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Drug-induced Photosensitivity

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161. Carrier-free, Self-assembled Pure Drug Nanorods Composed of 10-Hydroxycamptothecin and Chlorin e6 for Combinatorial Chemo-Photodynamic Antitumor Therapy in vivo (PubMed)

Carrier-free, Self-assembled Pure Drug Nanorods Composed of 10-Hydroxycamptothecin and Chlorin e6 for Combinatorial Chemo-Photodynamic Antitumor Therapy in vivo Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6

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2017 Nanoscale

162. Metal Atom Effect on the Photophysical Properties of Mg(II), Zn(II), Cd(II), and Pd(II) Tetraphenylporphyrin Complexes Proposed as Possible Drugs in Photodynamic Therapy (PubMed)

Metal Atom Effect on the Photophysical Properties of Mg(II), Zn(II), Cd(II), and Pd(II) Tetraphenylporphyrin Complexes Proposed as Possible Drugs in Photodynamic Therapy The effects of Mg, Zn, Cd, and Pd dications on the photophysical properties of the tetraphenylporphyrin ligand have been explored, considering the corresponding complexes and by using the density functional theory and its time-dependent extension. Results show that absorption wavelengths do not change significantly when (...) the metal ion changes contrary to what happens to the singlet-triplet energy gaps (ΔES-T) and the spin-orbit matrix elements ΨSnHsoΨTm. The most probable intersystem spin crossing (ISC) pathways for the population of the lowest triplet states have been explored. Our findings can contribute to rationalize the available experimental data and promote the potential therapeutic use of these compounds as photosensitizers in photodynamic therapy (PDT).

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2017 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

163. A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance (PubMed)

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug (...) resistance in synchrony with a photoinitiated and rapid release of antitumor drug. The PNLs consist of a nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether [HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX) encapsulated inside. PNLs have several distinctive capabilities: 1) carrying high loadings of DOX and HMME and releasing the payloads in a photo-cleavage manner with high spatial/temporal resolution at the site of actions via photocatalysis; 2) reducing drug

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2017 International journal of nanomedicine

164. Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (PubMed)

. By adopting nanoparticle (NP) as the drug carrier, a reservoir of drug can be maintained inside the cells upon effective cellular uptake of these NPs via endocytosis. This study shows that gradual release of the drug from the NP carrier provides a feasible scheme for sustained drug release in cells, resulting in relatively stable cytosolic drug concentration level, particularly in the drug resistant case. By implementing an "optical switch" with light irradiation on photosensitizer in the same (...) Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir It is discovered that sustained cytosolic drug release at a sufficient concentration is an effective mechanism to circumvent multidrug resistance and consequently enhance antitumor drug efficacy. It is showed that a simple way to enable this mechanism is to reach an intracellular kinetic balance of the drug movement between the drug released from the carrier into the cytosol and the one removed from the cell interior

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2017 Advanced Science

165. Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs (PubMed)

efficiency by several cancer cell lines and were colocalized with the endolysosomal marker LAMP-1 within 6 h, whereas VLPs labeled externally on lysine residues were taken up with lower efficiency, probably reflecting differences in surface charge and the propensity to bind to the cell surface. The infusion of dye and drug molecules into the cavity of the VLPs revealed that the photosensitizer (PS), Zn-EpPor, and the drugs crystal violet, mitoxantrone (MTX), and doxorubicin (DOX) associated stably (...) Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs Platform technologies based on plant virus nanoparticles (VNPs) and virus-like particles (VLPs) are attracting the attention of researchers and clinicians because the particles are biocompatible, biodegradable, noninfectious in mammals, and can readily be chemically and genetically engineered to carry imaging agents and drugs. When the Physalis mottle virus (PhMV) coat protein is expressed in Escherichia coli

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2017 Biomacromolecules

166. Vitamin D and prolonged photosensitive antibiotic treatment. (PubMed)

Vitamin D and prolonged photosensitive antibiotic treatment. 24100505 2014 06 19 2018 11 13 1098-6596 57 12 2013 Dec Antimicrobial agents and chemotherapy Antimicrob. Agents Chemother. Vitamin D and prolonged treatment with photosensitivity-associated antibiotics. 6409-10 10.1128/AAC.01969-13 Angelakis Emmanouil E Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, URMITE CNRS-IRD 198 UMR 6236, Université de la Méditerranée, Faculté de Médecine, Marseille, France. Oddoze (...) Christiane C Raoult Didier D eng Letter 2013 10 07 United States Antimicrob Agents Chemother 0315061 0066-4804 0 Anti-Bacterial Agents 1406-16-2 Vitamin D 4QWG6N8QKH Hydroxychloroquine N12000U13O Doxycycline IM Adult Aged Anti-Bacterial Agents adverse effects therapeutic use Doxycycline adverse effects therapeutic use Endocarditis blood drug therapy etiology Female Humans Hydroxychloroquine administration & dosage therapeutic use Male Middle Aged Q Fever blood complications drug therapy Retrospective

