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Drug-Induced Pemphigus

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1. Drug-Induced Pemphigus

Drug-Induced Pemphigus Drug-Induced Pemphigus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-Induced Pemphigus Drug-Induced (...) Pemphigus Aka: Drug-Induced Pemphigus , Drug-Triggered Pemphigus From Related Chapters II. Mechanism of Drug-Induced Pemphigus Sulfhydryl groups lyse disulfide bonds Results in formation III. Causes of Drug-Induced Pemphigus (5% with ) IV. Signs of Drug-Induced Pemphigus follows medication use of >2 month duration Similar to ( ) Most cases are mild V. Differential Diagnosis of Drug-Induced Pemphigus Drug-Triggered Pemphigus (unmasks ) Gold Piroxicam Phenobarbital VI. Course Drug-Induced Pemphigus Remits

2018 FP Notebook

2. Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. (Abstract)

Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about immunological profiles in DIP.To characterize clinical and immunological profiles in patients with DIP.We studied 17 Japanese patients with DIP who were treated at Kurume University Hospital or who consulted from other hospitals between 1997 (...) and 2012. Complicated diseases, clinical and histopathological manifestations, responsible drugs and findings in immunofluorescence, enzyme-linked immunosorbent assays (ELISAs), immunoblotting (IB) and prognosis were analysed.Eight of the 17 patients with DIP showed pemphigus foliaceus-like appearance, three showed pemphigus herpetiformis-like appearance, and six showed atypical bullous lesions. Responsible drugs were thiol-containing drugs in 16 patients (bucillamine in nine cases, d-penicillamine

2014 British Journal of Dermatology

3. Pemphigus, Drug-Induced (Diagnosis)

Pemphigus, Drug-Induced (Diagnosis) Drug-Induced Pemphigus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MzY4NC1vdmVydmlldw== processing > Drug-Induced Pemphigus (...) Updated: Jun 28, 2017 Author: Chris G Adigun, MD, FAAD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pemphigus Overview Background Pemphigus is an autoimmune bullous disease characterized by blisters and erosions of the skin and mucous membranes. Several variants of the disease exist, including pemphigus vulgaris, pemphigus foliaceous, and drug-induced pemphigus. Patients with drug-induced pemphigus have autoantibodies that are either circulating

2014 eMedicine.com

4. Pemphigus, Drug-Induced (Treatment)

Pemphigus, Drug-Induced (Treatment) Drug-Induced Pemphigus Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MzY4NC10cmVhdG1lbnQ= processing > Drug (...) -Induced Pemphigus Treatment & Management Updated: Jun 28, 2017 Author: Chris G Adigun, MD, FAAD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pemphigus Treatment Medical Care Withdrawal of the offending agent is the first step in treatment. In addition, use of steroids (prednisolone) has shown to be an effective treatment for drug-induced pemphigus. [ ] Most, but not all, patients go into remission once the offending agent is stopped. Some patients

2014 eMedicine.com

5. Pemphigus, Drug-Induced (Overview)

Pemphigus, Drug-Induced (Overview) Drug-Induced Pemphigus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MzY4NC1vdmVydmlldw== processing > Drug-Induced Pemphigus (...) Updated: Jun 28, 2017 Author: Chris G Adigun, MD, FAAD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pemphigus Overview Background Pemphigus is an autoimmune bullous disease characterized by blisters and erosions of the skin and mucous membranes. Several variants of the disease exist, including pemphigus vulgaris, pemphigus foliaceous, and drug-induced pemphigus. Patients with drug-induced pemphigus have autoantibodies that are either circulating

2014 eMedicine.com

6. Pemphigus, Drug-Induced (Follow-up)

Pemphigus, Drug-Induced (Follow-up) Drug-Induced Pemphigus Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MzY4NC10cmVhdG1lbnQ= processing > Drug (...) -Induced Pemphigus Treatment & Management Updated: Jun 28, 2017 Author: Chris G Adigun, MD, FAAD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pemphigus Treatment Medical Care Withdrawal of the offending agent is the first step in treatment. In addition, use of steroids (prednisolone) has shown to be an effective treatment for drug-induced pemphigus. [ ] Most, but not all, patients go into remission once the offending agent is stopped. Some patients

