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Drug-induced Photosensitivity

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121. Safety of novel amino-5-laevulinate photosensitizer precursors in photodynamic therapy for healthy human skin. (PubMed)

& derivatives Double-Blind Method Erythema etiology Healthy Volunteers Humans Pain etiology Photochemotherapy methods Photosensitizing Agents administration & dosage adverse effects Pilot Projects Prodrugs administration & dosage adverse effects Skin drug effects radiation effects Time Factors 2015 5 6 6 0 2015 5 6 6 0 2016 10 19 6 0 ppublish 25940811 10.2340/00015555-2131 (...) Safety of novel amino-5-laevulinate photosensitizer precursors in photodynamic therapy for healthy human skin. 25940811 2016 10 17 2017 01 03 1651-2057 96 1 2016 Jan Acta dermato-venereologica Acta Derm. Venereol. Safety of Novel Amino-5-laevulinate Photosensitizer Precursors in Photodynamic Therapy for Healthy Human Skin. 108-10 10.2340/00015555-2131 Neittaanmäki-Perttu Noora N Department of Dermatology and Allergology, Helsinki University Central Hospital, FIN-00029 Helsinki, Finland

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2015 Acta Dermato-Venereologica

122. Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer. (PubMed)

Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer. Preoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using (...) a murine draining LN metastasis model of gastric cancer.In the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.In vivo imaging revealed metastatic LNs in the ICGm

2015 Annals of Surgical Oncology

123. Photosensitivity, Apoptosis, and Cytokines in the Pathogenesis of Lupus Erythematosus: a Critical Review. (PubMed)

Photosensitivity, Apoptosis, and Cytokines in the Pathogenesis of Lupus Erythematosus: a Critical Review. The underlying pathomechanisms of lupus erythematosus (LE), a multifactorial autoimmune disease, remain elusive. Due to the clinical evidence demonstrating a clear relationship between ultraviolet (UV) light exposure and skin lesions of LE, photosensitivity has been proven to be an important factor in the pathogenesis of the disease. Standardised photoprovocation with UVA and UVB (...) irradiation has been shown to be a reliable model for evaluating photosensitivity in patients with cutaneous LE (CLE) and analysing the underlying medical conditions of the disease. In this respect, UV irradiation can cause aberrant induction of apoptosis in keratinocytes and contribute to the appearance of excessive apoptotic cells in the skin of CLE patients. Moreover, apoptotic cells that cannot be cleared by phagocytes may undergo secondary necrosis and release proinflammatory compounds and potential

2014 Clinical Reviews in Allergy & Immunology

124. The Tryptophan-Derived Endogenous Arylhydrocarbon Receptor Ligand 6-Formylindolo[3,2-B]Carbazole (Ficz) Is A Nanomolar Uva-Photosensitizer In Epidermal Keratinocytes. (PubMed)

), a tryptophan photoproduct and endogenous high-affinity aryl hydrocarbon receptor (AhR) agonist, acts as a nanomolar photosensitizer potentiating UVA-induced oxidative stress irrespective of AhR ligand activity. In human HaCaT and primary epidermal keratinocytes, photodynamic induction of apoptosis was elicited by the combined action of solar-simulated UVA and FICZ, whereas exposure to the isolated action of UVA or FICZ did not impair viability. In a human epidermal tissue reconstruct, FICZ/UVA cotreatment (...) caused pronounced phototoxicity inducing keratinocyte cell death, and FICZ photodynamic activity was also substantiated in a murine skin exposure model. Array analysis revealed pronounced potentiation of cellular heat shock, endoplasmic reticulum stress, and oxidative stress response gene expression observed only upon FICZ/UVA cotreatment. FICZ photosensitization caused intracellular oxidative stress, and comet analysis revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive

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2014 Journal of Investigative Dermatology

125. Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients

Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients - a Phase IIa/IIb Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients - a Phase IIa/IIb Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02052193 Recruitment Status : Terminated (Second cohort not opened

2014 Clinical Trials

126. Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey (PubMed)

Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey Circadian rhythms generated by the suprachiasmatic nucleus (SCN) are entrained to the environmental light/dark cycle via intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP). The ipRGCs regulate other nonimage-forming visual functions such as the pupillary light reflex (...) , masking behavior, and light-induced melatonin suppression. To evaluate whether PACAP-immunoreactive retinal projections are useful as a marker for central projection of ipRGCs in the monkey brain, we characterized the occurrence of PACAP in melanopsin-expressing ipRGCs and in the retinal target areas in the brain visualized by the anterograde tracer cholera toxin subunit B (CtB) in combination with PACAP staining. In the retina, PACAP and melanopsin were found to be costored in 99% of melanopsin

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2014 The Journal of comparative neurology

