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Double-Crush Syndrome

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181. 65 YEARS OF THE DOUBLE HELIX: Endocrine tumour syndromes in children and adolescents. (Full text)

65 YEARS OF THE DOUBLE HELIX: Endocrine tumour syndromes in children and adolescents. As medicine is poised to be transformed by incorporating genetic data in its daily practice, it is essential that clinicians familiarise themselves with the information that is now available from more than 50 years of genetic discoveries that continue unabated and increase by the day. Endocrinology has always stood at the forefront of what is called today 'precision medicine': genetic disorders (...) cancer or guiding the choice of tyrosine kinase inhibitors in cancer treatment. New information emerges every day in the genetics or system biology of endocrine disorders. This review goes over most of these discoveries and the known endocrine tumour syndromes. We cover key genetic developments for each disease and provide information that can be used by the clinician in daily practice.© 2018 Society for Endocrinology.

2018 Endocrine-Related Cancer

182. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. (Full text)

Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients.Prospective, single-center, double-blinded, randomized clinical pilot study.Tertiary-care university children's hospital postoperative pediatric (...) . Central venous oxygen saturation, serum lactate levels, urine output, time to chest tube removal, length of mechanical ventilation, ICU, and hospital stay were similar in both groups. Both drugs were well tolerated, no serious adverse events occurred.Dobutamine and milrinone are safe, well tolerated, and equally effective in prevention of low cardiac output syndrome after pediatric cardiac surgery. The hemodynamic response of the two drugs is comparable. In uncomplicated cases, a trend toward the more

2018 Pediatric Critical Care Medicine Controlled trial quality: uncertain

183. Pilocarpine and Artificial Saliva for the Treatment of Xerostomia and Xerophthalmia of Sjögren's Syndrome: A double blind control trial. (PubMed)

Pilocarpine and Artificial Saliva for the Treatment of Xerostomia and Xerophthalmia of Sjögren's Syndrome: A double blind control trial. Sjögren syndrome (SS) is associated with xerostomia and xerophthalmia. Pilocarpine has been shown to stimulate the secretion of saliva.To investigate and compare the efficacy of pilocarpine and artificial saliva as symptomatic treatments for xerostomia and xerophthalmia in patients with SS.A double-blind randomized controlled study was performed. A total of 72

2018 British Journal of Dermatology Controlled trial quality: predicted high

184. An overlap case of Parry–Romberg syndrome and en coup de sabre with striking ocular involvement and anti-double-stranded DNA positivity (Full text)

An overlap case of Parry–Romberg syndrome and en coup de sabre with striking ocular involvement and anti-double-stranded DNA positivity Parry-Romberg syndrome (PRS) may overlap localized scleroderma (morphea) lesions with linear depression (en coup de sabre [ECDS]). Overlap case with PRS and ECDS was presented. Enophthalmos, uveitis, ocular torticollis, keratic linear precipitates, and anti-double-stranded DNA positivity were identified. Subendothelial keratic precipitates detected

2018 Indian journal of ophthalmology

185. Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome

this by dividing each of the 3 drop seizure health states into 3 substates based on different numbers of seizure- free days. This was based on an exploratory end point in the clinical trials. The company explained that it had chosen this structure because both seizure frequency and days without seizures benefit people with Lennox–Gastaut syndrome. In response to a committee concern, the company stated that it designed the substates so that each health state in the model was mutually exclusive to avoid 'double (...) (see section 3.1). The company included a scenario analysis increasing the number of carers in the model to 3 to account for this. For the analysis using 2 carers, the company doubled the decrements from the vignette study (see Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome (TA615) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 19 of 25section 3.18) and subtracted this from

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

186. Cannabidiol with clobazam for treating seizures associated with Dravet syndrome

because both seizure frequency and days without seizures benefit people with Dravet syndrome. In response to a committee concern, the company stated that it designed the substates so that each health state in the model was mutually exclusive to avoid 'double counting' the benefit. The committee recalled that patients value both fewer seizures and more seizure-free days (see section 3.2) so it was appropriate to capture both in the model. However, the committee considered that other approaches (...) on evidence from the literature (Lagae et al. 2017). It noted that other family members of people with Dravet syndrome may have responsibilities for care, which would lower their quality of life (see section 3.1). The company included a scenario analysis increasing the number of carers in the model to 3 to account for this. For the analysis using 2 carers, the company doubled the decrements from the vignette study (see section 3.18) and subtracted this from the value reflecting the patient's utility

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

187. Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome

Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Beta-Agonist Lung (...) injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome Gates S, Perkins G, Lamb S, Kelly C, Thickett D, Young J, McAuley D, Snaith C, McCabe C, Hulme C, Gao Smith F Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been