2014 eMedicine.com

7. Drug-Induced Pemphigus

Drug-Induced Pemphigus Drug-Induced Pemphigus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-Induced Pemphigus Drug-Induced (...) Pemphigus Aka: Drug-Induced Pemphigus , Drug-Triggered Pemphigus From Related Chapters II. Mechanism of Drug-Induced Pemphigus Sulfhydryl groups lyse disulfide bonds Results in formation III. Causes of Drug-Induced Pemphigus (5% with ) IV. Signs of Drug-Induced Pemphigus follows medication use of >2 month duration Similar to ( ) Most cases are mild V. Differential Diagnosis of Drug-Induced Pemphigus Drug-Triggered Pemphigus (unmasks ) Gold Piroxicam Phenobarbital VI. Course Drug-Induced Pemphigus Remits

2015 FP Notebook

8. Severe drug-induced dermatoses. (Abstract)

Severe drug-induced dermatoses. A variety of common dermatoses are known to have drug-induced variants. This article discusses the clinical presentation, time frames, reported culprit medications, pathophysiology and management of drug-induced lupus, cutaneous vasculitis, pemphigus, pemphigoid, linear IgA bullous dermatosis, Sweet's syndrome, erythema nodosum, pyoderma gangrenosum, pseudolymphoma, lichen planus, and psoriasis.

2014 Seminars in Cutaneous Medicine and Surgery

9. Drug-Induced Bullous Disorders (Treatment)

. J Am Acad Dermatol . 2005 May. 52(5 Suppl 1):S93-5. . Korman NJ, Eyre RW, Zone J, Stanley JR. Drug-induced pemphigus: autoantibodies directed against the pemphigus antigen complexes are present in penicillamine and captopril-induced pemphigus. J Invest Dermatol . 1991 Feb. 96(2):273-6. . Pinto GM, Lamarao P, Vale T. Captopril-induced pemphigus vegetans with Charcot-Leyden crystals. J Am Acad Dermatol . 1992 Aug. 27(2 Pt 2):281-4. . Ben Salem C, Chenguel L, Ghariani N, Denguezli M, Hmouda H (...) pemphigus). Small vesicle at edge of urticarial plaque (drug-induced pemphigoid). Tense vesicles in annular array (linear immunoglobulin A dermatosis). Erosions, scars, milia, and vesicle (pseudoporphyria). of 9 Tables Contributor Information and Disclosures Author David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic David F

2014 eMedicine.com

10. Drug-Induced Pigmentation (Overview)

Drug-Induced Pigmentation (Overview) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

11. Drug-Induced Bullous Disorders (Overview)

implicated in the development of EM minor in an HIV-positive patient and confirmed with patch testing. [ ] Topical mechlorethamine reportedly caused a subepidermal bullous reaction in a patient with mycosis fungoides. [ ] Methotrexate has been reported to be associated with bullous acral erythema in a child. [ ] The thiol group of drugs is the most common agent implicated in drug-induced pemphigus. Drugs known to cause pemphigus include amoxicillin, ampicillin, captopril, [ , ] cephalosporins (...) , penicillamine, penicillin, pyritinol, and rifampin. Thiol drugs are more likely to cause pemphigus whereas nonthiol drugs are more likely to trigger pemphigus. For this reason, spontaneous recovery is lower in non–thiol-induced pemphigus where other factors may be predisposing a patient to develop pemphigus. Captopril has been reported to cause lichen planus pemphigoides. [ ] Sulfur-containing drugs commonly cause drug-induced pemphigoid, with furosemide being the most common cause. Other agents commonly

