How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

240 results for

Drug-induced Photosensitivity

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Systemic Lupus Erythematosus (Follow-up)

. [ ] Patients with class III or IV disease, as well as those with a combination of class V and class III or IV disease, generally undergo aggressive therapy with glucocorticoid drugs and immunosuppressants. [ ] Immunosuppressive therapy consists of induction and maintenance therapy. Induction therapy involves potent immunosuppressive drugs (eg, mycophenolate mofetil, cyclophosphamide) to achieve remission; these drugs are generally used for 3 months to 1 year, with an average of 6 months’ treatment having (...) endothelial function, which may reduce cardiovascular disease. [ , , ] No diet-based treatment of SLE has been proven effective. Patients with SLE should be reminded that activity may need to be modified as tolerated. Specifically, stress and physical illness may precipitate SLE flares. Additionally, persons with SLE should wear sunscreen and protective clothing or avoid sun exposure to limit photosensitive rash or disease flares. Consultations The multisystemic nature of SLE often requires involvement

2014 eMedicine.com

183. Drug Eruptions (Diagnosis)

Author: Jonathan E Blume, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug Eruptions Overview Practice Essentials Drug eruptions can mimic a wide range of dermatoses. The morphologies are myriad and include morbilliform (see the image below), urticarial, papulosquamous, pustular, and bullous. Medications can also cause pruritus and dysesthesia without an obvious eruption. A drug-induced reaction should be considered in any patient who is taking medications (...) detail. Next: Background Drug eruptions can mimic a wide range of dermatoses. The morphologies are myriad and include morbilliform (most common, see image below), urticarial, papulosquamous, pustular, and bullous. Medications can also cause pruritus and dysesthesia without an obvious eruption. Both calcium channel blockers and interferon are strongly associated with eczematous eruptions. Morbilliform drug eruption. A drug-induced reaction should be considered in any patient who is taking medications

2014 eMedicine.com

184. Dermatomyositis (Diagnosis)

to cytoplasmic antigens (ie, antitransfer RNA synthetases) may be present. Although their presence may help to define subtypes of dermatomyositis and polymyositis, their role in pathogenesis is uncertain. Infectious agents have been suggested as possible triggers of dermatomyositis. These include the following: Viruses (eg, , , , [HTLV-1], ) species Borrelia species Cases of drug-induced dermatomyositis have been reported. Dermatomyositis-like skin changes have been reported with hydroxyurea in patients (...) . Diagnosis Examination for cutaneous dermatomyositis may reveal the following findings: Characteristic, possibly pathognomonic cutaneous features: Heliotrope, Gottron papules Characteristic but not pathognomonic features: Malar erythema, violaceous erythema or poikiloderma in a photosensitive distribution, violaceous erythema on the extensor surfaces, and periungual and cuticular changes Violaceous erythema or poikiloderma involving the anterior chest is referred to as the “V-neck sign” whereas

2014 eMedicine.com

185. Dermatomyositis (Diagnosis)

to cytoplasmic antigens (ie, antitransfer RNA synthetases) may be present. Although their presence may help to define subtypes of dermatomyositis and polymyositis, their role in pathogenesis is uncertain. Infectious agents have been suggested as possible triggers of dermatomyositis. These include the following: Viruses (eg, , , , [HTLV-1], ) species Borrelia species Cases of drug-induced dermatomyositis have been reported. Dermatomyositis-like skin changes have been reported with hydroxyurea in patients (...) . Diagnosis Examination for cutaneous dermatomyositis may reveal the following findings: Characteristic, possibly pathognomonic cutaneous features: Heliotrope, Gottron papules Characteristic but not pathognomonic features: Malar erythema, violaceous erythema or poikiloderma in a photosensitive distribution, violaceous erythema on the extensor surfaces, and periungual and cuticular changes Violaceous erythema or poikiloderma involving the anterior chest is referred to as the “V-neck sign” whereas