2013 Health Technology Assessment (HTA) Database.

188. Crush syndrome chez l’adulte et problematique de sa prise en charge a la phase aiguë (Full text)

Crush syndrome chez l’adulte et problematique de sa prise en charge a la phase aiguë Le crush syndrome se définit comme l'ensemble des manifestations locales et générales secondaires à une rhabdomyolyse traumatique avec ischémie de grosses masses musculaires par compression prolongée, à l'origine d'un syndrome compartimental ou syndrome des loges. Rarement isolé, il peut passer inaperçu dans les 24 à 48 premières heures de la phase aiguë d'un traumatisme sévère quand les principales (...) préoccupations médicales sont la sauvegarde des fonctions vitales. La souffrance musculaire liée au syndrome compartimental entraîne la libération de myoglobine dans la circulation générale. La précipitation de la myoglobine dans les tubules rénaux est un facteur de tubulopathie, s'ajoutant à l'atteinte ischémique éventuelle, concomitante du traumatisme initial. Il s'ensuit une insuffisance rénale aiguë avec, entre autres, acidose et hyperkaliémie. Le crush syndrome constitue une urgence médico-chirurgicale

2015 Annals of burns and fire disasters

189. Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury (Full text)

Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury Crush injury patients often have systemic inflammatory response syndrome that leads to multiple organ failure. Receptor for advanced glycation endproducts (RAGE) functions as a pattern recognition receptor that regulates inflammation. We evaluated the effects of anti-RAGE antibody in a crush injury model. Pressure was applied to both hindlimbs of rats for 6 h by 3.0-kg blocks and then released. Animals (...) were randomly divided into the sham (RAGE-Sh) group, crush (RAGE-Ctrl) group or anti-RAGE antibody-treated crush (RAGE-Tx) group. Samples were collected at 3, 6 and 24 h after releasing pressure. In the RAGE-Ctrl group, fluorescent immunostaining in the lung showed upregulated RAGE expression at 3 h. The serum soluble RAGE (sRAGE) level, which reflects the amount of RAGE expression in systemic tissue, increased at 6 h. Serum interleukin 6 (IL-6; systemic inflammation marker) increased immediately

2017 Scientific reports

190. Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway (Full text)

Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway Inflammation plays a crucial role in kidney damage after crush syndrome (CS). Several researchers report that high mobility group box-1 protein (HMGB1) may be the vital trigger in kidney damage, and tumor necrosis factor-α (TNF-α) and c-Jun N-terminal kinase (JNK) are involve (...) in this pathophysiological process, but their biological roles are unclear. This study aimed to explore the relationship between HMGB1, JNK, and TNF-α in kidney damage.The crush injury model was established using weight compression. The reliability of the crush injury model was determined by hematoxylin-eosin (HE) staining. Western blot was used to detect the expression of HMGB1, JNK, and TNF-α, and TUNEL was used to mark apoptotic cells in the renal cortex.The results showed that the highest expression of HMGB1

2017 Journal of orthopaedic surgery and research

191. Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI

Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Inhibition (...) With Cangrelor and Crushed Ticagrelor in STEMI (CANTIC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03247738 Recruitment Status : Completed First Posted : August 14, 2017 Last Update Posted : December 14, 2018 Sponsor: University of Florida Collaborator: Chiesi Farmaceutici S.p.A. Information provided

2017 Clinical Trials

192. Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis

Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis (MIMAS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

193. Ultrasound Guided Axillary Brachial Plexus Block Versus Supraclavicular Block in Emergency Crushed Hand Patients

Ultrasound Guided Axillary Brachial Plexus Block Versus Supraclavicular Block in Emergency Crushed Hand Patients Ultrasound Guided Axillary Brachial Plexus Block Versus Supraclavicular Block in Emergency Crushed Hand Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Ultrasound Guided Axillary Brachial Plexus Block Versus Supraclavicular Block in Emergency Crushed Hand Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03377985 Recruitment Status : Completed First Posted : December 19, 2017

2017 Clinical Trials

194. Crush Injuries of the Hand. (PubMed)

, and soft tissues. A wide zone of injury results from a delayed inflammatory reaction involving the zone bordering the crushed cells, which may initially belie the severity of the injury. As such, these injuries go on to produce tremendous inflammation and swelling, potentially followed by compartment syndrome or other vascular damage, infection, neurological injury, and tissue necrosis. Crush injuries with minimal skin disruptions can be particularly challenging to accurately diagnose and manage (...) Crush Injuries of the Hand. Crush injuries of the hand are a rare but devastating phenomenon, with historically poor outcomes. A compressive force, usually caused by a high-energy mechanism such as a motor vehicle or industrial accident, crushes and transiently increases the pressures within the hand. This force acts on the incompressible blood in the vasculature and leads to a dramatic rise in tissue pressures and damage to multiple tissue types, including bones, blood vessels, nerves

2017 Journal of Hand Surgery - American

195. Double-Crush Syndrome

Double-Crush Syndrome Double-Crush Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Double-Crush Syndrome Double-Crush (...) Syndrome Aka: Double-Crush Syndrome From Related Chapters II. Pathophysiology compression at two sites Cervical disc and Cervical compression predisposes to more susceptible to injury III. Causes Proximal Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Double-Crush Syndrome." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Wrist Disorders

