How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,328 results for

Drug-induced Photosensitivity

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy (Full text)

Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy PDT efficacy depends on the concentration of photosensitizer, oxygen, and light delivery in patient tissues. In this study, we measure the in-vivo distribution of important dosimetric parameters, namely the tissue optical properties (absorption μa (λ) and scattering μs ' (λ) coefficients), photofrin concentration (cphotofrin), blood

2018 Proceedings of SPIE--the International Society for Optical Engineering PubMed

142. Sunscreen-Based Photocages for Topical Drugs: A Photophysical and Photochemical Study of A Diclofenac-Avobenzone Dyad (Full text)

Sunscreen-Based Photocages for Topical Drugs: A Photophysical and Photochemical Study of A Diclofenac-Avobenzone Dyad Photosensitization by drugs is a problem of increasing importance in modern life. This phenomenon occurs when a chemical substance in the skin is exposed to sunlight. Photosensitizing drugs are reported to cause severe skin dermatitis, and indeed, it is generally advised to avoid sunbathing and to apply sunscreen. In this context, the nonsteroidal anti-inflammatory drug (NSAID (...) ) diclofenac is a photosensitive drug, especially when administered in topical form. In this work, efforts have been made to design and study an innovative pro-drug/pro-filter system containing diclofenac and the UVA filter avobenzone in order to develop a safer use of this topical drug. The design is based on the presence of a well-established photoremovable phenacyl group in the avobenzone structure. Steady-state photolysis of the dyad in hydrogen-donor solvents, monitored by UV-Vis spectrophotometry

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry PubMed

143. Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients (Full text)

was disease-related in 83.4% (n=166) and medication-related in 16.6% (n=33) of the patients. In cases of drug-induced cytopenia, azathioprine was the most frequently prescribed drug. In patients with cytopenia at the time of diagnosis, erythrocyte sedimentation rates (ESR) were higher, C3 and C4 hypocomplementemia was more prevalent, and they were positive for anti-ds-DNA at a greater proportion (p<0.001, p=0.015, p=0.028, and p=0.019, respectively). Moreover, photosensitivity, renal involvement (...) Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients Systemic lupus erythematosus (SLE) may affect a number of systems, with the hematological system being one of the most common. Our aim is to determine the existence of cytopenia at diagnosis or during follow-up of our SLE patients as well as the associated factors.A cohort of SLE patients that had been followed-up in the Department

2017 European journal of rheumatology PubMed

144. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies (Full text)

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely (...) from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin. Melanopsin-expressing cells constitute 1-2% of retinal ganglion cells in the adult mammalian retina, are intrinsically photosensitive, and integrate photic information from rods and cones to control nonimage-forming adaptation. Action spectra of ipRGCs and of melanopsin photopigment peak around 480 nm blue light

2017 NPJ aging and mechanisms of disease PubMed

145. Lupus Erythematosus, Drug-Induced (Diagnosis)

Lupus Erythematosus, Drug-Induced (Diagnosis) Drug-Induced Lupus Erythematosus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NTA4Ni1vdmVydmlldw== processing > Drug (...) -Induced Lupus Erythematosus Updated: Jul 10, 2018 Author: Catharine Lisa Kauffman, MD, FACP; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Lupus Erythematosus Overview Background Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to drugs prescribed

2014 eMedicine.com

146. Drug-Induced Pigmentation (Diagnosis)

Drug-Induced Pigmentation (Diagnosis) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

147. Lupus Erythematosus, Drug-Induced (Overview)

Lupus Erythematosus, Drug-Induced (Overview) Drug-Induced Lupus Erythematosus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NTA4Ni1vdmVydmlldw== processing > Drug (...) -Induced Lupus Erythematosus Updated: Jul 10, 2018 Author: Catharine Lisa Kauffman, MD, FACP; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Lupus Erythematosus Overview Background Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to drugs prescribed

2014 eMedicine.com

148. Drug-Induced Pigmentation (Overview)

Drug-Induced Pigmentation (Overview) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

149. Drug-Induced Pigmentation (Treatment)

Drug-Induced Pigmentation (Treatment) Drug-Induced Pigmentation Treatment & Management: Medical Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni10cmVhdG1lbnQ= processing (...) > Drug-Induced Pigmentation Treatment & Management Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Treatment Medical Care The most important factor in the management of drug-induced dyspigmentation involves the identification and discontinuation of the offending drug. Most mucocutaneous pigmentation is reversible and spontaneously resolves with avoidance of the inciting drug. In a scenario

