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Drug-Induced Fatigue

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1. Drug-Induced Fatigue

Drug-Induced Fatigue Drug-Induced Fatigue Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-Induced Fatigue Drug-Induced Fatigue (...) Aka: Drug-Induced Fatigue , Medication Causes of Fatigue II. Causes See s Psychotropic medications s Doxepin s s cause in up to 15% of patients Cardiovascular medications s Antihypertensive medications s (e.g. ) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Drug-Induced Fatigue." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics

2018 FP Notebook

2. Assessment of fatigue

anaemia Chronic heart failure Diabetes mellitus Hypothyroidism Hyperthyroidism EBV infection Influenza infection Medicine-induced fatigue Alcohol dependence Drug dependence HIV infection Acute myocardial ischaemia Atrial fibrillation COPD Tuberculosis Toxoplasmosis Stroke Obstructive sleep apnoea Restless legs syndrome Coeliac disease Addison's disease Hypopituitarism Myelodysplastic syndrome Chronic myeloid leukaemia Non-Hodgkin's lymphoma Hodgkin's lymphoma Cytomegalovirus infection Lyme disease (...) not necessarily be an initial complaint, but is still regarded as a markedly significant and debilitating symptom, are also included. Definition There are numerous definitions and classifications of fatigue, reflecting the multitude of interpretations, depending on being a patient, a physician, a biologist, or a physiologist. A common and practical definition defined fatigue as a sensation of exhaustion during or after usual activities, or a feeling of inadequate energy to begin these activities. Chen MK

2018 BMJ Best Practice

3. The first reported case of drug-induced hemolytic anemia caused by dimethyl fumarate in a patient with multiple sclerosis. (Abstract)

The first reported case of drug-induced hemolytic anemia caused by dimethyl fumarate in a patient with multiple sclerosis. Drug-induced hemolytic anemia is a rare and potentially fatal complication of drug treatment. Specific laboratory tests are crucial to confirm the diagnosis.A 38-year-old woman on treatment with dimethyl fumarate for multiple sclerosis presented with a 7-day history of weakness and fatigue. Laboratory tests revealed profound hemolytic anemia with hemoglobin levels of 4.7 g

2019 Transfusion

4. Drug Induced Thrombotic Microangiopathy with Certolizumab Pegol Full Text available with Trip Pro

Drug Induced Thrombotic Microangiopathy with Certolizumab Pegol Certolizumab pegol is used to treat ankylosing spondylitis, Crohn’s disease, psoriatic arthritis, and rheumatoid arthritis. Unlike other monoclonal antibodies such as infliximab and adalimumab, certolizumab does not contain an Fc fraction and hence does not induce complement activation. In this report, we describe the case of a patient with thrombotic microangiopathy caused due to certolizumab pegol, with a brief description about (...) was started. There was a dramatic improvement within a week, and after 10 sessions of plasma exchange, the patient was discharged on corticosteroids with a tapering plan. ADAMTS13 enzyme activity was determined to be normal.The development of drug-induced thrombotic microangiopathy may be either immune-mediated or dose-dependent toxicity-mediated Anti-drug antibodies and their immunological aspects are still unclear and yet to be elucidated.

2018 Balkan medical journal

5. ‘The efficacy of extracorporeal liver support with molecular adsorbent recirculating system in severe drug-induced liver injury’ Full Text available with Trip Pro

‘The efficacy of extracorporeal liver support with molecular adsorbent recirculating system in severe drug-induced liver injury’ We report a case of a 26-year-old man with no significant medical history, who presented with fatigue, pruritus, jaundice, dark urine and clay colored stool for one month. He had been taking methyl-1-etiochoenolol-epietiocholanolone, an androgenic anabolic steroid (AAS). He was initially found to have a total bilirubin (Tbili) of 6 mg/dL. He discontinued the AAS (...) but the patients' symptoms worsened and Tbili increased to 36 mg/d. This prompted inpatient management of his drug-induced liver injury (DILI). Molecular adsorbent recirculating system (MARS) is an extracorporeal liver support system that replaces the detoxification function of the liver. The patient was initiated on a 4-day trial of MARS therapy. Over the course of his therapy, he clinically improved and his Tbili decreased to 20.7 mg/dL. At follow-up, his symptoms resolved and Tbili was 3.3 mg/dl. This case

2018 Oxford Medical Case Reports

6. Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications. Full Text available with Trip Pro

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications. A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst. Otherwise, she was only on the oral contraceptive pill and reported minimal alcohol intake. On examination, she (...) transplant. Human leucocyte antigen (HLA) typing was performed as a part of preparatory investigations and showed the patient carried the HLA haplotype HLA-DRB1∗15:02-DQB1∗06:01. Following orthotopic transplantation of a deceased donor graft her explant histology revealed severe ongoing hepatitis with multi-acinar necrosis (Fig. 1A and B). This case raised a number of important questions about the diagnosis of drug-induced liver injury and tools available for clinicians to make the best decisions

