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Drug-induced Photosensitivity

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1. Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients Full Text available with Trip Pro

was disease-related in 83.4% (n=166) and medication-related in 16.6% (n=33) of the patients. In cases of drug-induced cytopenia, azathioprine was the most frequently prescribed drug. In patients with cytopenia at the time of diagnosis, erythrocyte sedimentation rates (ESR) were higher, C3 and C4 hypocomplementemia was more prevalent, and they were positive for anti-ds-DNA at a greater proportion (p<0.001, p=0.015, p=0.028, and p=0.019, respectively). Moreover, photosensitivity, renal involvement (...) Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients Systemic lupus erythematosus (SLE) may affect a number of systems, with the hematological system being one of the most common. Our aim is to determine the existence of cytopenia at diagnosis or during follow-up of our SLE patients as well as the associated factors.A cohort of SLE patients that had been followed-up in the Department

2017 European journal of rheumatology

2. Drug-induced Photosensitivity

Drug-induced Photosensitivity Drug-induced Photosensitivity Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-induced (...) Photosensitivity Drug-induced Photosensitivity Aka: Drug-induced Photosensitivity , Photosensitizer , Medication Causes of Phototoxic Reaction , Phytodermatitis , Phytophotodermatitis From Related Chapters II. Background Drugs below are Photosensitizers Skin reactions secondary to Photosensitizers III. Signs Linear or drip pattern of erythema or inflammation May follow pattern of Photosensitizer contact with skin (e.g. lime or lemon) in well demarcated area (contact with Photosensitizer) Early Erythema Pain

2018 FP Notebook

3. Photodynamic Therapy-Induced Immune Modulation: Part III

Photodynamic Therapy-Induced Immune Modulation: Part III Photodynamic Therapy-Induced Immune Modulation: Part III - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Photodynamic Therapy-Induced Immune (...) (Participant, Investigator) Primary Purpose: Prevention Official Title: Photodynamic Therapy-Induced Immune Modulation: Part III Estimated Study Start Date : September 2018 Estimated Primary Completion Date : November 2019 Estimated Study Completion Date : November 2019 Resource links provided by the National Library of Medicine available for: resources: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: PDT + Celecoxib Patient receiving PDT taking 200mg celecoxib. Drug: Celecoxib

2018 Clinical Trials

4. Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands Full Text available with Trip Pro

Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced forms of SCLE are analogous in their clinical, serological and histological features. Drug (...) consistent with SCLE. We propose that our patient's unique presentation of SCLE may be explained by a prolonged occupational exposure to topical terbinafine as a foot masseuse. While oral terbinafine is a drug known to cause drug-induced SCLE, to our knowledge, this is the first topically induced form of the disease.

2017 Lupus science & medicine

5. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. Full Text available with Trip Pro

Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy of primary treatment in killing all cancer cells. Photodynamic therapy (PDT), an approach that causes tissue destruction by visible light in the presence of a photosensitizer (Ps) and oxygen, appears as a promising alternative therapy that could be used adjunct

2017 BMC Cancer

6. Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. (Abstract)

Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. Drug-induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually ultraviolet A) leading to chemical reactions that cause cellular damage (phototoxicity) or, more rarely, form photoallergens (photoallergy). The manifestation varies considerably in presentation and severity from mild pain to severe blistering. Despite screening (...) strategies and guidelines in place to predict photoreactive drugs during development there are still new drugs coming onto the market that cause photosensitivity. Thus, there is a continuing need for dermatologists to be aware of the different forms of presentation and the culprit drugs. Management usually involves photoprotection and cessation of drug treatment. However, there are always cases where the culprit drug is indispensable. The reason why some patients are susceptible while others remain

2016 British Journal of Dermatology

7. Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues Full Text available with Trip Pro

Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues Photodynamic therapy (PDT) has recently emerged as an approach to enhance intratumoral accumulation of nanoparticles. However, conventional PDT is greatly limited by the inability of the excitation light to sufficiently penetrate tissue, rendering PDT ineffective in the relatively deep tumors. To address this limitation (...) , we developed a novel PDT platform and reported for the first time the effect of deep-tissue PDT on nanoparticle uptake in tumors. This platform employed c(RGDyK)-conjugated upconversion nanoparticles (UCNPs), which facilitate active targeting of the nanoconstruct to tumor vasculature and achieve the deep-tissue photosensitizer activation by NIR light irradiation. Results indicated that our PDT system efficiently enhanced intratumoral uptake of different nanoparticles in a deep-seated tumor model

2016 Theranostics

8. Drug-Induced Photosensitivity (Treatment)

Drug-Induced Photosensitivity (Treatment) Drug-Induced Photosensitivity Treatment & Management: Medical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA0OTY0OC10cmVhdG1lbnQ= processing > Drug (...) -Induced Photosensitivity Treatment & Management Updated: Jun 12, 2018 Author: Alexandra Y Zhang, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Photosensitivity Treatment Medical Care The mainstays of treatment of drug-induced photosensitivity include identification and avoidance of the causative agent, the use of sun protection, and the institution of measures for symptomatic relief. Topical corticosteroids and cool compresses may alleviate drug

2014 eMedicine.com

9. Drug-Induced Photosensitivity (Overview)

Drug-Induced Photosensitivity (Overview) Drug-Induced Photosensitivity: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA0OTY0OC1vdmVydmlldw== processing > Drug-Induced (...) Photosensitivity Updated: Jun 12, 2018 Author: Alexandra Y Zhang, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Photosensitivity Overview Background Drug-induced photosensitivity refers to the development of cutaneous disease as a result of the combined effects of a chemical and light. [ ] Exposure to either the chemical or the light alone is not sufficient to induce the disease; however, when photoactivation of the chemical occurs, one or more cutaneous

