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Dry Skin

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1. Noninvasive monitoring of plant-based formulations on skin barrier properties in infants with dry skin and risk for atopic dermatitis (PubMed)

Noninvasive monitoring of plant-based formulations on skin barrier properties in infants with dry skin and risk for atopic dermatitis Dry skin and the associated impaired epidermal barrier function are postulated to constitute a major element in the development of atopic dermatitis.The aim of this study was to evaluate the effect of two plant-based formulations on the epidermal barrier function in a defined cohort of infants with a predisposition for atopic dermatitis.Over a period of 16 weeks (...) , 25 infants who were ages 3 to 12 months and had an atopic predisposition and dry skin received two emollients that contained pressed juice of the ice plant. The infants received both cream and lotion on the forearm, only cream on the face, and only lotion on the leg. Stratum corneum hydration (SCH), transepidermal water loss (TEWL), skin surface pH, and sebum were assessed on the infants' forehead, leg, and forearm. The Scoring Atopic Dermatitis (SCORAD) index was used for the clinical

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2018 International journal of women's dermatology

2. Dry skin and skin barrier in early infancy. (PubMed)

Dry skin and skin barrier in early infancy. Atopic dermatitis (AD) usually begins in infancy, commonly involving the cheeks and extensor surfaces of the extremities. It is associated with a dysfunctional skin barrier, which can be measured as increased transepidermal water loss (TEWL) in both lesional and non-lesional skin in AD patients. Dry skin, a cardinal sign of AD, is associated with higher TEWL in adult AD patients. The documentation of the prevalence and manifestation of dry skin (...) in infancy and its association to TEWL, is however limited. Therefore, we aimed to determine the prevalence of dry skin in early infancy and to assess if dry skin in general, or more specifically on cheeks and extensor surfaces of the extremities, was associated with dysfunctional skin barrier. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

3. Dry skin management: Practical approach in light of latest research on skin structure and function. (PubMed)

Dry skin management: Practical approach in light of latest research on skin structure and function. Dry skin is a common condition that is attributed to a lack of water in the stratum corneum. With the availability of new technologies, light has been shed on the pathophysiology of dry skin at the molecular level. With the aim to discuss implications of this latest research for the optimal formulation of emollients designed to treat dry skin, five specialists met in November 2017. Research (...) on three topics thereby provided particularly detailed new insights on how to manage dry skin: research on the lipid composition and organization of the stratum corneum, research on natural moisturizing factors, and research on the peripheral nervous system. There was consensus that latest research expands the rationale to include physiological lipids in an emollient used for dry skin, as they were found to be essential for an adequate composition and organization in the stratum corneum but are reduced

2019 Journal of Dermatological Treatment

4. Elastic MCF Rubber with Photovoltaics and Sensing for Use as Artificial or Hybrid Skin (H-Skin): 1st Report on Dry-Type Solar Cell Rubber with Piezoelectricity for Compressive Sensing (PubMed)

Elastic MCF Rubber with Photovoltaics and Sensing for Use as Artificial or Hybrid Skin (H-Skin): 1st Report on Dry-Type Solar Cell Rubber with Piezoelectricity for Compressive Sensing Ordinary solar cells are very difficult to bend, squash by compression, or extend by tensile strength. However, if they were to possess elastic, flexible, and extensible properties, in addition to piezo-electricity and resistivity, they could be put to effective use as artificial skin installed over human-like (...) robots or humanoids. Further, it could serve as a husk that generates electric power from solar energy and perceives any force or temperature changes. Therefore, we propose a new type of artificial skin, called hybrid skin (H-Skin), for a humanoid robot having hybrid functions. In this study, a novel elastic solar cell is developed from natural rubber that is electrolytically polymerized with a configuration of magnetic clusters of metal particles incorporated into the rubber, by applying a magnetic

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2018 Sensors (Basel, Switzerland)

5. The effect of massage and topical violet oil on the severity of pruritus and dry skin in hemodialysis patients: A randomized controlled trial. (PubMed)

The effect of massage and topical violet oil on the severity of pruritus and dry skin in hemodialysis patients: A randomized controlled trial. Pruritus is one of the common problems in hemodialysis patients that involves more than 45% of Iranian patients. Its exact pathogenesis is unclear. Meanwhile, violet is an old plant with anti-scratching effects, which is extensively used to treat diseases in the Persian medicine. This study aimed to evaluate the effect of massaging the body (...) , a significant difference was observed within each group and between the groups in terms of skin dryness score, severity, location, and frequency of pruritus, which were recovered significantly in both groups.The results of this study indicated that massage with violet oil is more effective than massage alone and is recommended as a complementary treatment for patients with uremic pruritis.Copyright © 2019 Elsevier Ltd. All rights reserved.