2014 eMedicine.com

186. Dermatologic Manifestations of Gastrointestinal Disease (Diagnosis)

uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. Cutaneous findings are characterized by skin photosensitivity with increased skin fragility, facial hypertrichosis, blisters, scarring with milia formation, and skin hyperpigmentation on the hands and other sun-exposed areas. Porphyria cutanea tarda results from the decreased activity of the enzyme uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. The disease can be either sporadic

2014 eMedicine.com

187. Cutaneous Manifestations of HIV Disease (Diagnosis)

, an HIV-1 protease inhibitor. Previous Next: Photosensitivity and Drug-Induced Pigmentation A study by Vin-Christian et al found that photosensitivity in HIV-infected patients appears to be a manifestation of advanced disease. [ ] Most of the patients in that study were sensitive to ultraviolet B (UV-B) light; however, the patients who were most severely affected were sensitive to both UV-B and UV-A light. [ ] Photo-induced lichenoid drug reactions may occur in HIV-infected patients, particularly (...) those with dark skin. In addition, HIV-infected patients may experience drug-induced pigmentation of skin exposed to light. Previous Next: Miscellaneous Dermatologic Disorders The following dermatologic conditions may be associated with HIV disease: HIV-related CD8+ cutaneous pseudolymphoma: This is an inflammatory process that results from a massive infiltration of the skin by activated, oligoclonal, HIV-specific, cytotoxic T lymphocytes and is most often seen in those that are markedly

2014 eMedicine.com

188. Berloque Dermatitis (Diagnosis)

, Kim S. Comparative study of skin phototoxicity with three drugs by an in vivo mouse model. J Toxicol Sci . Jan 2010. 35:97-100. . Zhai H, Wilhelm K, Maibach HI. Photoirritation (phototoxicity/phototoxic dermatitis). Dermatotoxicology . 7th ed. Washington, DC: Taylor & Francis; 2008. 209-14, 537-46. Holtz R. REACH and In Vitro Alternatives: Phototoxicity Testing. Cosmet Toilet . 2008 May. 123:61-3. Onoue S, Seto Y, Gandy G, Yamada S. Drug-induced phototoxicity; an early in vitro identification (...) , such as aftershave lotion, also may develop berloque dermatitis. Age Berloque dermatitis usually occurs in women, although it can occur in persons of any age who apply fragrances containing oil of bergamot. Previous References Rosenthal O. Berloque dermatitis: Berliner Dermatologische Gesellschaft. Dermatologische Zeitschrift . 1925. 42:295. Freund E. Uber bisher noch nicht bershriebene Kunstlicke hauverfarbungen. Dermatol Wochenschr . 1916. 63:931-3. Elkeeb D, Elkeeb L, Maibach H. Photosensitivity: a current

2014 eMedicine.com

189. Absence Seizures (Diagnosis)

by carbamazepine. N Engl J Med . 1985 Oct 10. 313(15):916-21. . Liu L, Zheng T, Morris MJ, Wallengren C, Clarke AL, Reid CA, et al. The mechanism of carbamazepine aggravation of absence seizures. J Pharmacol Exp Ther . 2006 Nov. 319(2):790-8. . Vendrame M, Khurana DS, Cruz M, Melvin J, Valencia I, Legido A, et al. Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapy. Epilepsia . 2007 Nov. 48(11):2116-20. . Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced (...) , with the faster frequencies seen in syndromes with older age of onset. Bursts of generalized polyspikes and waves (multiple spike-and-slow-wave complexes) may also be seen, [ ] especially during sleep and in syndromes with older age of onset. The onset and ending of these seizures are abrupt; no postictal EEG slowing is noted. Hyperventilation often provokes these seizures and should be a routine part of all EEGs in children. Photosensitivity may be present in idiopathic generalized epilepsies and is more

2014 eMedicine.com

190. Fixed Drug Eruptions (Diagnosis)

: Jun 07, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Fixed Drug Eruptions Overview Background Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous

2014 eMedicine.com

191. Porokeratosis (Diagnosis)

) porokeratosis Sun exposure and/or artificial ultraviolet radiation exposure in a patient who is genetically predisposed causes disseminated superficial actinic porokeratosis (DSAP). Exacerbations have been reported following prolonged sun exposure, repeated tanning bed exposure, electron beam radiation therapy, and therapeutic phototherapy or photochemotherapy for psoriasis. Drug-induced photosensitivity may play a role. Protection from ultraviolet radiation may lead to spontaneous resolution. Additionally

2014 eMedicine.com

192. Porphyria, Cutaneous (Follow-up)

Imipramine Indomethacin Insulin Labetalol Lithium Methylphenidate Naproxen Narcotics Neostigmine Nitrous oxide Penicillamine Penicillin Phenothiazines Procaine Propranolol Succinylcholine Tetracycline Thyroxine Tubocurarine Many medications induce or worsen acute and cutaneous porphyria. Many of these medications are metabolized, at least to some extent, by the liver. Liver metabolism may induce the cytochrome P-450 enzymes that require heme, thus inducing heme production. Other medications sensitize (...) and cirrhosis. Erythropoietic protoporphyria (EPP) is associated with cholelithiasis in a significant number of cases. Severe liver disease may develop as a result of periportal fibrosis and cirrhosis, leading to death in 20% of cases. Rapidly progressive liver failure associated with accelerating photosensitivity and cholestasis can occur and is accompanied by abdominal pain, splenomegaly, and hemolysis. Previous Next: Prognosis CEP is associated with a significantly decreased lifespan, whereas the other

2014 eMedicine Pediatrics

193. Systemic Lupus Erythematosus (Diagnosis)

in women, frequently starting at childbearing age. See the image below. Photosensitive systemic lupus erythematosus (SLE) rashes typically occur on the face or extremities, which are sun-exposed regions. Although the interphalangeal spaces are affected, the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints are spared. Photo courtesy of Dr. Erik Stratman, Marshfield Clinic. See , a Critical Images slideshow, to help recognize cutaneous manifestations (...) [ ] : Constitutional (eg, fatigue, fever, arthralgia, weight changes) Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis) Dermatologic (eg, malar rash, photosensitivity, discoid lupus) Renal (eg, acute or chronic renal failure, acute nephritic disease) Neuropsychiatric (eg, seizure, psychosis) Pulmonary (eg, pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease) Gastrointestinal (eg, nausea, dyspepsia, abdominal pain) Cardiac (eg

2014 eMedicine Emergency Medicine

194. Systemic Lupus Erythematosus (Overview)

in women, frequently starting at childbearing age. See the image below. Photosensitive systemic lupus erythematosus (SLE) rashes typically occur on the face or extremities, which are sun-exposed regions. Although the interphalangeal spaces are affected, the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints are spared. Photo courtesy of Dr. Erik Stratman, Marshfield Clinic. See , a Critical Images slideshow, to help recognize cutaneous manifestations (...) [ ] : Constitutional (eg, fatigue, fever, arthralgia, weight changes) Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis) Dermatologic (eg, malar rash, photosensitivity, discoid lupus) Renal (eg, acute or chronic renal failure, acute nephritic disease) Neuropsychiatric (eg, seizure, psychosis) Pulmonary (eg, pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease) Gastrointestinal (eg, nausea, dyspepsia, abdominal pain) Cardiac (eg