2014 eMedicine.com

150. Drug-Induced Pigmentation (Follow-up)

Drug-Induced Pigmentation (Follow-up) Drug-Induced Pigmentation Treatment & Management: Medical Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni10cmVhdG1lbnQ= processing (...) > Drug-Induced Pigmentation Treatment & Management Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Treatment Medical Care The most important factor in the management of drug-induced dyspigmentation involves the identification and discontinuation of the offending drug. Most mucocutaneous pigmentation is reversible and spontaneously resolves with avoidance of the inciting drug. In a scenario

2014 eMedicine.com

151. Inhibition of cyclin-dependent kinase activity exacerbates H<sub>2</sub> 0<sub>2</sub> -induced DNA damage in Kindler syndrome keratinocytes. (PubMed)

Inhibition of cyclin-dependent kinase activity exacerbates H2 02 -induced DNA damage in Kindler syndrome keratinocytes. Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering and photosensitivity. KS is caused by loss of function mutations in FERMT1, which encodes Kindlin-1. Kindlin-1 is a FERM domain containing adaptor protein that is found predominantly at cell-extracellular matrix adhesions where it binds to integrin β subunits (...) and is required for efficient integrin activation. Using keratinocytes derived from a patient with KS, into which wild type Kindlin-1 (Kin1WT) has been expressed, we show that Kindlin-1 binds to cyclin-dependent kinase (CDK)1 and CDK2. CDK1 and CDK2 are key regulators of cell cycle progression, however, cell cycle analysis showed only small differences between the KS and KS-Kin1WT keratinocytes. In contrast, G2/M cell cycle arrest in response to oxidative stress induced by hydrogen peroxide (H2 O2

2019 Experimental Dermatology

152. Use of Antihypertensive Drugs and Risk of Malignant Melanoma: A Meta-analysis of Observational Studies. (PubMed)

Use of Antihypertensive Drugs and Risk of Malignant Melanoma: A Meta-analysis of Observational Studies. Several antihypertensive drugs are photosensitizing and may promote the development of malignant melanoma (MM), but evidence remains inconsistent. We sought to quantify the association between use of antihypertensive drugs and MM risk.We systematically searched PubMed, Embase, and CENTRAL from inception to August 17, 2017 to identify observational studies that reported the MM risk associated (...) with the use of antihypertensive drugs. A random-effects meta-analysis was used to estimate the odds ratio (OR) with 95% confidence interval (CI).Overall, we included eight observational studies (two cohort studies and six case-control studies). Compared with non-use, use of diuretics (OR 1.10; 95% CI 1.03-1.17) or β-adrenergic blocking agents (OR 1.19; 95% CI 1.04-1.37) was significantly associated with increased risk of MM. The use of angiotensin-converting enzyme inhibitors (OR 1.08; 95% CI 0.95-1.23

2017 Drug Safety

153. Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders. (PubMed)

Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders. Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures (...) . Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT. Over time, the modality has undergone increasing refinement and offers the potential advantages of reduced treatment durations, shortened incubation times, and the replacement of cumbersome, patient-dependent treatment regimens

2017 Seminars in Cutaneous Medicine and Surgery

154. Pirfenidone and nintedanib for pulmonary fibrosis in clinical practice: Tolerability and adverse drug reactions. (Full text)

 ± 14% predicted. Drug discontinuation as a result of an adverse event occurred in 20.9% of subjects on pirfenidone and 26.3% on nintedanib. Drug discontinuation rates for both pirfenidone and nintedanib did not significantly differ from corresponding large clinical trials (ASCEND/CAPACITY and INPULSIS 1 and 2, respectively). Adverse events that occurred with highest frequency on pirfenidone were nausea (26.4%), rash/photosensitivity (14.7%) and dyspepsia/gastroesophageal reflux disease (GERD) (12.4 (...) Pirfenidone and nintedanib for pulmonary fibrosis in clinical practice: Tolerability and adverse drug reactions. The real-world tolerability of pirfenidone and nintedanib in non-clinical trial patients is unknown. Many patients with pulmonary fibrosis have significant medical co-morbidities or baseline characteristics that exclude them from clinical trial participation.We conducted a retrospective chart review study on subjects prescribed nintedanib or pirfenidone for pulmonary fibrosis

2017 Respirology PubMed

155. Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody-drug conjugate (Full text)

comparing BE and EA to squamous epithelium respectively. MUC1 gene expression was x2.3 and x2.2 higher in BE (p=<0.001) and EA (p=0.03). MUC1 immunohistochemical expression increased during progression to EA and followed tumor invasion. HuHMFG1 based photosensitive antibody drug conjugates (ADC) showed cell internalization, MUC1 selective and light-dependent cytotoxicity (p=0.0006) and superior toxicity over photosensitizer alone (p=0.0022).Gene set enrichment analysis (GSEA) evaluated pathways during (...) Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody-drug conjugate Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1.MUC1 was present in 21% and 30% of significantly enriched pathways

