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Dry Mouth

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1. A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. (Abstract)

A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. This study examined ratings of two subjective aspects (moisturization and dry mouth relief) that may be changed following the use of dry mouth relief products (an oral gel, an oral rinse, or a mouth spray), in comparison to water over a period of four hours following a single supervised use on two separate occasions.This was a single-center, two site, randomized (...) , examiner blind, four treatment arm, stratified (by dry mouth screening score at baseline), parallel group study in healthy subjects with a self-reported feeling of dry mouth. Prior to product use, subjects rated their current subjective perception of moisturization and dry mouth on an 11-point scale. Subjects then rated the two questions immediately after product use and 30, 60, 90, 120, and 240 minutes later. At the 240-minute time point, subjects also rated global efficacy questions regarding

2018 The Journal of clinical dentistry Controlled trial quality: uncertain

2. Improvement of salivary flow and oral wetness by a lip trainer device and sonic toothbrush in older Japanese men and women with dry mouth. Full Text available with Trip Pro

Improvement of salivary flow and oral wetness by a lip trainer device and sonic toothbrush in older Japanese men and women with dry mouth. Dry mouth, caused by decreased salivary gland function and/or weak salivary stimulation, can severely affect oral health in older individuals. Therefore, the aim of this study is to evaluate whether a lip trainer device and sonic toothbrush can improve salivary flow and oral wetness in older patients complaining of dry mouth. Overall, 39 subjects aged ≥60 (...) significantly increased in group P (P < 0.01) compared with the level at baseline. However, no significant difference was observed over time in group S. Oral wetness of the tongue and buccal mucosa in group P had significantly improved at 1 and 6 months (P < 0.05). Dry mouth in older individuals may be improved by using a lip trainer device or a sonic toothbrush.

2019 Journal of oral science Controlled trial quality: uncertain

3. Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients. Full Text available with Trip Pro

Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by reduced lacrimal and salivary secretion. Sicca symptoms together with fatigue and musculoskeletal pain can significantly reduce the patients' quality of life. Furthermore, low salivary secretion may disrupt the oral microbial homeostasis. The aim of this study was to compare the salivary microbiota from pSS patients with patients (...) with sicca symptoms not fulfilling the classification criteria for pSS (non-SS), and with healthy controls without sicca complaints.Pellets from centrifuged chewing-stimulated whole saliva from pSS patients (n = 15), non-SS sicca patients (n = 15) and healthy controls (n = 15) were prepared. DNA was extracted and analyzed by 16S rRNA gene sequencing. The acquired sequencing data were performed using the human oral microbiome database (HOMD).We detected 42, 45, and 34 bacterial genera in saliva samples

2019 PLoS ONE

4. Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth Full Text available with Trip Pro

Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth To identify in patients with dry mouth the effects of a novel test agent (Oral Essentials Hydrating Formula Mouthwash, Beverly Hills, CA) versus a control agent (Biotène Dry Mouth Oral Rinse, GlaxoSmithKline Consumer Healthcare L.P., Moon Township, PA, USA) versus no treatment on dry mouth, plaque, salivary pH and buffering capacity, gingival health, and tooth sensitivity.In this cross (...) -over study, ten subjects with dry mouth used test and control dry mouth interventions, as well as no dry mouth intervention in randomized sequence. Plaque Index, Gingival Index, Sulcus Bleeding Index, Plaque staining, and photographs were recorded at baseline and end of each study arm. Salivary volume, pH, and buffering capacity were also recorded at these time points. Additionally, subjects completed a questionnaire for dry mouth and dentinal sensitivity at each visit.Reductions in plaque presence

2018 International journal of dentistry Controlled trial quality: uncertain

5. Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women Full Text available with Trip Pro

Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan.A population-based frequency-matched case-control study was conducted in which data were analyzed from the National Health