127. A Severe Photosensitivity Dermatitis Caused by Crizotinib (PubMed)

Photosensitivity Disorders chemically induced Pyrazoles adverse effects Pyridines adverse effects 2014 6 14 6 0 2014 6 14 6 0 2015 2 11 6 0 ppublish 24926554 10.1097/JTO.0000000000000163 S1556-0864(15)30344-0 PMC4372847 NIHMS671206 Arch Dermatol. 2009 Aug;145(8):923-5 19687425 N Engl J Med. 2009 Sep 3;361(10):947-57 19692680 N Engl J Med. 2013 Jun 20;368(25):2385-94 23724913 Lancet Oncol. 2012 Oct;13(10):1011-9 22954507 Photodermatol Photoimmunol Photomed. 2012 Feb;28(1):2-5 22211996 (...) A Severe Photosensitivity Dermatitis Caused by Crizotinib 24926554 2015 02 09 2018 12 02 1556-1380 9 7 2014 Jul Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer J Thorac Oncol A severe photosensitivity dermatitis caused by crizotinib. e51-3 10.1097/JTO.0000000000000163 Oser Matthew G MG *Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; †Department of Medicine, Brigham

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2014 Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

128. Development of a multifunctional luciferase reporters system for assessing endoplasmic reticulum-targeting photosensitive compounds (PubMed)

Development of a multifunctional luciferase reporters system for assessing endoplasmic reticulum-targeting photosensitive compounds Photodynamic therapy (PDT) is a recently developed antitumor modality utilizing the generation of reactive oxygen species (ROS), through light irradiation of photosensitizers (PSs) localized in tumor. Interference with proper functioning of endoplasmic reticulum (ER) by ER-targeting PDT is a newly proposed strategy to achieve tumor cell death. The aim of this study (...) is to establish a multifunctional model to screen and assess ER-targeting PSs based on luciferase reporters system. Upregulation of GRP78 is a biomarker for the onset of ER stress. CHOP is a key initiating player in ER stress-induced cell death. Here, the most sensitive fragments of GRP78 and CHOP promoters responding to ER-targeting PDT were mapped and cloned into pGL3-basic vector, forming -702/GRP78-Luc and -443/CHOP-Luc construct, respectively. We demonstrated that -702/GRP78-Luc expression can be used

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2014 Cell stress & chaperones

129. Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study. (PubMed)

complexion, freckles and nevi are established risk factors, yet the aetiology of melanoma is multifactorial. Certain prescription drugs may have carcinogenic side effects on the risk of melanoma. Some cardiovascular, antidepressant and immunosuppressive drugs can influence certain biological processes that modulate photosensitivity and immunoregulation. We aim to study whether these drugs are related to melanoma risk.A population-based matched case-control study will be conducted using nation-wide (...) Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study. The incidence of cutaneous melanoma (hereafter melanoma) has increased dramatically among fair-skinned populations worldwide. In Norway, melanoma is the most rapidly growing type of cancer, with a 47% increase among women and 57% among men in 2000-2016. Intermittent ultraviolet exposure early in life and phenotypic characteristics like a fair

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2019 BMJ open

130. A drug not recognised as a photosensitiser? (PubMed)

A drug not recognised as a photosensitiser? Numerous drugs are recognised as triggers for phototoxic or photoallergic reactions. In the case reported here, the culprit drug, amoxicillin, is a well-known cause of cutaneous drug-adverse reactions but is so far not recognised as a photosensitizer. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Contact Dermatitis

131. Use of antiepileptic drugs and risk of skin cancer: A nationwide case-control study. (PubMed)

Use of antiepileptic drugs and risk of skin cancer: A nationwide case-control study. Several antiepileptic drugs are photosensitizing; however, it is not known whether this confers an increased risk of skin cancer.To examine the association between common antiepileptic drugs and basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM).We conducted a nested case-control study identifying skin cancer cases in Denmark 2004-2015 matched 1:10 to disease-free controls (...) . We estimated odds ratios (ORs) for skin cancer associated with high cumulative use of antiepileptic drugs (≥500 defined daily doses) compared with non-use.Most antiepileptic drugs were not associated with skin cancer. SCC was associated with use of carbamazepine (OR 1.88, 95%CI: 1.42 to 2.49) and lamotrigine (OR 1.57, 95%CI: 1.12 to 2.22) with evidence of a dose-response relationship for carbamazepine. The estimated absolute risks were low, e.g. 6335 person-years of high cumulative exposure

2019 Journal of American Academy of Dermatology

132. Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA. (PubMed)

Individual Photosensitivity of Human Skin and UVA-Induced Pyrimidine Dimers in DNA. Delineation of the DNA-damaging properties of UVA radiation is a major issue in understanding solar carcinogenesis. Emphasis was placed in this study on the formation of cyclobutane pyrimidine dimers (CPDs), which are now well established as the most frequent UVA-induced DNA lesions in human skin. The yield of CPDs was determined by a chromatographic assay following ex vivo UVA and UVB irradiation of biopsies (...) taken from either phototype II or IV volunteers. A clear correlation was found between the frequency of UVB-induced CPDs and both the phototype and the minimum erythemal dose (MED). Similar results were obtained for the induction of CPDs upon exposure to UVA. Moreover, an excellent correlation was observed for each donor between the yield of DNA damage induced by either UVB or UVA. These observations show that the key parameters driving UVA-induced formation of CPDs are attenuation of radiation

