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Dry Mouth

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1. A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. (PubMed)

A Randomized Clinical Trial to Measure Mouth Moisturization and Dry Mouth Relief in Dry Mouth Subjects Using Dry Mouth Products. This study examined ratings of two subjective aspects (moisturization and dry mouth relief) that may be changed following the use of dry mouth relief products (an oral gel, an oral rinse, or a mouth spray), in comparison to water over a period of four hours following a single supervised use on two separate occasions.This was a single-center, two site, randomized (...) , examiner blind, four treatment arm, stratified (by dry mouth screening score at baseline), parallel group study in healthy subjects with a self-reported feeling of dry mouth. Prior to product use, subjects rated their current subjective perception of moisturization and dry mouth on an 11-point scale. Subjects then rated the two questions immediately after product use and 30, 60, 90, 120, and 240 minutes later. At the 240-minute time point, subjects also rated global efficacy questions regarding

2018 The Journal of clinical dentistry

2. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. (PubMed)

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Salivary gland dysfunction is an 'umbrella' term for the presence of either xerostomia (subjective sensation of dryness), or salivary gland hypofunction (reduction in saliva production). It is a predictable side effect of radiotherapy to the head and neck region, and is associated with a significant impairment of quality of life. A wide range of pharmacological interventions (...) , antiseptic mouthrinse, antimicrobial lozenge, polaprezinc, azulene rinse, and Venalot Depot (coumarin plus troxerutin).There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy). However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy. The benefits of amifostine

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2017 Cochrane

3. Pilocarpine improves dry mouth caused by radiotherapy

Pilocarpine improves dry mouth caused by radiotherapy Pilocarpine improves dry mouth caused by radiotherapy Discover Portal Discover Portal Pilocarpine improves dry mouth caused by radiotherapy Published on 7 November 2017 doi: Out of several treatments tested, the drug pilocarpine gave the most significant improvement in dry mouth following radiotherapy for head and neck cancer. Less dry mouth and increased salivary flow were twice as likely after taking pilocarpine than after a dummy pill (...) . Dry mouth from radiotherapy impairs quality of life. Although people can try simple measures at home, such as sucking ice cubes, they may wish to discuss pilocarpine treatment with their GP. Side effects from this medication are usually short-lived but if they are troublesome other options are available, though not supported by such good evidence as pilocarpine. Share your views on the research. Why was this study needed? Every day in the UK, 31 people are diagnosed with a type of head and neck

2019 NIHR Dissemination Centre

4. Pilocarpine improves dry mouth caused by radiotherapy

Pilocarpine improves dry mouth caused by radiotherapy Pilocarpine improves dry mouth caused by radiotherapy Discover Portal Discover Portal Pilocarpine improves dry mouth caused by radiotherapy Published on 7 November 2017 doi: Out of several treatments tested, the drug pilocarpine gave the most significant improvement in dry mouth following radiotherapy for head and neck cancer. Less dry mouth and increased salivary flow were twice as likely after taking pilocarpine than after a dummy pill (...) . Dry mouth from radiotherapy impairs quality of life. Although people can try simple measures at home, such as sucking ice cubes, they may wish to discuss pilocarpine treatment with their GP. Side effects from this medication are usually short-lived but if they are troublesome other options are available, though not supported by such good evidence as pilocarpine. Share your views on the research. Why was this study needed? Every day in the UK, 31 people are diagnosed with a type of head and neck

2018 NIHR Dissemination Centre

5. Sjögren’s syndrome: treatments for dry mouth and hyposalivation

Sjögren’s syndrome: treatments for dry mouth and hyposalivation Sjögren's syndrome: treatments for dry mouth and hyposalivation - National Elf Service Search National Elf Service Search National Elf Service » » » » Sjögren’s syndrome: treatments for dry mouth and hyposalivation Oct 24 2018 Posted by One of Sjögren’s syndrome (SS) commonest features is persistent salivary gland hypofunction which typically leads to chronic dry mouth (xerostomia) intra‐oral discomfort, difficulty with speaking (...) cevimeline versus placebo and systemic pilocarpine versus placebo. Patients using pilocarpine were significantly more likely to have a 25 mm or higher reduction (probably short‐term) in xerostomia VAS score compared to placebo; OR= 3.79 (95%CI; 2.63–5.47) [ 3 studies,517 patients] Use of cevimeline was associated with a higher short‐term reduction in dry mouth symptoms than placebo; MD = 9.85 (95%CI; 1.76–17.94) [ 2 studies,180 patients]. In relation to the secondary outcome of salivary function increase

