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Drug-induced Photosensitivity

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21. Drug-Induced Pigmentation (Diagnosis)

Drug-Induced Pigmentation (Diagnosis) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

22. Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy Full Text available with Trip Pro

Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy Drug-induced lupus erythematosus (dile) syndromes are documented complications of chemotherapeutic agents, including paclitaxel. Subacute cutaneous lupus erythematosus (scle) is a distinct dile syndrome presenting with characteristic annular or papulosquamous skin lesions in a photosensitive distribution with associated high anti-ssa titres. Previously, dile syndromes complicating paclitaxel therapy have (...) been attributed to polyethoxylated castor oil (Kolliphor EL: BASF, Ludwigshafen, Germany), the biologic solvent included in the drug's original formulation (Taxol: Bristol-Myers Squibb, Montreal, QC), rather than the parent chemotherapy molecule. Here, we report a characteristic case of drug-induced scle complicating treatment with nanoparticle albumin bound (nab)-paclitaxel (Abraxane: Celgene, Summit, NJ, U.S.A.), a solvent-free taxane formulation. The pertinent English-language literature is also

2013 Current Oncology

23. Drug-Induced Generalized Skin Eruption in a Diabetes Mellitus Patient Receiving a Dipeptidyl Peptidase-4 Inhibitor Plus Metformin Full Text available with Trip Pro

Drug-Induced Generalized Skin Eruption in a Diabetes Mellitus Patient Receiving a Dipeptidyl Peptidase-4 Inhibitor Plus Metformin A generalized skin eruption with strong itching was induced by sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in a patient almost 6 months after initiation of the drug. Physical examination revealed a spread of skin rash from chest to back, and abdomen and thigh. Discontinuation of the drug eliminated the skin rash immediately. The emergence of new rash (...) ended, and the rash itself withered after 1 week. The spread of the rash gradually shrank and the skin lesions subsided, leaving pigmentation 1 month later. Two months after cessation of sitagliptin, the skin eruption had subsided and oral steroid medication was stopped, but some small eczematous eruptions continued to appear intermittently. Although a drug-induced lymphocyte stimulation test was negative for sitagliptin, nonspecific radioimmunosorbent test for immunoglobulin E was increased to 532

2012 Diabetes Therapy

24. Drug-induced skin diseases. Full Text available with Trip Pro

Drug-induced skin diseases. 155489 1979 07 25 2018 11 13 0007-1447 1 6168 1979 Apr 07 British medical journal Br Med J Drug-induced skin diseases. 935-7 Hardie R A RA Savin J A JA eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Drug Eruptions etiology Drug-Related Side Effects and Adverse Reactions Erythema chemically induced Humans Photosensitivity Disorders chemically induced Pigmentation Disorders chemically induced Skin Diseases chemically induced diagnosis drug therapy Skin

1979 British medical journal

25. The frequency of photosensitizing drug dispensings in Austria and Germany: A correlation with their photosensitizing potential based on published literature. Full Text available with Trip Pro

The frequency of photosensitizing drug dispensings in Austria and Germany: A correlation with their photosensitizing potential based on published literature. Drug-induced photosensitivity refers to the development of cutaneous adverse events due to interaction between a pharmaceutical compound and sunlight. Although photosensitivity is a very commonly listed side effect of systemic drugs reliable data on its actual incidence are lacking so far.A possible approach to evaluate the real-life (...) extent of drug-induced photosensitivity would be an analysis of the frequency of exposure to a given photosensitizing drug combined with an indicator of its photosensitizing potential. This could serve as a basis for developing a pharmaceutical 'heatmap' of photosensitivity.The presented study investigated the number of reimbursed dispensed packages of potentially photosensitizing drugs in Germany (DE) and Austria (AT) between 2010 and 2017 based on nationwide health insurance-based databases

2019 Journal of the European Academy of Dermatology and Venereology

26. Recent Developments in the Diagnosis and Management of Photosensitive Disorders. (Abstract)

Recent Developments in the Diagnosis and Management of Photosensitive Disorders. Photodermatoses occur in males and females of all races and ages. Onset can be variable in timing and influenced by genetic and environmental factors. Photodermatoses are broadly classified as immunologically mediated, chemical- and drug-induced, photoaggravated, and genetic (defective DNA repair or chromosomal instability) diseases. Advances in the field have led to improved recognition and treatment of many

