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226 results for

Drug-induced Photosensitivity

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221. Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications. Full Text available with Trip Pro

cell morphology and cytoskeleton structures were studied with immunofluorescence staining.Vascular-targeting photodynamic therapy induced vascular barrier dysfunction in the MatLyLu tumors. Thus, tumor uptake of macromolecules was significantly increased following photodynamic therapy treatments. In addition to vascular permeability increase, blood cell adherence to vessel wall was observed shortly after treatment, further suggesting the loss of endothelial integrity. Blood cell adhesion led (...) Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications. Loss of vascular barrier function has been observed shortly following vascular-targeting photodynamic therapy. However, the mechanism involved in this event is still not clear, and the therapeutic implications associated with this pathophysiologic change have not been fully explored.The effect of vascular-targeting photodynamic therapy on vascular barrier function

2006 Clinical Cancer Research

222. Photosensitive Eruptions (Photodermatoses)

potential treatments include thalidomide, retinoids, interferon and immunosuppressants. [ ] Metabolic photodermatoses Porphyrias - see separate article which provides more detail. Pellagra - see separate article which provides more detail. Exogenous photodermatoses Drug-induced photosensitivity [ ] Photosensitivity reactions can occur as adverse effects of some commonly prescribed topical or systemic medications. Reactions can be phototoxic (where the damage to the tissues is direct), or photo-allergic (...) a nutritional supplement containing lycopene, beta-carotene and Lactobacillus johnsonii. [ ] See also separate article . Chronic actinic dermatitis (actinic reticuloid) This is a rare condition affecting mainly middle-aged and elderly men. It often follows years of . Presentation Lichenified plaques on light-exposed skin. It is initially worse in the summer but can become perennial. There is usually little doubt about the diagnosis; however, consider the possibility of a drug-induced photodermatosis

2008 Mentor

223. Evidence-Based Guidelines for the Classification and Management of Drug Induced Phototoxicity

; however, when photoactivation of the chemical (chromophore; a radiation absorbing substance) occurs, the abnormal reaction may arise. Most commonly, wavelengths within the UV-A spectrum (320-400 nm) cause drug- induced photosensitivity reactions, although occasionally some compounds have a peak absorption within the UV-B or visible range. Incidence The incidence of phototoxicity due to systemic medication varies greatly from drug to drug and even within subjects taking a particular agent. It usually (...) relates to drug dosage, the local intensity of the relevant wavelengths and individual factors, such as skin type and drug handling. Phototoxic reactions develop in most individuals if they are exposed to sufficient amounts of light and drug. Typically, they appear as an exaggerated sunburn response. Photosensitivity reactions can occur also in darker skin types with heavily pigmented skin. Although the incidence of drug-induced photosensitivity is unknown, phototoxic reactions are probably more

2007 European Dermatology Forum

224. Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion Full Text available with Trip Pro

Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a tumor-localizing photosensitizer. Athymic nude mice

2008 Cancer Letters

225. Role of cytokines in photodynamic therapy-induced local and systemic inflammation Full Text available with Trip Pro

Role of cytokines in photodynamic therapy-induced local and systemic inflammation Photodynamic therapy (PDT) of tumour results in the rapid induction of an inflammatory response that is considered important for the activation of antitumour immunity, but may be detrimental if excessive. The response is characterised by the infiltration of leucocytes, predominantly neutrophils, into the treated tumour. Several preclinical studies have suggested that suppression of long-term tumour growth (...) following PDT using Photofrin((R)) is dependent upon the presence of neutrophils. The inflammatory pathways leading to the PDT-induced neutrophil migration into the treated tumour are unknown. In the following study, we examined, in mice, the ability of PDT using the second-generation photosensitiser 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) to induce proinflammatory cytokines and chemokines, as well as adhesion molecules, known to be involved in neutrophil migration. We also examined

2003 British journal of cancer

226. Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. (Abstract)

improves or resolves on discontinuation of the offending drug treatment. It is not known if these drugs precipitate disease in patients who have subclinical disease. Drug-induced Ro/SSA-positive CLE should be included on the differential diagnosis in patients presenting with photosensitive or subacute CLE-type eruptions. (...) Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. To study the clinical and immunopathologic findings of drug-induced, Ro/SSA-positive cutaneous lupus erythematosus (CLE).Retrospective medical and laboratory record review.Immunodermatology Division of Johns Hopkins Hospital (Baltimore, Md).Of 120 patients found to have anti-Ro/SSA antibodies by hemagglutination and/or double immunodiffusion, 70 had clinical and immunopathologic confirmation of CLE. Fifteen of these 70 patients had

2003 Archives of Dermatology

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