2018 The Dental Elf

6. Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients. (PubMed)

Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients. Thirst is a common, intense symptom reported by hospitalized patients. No studies indicate frequency of use of ice water and lip moisturizer with menthol to ameliorate thirst and dry mouth. In an audit of 30 intensive care unit patients at a 580-bed community teaching hospital, 66% reported dry mouth with higher thirst distress and intensity scores than in published studies.To evaluate the effectiveness (...) of scheduled use of ice water oral swabs and lip moisturizer with menthol compared with unscheduled use in relieving thirst and dry mouth for intensive care unit patients.In a quasi-experimental design, adult patients admitted to 2 intensive care units at a community hospital were provided with ice water oral swabs and lip moisturizer with menthol upon request. The intervention was unscheduled in 1 unit and scheduled in the other unit. The scheduled intervention was provided hourly during a 7-hour period

2019 American Journal of Critical Care

7. Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. (PubMed)

Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder. The aim of the present study was to prospectively evaluate the effect of aclatonium on dry mouth in patients with overactive bladder (OAB) after treatment with solifenacin.A multicenter randomized double-blind controlled trial was conducted. The study subjects were men and women who had been diagnosed with OAB for ≥3 months and presented with a total Overactive Bladder Symptom Score (OABSS (...) ) ≥3. Eligible subjects were randomized to receive 5 mg solifenacin with placebo or 5 mg solifenacin with 150 mg aclatonium once daily for 8 weeks. Subjects rated dry mouth using a visual analog scale (VAS) and completed the OAB-questionnaire (OAB-q) short form (SF) and OABSS questionnaires at baseline and after 8 weeks treatment. Dry mouth was defined as a VAS score >30 points (range 0-100).Overall, 92 patients (49 and 43 in the placebo and aclatonium groups, respectively) completed the 8-week

2019 Lower urinary tract symptoms

8. Interventions for the management of dry mouth: non-pharmacological interventions. (PubMed)

Interventions for the management of dry mouth: non-pharmacological interventions. Xerostomia is the subjective sensation of dry mouth. Common causes of xerostomia include adverse effects of many commonly prescribed medications, disease (e.g. Sjogren's Syndrome) and radiotherapy treatment for head and neck cancers. Non-pharmacological techniques such as acupuncture or mild electrostimulation may be used to improve symptoms.To assess the effects of non-pharmacological interventions administered (...) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrials.gov) were also searched to identify ongoing and completed trials. References lists of included studies and relevant reviews were also searched. There were no restrictions on the language of publication or publication status.We included parallel group randomised controlled trials of non-pharmacological interventions to treat dry mouth, where participants had dry mouth symptoms at baseline.At least two review authors assessed each

2013 Cochrane

9. Interventions for the management of dry mouth: non-pharmacological interventions. (PubMed)

Interventions for the management of dry mouth: non-pharmacological interventions. Xerostomia is the subjective sensation of dry mouth. Common causes of xerostomia include adverse effects of many commonly prescribed medications, disease (e.g. Sjogren's Syndrome) and radiotherapy treatment for head and neck cancers. Non-pharmacological techniques such as acupuncture or mild electrostimulation may be used to improve symptoms.To assess the effects of non-pharmacological interventions administered (...) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrials.gov) were also searched to identify ongoing and completed trials. References lists of included studies and relevant reviews were also searched. There were no restrictions on the language of publication or publication status.We included parallel group randomised controlled trials of non-pharmacological interventions to treat dry mouth, where participants had dry mouth symptoms at baseline.At least two review authors assessed each