2018 Cancer management and research

6. A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction

A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better (...) Evidence Education * Associated Topics A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction Yumi Ogata, DDS,DMD, MS . Overview Systematic Review Conclusion Oral contraceptive use may increase the incidence of dry socket in women after impacted mandibular third-molar extraction. Critical Summary Assessment The results of this summarizing the evidence from 12 articles reporting on 16 studies suggest that female patients using

2016 ADA Center for Evidence-Based Dentistry

7. A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction

A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better (...) Evidence Education * Associated Topics A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction Yumi Ogata, DDS,DMD, MS . Overview Systematic Review Conclusion Oral contraceptive use may increase the incidence of dry socket in women after impacted mandibular third-molar extraction. Critical Summary Assessment The results of this summarizing the evidence from 12 articles reporting on 16 studies suggest that female patients using

2016 ADA Center for Evidence-Based Dentistry

8. A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction

A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better (...) Evidence Education * Associated Topics A higher incidence of dry socket may be related to the use of oral contraceptives after impacted mandibular third-molar extraction Yumi Ogata, DDS,DMD, MS . Overview Systematic Review Conclusion Oral contraceptive use may increase the incidence of dry socket in women after impacted mandibular third-molar extraction. Critical Summary Assessment The results of this summarizing the evidence from 12 articles reporting on 16 studies suggest that female patients using

2016 ADA Center for Evidence-Based Dentistry

9. The combined effect of individually tailored xerostomia and nutritional interventions on dry mouth among nutritionally compromised old home care clients. (Abstract)

The combined effect of individually tailored xerostomia and nutritional interventions on dry mouth among nutritionally compromised old home care clients. To examine the effectiveness of tailored xerostomia and nutritional 6-month interventions on xerostomia among home care clients aged 75 years or over who were malnourished or at risk of malnutrition.A subjective feeling of dry mouth (xerostomia) is common among older adults and affects their quality of life, nutrition and oral health. Medical (...) conditions, polypharmacy, dehydration and malnutrition are often underlying causes of xerostomia.The data are based on the NutOrMed study with a dietary intervention group of 119 patients and control group of 97 patients. In-home interviews were carried out by home care nurses, nutritionists, dental hygienists and pharmacists and tailored interventions by nutritionist and dental hygienists. Xerostomia intervention included individual counselling on dry mouth care and was applied to all those suffering

2019 Gerodontology Controlled trial quality: uncertain

10. Evaluate five different diagnostic tests for dry mouth assessment in geriatric residents in long-term institutions in Taiwan. Full Text available with Trip Pro

residents were recruited from several LTC institutions in central Taiwan. The research instruments and tools comprised of the characteristics of the residents, state of oral health care, self-perceived ability to chew food, Taiwanese short-form of the Oral Health Impact Profile (OHIP-7 T), self-perceived levels of dry mouth, oral moisture checking, and a repetitive saliva swallowing test (RSST). The data collected were analyzed through demographic analysis, Correlation coefficient and chi-squared (...) Evaluate five different diagnostic tests for dry mouth assessment in geriatric residents in long-term institutions in Taiwan. Residents in long-term care (LTC) institutions require care plans to effectively resolve dry mouth. Simple and easily comprehensible dry mouth indices must be developed to assist care professionals in determining dry mouth among residents. Therefore, this study aim of the study was to evaluate five different diagnostic tests for dry mouth assessment.A total of 568

2019 BMC Oral Health

11. A Dose-Response Study to Examine the Methodology for Demonstrating the Local Therapeutic Equivalence of the Fluticasone Propionate Component of an Orally Inhaled Combination Therapy of Fluticasone Propionate/Salmeterol Dry Powder. (Abstract)

A Dose-Response Study to Examine the Methodology for Demonstrating the Local Therapeutic Equivalence of the Fluticasone Propionate Component of an Orally Inhaled Combination Therapy of Fluticasone Propionate/Salmeterol Dry Powder. Background: Asthma is widely treated using inhaled corticosteroid/long-acting beta-agonist combinations, such as fluticasone propionate/salmeterol (FPS) dry powder inhaler. Some regulators require generic medications to demonstrate local therapeutic equivalence (LTE

