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Drug-induced Photosensitivity

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1. The frequency of photosensitizing drug dispensings in Austria and Germany: A correlation with their photosensitizing potential based on published literature. (PubMed)

The frequency of photosensitizing drug dispensings in Austria and Germany: A correlation with their photosensitizing potential based on published literature. Drug-induced photosensitivity refers to the development of cutaneous adverse events due to interaction between a pharmaceutical compound and sunlight. Although photosensitivity is a very commonly listed side effect of systemic drugs reliable data on its actual incidence are lacking so far.A possible approach to evaluate the real-life (...) extent of drug-induced photosensitivity would be an analysis of the frequency of exposure to a given photosensitizing drug combined with an indicator of its photosensitizing potential. This could serve as a basis for developing a pharmaceutical 'heatmap' of photosensitivity.The presented study investigated the number of reimbursed dispensed packages of potentially photosensitizing drugs in Germany (DE) and Austria (AT) between 2010 and 2017 based on nationwide health insurance-based databases

2019 Journal of the European Academy of Dermatology and Venereology

2. Reviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer. (PubMed)

Reviewing the effects of thiazide and thiazide-like diuretics as photosensitizing drugs on the risk of skin cancer. Thiazide diuretics and particularly hydrochlorothiazide were recently linked to an increased risk of skin cancer, which was attributed to the photosensitizing properties of these drugs. Given the widespread use of thiazide diuretics, a potential skin cancer promoting effect would impose an important public health concern.To critically appraise in a narrative review (...) , the association between use of thiazide and thiazide-like diuretics and risk of skin cancer.We evaluated chemical structures and photosensitizing potential of selected thiazide and thiazide-like diuretics. Moreover, we searched PubMed up to December 2018 for observational studies assessing the association between use of thiazide or thiazide-like diuretics and risk of skin cancer. Study quality was assessed for major methodological biases.Commonly used thiazide and thiazide-like diuretics carry resonating

2019 Journal of Hypertension

3. Drug-induced Photosensitivity

Drug-induced Photosensitivity Drug-induced Photosensitivity Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-induced (...) Photosensitivity Drug-induced Photosensitivity Aka: Drug-induced Photosensitivity , Photosensitizer , Medication Causes of Phototoxic Reaction , Phytodermatitis , Phytophotodermatitis From Related Chapters II. Background Drugs below are Photosensitizers Skin reactions secondary to Photosensitizers III. Signs Linear or drip pattern of erythema or inflammation May follow pattern of Photosensitizer contact with skin (e.g. lime or lemon) in well demarcated area (contact with Photosensitizer) Early Erythema Pain

2018 FP Notebook

4. Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. (PubMed)

Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. Drug-induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually ultraviolet A) leading to chemical reactions that cause cellular damage (phototoxicity) or, more rarely, form photoallergens (photoallergy). The manifestation varies considerably in presentation and severity from mild pain to severe blistering. Despite screening (...) strategies and guidelines in place to predict photoreactive drugs during development there are still new drugs coming onto the market that cause photosensitivity. Thus, there is a continuing need for dermatologists to be aware of the different forms of presentation and the culprit drugs. Management usually involves photoprotection and cessation of drug treatment. However, there are always cases where the culprit drug is indispensable. The reason why some patients are susceptible while others remain

2016 British Journal of Dermatology

5. Effects of topical 0.8% piroxicam and 50+ sunscreen filters on actinic keratosis in hypertensive patients treated with or without photosensitizing diuretic drugs: an observational cohort study (PubMed)

Effects of topical 0.8% piroxicam and 50+ sunscreen filters on actinic keratosis in hypertensive patients treated with or without photosensitizing diuretic drugs: an observational cohort study Photosensitizing diuretics use (especially thiazide compounds) is associated with a significantly higher risk of squamous cell carcinoma (SCC). Actinic keratosis (AK) is a precursor of SCC.To evaluate in a prospective cohort study the efficacy of topical piroxicam 0.8% and sunscreen 50+ (ACTX (...) ) in the treatment of AK in hypertensive subjects with or without TD treatment.A total of 119 hypertensive subjects with multiple AK (39 under chronic TD treatment; and 80 treated with other non-TD, non-photosensitizing antihypertensive drugs) were enrolled after their informed consent in a 6-month observational cohort study. All the subjects were treated with ACTX twice daily. The primary endpoint was the evolution of AK lesions at baseline, after 3 and 6 months. The secondary endpoint was the clearance of AK

