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Drug-induced Photosensitivity

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101. Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells (PubMed)

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells Photodynamic therapy (PDT) is a promising treatment in cancer therapy, with a photosensitizer activated by visible light. Aloe-emodin (AE) is a promising photosensitive agent. In this study, the photosensitizing effects and possible mechanisms of AE-PDT in MG63 cells were evaluated. The efficiency of AE-PDT was analyzed by MTT assay. The mode of cell death (...) concentration and irradiation dose. Confocal microscopy showed that AE was primarily localized on the mitochondria and endoplasmic reticulum (ER) of MG63 cells. AE-PDT resulted in rapid increases of intracellular ROS production, which reached a peak at 2 h, followed by declining of mitochondrial membrane potential, releasing of cytochrome c from mitochondria into the cytoplasm, and up-regulation of caspase-3, -9, and -12, CHOP and GRP78. These results suggest that death of MG63 cells induced by AE-PDT

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2016 Cancer medicine

102. Drug-induced Photosensitivity

Drug-induced Photosensitivity Drug-induced Photosensitivity Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-induced (...) Photosensitivity Drug-induced Photosensitivity Aka: Drug-induced Photosensitivity , Photosensitizer , Medication Causes of Phototoxic Reaction , Phytodermatitis , Phytophotodermatitis From Related Chapters II. Background Drugs below are Photosensitizers Skin reactions secondary to Photosensitizers III. Signs Linear or drip pattern of erythema or inflammation May follow pattern of Photosensitizer contact with skin (e.g. lime or lemon) in well demarcated area (contact with Photosensitizer) Early Erythema Pain

2015 FP Notebook

103. Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells (PubMed)

Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells Photodynamic therapy is useful for the treatment of cancer because it is minimally invasive for patients. Certain porphyrin compounds and their derivatives have been used as the photosensitizer because they accumulate specifically in cancerous tissues. However, the detailed mechanism of this phenomenon has not been clarified. We previously reported (...) that indomethacin improved the effect of photodynamic therapy by inducing increased mitROS generation in cancer cells.

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2016 Journal of clinical biochemistry and nutrition

104. Severe photosensitivity reaction induced by topical diclofenac (PubMed)

Severe photosensitivity reaction induced by topical diclofenac Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

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2013 Indian journal of pharmacology

105. Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. (PubMed)

Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. Although topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is applied for skin tumors including actinic keratosis, Bowen disease, and squamous cell carcinoma, there are no approved photosensitizers in dermatological field in Japan. TONS501 and TONS504 are novel hydrophobic photosensitizers with anionic (...) and cationic chemical characteristics, respectively.Using 7, 12-dimethylbenz[a]anthracene (DMBA) and 12-ο-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin papilloma model, we compared the efficacy of ALA-, TONS501-, and TONS504-PDT on the skin tumor regression.Following application of ALA, TONS501, TONS504 ointment or TONS501 lotion on DMBA- and TPA-induced mouse papillomas, 670 nm laser irradiation by LD670-05 diode laser was performed. Then tumor regression rate was calculated at the indicated

2012 Journal of dermatological science

106. PF-06372865 in Subjects With Photosensitive Epilepsy

to Brief Summary: PF-06372865 in subjects with photosensitive epilepsy Condition or disease Intervention/treatment Phase Reflex Epilepsy, Photosensitive Drug: PF-06372865 Drug: Placebo Drug: Lorazepam Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 7 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double (Participant, Investigator) Primary Purpose: Basic Science Official Title: A Double (...) 17.5 milligram (mg) single dose Drug: PF-06372865 Single dose Experimental: PF-06372865 dose level 2 52.5 mg single dose Drug: PF-06372865 Single dose Placebo Comparator: Placebo Single dose Drug: Placebo Placebo for PF-06372865 and placebo for lorazepam Active Comparator: Lorazepam 2mg single dose Drug: Lorazepam 2 mg single oral dose Outcome Measures Go to Primary Outcome Measures : The Standardized Photosensitivity Range (SPR) in the Subject's Most Sensitive Eye Condition [ Time Frame: Pre-dose

2015 Clinical Trials

107. Quality of life and psychological impact of cutaneous photosensitivity disorders: a systematic review

Quality of life and psychological impact of cutaneous photosensitivity disorders: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web (...) subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other Subgroup analysis or meta-regression are used to explore between-study heterogeneity and can provide insight into the relationship between study characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup

2018 PROSPERO

108. Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL)

Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02464709 Recruitment Status : Completed First Posted : June 8, 2015 Last

2015 Clinical Trials

109. Safety Dermatological Assessment of Topical Use Product Through Dressings Predictive Studies for Evaluation of Photoirritation and Dermal Photosensitivity

of informed consent form Exclusion Criteria: Pregnancy and lactation Use of anti-inflammatory and immunosuppressive from 30 days up to three months prior to selection; Diseases that cause immune suppression; Use of photosensitizing drugs; History or photodermatoses activities; Personal or family history of photoinduced skin cancer; Presence of precursor lesions of skin cancer, such as melanocytic nevi and actinic keratoses; Intense sun exposure in the experiment area Use of new drugs and/or cosmetics (...) Safety Dermatological Assessment of Topical Use Product Through Dressings Predictive Studies for Evaluation of Photoirritation and Dermal Photosensitivity Safety Dermatological Assessment of Topical Use Product Through Dressings Predictive Studies for Evaluation of Photoirritation and Dermal Photosensitivity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail

