mouthwash group (n = 53) or the water-only group (n = 47). For 8 days, the mouthwash (...) Performance and Attributes Questionnaire 3-Question 1 ("Relieves the discomfort of dry mouth"; the predefined primary efficacy variable) in favor of mouthwash versus water (0.63 [95% confidence interval 0.17-1.10]; P = .0084). Subgroup analysis found a significant difference that favored mouthwash in participants without Sjögren syndrome (0.67 [0.11,1.23]; P = .0203) but not with Sjögren syndrome (0.52 [-0.35,1.38; P = .2272). Eight, non-serious, oral treatment-related adverse events were reported

2018 Oral surgery, oral medicine, oral pathology and oral radiology Controlled trial quality: uncertain

20. New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Full Text available with Trip Pro

New low-dose liquid pilocarpine formulation for treating dry mouth in Sjögren’s syndrome: clinical efficacy, symptom relief, and improvement in quality of life Patients with Sjögren's syndrome (SS) typically present clinically with xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LPA) solution with pilocarpine hydrochloride to inhibit systemic adverse effects by administering via the oral mucosa (...) . The purpose of this study was to assess its stability, safety, and efficacy.The pilocarpine concentration in an LPA liquid formulation was measured 3, 7, 14, and 28 days after preparation to assess its stability. A prospective clinical trial was undertaken to assess the efficacy and safety of the LPA solution as a symptomatic treatment for dry mouth in SS. Patients (n = 24) with clinically significant xerostomia were enrolled after providing written informed consent. Whole-mouth salivary flow rate

2018 Journal of pharmaceutical health care and sciences

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