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2018 Clinical, cosmetic and investigational dermatology

6. Photosensitizing Antihypertensive Drug Use and Risk of Cutaneous Squamous Cell Carcinoma. (PubMed)

Photosensitizing Antihypertensive Drug Use and Risk of Cutaneous Squamous Cell Carcinoma. Many antihypertensive drugs (ADs) are photosensitizing, heightening reactivity of the skin to sunlight. Photosensitizing ADs have been associated with lip cancer, but whether they impact the risk of cutaneous squamous cell carcinoma (cSCC) is unknown.To examine the association between AD use and cSCC risk among a cohort of non-Hispanic white individuals with hypertension enrolled in a comprehensive (...) integrated healthcare delivery system in northern California (n = 28 357).Electronic pharmacy data were used to determine exposure to ADs, which were classified as photosensitizing, nonphotosensitizing or unknown, based on published literature. We identified patients who developed a cSCC during follow-up (n = 3010). We used Cox modelling to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Covariates included age, sex, smoking, comorbidities, history of cSCC and actinic keratosis

2018 British Journal of Dermatology

7. Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation (PubMed)

Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation Photosensitizing fluorescent proteins, which generate reactive oxygen species (ROS) upon light irradiation, are useful for spatiotemporal protein inactivation and cell ablation. They give us clues about protein function, intracellular signaling pathways and intercellular interactions. Since ROS generation of a photosensitizer is specifically controlled by certain excitation (...) wavelengths, utilizing colour variants of photosensitizing protein would allow multi-spatiotemporal control of inactivation. To expand the colour palette of photosensitizing protein, here we developed SuperNova Green from its red predecessor, SuperNova.SuperNova Green is able to produce ROS spatiotemporally upon blue light irradiation. Based on protein characterization, SuperNova Green produces insignificant amounts of singlet oxygen and predominantly produces superoxide and its derivatives. We utilized

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2018 BMC biology

8. Laser-Induced Antibacterial Activity of Novel Symmetric Carbazole-Based Ethynylpyridine Photosensitizers (PubMed)

Laser-Induced Antibacterial Activity of Novel Symmetric Carbazole-Based Ethynylpyridine Photosensitizers In this study, two kinds of novel carbazole-based ethynylpyridine salts: 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-pentyl-carbazole diiodide (BMEPC) and 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-methyl-carbazole diiodide (BMEMC) have been employed as photosensitizers owing to their excellent antibacterial activity. These molecules possess symmetric A-π-D-π-A-type structures, which would bring (...) . In the dark experiments as a control, the MIC value is between 6.9 and 13.8 μM for BMEPC, whereas it is between 187.5 and 225.0 μM for BMEMC. By the comparison of the MIC values of BMEPC and BMEMC with laser irradiation and in dark, the laser-induced toxicity on bacteria is more evident, though both of the derivatives have dark toxicity. With the laser irradiation duration of 30 s and 10 min for BMEPC and BMEMC, respectively, the survival rate of E. coli approximates zero. An antibacterial mechanism has

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2018 ACS Omega

9. Tamsulosin-induced photosensitivity rash (PubMed)

Tamsulosin-induced photosensitivity rash 29974124 2018 11 15 2018 12 02 0037-5675 59 6 2018 06 Singapore medical journal Singapore Med J Tamsulosin-induced photosensitivity rash. 336-337 10.11622/smedj.2018072 Tan Chin Kwok CK Geriatric Medicine, Department of Medicine, Ng Teng Fong General Hospital, Singapore. Yap Keng Bee KB Geriatric Medicine, Department of Medicine, Ng Teng Fong General Hospital, Singapore. eng Case Reports Letter Singapore Singapore Med J 0404516 0037-5675 0 Adrenergic (...) Photosensitivity Disorders chemically induced Prostatic Hyperplasia complications Pulmonary Disease, Chronic Obstructive complications Steroids administration & dosage Sulfonamides adverse effects Tamsulosin Tuberculosis, Pulmonary complications 2018 7 6 6 0 2018 7 6 6 0 2018 11 16 6 0 ppublish 29974124 j59/6/336 10.11622/smedj.2018072 PMC6024218 Allergol Int. 2016 Apr;65(2):219-220 26806055 BJU Int. 2000 Mar;85(4):446-50 10691824 J Eur Acad Dermatol Venereol. 2007 Apr;21(4):577-8 17374017 Arch Dermatol. 2006