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2013 Antimicrobial Agents and Chemotherapy

167. Energy saving lamps and their impact on photosensitive and normal individuals. (PubMed)

Energy saving lamps and their impact on photosensitive and normal individuals. A preliminary investigation showed that ultraviolet radiation (UVR) emissions from compact fluorescent lamps (CFLs) can pose a risk to the skin of photosensitive individuals.To carry out a larger-scale study, in patients with a range of photodermatoses, to assess this risk. To determine a safe alternative light source for photosensitive individuals. To investigate if CFL emissions have the potential to induce skin (...) of photosensitive and healthy individuals when situated in close proximity. Double-envelope lamps reduce this risk. LEDs offer a safer alternative light source that eliminates the risk of UVR-induced skin erythema.© 2013 British Association of Dermatologists.

2013 British Journal of Dermatology

168. Characterization of clinical photosensitivity in cutaneous lupus erythematosus. (PubMed)

Characterization of clinical photosensitivity in cutaneous lupus erythematosus. Photosensitivity (PS) in lupus erythematosus (LE) is frequently determined by patient report.We sought to characterize self-reported PS in cutaneous LE (CLE).The PS survey was used to classify subject responses into 5 phenotypes: direct sun-induced CLE flare (directCLE); general exacerbation of CLE (genCLE); polymorphic light eruption-like reactions (genSkin); general pruritus/paresthesias (genRxn); and sun-induced (...) systemic symptoms (genSys). In all, 91 subjects with CLE alone or with CLE and systemic LE were interviewed.In all, 81% ascribed to 1 or more PS phenotypes. CLE-specific reactions (direct sun-induced CLE flare or general exacerbation of CLE) were reported by 86% of photosensitive subjects. Higher CLE disease activity (measured by CLE Disease Area and Severity Index activity scores) was suggestive of direct sun-induced CLE flare reactions (P = .09). In all, 60% of photosensitive subjects described CLE

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2013 Journal of American Academy of Dermatology

169. Photosensitized Oxidative Stress to ARPE-19 Cells Decreases Protein Receptors that Mediate Photoreceptor Outer Segment Phagocytosis. (PubMed)

Photosensitized Oxidative Stress to ARPE-19 Cells Decreases Protein Receptors that Mediate Photoreceptor Outer Segment Phagocytosis. To determine whether previously shown photodynamic (PD)-induced inhibition of specific photoreceptor outer segment (POS) phagocytosis by ARPE-19 cells is associated with reductions in receptor proteins mediating POS phagocytosis, and if PD treatment with merocyanine-540 (MC-540) produces additional effects leading to its inhibition of nonspecific phagocytosis.ARPE (...) . The distribution of N-cadherin, ZO-1, and F-actin was visualized by fluorescence microscopy.Mild PD stress mediated by both photosensitizers that elicits no significant morphologic changes produces transient and recoverable reductions in MerTK. The individual αv and β5 integrin subunits are also reduced but only partially recover. However, there is sufficient recovery to support full recovery of the functional heterodimer. Light stress mediated by MC-540 also reduced levels of actin, which is known

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2013 Investigative Ophthalmology & Visual Science

170. Guidelines for the Clinical and Operational Management of Drug-Resistant Tuberculosis

Guidelines for the Clinical and Operational Management of Drug-Resistant Tuberculosis Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis 2013 International Union Against Tuberculosis and Lung DiseaseJosé A. Caminero, editor with contributions from Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis 2013 International Union Against Tuberculosis and Lung Disease Armand Van Deun Ignacio Monedero Hans L. Rieder Einar Heldal Edith Alarcón (...) Paris, France Suggested citation Caminero JA, ed. Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis. Paris, France: International Union Against Tuberculosis and Lung Disease, 2013. First published online 22 March 2013; revised 6 May 2013. © International Union Against Tuberculosis and Lung Disease (The Union) 68 boulevard St Michel, 75006 Paris, France March 2013 All rights reserved. No part of this publication may be reproduced without the permission of the authors