2014 eMedicine.com

10. Drug-Induced Photosensitivity (Follow-up)

Drug-Induced Photosensitivity (Follow-up) Drug-Induced Photosensitivity Treatment & Management: Medical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA0OTY0OC10cmVhdG1lbnQ= processing > Drug (...) -Induced Photosensitivity Treatment & Management Updated: Jun 12, 2018 Author: Alexandra Y Zhang, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Photosensitivity Treatment Medical Care The mainstays of treatment of drug-induced photosensitivity include identification and avoidance of the causative agent, the use of sun protection, and the institution of measures for symptomatic relief. Topical corticosteroids and cool compresses may alleviate drug

2014 eMedicine.com

11. Drug-Induced Photosensitivity (Diagnosis)

Drug-Induced Photosensitivity (Diagnosis) Drug-Induced Photosensitivity: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA0OTY0OC1vdmVydmlldw== processing > Drug-Induced (...) Photosensitivity Updated: Jun 12, 2018 Author: Alexandra Y Zhang, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Photosensitivity Overview Background Drug-induced photosensitivity refers to the development of cutaneous disease as a result of the combined effects of a chemical and light. [ ] Exposure to either the chemical or the light alone is not sufficient to induce the disease; however, when photoactivation of the chemical occurs, one or more cutaneous

2014 eMedicine.com

12. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Full Text available with Trip Pro

Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an anti-tumor immune response. However, some tumor types, including perihilar (...) . In vitro toxicogenomics and toxicological testing in chicken embryos and mice revealed that the ZnPC-encapsulating liposomes are non-toxic.PDT-treated perihilar cholangiocarcinoma cells exhibit extensive survival signaling that may translate to a suboptimal therapeutic response and possibly tumor recurrence. These findings encourage the development of photosensitizer delivery systems with co-encapsulated inhibitors of survival pathways.

2015 BMC Cancer

13. Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis Full Text available with Trip Pro

Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis The conventional photosensitizers used in photodynamic therapy (PDT), such as haematoporphyrin (HP), have not yet reached satisfactory therapeutic effects on port-wine stains (PWSs), due largely to the long-term dark toxicity. Previously we have showed that hypericin exhibited potent photocytotoxic effects on Roman chicken cockscomb model of PWSs. However, the molecular mechanism of hypericin-mediated

2015 Scientific reports

14. Drug-induced Photosensitivity

Drug-induced Photosensitivity Drug-induced Photosensitivity Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-induced (...) Photosensitivity Drug-induced Photosensitivity Aka: Drug-induced Photosensitivity , Photosensitizer , Medication Causes of Phototoxic Reaction , Phytodermatitis , Phytophotodermatitis From Related Chapters II. Background Drugs below are Photosensitizers Skin reactions secondary to Photosensitizers III. Signs Linear or drip pattern of erythema or inflammation May follow pattern of Photosensitizer contact with skin (e.g. lime or lemon) in well demarcated area (contact with Photosensitizer) Early Erythema Pain

2015 FP Notebook

15. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro Full Text available with Trip Pro

Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro Photodynamic therapy (PDT) is becoming a promising therapeutic modality for hematological malignancies. Hypericin is a natural photosensitizer possessing anti-depressant, anti-virus and anti-cancer activities. The present study was designed to explore the effect and mechanism of hypericin-mediated PDT on the mouse multiple myeloma (MM) cells in vitro.The mouse myeloma SP2/0

2014 Cancer cell international

16. Lupus Erythematosus, Drug-Induced (Diagnosis)

Lupus Erythematosus, Drug-Induced (Diagnosis) Drug-Induced Lupus Erythematosus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NTA4Ni1vdmVydmlldw== processing > Drug (...) -Induced Lupus Erythematosus Updated: Jul 10, 2018 Author: Catharine Lisa Kauffman, MD, FACP; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Lupus Erythematosus Overview Background Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to drugs prescribed

2014 eMedicine.com

17. Drug-Induced Pigmentation (Treatment)

Drug-Induced Pigmentation (Treatment) Drug-Induced Pigmentation Treatment & Management: Medical Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni10cmVhdG1lbnQ= processing (...) > Drug-Induced Pigmentation Treatment & Management Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Treatment Medical Care The most important factor in the management of drug-induced dyspigmentation involves the identification and discontinuation of the offending drug. Most mucocutaneous pigmentation is reversible and spontaneously resolves with avoidance of the inciting drug. In a scenario

2014 eMedicine.com

18. Lupus Erythematosus, Drug-Induced (Overview)

Lupus Erythematosus, Drug-Induced (Overview) Drug-Induced Lupus Erythematosus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NTA4Ni1vdmVydmlldw== processing > Drug (...) -Induced Lupus Erythematosus Updated: Jul 10, 2018 Author: Catharine Lisa Kauffman, MD, FACP; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Lupus Erythematosus Overview Background Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to drugs prescribed

2014 eMedicine.com

19. Drug-Induced Pigmentation (Overview)

Drug-Induced Pigmentation (Overview) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

20. Drug-Induced Pigmentation (Follow-up)

Drug-Induced Pigmentation (Follow-up) Drug-Induced Pigmentation Treatment & Management: Medical Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni10cmVhdG1lbnQ= processing (...) > Drug-Induced Pigmentation Treatment & Management Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Treatment Medical Care The most important factor in the management of drug-induced dyspigmentation involves the identification and discontinuation of the offending drug. Most mucocutaneous pigmentation is reversible and spontaneously resolves with avoidance of the inciting drug. In a scenario

2014 eMedicine.com

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