2015 Clinical Trials

110. Emergence of Photosensitivity with Decreased Treg Cells in Mycosis Fungoides Patient Treated with Anti-CC Chemokine Receptor 4 Antibody Mogamulizumab. (PubMed)

Antineoplastic Agents adverse effects Chemoradiotherapy adverse effects Female Humans Middle Aged Mycosis Fungoides immunology pathology therapy Photosensitivity Disorders chemically induced diagnosis immunology Radiation Injuries chemically induced diagnosis immunology Receptors, CCR4 antagonists & inhibitors immunology metabolism Skin Neoplasms immunology pathology therapy T-Lymphocytes, Regulatory drug effects immunology pathology radiation effects Treatment Outcome Ultraviolet Therapy adverse effects (...) Emergence of Photosensitivity with Decreased Treg Cells in Mycosis Fungoides Patient Treated with Anti-CC Chemokine Receptor 4 Antibody Mogamulizumab. 26463269 2017 01 10 2017 11 16 1651-2057 96 3 2016 Mar Acta dermato-venereologica Acta Derm. Venereol. Emergence of Photosensitivity with Decreased Treg Cells in a Patient with Mycosis Fungoides Treated with Anti-CC Chemokine Receptor 4 Antibody Mogamulizumab. 420-1 10.2340/00015555-2257 Tatsuno Kazuki K Department of Dermatology, Hamamatsu

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2015 Acta Dermato-Venereologica

111. A Nanosystem Capable of Releasing a Photosensitizer Bioprecursor under Two‐Photon Irradiation for Photodynamic Therapy (PubMed)

processes. The subsequent red light irradiation induces this endogenously synthesized photosensitizer to generate singlet oxygen, thereby causing oxidant damage to mitochondria and then the apoptosis of the cells. Analysis via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assays indicate that the novel PDT system exhibits enhanced cytotoxicity toward cancer cells. This study may offer a new strategy for designing PDT systems with high efficacy and low side effects. (...) A Nanosystem Capable of Releasing a Photosensitizer Bioprecursor under Two‐Photon Irradiation for Photodynamic Therapy The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half-life. Herein, a mitochondria-targeted nanosystem is demonstrated to enhance the PDT efficacy by releasing a bio-precursor of photosensitizer under two-photon irradiation. A phototriggerable coumarin derivative is first synthesized by linking 5

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2015 Advanced Science

112. Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity (PubMed)

Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity Stem-toxic small molecules have been developed to induce selective cell death of pluripotent stem cells (PSCs) to lower the risk of teratoma formation. However, despite their high efficacies, chemical-based approaches may carry unexpected toxicities on specific differentiated cell types. Herein, we took advantage of KillerRed (KR) as a suicide gene, to selectively induce

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2015 Stem cell reports

113. Photodynamic therapy with a novel porphyrin-based photosensitizer against human gastric cancer (PubMed)

conditions make the novel photosensitizer DTP a promising potential PDT drug for future use in the treatment of human gastric cancer. (...) Photodynamic therapy with a novel porphyrin-based photosensitizer against human gastric cancer The objective of the present study was to evaluate the effects of novel porphyrin-based photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid- aminophenyl]-10,15,20-triphenyl-porphyrin (DTP)-mediated photodynamic therapy (PDT) on the HGC27 and SNU-1 human gastric cancer cell lines. The absorption spectrum of DTP was analyzed using a microplate spectrophotometer. The HGC27 or SNU-1 cells were

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2015 Oncology letters

114. Towards PDT with Genetically Encoded Photosensitizer KillerRed: A Comparison of Continuous and Pulsed Laser Regimens in an Animal Tumor Model (PubMed)

mouse tumors expressing KillerRed in fusion with histone H2B. The results showed that the pulsed mode provided a higher rate of photobleaching of KillerRed without any temperature increase on the tumor surface. PDT with the continuous wave laser was ineffective against CT26 tumors in mice, whereas the pulsed laser induced pronounced histopathological changes and inhibition of tumor growth. Therefore, we selected an effective regimen for PDT when using the genetically encoded photosensitizer (...) Towards PDT with Genetically Encoded Photosensitizer KillerRed: A Comparison of Continuous and Pulsed Laser Regimens in an Animal Tumor Model The strong phototoxicity of the red fluorescent protein KillerRed allows it to be considered as a potential genetically encoded photosensitizer for the photodynamic therapy (PDT) of cancer. The advantages of KillerRed over chemical photosensitizers are its expression in tumor cells transduced with the appropriate gene and direct killing of cells through