2019 Complementary Therapies In Medicine

6. Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin

Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03093597 Recruitment Status : Completed First Posted : March 28, 2017 Last Update Posted : October 11, 2018 Sponsor: University

2017 Clinical Trials

7. A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin (PubMed)

A Double-Blind, Randomised Study Comparing the Skin Hydration and Acceptability of Two Emollient Products in Atopic Eczema Patients with Dry Skin Healthcare professionals tend to recommend emollients based primarily on patient/consumer preference and cost, with cheaper options assumed to be therapeutically equivalent. The aim of this study was therefore to compare the effects on skin hydration of two emollients prescribed in the UK, Doublebase Dayleve™ gel (DELP) and a cheaper alternative (...) , Zerobase Emollient™ cream (ZBC).This was a single-centre, randomised, double-blind, concurrent bi-lateral (within-patient) comparison in 18 females with atopic eczema and dry skin on their lower legs. DELP gel and ZBC cream were each applied to one lower leg twice daily for 4 days and on the morning only on day 5. The efficacy of both products was assessed by hydration measurements using a Corneometer CM825 probe (Courage-Khazaka Electronic). The measurements were made three times daily on days 1 to 5

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2017 Dermatology and therapy

8. Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. (PubMed)

Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. The objective of this 6-week clinical study was to demonstrate the effectiveness of a natural ingredient-based moisturizing cream versus a colloidal oatmeal moisturizing cream in improving the hydration, barrier function, appearance, and feel of dry leg skin. Thirty-two subjects completed the study. After a 5-day washout, subjects used the natural (...) to improve stratum corneum barrier function. Clinical evaluations showed that both products significantly decreased visual dryness and tactile roughness during the treatment phase. Improvements in the assessed clinical parameters persisted even after treatment cessation. In conclusion, the natural ingredient-based moisturizing cream was highly effective in providing moisturization and improving the skin barrier of subjects with very dry leg skin. It also produced significant improvements in visual

2018 Journal of drugs in dermatology : JDD

9. Prevalence, Predictors and Comorbidity of Dry Skin in the General Population. (PubMed)

Prevalence, Predictors and Comorbidity of Dry Skin in the General Population. Dry skin is a frequent and multifaceted condition which can be associated with skin irritation, itch, patient discomfort and manifest skin disease. In spite of being frequent, little is known about the epidemiology of dry skin in the population.To determine the prevalence of dry skin in the German adult population.Data of 48 630 employed persons were assessed on a cross-sectional level in whole-body examinations (...) by experienced dermatologists during company-based skin screenings conducted in 343 German companies. Next to the current dermatologic findings, age, gender, allergies, atopic diseases and the skin type were assessed.In total, n = 14 300 persons (29.4%) were rated as having xerotic skin. Older age but not gender was associated with xerosis. In the regression analyses controlling for age and gender, dry skin was a significant predictor for: axillary dermatitis (OR: 4.51; CI 2.70-7.54), atopic eczema (OR: 3.99

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2018 Journal of the European Academy of Dermatology and Venereology

10. Measurement of the Biomechanical Function and Structure of Ex Vivo Drying Skin Using Raman Spectral Analysis and its Modulation with Emollient Mixtures. (PubMed)