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2013 Cochrane

10. Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics

Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics UTCAT2668, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Patients with Type I or Type II Diabetes Exhibit More Dry Mouth Symptoms and Xerostomia Compared to Non-Diabetics Clinical Question In patients with Type I or Type II diabetes, is there an increased incidence of xerostomia, compared to non-diabetics (...) and measures needed to treat diabetic patients who may not only suffer from decreased salivary flow, but also other symptoms that can emanate from xerostomia, such as dysesthesia, periodontitis and increased risk for caries. In particular, the article by Moore/2001 addresses the possibility that xerostomia in diabetics may be due to correlative issues relating to consumption of prescription drugs as opposed to diabetes being a direct cause of dry mouth symptoms. Applicability Because of the high prevalence

2014 UTHSCSA Dental School CAT Library

11. A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. (PubMed)

A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. The aim of this study was to evaluate the efficacy and tolerability of an experimental moisturizing mouthwash versus water only in participants experiencing dry mouth symptoms, including those with Sjögren syndrome (n = 28).Participants were randomized to the experimental mouthwash group (n = 53) or the water-only group (n = 47). For 8 days, the mouthwash (...) Performance and Attributes Questionnaire 3-Question 1 ("Relieves the discomfort of dry mouth"; the predefined primary efficacy variable) in favor of mouthwash versus water (0.63 [95% confidence interval 0.17-1.10]; P = .0084). Subgroup analysis found a significant difference that favored mouthwash in participants without Sjögren syndrome (0.67 [0.11,1.23]; P = .0203) but not with Sjögren syndrome (0.52 [-0.35,1.38; P = .2272). Eight, non-serious, oral treatment-related adverse events were reported

2018 Oral surgery, oral medicine, oral pathology and oral radiology

12. Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. (PubMed)

Insufficient evidence for interventions to prevent dry mouth and salivary gland dysfunction post head and neck radiotherapy. Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, EBSCO (Cumulative Index to Nursing and Allied Health Literature, LILACS, BIREME, Virtual Health Library (Latin American and Caribbean Health Science Information database), Zetoc Conference Proceedings, the US National Institutes (...) , selenium, antiseptic mouthrinse, antimicrobial lozenge, polaprezinc, azulene rinse and Venalot Depot (coumarin plus troxerutin).ConclusionsThere is some low quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three-month post radiotherapy). However, it is less clear whether or not this effect is sustained to 12-month post radiotherapy

2018 Evidence Based Dentistry

13. Meta-analysis: Risk of dry mouth with second generation antidepressants.

Meta-analysis: Risk of dry mouth with second generation antidepressants. The goal of this meta-analysis was to quantify the risk of dry mouth associated with commonly prescribed antidepressant agents and examine the potential implications of medication class, dose, and pharmacodynamics and dose on risk of treatment-induced dry mouth.A PubMed search was conducted to identify double-blind, randomized, placebo-controlled trials examining the efficacy and tolerability of second generation (...) antidepressant medications for adults with depressive disorders, anxiety disorders, and OCD.A random-effects meta-analysis was used to quantify the pooled risk ratio of treatment-emergent dry mouth with second generation antidepressants compared to placebo. Stratified subgroup analysis and meta-regression was utilized to further examine the effects antidepressant agent, class, dosage, indication, and receptor affinity profile on the measured risk of dry mouth.99 trials involving 20,868 adults. SNRIs

2018 Progress in neuro-psychopharmacology & biological psychiatry

14. Topical Management of Xerostomia With Dry Mouth Products

Topical Management of Xerostomia With Dry Mouth Products Topical Management of Xerostomia With Dry Mouth Products - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Management of Xerostomia With Dry (...) Complutense de Madrid Study Details Study Description Go to Brief Summary: Objectives: To assess the effects of topical dry mouth products (toothpaste and mouthwash) containing olive oil, parsley oil, provitamin B5, allantoin, betaine and xylitol in Primary Sjögren's syndrome patients with xerostomia. Subjects and Methods: A double-blinded, placebo-controlled, randomized design where participants were randomly assigned at baseline test or placebo products. Participants used the products 3 times/day/28