2019 Journal of aerosol medicine and pulmonary drug delivery Controlled trial quality: uncertain

12. Perceived Stress, Social Support, and Dry Mouth Among US Older Chinese Adults. Full Text available with Trip Pro

Perceived Stress, Social Support, and Dry Mouth Among US Older Chinese Adults. Dry mouth is a common condition among older adults that negatively influences oral health, general health, and quality of life. The role of psychosocial factors in oral health conditions and diseases remains largely unknown. We conducted a study to examine the relationship between perceived stress and dry mouth among US older Chinese adults and further investigated the potential moderating role of social support (...) -point scale, ranging from 0 ("never") to 4 ("very often"). Dry mouth was a binary self-reported outcome variable (1 = "dry mouth"). Social support was measured by the Health and Retirement Study's social support and strain scale from sources including spouse, other family members, and friends with a 3-point response set, ranging from 0 ("hardly ever") to 2 ("often"). Sociodemographics and disease processes were assessed as covariates. We conducted stepwise logistic regressions with interaction

2019 Journal of the American Geriatrics Society

13. Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. Full Text available with Trip Pro

Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. The aim of the present study was to prospectively evaluate the effect of aclatonium on dry mouth in patients with overactive bladder (OAB) after treatment with solifenacin.A multicenter randomized double-blind controlled trial was conducted. The study subjects were men and women who had been diagnosed with OAB for ≥3 months and presented with a total Overactive Bladder Symptom Score (OABSS (...) ) ≥3. Eligible subjects were randomized to receive 5 mg solifenacin with placebo or 5 mg solifenacin with 150 mg aclatonium once daily for 8 weeks. Subjects rated dry mouth using a visual analog scale (VAS) and completed the OAB-questionnaire (OAB-q) short form (SF) and OABSS questionnaires at baseline and after 8 weeks treatment. Dry mouth was defined as a VAS score >30 points (range 0-100).Overall, 92 patients (49 and 43 in the placebo and aclatonium groups, respectively) completed the 8-week

2019 Lower urinary tract symptoms Controlled trial quality: predicted high

14. Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients. (Abstract)

of scheduled use of ice water oral swabs and lip moisturizer with menthol compared with unscheduled use in relieving thirst and dry mouth for intensive care unit patients.In a quasi-experimental design, adult patients admitted to 2 intensive care units at a community hospital were provided with ice water oral swabs and lip moisturizer with menthol upon request. The intervention was unscheduled in 1 unit and scheduled in the other unit. The scheduled intervention was provided hourly during a 7-hour period (...) (n = 62 participants). The unscheduled intervention consisted of usual care (n = 41 participants). A numeric rating scale (0-10) was used to measure thirst intensity, thirst distress, and dry mouth before and after 7 hours in both groups.The scheduled-use group had significant lessening of thirst intensity (P = .02) and dry mouth (P = .008). Thirst distress in the scheduled-use group did not differ from that in the unscheduled-use group (P = .07).Scheduled use of ice water oral swabs and lip

2019 American Journal of Critical Care Controlled trial quality: uncertain

15. Sjögren’s syndrome: treatments for dry mouth and hyposalivation

Sjögren’s syndrome: treatments for dry mouth and hyposalivation Sjögren's syndrome: treatments for dry mouth and hyposalivation - National Elf Service Search National Elf Service Search National Elf Service » » » » Sjögren’s syndrome: treatments for dry mouth and hyposalivation Oct 24 2018 Posted by One of Sjögren’s syndrome (SS) commonest features is persistent salivary gland hypofunction which typically leads to chronic dry mouth (xerostomia) intra‐oral discomfort, difficulty with speaking (...) and the level of adverse effects need to be taken into account and further high quality studies using common outcome are needed in relation to treatments for dry mouth. Links Primary Paper Al Hamad A, Lodi G, Porter S, Fedele S, Mercadante V. Oral Dis. 2018 Aug 7. doi: 10.1111/odi.12952. [Epub ahead ofprint] Review. PubMed PMID: 30086205. Other references Dental Elf – 3 rd Sep 2013 Dental Elf – 14 th Dec 2011 Share on Facebook Tweet this on Twitter Share on LinkedIn Share on Google+ Share this post: Share