2013 International Union Against TB and Lung Disease

171. Chlorin e6-Mediated Photodynamic Therapy Suppresses P. acnes-Induced Inflammatory Response via NFκB and MAPKs Signaling Pathway. (PubMed)

Chlorin e6-Mediated Photodynamic Therapy Suppresses P. acnes-Induced Inflammatory Response via NFκB and MAPKs Signaling Pathway. Photodynamic therapy (PDT), consisting of photosensitizer, light, and oxygen has been used for the treatment of various diseases including cancers, microbial infections and skin disorders. In this study, we examined the anti-inflammatory effect of chlorin e6-mediated PDT in P. acnes-infected HaCaT cells using photosensitizer chlorin e6 (Ce6) and halogen light (...) -mediated PDT also reduced the phosphorylation of IKKα/β, IĸBα and NFκB p65 in P. acnes-stimulated HaCaT cells. In addition, the dramatic increase in the nuclear translocation of NFκB p65 observed upon stimulation with P. acnes was markedly impaired by Ce6-based PDT. This is the first suggestion that Ce6-mediated PDT suppresses P. acnes-induced inflammation through modulating NFκB and MAPKs signaling pathways.

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2017 PLoS ONE

172. Effects of Blue-Light-Induced Free Radical Formation from Catechin Hydrate on the Inactivation of Acinetobacter baumannii, Including a Carbapenem-Resistant Strain (PubMed)

the photolytic treatment of catechin hydrate decreased the dimer formation, suggesting that ascorbic acid can suppress the photosensitive oxidation of catechin. When catechin hydrate was irradiated by blue light in an alkaline solution, O₂•− was produced via photosensitized oxidation, enhancing the inactivation of A. baumannii and CRAB. The present findings on the photon-induced oxidation of catechin hydrate provides a safe practice for the inactivation of environmental microorganisms. (...) Effects of Blue-Light-Induced Free Radical Formation from Catechin Hydrate on the Inactivation of Acinetobacter baumannii, Including a Carbapenem-Resistant Strain Catechin is a flavan-3-ol, a derivative of flavans, with four phenolic hydroxyl groups, which exhibits a wide range of physiological properties. Chromatographic analyses were employed to examine the effects of blue light irradiation on the changes of catechin hydrate in an alkaline condition. In particular, the detection

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2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

173. Visualizing Photodynamic Therapy in Transgenic Zebrafish Using Organic Nanoparticles with Aggregation-Induced Emission (PubMed)

Visualizing Photodynamic Therapy in Transgenic Zebrafish Using Organic Nanoparticles with Aggregation-Induced Emission Photodynamic therapy (PDT) employs accumulation of photosensitizers (PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration (...) PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example.

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2018 Nano-Micro Letters

174. ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02210k (PubMed)

ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02210k Porphyrinic metal-organic framework (MOF) nanoparticles for photodynamic therapy solve the photosensitizer problems of poor solubility, self-quenching and aggregation. However, their low selectivity towards malignant tissues is an obstacle for bioimaging and a bottle-neck to cellular uptake (...) for highly efficient photodynamic therapy of cancer. Here, ZrMOF nanoparticles as quenchers to conjugate DNA aptamers were developed for target-induced bioimaging and photodynamic therapy. A phosphate-terminal aptamer prepared by solid-phase DNA synthesis was anchored on the surface of ZrMOF nanoparticles through strong coordination between phosphate and zirconium. Based on π-π stacking-induced quenching of TAMRA by ZrMOF nanoparticles, target-induced imaging is achieved due to the structural change

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2018 Chemical Science

175. Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo (PubMed)

Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo Photodynamic therapy (PDT) utilize a photosensitizing agent and light for cancer therapy. It exerts anti-cancer effect mainly by inducing vascular occlusion at the irradiated site. By controlling the irradiation area, PDT can be used in a tumor-specific manner. However, the non-specific cellular damage in the surrounding (...) APC, but not the negative control, was cytotoxic to EpCAM expressing COLO 205 cells after photoirradiation, suggesting that the cytotoxicity is antigen-dependent. However, in our in vivo analysis using a mouse xenograft tumor model, decreased volume of the tumors was observed in all the mice treated with irradiation, regardless of whether they were treated with the EpCAM APC or the negative control. Detailed investigation of the mechanism of these in vivo reveal that both APCs induce vascular

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2018 Oncotarget

176. Mogamulizumab-induced phosensitivity in patients with mycosis fungoides and other T cell neoplasms. (PubMed)

Mogamulizumab-induced phosensitivity in patients with mycosis fungoides and other T cell neoplasms. Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma.To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment (...) lesions.Increased incidence of photosensitivity reaction was observed during Mog treatment. Decreased number of Tregs in the lesional skin suggests that this reaction is possibly induced by autoreactive cytotoxic T cells.© 2018 European Academy of Dermatology and Venereology.