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2018 Singapore medical journal

10. Commentary to “Mogamulizumab‐induced photosensitivity in patients with mycosis fungoides and other T‐cell neoplasms” by Y. Masuda et al. (PubMed)

Commentary to “Mogamulizumab‐induced photosensitivity in patients with mycosis fungoides and other T‐cell neoplasms” by Y. Masuda et al. 30303306 2018 12 07 1468-3083 32 10 2018 Oct Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Commentary to "Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms" by Y. Masuda et al. 1626 10.1111/jdv.15214 Hönigsmann H H Department of Dermatology (...) Dermatol Venereol. 2018 Sep;32(9):1456-1460 29341283 Expert Opin Drug Discov. 2014 May;9(5):467-83 24641500 Int J Clin Exp Pathol. 2014 Aug 15;7(9):6278-90 25337281

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2018 Journal of the European Academy of Dermatology and Venereology

11. Doxycycline-induced photosensitivity in patients treated for erythema migrans. (PubMed)

Doxycycline-induced photosensitivity in patients treated for erythema migrans. Doxycycline is one of the recommended antibiotics for treating erythema migrans (EM). Since EM predominantly occurs during summer, the potential of doxycycline to induce photosensitivity is of concern. In studies on the efficacy of doxycycline for treating relatively small numbers of patients with EM, the reported frequency of photosensitivity has varied from none to 15%. The aim of this study was to elucidate (...) the frequency and clinical symptoms of doxycycline-induced photosensitivity in a large cohort of patients with EM treated in a single medical centre.Prospectively collected data on adverse events were analysed in adult patients with EM treated with doxycycline 100 mg twice daily for 10-15 days.Photosensitivity reactions ranging from itching and burning sensations to transient mild erythema of sun-exposed skin were documented in 16/858 (1.9, 95% CI 1.1-3.0%) patients and appeared from June to October

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2018 BMC Infectious Diseases

12. A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli (PubMed)

A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli Carbon monoxide-releasing molecules (CORMs) are a promising class of new antimicrobials, with multiple modes of action that are distinct from those of standard antibiotics. The relentless increase in antimicrobial resistance, exacerbated by a lack of new antibiotics, necessitates a better understanding of how such novel agents act and might be used (...) synergistically with established antibiotics. This work aimed to understand the mechanism(s) underlying synergy between a manganese-based photoactivated carbon monoxide-releasing molecule (PhotoCORM), [Mn(CO)3(tpa-κ3N)]Br [tpa=tris(2-pyridylmethyl)amine], and various classes of antibiotics in their activities towards Escherichia coli EC958, a multi-drug-resistant uropathogen. The title compound acts synergistically with polymyxins [polymyxin B and colistin (polymyxin E)] by damaging the bacterial cytoplasmic

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2017 Microbiology

13. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process (PubMed)

Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process Nonsteroidal 2-arylproprionic acids are widely used, over-the-counter, anti-inflammatory drugs. Photosensitivity is a commonly overlooked adverse effect of these drugs. Based on the combined use of cell viability assays and molecular modeling, we prove and rationalize the photochemical pathways triggering photosensitization for two drugs, ibuprofen and ketoprofen. As its parent compound benzophenone (...) , ketoprofen produces singlet oxygen, upon triplet manifold population. However, ibuprofen and ketoprofen photodissociate and hence may generate two highly reactive radicals. The formation of metastable aggregates between the two drugs and B-DNA is also directly probed by molecular dynamics. Our approach characterizes the coupled influence of the drug's intrinsic photochemistry and the interaction pattern with DNA. The photosensitization activity of nonsteroidal 2-arylproprionic acids, being added to gels

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2017 Scientific reports

14. Visible light-induced transition metal-catalyzed transformations: beyond conventional photosensitizers (PubMed)

Visible light-induced transition metal-catalyzed transformations: beyond conventional photosensitizers Employment of simple transition metal (TM = Co, Fe, Cu, Pd, Pt, Au)-based photocatalyst (PC) has led to the dramatic acceleration of known TM-catalyzed reactions, as well as to the discovery of unprecedented chemical transformations. Compared to the conventional cooperative/dual photocatalysis (type B), this new class of unconventional PCs operates via a single photoexcitation/catalytic cycle

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2017 Chemical Society reviews

15. Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells (PubMed)

Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells Strongly luminescent iridium(III) complexes, [Ir(C,N)2 (S,S)]+ (1) and [Ir(C,N)2 (O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X-ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1 O2 , with large 2-photon (...) absorption cross-sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroids with 2-photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase

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2017 Angewandte Chemie (International ed. in English)

16. Detergent-induced self-assembly and controllable photosensitizer activity of diester phenylene ethynylenes (PubMed)

Detergent-induced self-assembly and controllable photosensitizer activity of diester phenylene ethynylenes Photodynamic therapy, in which malignant tissue is killed by targeted light exposure following administration of a photosensitizer, can be a valuable treatment modality but currently relies on passive transport and local irradiation to avoid off-target oxidation. We present a system of excited-state control for truly local delivery of singlet oxygen. An anionic phenylene ethynylene (...) oligomer is initially quenched by water, producing minimal fluorescence and no measurable singlet oxygen generation. When presented with a binding partner, in this case an oppositely charged surfactant, changes in solvent microenvironment result in fluorescence unquenching, restoration of intersystem crossing to the triplet state, and singlet oxygen generation, as assayed by transient absorption spectroscopy and chemical trapping. This solvation-controlled photosensitizer model has possible

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2017 Proceedings of the National Academy of Sciences of the United States of America

17. A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc00737f (PubMed)

A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc00737f Photodynamic therapy against cancer, especially multidrug resistant cancer, is limited seriously due to the efflux of photosensitizer molecules by P-glycoprotein, which leads to insufficient production of reactive oxygen species (ROS). For the purpose of abundant ROS generation and effective therapeutic (...) therapeutic effect of the dual-photosensitizer against cancer cells and drug-resistant cancer cells, as well as xenograft tumor models.

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2016 Chemical Science

18. Photosensitized UVA-Induced Cross-Linking between Human DNA Repair and Replication Proteins and DNA Revealed by Proteomic Analysis (PubMed)

Photosensitized UVA-Induced Cross-Linking between Human DNA Repair and Replication Proteins and DNA Revealed by Proteomic Analysis Long wavelength ultraviolet radiation (UVA, 320-400 nm) interacts with chromophores present in human cells to induce reactive oxygen species (ROS) that damage both DNA and proteins. ROS levels are amplified, and the damaging effects of UVA are exacerbated if the cells are irradiated in the presence of UVA photosensitizers such as 6-thioguanine (6-TG), a strong UVA (...) chromophore that is extensively incorporated into the DNA of dividing cells, or the fluoroquinolone antibiotic ciprofloxacin. Both DNA-embedded 6-TG and ciprofloxacin combine synergistically with UVA to generate high levels of ROS. Importantly, the extensive protein damage induced by these photosensitizer+UVA combinations inhibits DNA repair. DNA is maintained in intimate contact with the proteins that effect its replication, transcription, and repair, and DNA-protein cross-links (DPCs) are a recognized

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2016 Journal of proteome research

19. Inducing cellular senescence in vitro by using genetically encoded photosensitizers (PubMed)

Inducing cellular senescence in vitro by using genetically encoded photosensitizers Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild genotoxic stress. Specifically, we have shown that the formation of a small number of DNA (...) lesions in normal and cancer cells during S phase leads to cellular senescence-like arrest within the same cell cycle. Here, based on this mechanism, we suggest an approach to remotely induce premature senescence in human cell cultures using short-term light irradiation. We used the genetically encoded photosensitizers, tandem KillerRed and miniSOG, targeted to chromatin by fusion to core histone H2B to induce moderate levels of DNA damage by light in S phase cells. We showed that the cells

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2016 Aging (Albany NY)

20. X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield (PubMed)

X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield Singlet oxygen is a primary cytotoxic agent in photodynamic therapy. We show that CeF3 nanoparticles, pure as well as conjugated through electrostatic interaction with the photosensitizer verteporfin, are able to generate singlet oxygen as a result of UV light and 8 keV X-ray irradiation. The X-ray stimulated singlet oxygen quantum yield (...) per cell reported in the literature for photodynamic therapy using light activation. We confirmed that the CeF3-VP conjugates enhanced cell killing with 6 MeV radiation. This work confirms the feasibility of using X- or γ- ray activated nanoparticle-photosensitizer conjugates, either to supplement the radiation treatment of cancer, or as an independent treatment modality.

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2016 Scientific reports

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