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2011 Journal of Investigative Dermatology

133. Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase (PubMed)

Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase 1. DL-C-Allyglycine, 4-deoxypyridoxine hydrochloride and 3-mercaptopropionic acid have been studied with reference to their convulsant effects in mice and in baboons (Papio papio) with photosensitive epilepsy, and their action on the cerebral enzyme synthesizing gamma-aminobutyric acid (L-glutamate-1 (...) or posterior parietal cortex.4. In Papio papio photically-induced epileptic responses were enhanced 5-10 min after the intravenous injection of 3-mercaptopropionic acid (0.09-0.28 mmol/kg). A sequence of brief generalized seizures followed by complete recovery occurred 4-17 min after the injection of 3-mercaptopropionic acid (0.28-0.38 mmol/kg). Fatal status epilepticus followed the injection of 3-mercaptopropionic acid (0.57-0.75 mmol/kg). E.E.G. records showed generalized cortical involvement

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1973 British journal of pharmacology

134. "Dye/light" Dye-induced photosensitization of herpes virus. A clinical trial on humans. (PubMed)

"Dye/light" Dye-induced photosensitization of herpes virus. A clinical trial on humans. A series of 21 patients with herpetic corneal ulcers was treated by photodynamic inactivation (using a single application of neutral red 1 per cent solution followed by a 15-min exposure to a 40 watt light of 440--550 nm), carbolization, or idoxuridine (IDU) ointment. No significant difference was found in the number that healed, the mean healing time, or the number of recurrences after any of the three

1977 Transactions of the ophthalmological societies of the United Kingdom

135. Anti-hypertensive drugs and skin cancer risk: a review of the literature and meta-analysis. (PubMed)

Anti-hypertensive drugs and skin cancer risk: a review of the literature and meta-analysis. Several anti-hypertensive drugs have photosensitizing properties, however it remains unclear whether long-term users of these drugs are also at increased risk of skin malignancies. We conducted a literature review and meta-analysis on the association between use of anti-hypertensive drugs and the risk of cutaneous melanoma and non-melanoma skin cancer (NMSC).We searched PubMed, EMBASE, Google Scholar (...) and the Cochrane Library, and included observational and experimental epidemiological studies published until February 28th, 2017. We calculated summary relative risk (SRR) and 95% confidence intervals (95% CI) through random effect models to estimate the risk of skin malignancies among users of the following classes of anti-hypertensive drugs: thiazide diuretics, angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB), calcium channel blockers (CCB) and β-blockers. We conducted

2018 Critical reviews in oncology/hematology

136. Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy (PubMed)

Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately (...) controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully

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2018 Proceedings of the National Academy of Sciences of the United States of America

137. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy (PubMed)

tumors via microvesicle-mediated intercellular transfer. Most strikingly, the ADMOPs can serve as stimuli-responsive nanocarriers to efficiently load the photosensitizer phthalocyanine due to their inherent highly porous characteristics. Thus, the ADMOPs significantly enhance the chemotherapeutic efficacy by "on-demand" photodynamic therapy, which further induces a hypoxic environment that enhances the reduction of AQ4N to systematically increase the therapeutic efficiency. Taken together (...) Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy A novel metal-organic particle (MOP) based nanodrug formed by mild self-assembly of chemotherapeutic drugs, including banoxantrone and doxorubicin, through Cu(II)-mediated coordination effects, is reported. In this nanodrug, Cu(II) acts as a bridge to join AQ4N and DOX, and then, self-assembly of [-AQ4N-Cu(II)-(DOX)2-Cu(II)-] n

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2018 Advanced Science

138. Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators (PubMed)

-selective passage of molecules up to 1,000 Da. Herein, we discuss the particular case of the P2×7 receptor-associated pore as a drug delivery system for hydrophilic substances to be applied in PDT, which could also be carried out with other channels. Methylene blue (MB) is a low cost dye used as a prototype photosensitizer, approved for clinical use in several other clinical conditions, as well as photodynamic therapy for fungi infections. (...) Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators According to the World Health Organization (WHO), cancer is one of main causes of death worldwide, with 8.2 million people dying from this disease in 2012. Because of this, new forms of treatments or improvement of current treatments are crucial. In this regard, Photodynamic therapy (PDT) has been used to successfully treat cancers that can be easily accessed externally

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2018 Oncotarget

139. An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis

tuberculosis, osteoarthritic tuberculosis, tuberculosis meningitis), as judged by the Investigator. Corrected QT Interval > 450 milliseconds. History of allergy to any of the trial investigational product/s or related substances as confirmed by the clinical judgement of the Investigator. History of photosensitivity. Known or suspected, current or history of within the past 2 years, alcohol or drug abuse, that is, in the opinion of the Investigator, sufficient to compromise the safety or cooperation (...) An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

140. Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation (PubMed)

Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation (...) induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly

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2018 Nature communications

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