2018 Journal of the European Academy of Dermatology and Venereology

177. Peripherally Administered CGRP Induces Spontaneous Pain in Mice: Implications for Migraine. (PubMed)

Peripherally Administered CGRP Induces Spontaneous Pain in Mice: Implications for Migraine. Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the neuropeptide calcitonin gene-related peptide (CGRP) or its receptor to prevent migraine. Calcitonin gene (...) -related peptide is believed to contribute to trigeminal nerve hypersensitivity and photosensitivity in migraine, but a direct role in pain associated with migraine has not been established. In this study, we report that peripherally administered CGRP can act in a light-independent manner to produce spontaneous pain in mice that is manifested as a facial grimace. As an objective validation of the orbital tightening action unit of the grimace response, we developed a squint assay using a video-based

2018 Pain

178. A Novel Visual Psychometric Test for Light-Induced Discomfort Using Red and Blue Light Stimuli Under Binocular and Monocular Viewing Conditions. (PubMed)

), but not for red light stimulation.The light-induced discomfort characteristics reported here are consistent with features of the melanopsin-containing intrinsically photosensitive retinal ganglion cell light irradiance pathway, which may mediate photophobia, a prominent feature in many clinical disorders. This is the first psychometric assessment designed around melanopsin spectral properties that can be customized further to assess photophobia in different clinical populations. (...) A Novel Visual Psychometric Test for Light-Induced Discomfort Using Red and Blue Light Stimuli Under Binocular and Monocular Viewing Conditions. To develop an objective psychophysical method to quantify light-induced visual discomfort, and to measure the effects of viewing condition and stimulus wavelength.Eleven visually normal subjects participated in the study. Their pupils were dilated (2.5% phenylephrine) before the experiment. A Ganzfeld system presented either red (1.5, 19.1, 38.2, 57.3

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2018 Investigative Ophthalmology & Visual Science

179. A Tumor Vascular‐Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia (PubMed)

A Tumor Vascular‐Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia Vascular-targeted photodynamic therapy (VTP) is a recently approved strategy for treating solid tumors. However, the exacerbated hypoxic stress makes tumor eradication challenging with such a single modality approach. Here, a new graphene oxide (GO)-based nanosystem for rationally designed, interlocking trimodal cancer therapy that enables VTP using photosensitizer verteporfin (VP) (1) with codelivery (...) of banoxantrone dihydrochloride (AQ4N) (2), a hypoxia-activated prodrug (HAP), and HIF-1α siRNA (siHIF-1α) (3) is reported. The VTP-induced aggravated hypoxia is highly favorable for AQ4N activation into AQ4 (a topoisomerase II inhibitor) for chemotherapy. However, the hypoxia-induced HIF-1α acts as a "hidden brake," through downregulating CYP450 (the dominant HAP-activating reductases), to substantially hinder AQ4N activation. siHIF-1α is rationally adopted to suppress the HIF-1α expression upon hypoxia

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2018 Advanced Science

180. Plasmon-Induced Transparency Based on Triple Arc-Ring Resonators (PubMed)

Plasmon-Induced Transparency Based on Triple Arc-Ring Resonators This paper presents a plasmon-induced transparency (PIT) using an easy-fabricating metamaterial composed of three pieces of metallic arc-rings on top of a dielectric substrate. The transmission of the transparent peak of 1.32 THz reaches approximately 93%. The utilization of the coupled Lorentzian oscillator model and the distribution of electromagnetic fields together explain the cause of the transparent peak. The simulation (...) results further demonstrate that the bandwidth of the transmission peak can be narrowed by changing the sizes of the arc-rings. Moreover, an on/off effect based on the transparent peak is discussed by introducing photosensitive silicon into the air gaps of the suggested metamaterial structure.

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2018 Materials

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