2018 Journal of Hepatology

7. Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis. (Abstract)

Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis. Hydralazine is an antihypertensive medication that has been associated with drug-induced lupus erythematosus (DIL) as well as ANCA-associated vasculitis (AAV). Although rare, early diagnosis is critical since drug cessation is the mainstay of therapy. This retrospective study aims to characterize the clinical, laboratory, and histopathologic features of this disease.Once approval was obtained from (...) identified, of which 12 were exposed to hydralazine, all at the time of diagnosis. The average duration of hydralazine therapy was 22 months and mean cumulative dose was 146g. Patients were typically older (70.3 years old) with slight female preponderance (7 females). Eleven patients presented with dyspnea, fatigue, and unintentional weight loss. Five had polyarthralgias and 8 had lower extremity petechiae. All 12 patients were both ANA and ANCA positive. ANA titers ranged from 1:160 and 1:2560. Ten were

2018 Seminars in arthritis and rheumatism

8. Recurrent Drug-induced Liver Injury Caused by the Incidental Readministration of a Kampo Formula Containing Scutellariae Radix Full Text available with Trip Pro

Recurrent Drug-induced Liver Injury Caused by the Incidental Readministration of a Kampo Formula Containing Scutellariae Radix A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 (...) days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.

2018 Internal Medicine

9. Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion Full Text available with Trip Pro

to healthy human volunteers, G1T28 demonstrated excellent in vivo pharmacology and transiently inhibited bone marrow (BM) HSPC proliferation. These findings suggest that the combination of CDK4/6 inhibitors with cytotoxic chemotherapy should provide a means to attenuate therapy-induced BM exhaustion in patients with cancer.Copyright © 2017, American Association for the Advancement of Science. (...) Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion Conventional cytotoxic chemotherapy is highly effective in certain cancers but causes dose-limiting damage to normal proliferating cells, especially hematopoietic stem and progenitor cells (HSPCs). Serial exposure to cytotoxics causes a long-term hematopoietic compromise ("exhaustion"), which limits the use of chemotherapy and success of cancer therapy. We show that the coadministration of G1T28

2017 Science translational medicine

10. A Case Report of Drug-Induced Myopathy Involving Extraocular Muscles after Combination Therapy with Tremelimumab and Durvalumab for Non-Small Cell Lung Cancer Full Text available with Trip Pro

A Case Report of Drug-Induced Myopathy Involving Extraocular Muscles after Combination Therapy with Tremelimumab and Durvalumab for Non-Small Cell Lung Cancer Recently developed anti-tumour therapies targeting immune checkpoints include tremelimumab and durvalumab. These agents have incompletely characterised side effect profiles. The authors report a 68-year-old man treated for non-small cell lung cancer (NSCLC) with a combination of tremelimumab and durvalumab. After treatment he developed (...) diplopia, ptosis, fatigue, weakness, and an inflammatory myopathy affecting the extraocular muscles requiring hospitalisation. Electromyography (EMG) testing and muscle biopsy suggested inflammatory myopathy without sign of myasthenia. Within 1 month of withdrawal of cancer therapies and initiation of oral steroid therapy, ocular and systemic symptoms had resolved. This notable adverse effect has not been previously described for these drugs administered singly or in combination, and ophthalmologists

2017 Neuro-Ophthalmology

11. Drug-Induced Fatigue

Drug-Induced Fatigue Drug-Induced Fatigue Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Drug-Induced Fatigue Drug-Induced Fatigue (...) Aka: Drug-Induced Fatigue , Medication Causes of Fatigue II. Causes See s Psychotropic medications s Doxepin s s cause in up to 15% of patients Cardiovascular medications s Antihypertensive medications s (e.g. ) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Drug-Induced Fatigue." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics

2015 FP Notebook

12. Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients.

prescriptions of corticosteroids in the last 12 weeks Overt muscle wasting (defined as 2 standard deviations outside the age-related norm as measured by DEXA) Fatigue starting after the onset of thiopurine therapy Present arthritis or arthralgia Surgical intervention in the last 12 weeks Other aetiologies of chronic liver disease, specifically alcohol or drug induced liver disease, autoimmune or viral hepatitis, cholestatic or metabolic/genetic liver disease by specific clinical, biochemical, radiographic (...) Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients. Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

13. Drug-induced toxicity and patient reported outcomes in rheumatoid arthritis patients following intensive treated-to-target strategy: does ceasing therapy due to toxicity worsen outcomes in long term? Full Text available with Trip Pro