2018 The Dental Elf

16. Evaluation of the Oral Tolerance of Three Fluoride Toothpaste Formulations in a Dry Mouth Population: Results from Two Randomized Studies. (Abstract)

Evaluation of the Oral Tolerance of Three Fluoride Toothpaste Formulations in a Dry Mouth Population: Results from Two Randomized Studies. To evaluate the oral tolerance of three experimental toothpaste formulations containing sodium fluoride (NaF), compared with two marketed sodium monofluorophosphate (SMFP)-containing biotène® toothpastes, in a dry mouth population after 14 days (primary objective) and 7 days (secondary objective) of use.Toothpastes were tested in two separate dual-site (...) , examiner-blind, randomized, parallel group studies in subjects (35-84 years) with self-reported dry mouth. Oral soft tissue (OST) and oral hard tissue (OHT) examinations were performed at screening, followed by a 7- to 28-day wash-in period using a control toothpaste. Subjects were randomized to receive a NaF-containing toothpaste (Study 1: commercially available toothpaste Pronamel® for Children, n = 82; Study 2: experimental plaque biofilm-loosening formula [PBF] toothpaste, n = 79; or experimental

2017 The Journal of clinical dentistry Controlled trial quality: uncertain

17. A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. Full Text available with Trip Pro

Performance and Attributes Questionnaire 3-Question 1 ("Relieves the discomfort of dry mouth"; the predefined primary efficacy variable) in favor of mouthwash versus water (0.63 [95% confidence interval 0.17-1.10]; P = .0084). Subgroup analysis found a significant difference that favored mouthwash in participants without Sjögren syndrome (0.67 [0.11,1.23]; P = .0203) but not with Sjögren syndrome (0.52 [-0.35,1.38; P = .2272). Eight, non-serious, oral treatment-related adverse events were reported (...) A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. The aim of this study was to evaluate the efficacy and tolerability of an experimental moisturizing mouthwash versus water only in participants experiencing dry mouth symptoms, including those with Sjögren syndrome (n = 28).Participants were randomized to the experimental mouthwash group (n = 53) or the water-only group (n = 47). For 8 days, the mouthwash

2018 Oral surgery, oral medicine, oral pathology and oral radiology Controlled trial quality: uncertain

18. Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

will be applied to the interior of the mouth by means of a mouthwash. This research poses the first potential curative treatment for dry mouth - all other current dry mouth treatments are either symptomatic or lifestyle-based. Autologous blood has been shown to be effective in treating the epithelial surface of dry eyes. This has been attributed to the analogous growth factors in the blood to that of tears - and potentially in this case, saliva - in healing the oral epithelial surface (Herbst et al., 2004 (...) and differentiation of the oral epithelial cells (Klenkler et al., 2007). Therefore, as severe dry mouth disease (and a subsequent lack of saliva and growth factors) causes damage to the epithelial surface lining the mouth, a growth factor rich saliva substitute like FAB, should be an effective treatment for dry mouth. There is currently no study which details FAB for use in dry mouth. Whole or parts of the three major salivary glands have been surgically transplanted or redirected to provide a replacement tear

2018 Clinical Trials

19. Duration of Effect of Biotene Spray in Patients With Dry Mouth

Duration of Effect of Biotene Spray in Patients With Dry Mouth Duration of Effect of Biotene Spray in Patients With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duration of Effect of Biotene (...) Spray in Patients With Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03663231 Recruitment Status : Recruiting First Posted : September 10, 2018 Last Update Posted : January 4, 2019 See Sponsor: University

2018 Clinical Trials

20. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome.

Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03723798 Recruitment Status : Active, not recruiting First

2018 Clinical Trials

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