Measurement of the Biomechanical Function and Structure of Ex Vivo Drying Skin Using Raman Spectral Analysis and its Modulation with Emollient Mixtures. An important aspect of the biomechanical behaviour of the stratum corneum (SC) is the drying stresses that develop with water loss. These stresses act as a driving force for damage in the form of chapping and cracking. Betasitosterol is a plant sterol with a structure similar to cholesterol, a key component in the intercellular lipids (...) of the outermost layer of human skin, the SC. Cholesterol plays an important role in stabilizing the SC lipid structure, and altered levels of cholesterol have been linked with SC barrier abnormalities. Betasitosterol is currently applied topically to skin for treatment of wounds and burns. However, it is unknown what effect betasitosterol has on the biomechanical barrier function of skin. Here, by analysing the drying stress profile of SC generated during a kinetics of dehydration, we show that betasitosterol

2018 Experimental Dermatology

11. The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin (PubMed)

The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients (...) with skin diseases.Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.Skin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly

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2018 Clinical, cosmetic and investigational dermatology

12. Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis. (PubMed)

Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis. Epidermal barrier dysfunction is the initial event in the development of atopic dermatitis (AD). Recent studies have identified a crucial role for the aryl hydrocarbon receptor (AHR) in controlling the gene expression of filaggrin and other skin barrier proteins, suggesting an underlying association between AHR and AD pathogenesis.To investigate the role of AHR gene (...) between the three groups. However, patients with AD with the rs10249788 (CT/TT) or rs2066853 (AG + AA) genotype were more likely to have severe dry skin scores. In the stratification analysis, the AHR rs2066853 (AG + AA) and rs10249788 (CT + TT) genotypes could predict a higher risk of severe dry skin phenotypes in the male, early-onset and allergic rhinitis subgroups. Furthermore, the combined rs10249788 (CT + TT) and rs2066853 (AG + AA) genotypes led to a higher risk for severe dry skin in patients

2018 Clinical & Experimental Dermatology

13. The method used to dry washed hands affects the number and type of transient and residential bacteria remaining on the skin. (PubMed)

The method used to dry washed hands affects the number and type of transient and residential bacteria remaining on the skin. Widespread antibiotic resistance has led to fears that we are entering a post-antibiotic era and the relatively simple premise of hand washing to reduce transfer of bacteria and viruses has never been more important. Much of the emphasis has been on hand-washing technique, type of soap, and maintaining compliance but effective drying of the hands is just as important.To (...) compare the efficacy of drying washed hands with a jet air dryer or paper towels to remove transient bacterial contamination and to determine the effect on residential flora.Eighty volunteers were recruited. The entire surfaces of volunteers' hands were artificially contaminated with Escherichia coli before being washed and dried; then bacteria remaining on the skin were recovered and enumerated. In the second part of the study the number and types of bacteria comprising the natural flora remaining

2018 Journal of Hospital Infection

14. Dry skin conditions are related to the recovery rate of skin temperature after cold stress rather than to blood flow. (PubMed)

Dry skin conditions are related to the recovery rate of skin temperature after cold stress rather than to blood flow. Cutaneous blood flow plays an important role in the thermoregulation, oxygen supply, and nutritional support necessary to maintain the skin. However, there is little evidence for a link between blood flow and skin physiology. Therefore, we conducted surveys of healthy volunteers to determine the relationship(s) between dry skin properties and cutaneous vascular function.Water (...) content of the stratum corneum, transepidermal water loss, and visual dryness score were investigated as dry skin parameters. Cutaneous blood flow in the resting state, the recovery rate (RR) of skin temperature on the hand after a cold-stress test, and the responsiveness of facial skin blood flow to local cooling were examined as indices of cutaneous vascular functions. The relationships between dry skin parameters and cutaneous vascular functions were assessed.The RR correlated negatively

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2016 International Journal of Dermatology

15. Children with Dry Skin and Atopic Predisposition: Outcome Measurement with Validated Scores for Atopic Dermatitis. (PubMed)

Children with Dry Skin and Atopic Predisposition: Outcome Measurement with Validated Scores for Atopic Dermatitis. Dry skin is a common skin condition in childhood. Few studies exist investigating the influence of daily skin care on dry skin in infants at risk of developing atopic dermatitis (AD). We aimed to assess the effect of skin care on dry skin in this special cohort using validated scores for AD and analysis of skin microtopography.43 children were randomized to group 1 (G1) and group 2 (...) analyzed by PO-SCORAD was highly reduced after W12 in G1 and after W16 in G2 (p ≤ 0.030). The influence on the parents' anxiety was reduced in G3 at W12 and W16 (p = 0.016). The Visioscan parameter scaliness strongly diminished at W4 (p ≤ 0.049) and W16 (p ≤ 0.013) in all groups.This trial demonstrates improved skin conditions and sleep following daily emollient application in infants and children having dry skin and being at risk of AD. Especially parents of infants showed a reduced fear