2015 FP Notebook

196. Anti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled Trial. (PubMed)

Anti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled Trial. A growing body of evidence supports an important role of inflammatory cytokines in the development and progression of the Metabolic Syndrome (MetS), which explains, at least in part, its relationship with an increased cardiovascular-risk. Several studies have reported the therapeutic-impact of crocus-sativus in a preclinical/clinical

2017 Current clinical pharmacology Controlled trial quality: predicted high

197. Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial. (PubMed)

Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial. Marfan syndrome (MFS) is a multisystemic hereditary connective tissue disease. Aortic root aneurysms and dissections are the most common and life-threatening cardiovascular disorders affecting these patients. Other cardiac manifestations include mitral valve prolapse, ventricular dysfunction and arrhythmias. Medical treatment (...) of cardiovascular features is ultimately aimed at slowing down aortic root growth rate and preventing dissection. Losartan has been proposed as a new therapeutic tool for this purpose. To which extent losartan affects cardiac function has not been studied previously.We designed a prospective, double-blind, randomized placebo-controlled trial to evaluate the effect of losartan added to beta-blocker therapy on aortic growth and ventricular function in patients with MFS. Secondary outcomes were aortic dissection

2017 Acta cardiologica Controlled trial quality: predicted high

198. Correction to: Fuke, Aizawa, Suganuma, Takagi, and Naito, Effect of combined consumption of Lactobacillus brevis KB290 and β-carotene on minor diarrhoea-predominant irritable bowel syndrome-like symptoms in healthy subjects: a randomised, double-blind, p (Full text)

Correction to: Fuke, Aizawa, Suganuma, Takagi, and Naito, Effect of combined consumption of Lactobacillus brevis KB290 and β-carotene on minor diarrhoea-predominant irritable bowel syndrome-like symptoms in healthy subjects: a randomised, double-blind, p 28817999 2018 10 16 1465-3478 68 8 2017 12 International journal of food sciences and nutrition Int J Food Sci Nutr Correction to: Fuke, Aizawa, Suganuma, Takagi, and Naito, Effect of combined consumption of Lactobacillus brevis KB290 and β (...) -carotene on minor diarrhoea-predominant irritable bowel syndrome-like symptoms in healthy subjects: a randomised, double-blind, placebo-controlled, parallel-group trial. x 10.1080/09637486.2017.1363996 eng Journal Article Published Erratum 2017 08 18 England Int J Food Sci Nutr 9432922 0963-7486 Int J Food Sci Nutr. 2017 Dec;68(8):973-986 28391736 2017 8 19 6 0 2017 8 19 6 1 2017 8 19 6 0 ppublish 28817999 10.1080/09637486.2017.1363996

2017 International journal of food sciences and nutrition Controlled trial quality: predicted high

199. Imipramine versus placebo for multiple functional somatic syndromes (STreSS-3): a double-blind, randomised study. (PubMed)

Imipramine versus placebo for multiple functional somatic syndromes (STreSS-3): a double-blind, randomised study. Functional somatic syndromes, including chronic fatigue syndrome or irritable bowel syndrome, often co-exist. Treatment guidelines supported by high quality evidence exist for most functional somatic syndromes, but are lacking for multiple comorbid functional somatic syndromes. We aimed to assess the effect of the tricyclic antidepressant, imipramine, in patients with multiple (...) functional somatic syndromes defined by the criteria for multiorgan bodily distress syndrome, a unifying diagnosis that encompasses most functional somatic syndromes and somatoform disorders.In this single-centre, double-blind, randomised trial done in a Danish university hospital setting, participants were patients consecutively referred (age 20-50 years) fulfilling criteria for multiorgan bodily distress syndrome with no concurrent comorbid depression or anxiety disorder. Participants were randomly

2017 The Lancet. Psychiatry Controlled trial quality: predicted high

200. A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Oral ELND005 (scyllo-Inositol) in Young Adults with Down Syndrome without Dementia (Full text)

A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Oral ELND005 (scyllo-Inositol) in Young Adults with Down Syndrome without Dementia ELND005 (scyllo-Inositol; cyclohexane-1,2,3,4,5,6-hexol) has been evaluated as a potential disease-modifying treatment for Alzheimer's disease (AD). Individuals with Down syndrome (DS) have an increased risk for developing AD dementia.To evaluate the safety and tolerability of ELND005 and to determine its pharmacokinetics (PK) and relationship (...) between PK parameters, safety outcome measures, and exploratory efficacy outcome measures in young adults with DS without dementia.This was a prospective, randomized, double-blind, placebo-controlled, parallel-group, three-arm, multicenter Phase II study of the safety and pharmacokinetics of ELND005 administered orally for 4 weeks (ClinicalTrials.gov NCT01791725). Participants who met study eligibility criteria were randomly assigned in a 2 : 1:1 ratio to receive ELND005 at either 250 mg twice daily

2017 Journal of Alzheimer's disease : JAD Controlled trial quality: predicted high

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