2017 Oncotarget PubMed

156. A potent synthetic inorganic antibiotic with activity against drug-resistant pathogens (Full text)

A potent synthetic inorganic antibiotic with activity against drug-resistant pathogens The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has greatly outpaced the development of new therapeutics, necessitating an alternative strategy (...) , phosphopyricin would be evolutionarily foreign to microbes, thereby slowing the evolution of resistance. In addition, it loses antibiotic activity upon exposure to light, meaning that the active antibiotic will not accumulate in the general environment where strong selective pressures imposed by antibiotic residuals are known to accelerate resistance. Phosphopyricin represents an innovation in antimicrobials, having a synthetic core, and a photosensitive chemical architecture that would reduce accumulation

2017 Scientific reports PubMed

157. Nanophotosensitive drugs for light-based cancer therapy: what does the future hold? (Full text)

S10 OD020129 OD NIH HHS United States U54 CA199092 CA NCI NIH HHS United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2017 04 27 England Nanomedicine (Lond) 101278111 1743-5889 0 Photosensitizing Agents IM Animals Humans Nanomedicine methods Nanoparticles chemistry therapeutic use Nanotechnology methods Neoplasms drug therapy Photochemotherapy methods Photosensitizing Agents chemistry therapeutic use Cerenkov radiation cancer nanoparticles (...) Nanophotosensitive drugs for light-based cancer therapy: what does the future hold? 28447872 2018 11 20 2018 11 20 1748-6963 12 10 2017 05 Nanomedicine (London, England) Nanomedicine (Lond) Nanophotosensitive drugs for light-based cancer therapy: what does the future hold? 1101-1105 10.2217/nnm-2017-0077 Tang Rui R Optical Radiology Lab, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Habimana-Griffin LeMoyne M LM Optical Radiology Lab

2017 Nanomedicine PubMed

158. Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes (Full text)

efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC)-mimetic theranostic nanoparticles with long blood circulation, deep-red light-activated tumor imaging and drug release were reported. High loading capacities were achieved by camouflaging MSNs with RBC membrane to co-load an anticancer drug doxorubicin (Dox) (39.1 wt%) and a near-infrared photosensitizer chlorin e6 (Ce6) (21.1 wt%). The RBC membrane-coating protected drugs from leakage, and greatly improved the colloidal stability (...) Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery with a high loading capacity. However, easy aggregation in saline buffers and limited blood circulation lifetime hinder their delivery efficiency and the anticancer

2017 Theranostics PubMed

159. Quantitative Modeling of the Dynamics and Intracellular Trafficking of Far-Red Light-Activatable Prodrugs: Implications in Stimuli-Responsive Drug Delivery System (Full text)

Quantitative Modeling of the Dynamics and Intracellular Trafficking of Far-Red Light-Activatable Prodrugs: Implications in Stimuli-Responsive Drug Delivery System The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared wavelength light to site-specifically release PTX while generating singlet oxygen (SO (...) . The sensitivity analysis suggested that parameters related to extracellular concentration of released PTX, prodrug uptake, target engagement, and target abundance are critical in determining the combined killing efficacy of the prodrug. We found that released PTX cytotoxicity was most sensitive to the retention time of the drug in extracellular space. Modulating drug internalization and conjugating the agents targeted to abundant receptors may provide a new strategy for maximizing the killing capacity

2017 Journal of pharmacokinetics and pharmacodynamics PubMed

160. Human Antibody Fusion Proteins/Antibody Drug Conjugates in Breast and Ovarian Cancer (Full text)

induce necrosis/apoptosis in the tumor when conjugated to a photosensitizer upon exposure to a changeable wavelength of light. The dual nature of SNAP-tag fusions as both a diagnostic and therapeutic tool reinforces its significant role in cancer treatment in an era of precision medicine. (...) Human Antibody Fusion Proteins/Antibody Drug Conjugates in Breast and Ovarian Cancer Considerable research efforts have been dedicated to understanding ovarian and breast cancer mechanisms, but there has been little progress translating the research into effective clinical applications. Hence, personalized/precision medicine has emerged because of its potential to improve the accuracy of tumor targeting and minimize toxicity to normal tissue. Targeted therapy in both breast and ovarian cancer

2017 Transfusion Medicine and Hemotherapy PubMed

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>