Drug-induced toxicity and patient reported outcomes in rheumatoid arthritis patients following intensive treated-to-target strategy: does ceasing therapy due to toxicity worsen outcomes in long term? While the introduction of the treat-to-target (T2T) strategy has been an important advance in the management of rheumatoid arthritis (RA), the potential for increased toxicity due to use of concurrent drugs could adversely affect patient reported outcomes (PROs). The objective was to determine (...) whether the cessation of therapy due to toxicity affects long-term improvement in PROs in patients treated according to T2T strategy.A total of 149 patients from an inception cohort of early RA were included. The occurrence and severity of toxicity were monitored at each visit over 3 years. PROs studied were function (measured using health assessment questionnaire); pain, fatigue and patient global assessment (PtGA) all assessed using a 100 mm visual analogue scale; helplessness and health-related

2016 International journal of clinical practice

14. Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study Full Text available with Trip Pro

ibutilide-associated QTcI (443±17 vs 458±19 ms, p=0.003), maximum percent increase in QTcI from pretreatment value (7.5±2.4 vs 9.3±3.4%, p=0.02) and area under the effect (QTcI) curve during the first hour post-ibutilide (497±13 vs 510±16 ms-hr, p=0.002) were lower during the progesterone phase. Progesterone-associated adverse effects included fatigue/malaise and vertigo.Oral progesterone administration attenuates drug-induced QTcI lengthening. (...) Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening.Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening.In this prospective, double-blind, crossover study, 19 healthy female

2016 JACC. Clinical electrophysiology Controlled trial quality: predicted high

15. Drug-Induced Acute Interstitial Nephritis with Nifedipine Full Text available with Trip Pro

Drug-Induced Acute Interstitial Nephritis with Nifedipine Background. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report. Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud's syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μmol/L

2016 Case reports in nephrology

16. Drug-Induced Liver Injury during Antidepressant Treatment: Results of AMSP, a Drug Surveillance Program Full Text available with Trip Pro

Drug-Induced Liver Injury during Antidepressant Treatment: Results of AMSP, a Drug Surveillance Program Drug-induced liver injury is a common cause of liver damage and the most frequent reason for withdrawal of a drug in the United States. The symptoms of drug-induced liver damage are extremely diverse, with some patients remaining asymptomatic.This observational study is based on data of Arzneimittelsicherheit in der Psychiatrie, a multicenter drug surveillance program in German-speaking (...) countries (Austria, Germany, and Switzerland) recording severe drug reactions in psychiatric inpatients. Of 184234 psychiatric inpatients treated with antidepressants between 1993 and 2011 in 80 psychiatric hospitals, 149 cases of drug-induced liver injury (0.08%) were reported.The study revealed that incidence rates of drug-induced liver injury were highest during treatment with mianserine (0.36%), agomelatine (0.33%), and clomipramine (0.23%). The lowest probability of drug-induced liver injury

2015 International Journal of Neuropsychopharmacology

17. Medication-Induced Hypokalemia Full Text available with Trip Pro

Medication-Induced Hypokalemia A potassium deficiency can impair metabolic functions, and medications cause hypokalemia through a variety of mechanisms. The authors report on a 58-year-old female suffering from fatigue and weakness after a recent diagnosis of adrenal insufficiency.

2015 Pharmacy and Therapeutics

18. Drug-induced immune haemolytic anaemia caused by levofloxacin Full Text available with Trip Pro

Drug-induced immune haemolytic anaemia caused by levofloxacin Drug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of life-threatening DIIHA due to levofloxacin. This is the second case reported in the literature. A 51-year-old woman presented with complaints of fatigue after 4-5 days of levofloxacin therapy for a lung infection. At presentation, she was found to have haemolysis with a positive Coombs test and IgG autoantibodies. Levofloxacin was identified

2014 Singapore medical journal

19. Drug-Induced Pulmonary Toxicity (Overview)

Drug-Induced Pulmonary Toxicity (Overview) Drug-Induced Pulmonary Toxicity: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTM0MzQ1MS1vdmVydmlldw== processing (...) > Drug-Induced Pulmonary Toxicity Updated: Apr 09, 2019 Author: Klaus-Dieter Lessnau, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP Share Email Print Feedback Close Sections Sections Drug-Induced Pulmonary Toxicity Overview Practice Essentials More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should

2014 eMedicine.com

20. Drug-Induced Hepatotoxicity (Overview)

Drug-Induced Hepatotoxicity (Overview) Drug-Induced Hepatotoxicity: Overview, Metabolism of Drugs, Clinical and Pathological Manifestations of Drug-Induced Liver Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY5ODE0LW92ZXJ2aWV3 processing > Drug-Induced Hepatotoxicity Updated: Dec 08, 2016 Author: Nilesh Mehta, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Drug-Induced Hepatotoxicity Overview Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosyncratic

2014 eMedicine.com

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