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2015 PloS one

115. The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates (PubMed)

The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates In many drug delivery strategies, an inefficient transfer of macromolecules such as proteins and nucleic acids to the cytosol often occurs because of their endosomal entrapment. One of the methods to overcome this problem is photochemical internalization, which is achieved using a photosensitizer and light to facilitate the endosomal escape of the macromolecule. In this study (...) , we examined the molecular mechanism of photochemical internalization of cell penetrating peptide-cargo (macromolecule)-photosensitizer conjugates. We measured the photophysical properties of eight dyes (photosensitizer candidates) and determined the respective endosomal escape efficiencies using these dyes. Correlation plots between these factors indicated that the photogenerated (1)O2 molecules from photosensitizers were highly related to the endosomal escape efficiencies. The contribution of (1

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2015 Scientific reports

116. Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors (PubMed)

Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also nonspecific to brain stroma. These are major limitations in the effective treatment of brain cancer. Transferrin peptide (Tfpep) targeted gold nanoparticles (Tfpep-Au NPs) loaded with the photodynamic pro-drug, Pc 4, have been designed and compared with untargeted Au NPs for delivery (...) of the photosensitizer to brain cancer cell lines. In vitro studies of human glioma cancer lines (LN229 and U87) overexpressing the transferrin receptor (TfR) show a significant increase in cellular uptake for targeted conjugates as compared to untargeted particles. Pc 4 delivered from Tfpep-Au NPs clusters within vesicles after targeting with the Tfpep. Pc 4 continues to accumulate over a 4 hour period. Our work suggests that TfR-targeted Au NPs may have important therapeutic implications for delivering brain tumor

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2015 Nanoscale

117. Resistance of Lung Cancer Cells Grown as Multicellular Tumour Spheroids to Zinc Sulfophthalocyanine Photosensitization (PubMed)

Resistance of Lung Cancer Cells Grown as Multicellular Tumour Spheroids to Zinc Sulfophthalocyanine Photosensitization Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs (...) , proliferation, cytotoxicity and nuclear morphology. Photoactivated ZnPcSmix also showed no changes in cellular morphology and nuclear morphology. However, photoactivated ZnPcSmix resulted in a significant dose dependant decrease in viability and proliferation as well as an increase in cell membrane damage in MCTSs over time. ZnPcSmix photosensitization induces apoptotic cell death in MCTSs with a size of 500 µm and more resistantance when compared to monolayer cells and MCTSs with a size of 250 µm.

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2015 International journal of molecular sciences

118. Photodynamic Inactivation of Candida albicans with Imidazoacridinones: Influence of Irradiance, Photosensitizer Uptake and Reactive Oxygen Species Generation (PubMed)

Photodynamic Inactivation of Candida albicans with Imidazoacridinones: Influence of Irradiance, Photosensitizer Uptake and Reactive Oxygen Species Generation The increasing applicability of antifungal treatments, the limited range of available drug classes and the emergence of drug resistance in Candida spp. suggest the need for new treatment options. To explore the applicability of C. albicans photoinactivation, we examined nine structurally different imidazoacridinone derivatives (...) as photosensitizing agents. The most effective derivatives showed a >10(4)-fold reduction of viable cell numbers. The fungicidal action of the three most active compounds was compared at different radiant powers (3.5 to 63 mW/cm2), and this analysis indicated that 7 mW/cm2 was the most efficient. The intracellular accumulation of these compounds in fungal cells correlated with the fungicidal activity of all 9 derivatives. The lack of effect of verapamil, an inhibitor targeting Candida ABC efflux pumps, suggests

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2015 PloS one

119. Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses (PubMed)

Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses Taxanes [paclitaxel, nab-paclitaxel (Abraxane, Celgene Corp, USA), and docetaxel]-used in the treatment of lung, breast, and head and neck cancers-have been associated with cutaneous adverse effects, including photodermatoses.We describe a woman with non-small cell lung cancer who developed a photodistributed dermatitis associated with her nab-paclitaxel (...) therapy and review photodermatoses in patients receiving taxanes.The features of a woman with a nab-paclitaxel-associated photodistributed dermatitis are presented and the literature on nab-paclitaxel-associated photosensitivity is reviewed.Our patient developed nab-paclitaxel-associated photodistributed dermatitis on the sun-exposed surfaces of her upper extremities, which was exacerbated with each course of nab-paclitaxel. Biopsies revealed an interface dermatitis and laboratory studies were

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2015 Dermatology practical & conceptual

120. A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria

. A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria. Cellular and Molecular Biology 2009; 55(1): 84-97 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Ascorbic Acid /therapeutic use; Clinical Trials as Topic; Cysteine /therapeutic use; Humans; Protoporphyria, Erythropoietic /drug therapy; Treatment Outcome; beta Carotene /therapeutic use AccessionNumber 12009106422 Date bibliographic record published 05/08/2009 Date (...) A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria Minder EI, Schneider-Yin X, Steurer J, Bachmann LM CRD summary This review assessed treatment options for dermal photosensitivity in erythropoietic protoporphyria and concluded that available

2009 DARE.

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