2018 Clinical Trials

15. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03494985 Recruitment Status : Completed First Posted : April 11, 2018 Results First Posted : July 18, 2018 Last Update Posted : September

2018 Clinical Trials

16. Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth Finger-prick Autologous Blood (FAB) for Use in Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Finger-prick Autologous Blood (FAB) for Use (...) in Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03530735 Recruitment Status : Not yet recruiting First Posted : May 21, 2018 Last Update Posted : July 27, 2018 See Sponsor: Bedford Hospital NHS Trust

2018 Clinical Trials

17. Duration of Effect of Biotene Spray in Patients With Dry Mouth

Duration of Effect of Biotene Spray in Patients With Dry Mouth Duration of Effect of Biotene Spray in Patients With Dry Mouth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duration of Effect of Biotene (...) Spray in Patients With Dry Mouth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03663231 Recruitment Status : Recruiting First Posted : September 10, 2018 Last Update Posted : January 4, 2019 See Sponsor: University

2018 Clinical Trials

18. Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth (PubMed)

Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth To identify in patients with dry mouth the effects of a novel test agent (Oral Essentials Hydrating Formula Mouthwash, Beverly Hills, CA) versus a control agent (Biotène Dry Mouth Oral Rinse, GlaxoSmithKline Consumer Healthcare L.P., Moon Township, PA, USA) versus no treatment on dry mouth, plaque, salivary pH and buffering capacity, gingival health, and tooth sensitivity.In this cross (...) -over study, ten subjects with dry mouth used test and control dry mouth interventions, as well as no dry mouth intervention in randomized sequence. Plaque Index, Gingival Index, Sulcus Bleeding Index, Plaque staining, and photographs were recorded at baseline and end of each study arm. Salivary volume, pH, and buffering capacity were also recorded at these time points. Additionally, subjects completed a questionnaire for dry mouth and dentinal sensitivity at each visit.Reductions in plaque presence

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2018 International journal of dentistry

19. A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water. (PubMed)

A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water. This multicenter, randomized, parallel group study analyzed the effectiveness of an experimental oral gel, a commercially available oral rinse and a commercially available mouth spray versus water alone at relieving self-reported symptoms of dry mouth over a 28-day home use treatment period. The effects of the study treatments (...) on dry mouth-related quality of life (QoL) were also investigated.Eligible subjects were stratified by dry mouth severity (mild, moderate or severe) and randomized to receive one of the study treatments. Prior to first use they completed a questionnaire designed to assess their baseline dry mouth-related QoL. Following first use and on Day 8 (2 hours post-treatment only) and Day 29, subjects completed the modified Product Performance and Attributes Questionnaire (PPAQ) I at 0.5, 1, 2 and 4 hours post

2016 American journal of dentistry

20. Subjective Assessment of Enamelon® Preventive Treatment Gel in a Self-Reported Dry-Mouth Population. (PubMed)

Subjective Assessment of Enamelon® Preventive Treatment Gel in a Self-Reported Dry-Mouth Population. The efficacy of stannous fluoride toothpastes is well established for reducing caries, plaque, and gingivitis and relieving the discomfort of dentin hypersensitivity. Management of dry mouth may include relief remedies in addition to usual oral hygiene methods to maintain oral health and improve quality of life. This 6-week, single-blind, randomized, two-period crossover clinical study (...) was designed to evaluate the oral tolerance and potential of Enamelon® Preventive Treatment Gel (EPTG), with 0.4% stannous fluoride, to relieve subject-perceived dry-mouth symptoms in a self-reported dry-mouth population, after 14 days of use, compared to a marketed over-the-counter (OTC) artificial saliva gel product (Biotene® Oral Balance Gel [BOBG]).Following a 7-day washout period, 52 qualified subjects with self-reported dry-mouth symptoms received EPTG or BOBG for once-daily use for 14 days. All

2017 Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)

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