2014 eMedicine Emergency Medicine

195. Systemic Lupus Erythematosus (Follow-up)

. [ ] Patients with class III or IV disease, as well as those with a combination of class V and class III or IV disease, generally undergo aggressive therapy with glucocorticoid drugs and immunosuppressants. [ ] Immunosuppressive therapy consists of induction and maintenance therapy. Induction therapy involves potent immunosuppressive drugs (eg, mycophenolate mofetil, cyclophosphamide) to achieve remission; these drugs are generally used for 3 months to 1 year, with an average of 6 months’ treatment having (...) endothelial function, which may reduce cardiovascular disease. [ , , ] No diet-based treatment of SLE has been proven effective. Patients with SLE should be reminded that activity may need to be modified as tolerated. Specifically, stress and physical illness may precipitate SLE flares. Additionally, persons with SLE should wear sunscreen and protective clothing or avoid sun exposure to limit photosensitive rash or disease flares. Consultations The multisystemic nature of SLE often requires involvement

2014 eMedicine Emergency Medicine

196. Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage

: Male and female subjects older than 35 years of age and less than 65 years of age. Subjects with mild, moderate or severe facial photodamage as assessed by a 10-point scale. Subjects willing to sign an informed consent and adhere to all protocol requirements. Exclusion Criteria: Male and female subjects with suspected porphyria, systemic or cutaneous erythematosus lupus, or any other photosensitizing disorder or drug-induced photosensitization. Subjects with chronic or recurring skin disease

2013 Clinical Trials

197. Efficacy and Safety of Kinetin 0.1% for Treatment of Skin Photoaging

requirements. Exclusion Criteria: Suspected porphyria, systemic or cutaneous lupus erythematosus, or any other photosensitizing disorder or drug-induced photosensitization Chronic or recurring skin disease or disorder Any active infectious skin disorder (Herpes simplex, molluscum contagiosum, and facial warts) Skin cancer of the facial tissues Any laser/IPL/ chemical peel in the 2 months preceding the screening visit History of Isotretinoin use, 6 months prior to the screening disease Topical tretinoin

2013 Clinical Trials

198. Sun exposure behavior and protection: recommendations for travelers. Full Text available with Trip Pro

populations at increased risks of drug-induced photosensitivity reactions and UV-induced skin cancers; and recommend several effective photoprotection strategies for travelers, Internet search engines were queried with the key words as search terms to examine the latest references on photoprotection and the epidemiology of UV-associated skin cancers.Observational studies have demonstrated that the public knows little about proper sunscreen protection, selection, and use, and often abuses sunscreens (...) for intentional UV overexposures. Cohort studies have identified special populations at increased risks of UV-associated skin cancers without the proper use of sunscreens and photoprotective clothing including children, fair-skinned persons, patients taking photosensitizing drugs, and organ transplant recipients (OTRs). Clinical investigations support the regular use of broad-spectrum sunscreens to prevent the development of premalignant actinic keratoses (AK) in all sun-exposed subjects, especially OTRs

2013 Journal of Travel Medicine

199. Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). (Abstract)

. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6%) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2%) presented with LE-nonspecific manifestations. Drug-induced CLE and Sjögren's Syndrome had the highest prevalence in SCLE patients (13.1% and 14.0%, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those (...) , such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus

2013 Autoimmunity reviews

200. Age-Related Macular Degeneration

is that straight lines appear crooked. Regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. Treatment can slow vision loss. It does not restore vision. NIH: National Eye Institute Definition (CSP) deterioration of the macula lutea in the retina; may be inherited, drug induced, or due to aging; leads to a severe loss of central vision while peripheral vision is retained. Concepts Disease or Syndrome ( T047 ) SnomedCT 422338006 , 302891003 LNC MTHU020821 English (...) (Macugen) Aflibercept (Eylea) X. Management: Slow progression of CNV-related Vision Loss Laser photocoagulation of subretinal blood vessels Photodynamic therapy Give IV photosensitive drug (wavelength specific) Expose eye to targeted wavelength to activate drug Experimental External beam Vitreoretinal microsurgery XI. Management: Visual aids Magnifiers Increased light sources in home environment XII. Prevention: General measures is key Control Decrease UV Light exposure ( ) Nutrition See s below

2015 FP Notebook

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>