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2017 Skin pharmacology and physiology

16. Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. (PubMed)

Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin. The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse (...) model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Expression of nerve growth factor (NGF) levels in the epidermis was significantly decreased by oral administration of MPLs, whereas expression of semaphorin (Sema)3A, a nerve repulsion factor, was increased in the MPL group. These results suggest that dietary MPLs attenuate the penetration of nerve fibres into the epidermis by reducing epidermal NGF levels

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2017 Clinical & Experimental Dermatology

17. Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. (PubMed)

Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. Pruritus frequently reduces quality of life (QOL) in patients with senile xerosis. This study investigated the moisturizing and antipruritic effects of a topical emollient containing a diethylene glycol/dilinoleic acid copolymer (D/DC) in patients with pruritic senile xerosis.This single-blind study involved 50 subjects, aged 50-75 years (...) . Patients were randomized to self-applied treatment of the lower legs with 10% (n = 20) or 20% (n = 20) D/DC-containing cream, white petrolatum (n = 5), or no treatment (n = 5) thrice daily for four weeks. Clinical scores of skin dryness and scratch marks, skin conductance, and Skindex-16 were evaluated before and after treatment. The degree of pruritus was evaluated by visual analog scale (VAS) score once a week.Patients treated with 10% and 20% D/DC showed significant improvements in skin dryness

2017 Journal of cosmetic dermatology

18. Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study. (PubMed)

Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study. Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and intestinal tumor growth amongst others. Our previous investigations have suggested that oral intake of heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88™) suppresses dermatitis (...) by modulating the immune function in an atopic dermatitis mouse model. The aim of the present study was to investigate the effect of heat-killed L. brevis SBC8803 intake on skin hydration conditions in humans. A randomized, double-blind, placebo-controlled study was conducted with volunteers with slightly higher levels of transepidermal water loss (TEWL) on the forearm. The subjects (126 people aged between 21 and 59 years) were randomly allocated to three groups so that the level of TEWL and the age were

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2017 Experimental and therapeutic medicine

19. Characteristics and gelling properties of gelatin from goat skin as affected by drying methods (PubMed)

Characteristics and gelling properties of gelatin from goat skin as affected by drying methods Characteristics and gel properties of spray-dried goat skin gelatin (SDGG) and freeze-dried counterpart (FDGG) were determined, in comparison with commercial bovine gelatin (BG). SDGG gel had the similar gel strength to FDGG gel and their gel strengths were higher than that of BG gel. SDGG gel showed slightly higher a* and b* values as well as the higher solution turbidity than those of FDGG. Both (...) SDGG and FDGG solutions could set at room temperature (25-28 °C) within 18.52-19.30 min and showed the gelling and melting temperatures of 25.14-25.23 and 34.09-34.18 °C, respectively. Gels from SDGG and FDGG had the denser structure with smaller voids than that from BG. Therefore, drying methods affected the characteristics and gel properties of gelatin from goat skin to some degree.

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2017 Journal of food science and technology

20. Comparative effectiveness review of dry needling for mechanical neck and/or trapezius muscle pain in adults

database. Citation HAYES, Inc. Comparative effectiveness review of dry needling for mechanical neck and/or trapezius muscle pain in adults. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Dry needling (DN) is a skilled intervention by which thin filiform needles are used to penetrate the skin and stimulate underlying trigger points (TrPs), muscle, and connective tissues to manage neuromusculoskeletal pain and impaired movement. Rationale: Although its mechanism of action (...) Comparative effectiveness review of dry needling for mechanical neck and/or trapezius muscle pain in adults Comparative effectiveness review of dry needling for mechanical neck and/or trapezius muscle pain in adults Comparative effectiveness review of dry needling for mechanical neck and/or trapezius muscle pain in adults HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA

2017 Health Technology Assessment (HTA) Database.

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