2018 American journal of clinical dermatology

27. 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase Full Text available with Trip Pro

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase Photodynamic therapy (PDT) has been developed as an anticancer treatment, which is based on the tumor-specific accumulation of a photosensitizer that induces cell death after irradiation of light with a specific wavelength. Depending on the subcellular localization of the photosensitizer, PDT could trigger various signal transduction cascades and induce cell death such as apoptosis, autophagy

2010 Molecular Cancer

28. Photodynamic therapy induces interleukin secretion from dendritic cells Full Text available with Trip Pro

Photodynamic therapy induces interleukin secretion from dendritic cells Dendritic cells (DC) pulsed with tumor-derived peptides, proteins, genes, or lysates have been studied as therapeutic cancer vaccines. However, the overall therapeutic efficacy of this approach has been limited, indicating a need to either enhance its potency or combine it with other treatment modalities. Photodynamic therapy (PDT) process consists of injecting a photosensitizer, which selectively accumulates at the lesion

2010 International journal of clinical and experimental medicine

29. Drug-induced subacute cutaneous lupus erythematosus associated with omeprazole. (Abstract)

Drug-induced subacute cutaneous lupus erythematosus associated with omeprazole. Subacute cutaneous lupus erythematosus (SCLE) is characterized by annular scaly erythematous plaques in a photosensitive distribution, and the presence of anti-Ro (SSA) and/or anti-La (SSB) antibodies. Most cases of SCLE are idiopathic, but occasional cases may be drug-induced or associated with a hereditary deficiency of complement components. We report two cases of drug-induced SCLE precipitated by the proton pump (...) inhibitor, omeprazole. Drug-induced disease should be considered in all atypical or extensive cases of SCLE, especially in elderly patients.© The Author(s). CED © 2010 British Association of Dermatologists.

2010 Clinical & Experimental Dermatology

31. Plitidepsin (Aplidin) - Multiple Myeloma

is photosensitive. Samples of plitidepsin were also exposed to stressed conditions (heat, acid, alkali and oxidative conditions). Samples were stable under dry and moist heat conditions, moderately stable under acidic and oxidative conditions, but degraded rapidly under aqueous alkaline conditions. The stability results indicate that the active substance manufactured by the proposed supplier is sufficiently stable. The stability results justify the proposed retest period of 48 months at 5 ± 3 ºC in the proposed (...) characteristics, plitidpesin is lyophilised with mannitol as a bulking agent. A mixture of water and t BuOH was suitable to dissolve both components and also facilitated the freeze-drying process. Plitidepsin is hygroscopic, photosensitive and degrades in basic aqueous media. It is however, sufficiently stable in acidic aqueous media and so a slightly acidic pH (4-7.5) is stipulated for the infusion solution. The bulk plitidepsin was shown to be both physicochemically and microbiologically stable for up to 24

2018 European Medicines Agency - EPARs

33. Prasugrel besilate (Prasugrel Mylan) Acute Coronary Syndrome, Unstable Angina, Myocardial Infarction

have been demonstrated to be reliable and stability indicating. A photostability study has been performed on one commercial scale batch of Prasugrel film-coated tablets according to ICH Q1B Guideline. The following parameters were tested: description, assay, dissolution, water (KF) and degradation products. The obtained stability results indicated that there are no out of specification results and thus, it can be concluded that Prasugrel film-coated tablets are not photosensitive. Forced