2014 eMedicine.com

12. Drug-Induced Bullous Disorders (Follow-up)

. J Am Acad Dermatol . 2005 May. 52(5 Suppl 1):S93-5. . Korman NJ, Eyre RW, Zone J, Stanley JR. Drug-induced pemphigus: autoantibodies directed against the pemphigus antigen complexes are present in penicillamine and captopril-induced pemphigus. J Invest Dermatol . 1991 Feb. 96(2):273-6. . Pinto GM, Lamarao P, Vale T. Captopril-induced pemphigus vegetans with Charcot-Leyden crystals. J Am Acad Dermatol . 1992 Aug. 27(2 Pt 2):281-4. . Ben Salem C, Chenguel L, Ghariani N, Denguezli M, Hmouda H (...) pemphigus). Small vesicle at edge of urticarial plaque (drug-induced pemphigoid). Tense vesicles in annular array (linear immunoglobulin A dermatosis). Erosions, scars, milia, and vesicle (pseudoporphyria). of 9 Tables Contributor Information and Disclosures Author David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic David F

2014 eMedicine.com

13. Drug-Induced Pigmentation (Diagnosis)

Drug-Induced Pigmentation (Diagnosis) Drug-Induced Pigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTY4Ni1vdmVydmlldw== processing > Drug-Induced Pigmentation (...) Updated: Apr 30, 2018 Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Drug-Induced Pigmentation Overview Background Adverse cutaneous reactions to medications are a common reason for consultations with dermatologists. Drug-induced skin disorders may manifest in a variety of ways. Drugs may cause exanthems, urticaria, hypersensitivity syndromes, pustular eruptions, erythema multiforme, toxic epidermal necrolysis, cutaneous necrosis

2014 eMedicine.com

14. Drug-Induced Bullous Disorders (Diagnosis)

implicated in the development of EM minor in an HIV-positive patient and confirmed with patch testing. [ ] Topical mechlorethamine reportedly caused a subepidermal bullous reaction in a patient with mycosis fungoides. [ ] Methotrexate has been reported to be associated with bullous acral erythema in a child. [ ] The thiol group of drugs is the most common agent implicated in drug-induced pemphigus. Drugs known to cause pemphigus include amoxicillin, ampicillin, captopril, [ , ] cephalosporins (...) , penicillamine, penicillin, pyritinol, and rifampin. Thiol drugs are more likely to cause pemphigus whereas nonthiol drugs are more likely to trigger pemphigus. For this reason, spontaneous recovery is lower in non–thiol-induced pemphigus where other factors may be predisposing a patient to develop pemphigus. Captopril has been reported to cause lichen planus pemphigoides. [ ] Sulfur-containing drugs commonly cause drug-induced pemphigoid, with furosemide being the most common cause. Other agents commonly

2014 eMedicine.com

15. British Association of Dermatologists guidelines for the management of pemphigus vulgaris

British Association of Dermatologists guidelines for the management of pemphigus vulgaris GUIDELINES BJD British Journal of Dermatology British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017* K.E. Harman, 1 D. Brown, 2 L.S. Exton, 3 R.W. Groves, 4 P.J. Hampton, 5 M.F. Mohd Mustapa, 3 J.F. Setter?eld 4,6 and P.D. Yesudian 7 1 University Hospitals Leicester, Leicester Royal In?rmary, In?rmary Square, Leicester, LE1 5WW, U.K. 2 St John’s Institute (...) of pemphigus vulgaris (PV). The document aims to update and expand on the previous guidelines by (i) offering an appraisal of all relevant literature from January 2000 up to May 2016, focusing on any key developments; (ii) addressing important, practical, clinical questions relating to the primary guideline objective; (iii) providing guideline recommendations with, where appropriate, some health economic implications and (iv) discussing potential developments and future directions. The guideline

2017 British Association of Dermatologists

16. A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus

that do not intend to use effective methods of contraception during the study or within 90 days after the last dosing. Confirmed diagnosis of paraneoplastic pemphigus, drug-induced pemphigus or any other non-PV/non-PF autoimmune blistering disease. History of refractory disease to active third line therapy (e.g. intravenous polyvalent human immunoglobulins [IVIg], rituximab, plasma exchange/ immunoadsorption). Use of therapies other than oral prednisone and conventional immunosuppressants, that can (...) A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

17. Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus

months prior to screening; Change in dosing frequency, concentration, or applied surface area of topical steroids and/or topical calcineurin inhibitors within 2 weeks prior to screening; Paraneoplastic pemphigus; Pemphigus erythematosus; Pemphigus vegetans; Immunoglobulin A (IgA) pemphigus; Drug-induced pemphigus; Blood donation within 10 weeks prior to baseline visit (Day 0); Hemoglobin < 10 g/dL; White blood cell (WBC) count < 3,000/ mm^3 (equivalent to < 3 x10^9/L); Lymphocyte count < 800/mm^3 (...) Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Polyclonal Regulatory T Cells (PolyTregs

2017 Clinical Trials

18. A Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Rituximab Versus MMF in Patients With Pemphigus Vulgaris

Receiving standard-of-care corticosteroids consisting of 60-120 mg/day oral prednisone or equivalent and, in the judgment of the investigator, expected to benefit from the addition of immunosuppressive therapy For women who are not postmenopausal (>/=12 months of non-therapy-induced amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to remain abstinent or use two effective methods of contraception, including at least one method with a failure rate of less than (<) 1 percent (...) of peripheral venous access Pregnant or lactating, or intending to become pregnant during the study Women who are not postmenopausal (>/=12 months of non-therapy-induced amenorrhea) or surgically sterile must have two negative results with a sensitivity of >/=25 milli-international units per milliliter (mIU/mL): one from a serum pregnancy test at Day -8 to Day -10 of screening and another from a urine pregnancy test at Day 1 prior to randomization Participated in another interventional clinical trial within

2015 Clinical Trials

19. Pemphigus Foliaceus (Diagnosis)

), endemic pemphigus foliaceus, endemic pemphigus foliaceus with antigenic reactivity characteristic of paraneoplastic pemphigus (but with no neoplasm), immunoglobulin A (IgA) pemphigus foliaceus, and drug-induced pemphigus foliaceus. See ; ; ; and for more information. Senear and Usher originally described PE in 1926 as an unusual type of pemphigus with features of lupus erythematosus. PE (also known as Senear-Usher syndrome) is best viewed as a localized form of pemphigus foliaceus. Chorzelski et al (...) :447-452. Nagao K, Tanikawa A, Yamamoto N, Amagai M. Decline of anti-desmoglein 1 IgG ELISA scores by withdrawal of D-penicillamine in drug-induced pemphigus foliaceus. Clin Exp Dermatol . 2005 Jan. 30(1):43-5. . Martin LK, Werth V, Villanueva E, Segall J, Murrell DF. Interventions for pemphigus vulgaris and pemphigus foliaceus. Cochrane Database Syst Rev . 2009 Jan 21. CD006263. . Grando SA. New approaches to the treatment of pemphigus. J Investig Dermatol Symp Proc . 2004 Jan. 9(1):84-91

2014 eMedicine.com

20. Pemphigus Foliaceus (Treatment)

at various stages of diseaseactivity. Przegl Dermatol . 2002. 89:447-452. Nagao K, Tanikawa A, Yamamoto N, Amagai M. Decline of anti-desmoglein 1 IgG ELISA scores by withdrawal of D-penicillamine in drug-induced pemphigus foliaceus. Clin Exp Dermatol . 2005 Jan. 30(1):43-5. . Martin LK, Werth V, Villanueva E, Segall J, Murrell DF. Interventions for pemphigus vulgaris and pemphigus foliaceus. Cochrane Database Syst Rev . 2009 Jan 21. CD006263. . Grando SA. New approaches to the treatment of pemphigus. J (...) Pemphigus Foliaceus (Treatment) Pemphigus Foliaceus Treatment & Management: Medical Care Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NDAxOS10cmVhdG1lbnQ= processing > Pemphigus Foliaceus Treatment

2014 eMedicine.com

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