2018 European Medicines Agency - EPARs

35. Management of Atopic Eczema

%) Cream/Ointment Hydrocortisone Acetate 1% Cream/Ointment 1 - 2 times daily 1 - 2 times daily Worsening of untreated infection, contact dermatitis, perioral dermatitis, acne, depigmentation, dryness, hypertrichosis, secondary infection, skin atrophy, pruritus, tingling/stinging, rosacea, folliculitis, photosensitivity Moderate Betamethasone Valerate 1 in 2 dilution (0.05%) Cream/Ointment Betamethasone Valerate 1 in 4 dilution (0.025%) Cream/Ointment Clobetasone Butyrate 0.05% Cream/Ointment Untreated (...) Dipropionate 0.05% Cream/Ointment Betamethasone Valerate 0.1% Cream/Ointment Fluocinolone Acetonide 0.025% Cream Fluticasone Propionate 0.05% Cream Triamcinolone Acetonide 0.1% Cream 1 - 2 times daily 1 - 2 times daily Once daily Worsening of untreated infection, contact dermatitis, perioral dermatitis, acne, depigmentation, dryness, hypertrichosis, secondary infection, skin atrophy, pruritus, tingling/stinging, rosacea, folliculitis, photosensitivity Untreated bacterial, fungal or viral skin lesions

2019 Ministry of Health, Malaysia

36. Pruritus

pruritus) 10 4.1.4 Pruritus in metabolic and endocrine diseases 11 4.1.5 Pruritus in malignancy 11 4.1.6 Pruritus in infectious diseases 12 4.1.7 Pruritus in neurological diseases 13 4.1.8 Pruritus in psychiatric diseases 14 4.1.9 Drug-induced chronic pruritus 14 4.2 Specific patient populations 15 4.2.1 Chronic pruritus in the elderly 15 4.2.2 Chronic pruritus in pregnancy 15 4.2.3 Chronic pruritus in children 16 5 Diagnostic management 178 5.1 Patient history and clinical examination 178 5.2 (...) (Lepping, Huber et al. 2015). Overall, the psychiatric population is little studied with regard to skin symptoms, but it is now established that psychiatric morbidity contributes to the pathophysiology of CP in the absence of skin disease (Pereira, Kremer et al. 2016). 4.1.9 Drug-induced chronic pruritus Drug-induced pruritus without visible skin lesions accounts for approximately 5% of adverse cutaneous reactions. Almost any drug may induce pruritus by various pathomechanisms (Table 2) (Reich, Stander

2019 European Dermatology Forum

38. Acne - Guidelines for Prescribing Topical Treatment

at their lesions. A hallmark sign of this are scars in the absence of cysts or nodules, or hyperpigmentation of an area that can last years. Mechanical acne is the result of physical irritation to an area leading to the acne lesions, such as a sweat band rubbing against the forehead. Drug-induced acne. Medications that can cause/worsen acne: glucocorticoids (oral, inhaled, and topical), androgens, oral contraceptives containing progestins with more potent androgenic actiivity (norethindrone, levonorgestrel (...) to moderate comedonal (IE. Non-inflammatory lesions predominate) acne. There are three choices: Tretinoin, adapalene and tazarotene. Tretinoin is the most cost effective but also the most photosensitizing. Adapalene is the least irritating, but most expensive. A commercial product containing adapalene and benzoyl peroxide is also available. Tazarotene is the most potent, and therefore the most likely to cause irritation. Tretinoin is the most cost effective but also the most photosensitizing

2018 medSask

39. Targeted Immunomodulators for the Treatment of Moderate-to-Severe Plaque Psoriasis: Effectiveness and Value

A (PUVA) treatment. Narrowband UVB is more effective than broadband UVB; both can be delivered at home. Psoralen, a photosensitizing drug, can be used orally or topically, as a bath, to the affected areas. Psoralen is associated with nausea, and PUVA is associated with increased squamous cell cancer and possibly melanoma; as such, UVB by far the most common form of phototherapy delivered in current clinical practice. A final form of phototherapy involves the use of excimer lasers for focused UVB light

2018 California Technology Assessment Forum

40. Cladribine (Mavenclad) - multiple sclerosis

conditions. No trends were observed. A photostability study was conducted on one production scale batch according to ICH Q1B Guideline. No significant change was observed in any of the tested parameters (appearance, identification, assay, degradation products, water content and dissolution) and the results confirm that the product is not photosensitive and no storage restriction against light is found necessary. A thermal cycling study was performed with cladribine tablets packaged in aluminum/aluminium

2017 European Medicines Agency - EPARs

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