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Dobutamine

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1. Effects of intravenous home dobutamine in palliative end‐stage heart failure on quality of life, heart failure hospitalization, and cost expenditure (PubMed)

Effects of intravenous home dobutamine in palliative end‐stage heart failure on quality of life, heart failure hospitalization, and cost expenditure In patients with palliative end-stage heart failure, interventions that could provide symptomatic relief and prevent hospital admissions are important. Ambulatory continuous intravenous inotropes have been advocated by guidelines for such a purpose. We sought to determine the effect of intravenous dobutamine on symptomatic status, hospital stay (...) , mortality, and cost expenditure.All consecutive end-stage heart failure patients not amenable for advanced therapies and discharged with continuous intravenous home dobutamine from a single tertiary centre between April 2011 and January 2017 were retrospectively analysed. Dobutamine (fixed dose) was infused through a single-lumen central venous catheter with a small pump that was refilled by a nurse on a daily basis. Symptomatic status was longitudinally assessed as the change in New York Heart

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2018 ESC heart failure

2. Dobutamine stress-induced ischemic right ventricular dysfunction in patients with three-vessel coronary artery disease (PubMed)

Dobutamine stress-induced ischemic right ventricular dysfunction in patients with three-vessel coronary artery disease Dobutamine stress echocardiography (DSE) is a non-invasive technique to detect coronary artery diseases (CAD). There are limited studies on evaluation of the right ventricular function by stress echocardiography. The appropriate evaluation of RV function and early diagnosis of its failure can help to improve outcomes for the patients undergoing cardiac surgery.To determine (...) patients (9 males) with a mean age of 65.4±7.6 years. The mean of TAPS was 16.9±4.5 mm and 15.7±2.9 mm before and after stress echocardiography, respectively (p=0.69). Systolic right ventricular (SRV) peak increased from before DSE compared with after DSE (8.0±2.2 vs. 13.7±4.2 mm/s, p<0.001). In addition, after dobutamine injection, right ventricular (RV) cardiac output decreased in 7 patients and one patient was affected by post-ejection shortening.It seems that TAPS and RV cardiac output after

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2018 Electronic physician

3. Cardiac stress imaging for the prediction of very long-term outcomes: Dobutamine stress echocardiography or dobutamine 99mTc-sestamibi SPECT? (PubMed)

Cardiac stress imaging for the prediction of very long-term outcomes: Dobutamine stress echocardiography or dobutamine 99mTc-sestamibi SPECT? Both dobutamine stress echocardiography (DSE) and myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) are frequently used for cardiac risk stratification. The long-term relative prognostic value of these modalities has not been studied. Therefore, this study evaluated the long-term prognostic value of DSE compared (...) to MPI in patients unable to perform exercise testing.This prospective, single center study included 301 patients (mean age 59 ± 12 years, 56% men) unable to perform exercise tests who underwent DSE and dobutamine stress 99mTc-sestamibi MPI. End points during follow-up were all-cause mortality, cardiac mortality, and nonfatal myocardial infarction (MI). Univariable and multivariable Cox proportional hazards regression models were used to identify independent predictors of outcome. The probability

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2016 Journal of Nuclear Cardiology

4. Occurrence of Atrial Fibrillation During Dobutamine Stress Echocardiography. (PubMed)

Occurrence of Atrial Fibrillation During Dobutamine Stress Echocardiography. Dobutamine stress echocardiography (DSE) is a widely used examination for assessment of coronary ischemia, but several complications have been reported. The aim of this study was to assess the incidence of atrial fibrillation (AF) during DSE, and a systematic review and meta-analysis were also performed to determine an accurate estimate of the AF incidence. Over a 16-year period, we reviewed all patients referred

2019 American Journal of Cardiology

5. Diagnostic Performance of Dobutamine Stress Echocardiography in End-Stage Liver Disease. (PubMed)

Diagnostic Performance of Dobutamine Stress Echocardiography in End-Stage Liver Disease. This study determined the test performance of dobutamine stress echocardiography (DSE) in end-stage liver disease (ESLD).The reported sensitivity of DSE in ESLD has been variable.Data from 633 ESLD patients who had coronary angiography within 6 months after DSE was analyzed.The prevalence of coronary arterial disease (CAD) (≥70% stenosis by quantitative angiography) was 12% (74 of 633 patients). DSE

2019 JACC. Cardiovascular imaging

6. Effective dose of dobutamine in augmenting free flap blood flow during reconstructive surgery of the lower extremity. (PubMed)

Effective dose of dobutamine in augmenting free flap blood flow during reconstructive surgery of the lower extremity. Success of surgical free flap transfer depends on achieving and maintaining adequate perfusion across the microvascular anastomosis. The purpose of this prospective study was to determine the optimal infusion rate of dobutamine to augment duplex ultrasound measured blood flow to the tissue flap during surgery.Twenty-one patients undergoing general anesthesia for lower limb (...) reconstructive surgery were recruited. The optimal dobutamine dose was evaluated using the modified Dixon's up-and-down method, starting at 6 μg·kg·min, and then titrated in increments of 1 μg·kg·min.The optimal dose of dobutamine for improving blood flow to the tissue flap was 3.50 ± 0.57 μg·kg·min in 50% of patients. The 95% effective dose of dobutamine calculated by probit analysis was 4.46 μg·kg·min (95% confidence interval: 3.99-7.00 μg·kg·min).The results of our study suggest that a dobutamine infusion

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2019 Medicine

7. Prognostic value of dobutamine stress myocardial perfusion echocardiography in patients with known or suspected coronary artery disease and normal left ventricular function. (PubMed)

Prognostic value of dobutamine stress myocardial perfusion echocardiography in patients with known or suspected coronary artery disease and normal left ventricular function. We sought to determine the prognostic value of qualitative and quantitative analysis obtained by real-time myocardial perfusion echocardiography (RTMPE) in patients with known or suspected coronary artery disease (CAD).Quantification of myocardial blood flow reserve (MBFR) in patients with CAD using RTMPE has been (...) demonstrated to further improve accuracy over the analysis of wall motion (WM) and qualitative analysis of myocardial perfusion (QMP).From March 2003 to December 2008, we prospectively studied 168 patients with normal left ventricular function (LVF) who underwent dobutamine stress RTMPE. The replenishment velocity reserve (β) and MBFR were derived from RTMPE. Acute coronary events were: cardiac death, myocardial infarction and unstable angina with need for urgent coronary revascularization.During a median

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2017 PLoS ONE

8. Dobutamine and Nitroglycerin Versus Milrinone for Perioperative Management of Pulmonary Hypertension in Mitral Valve Surgery. A Randomized Controlled Study. (PubMed)

Dobutamine and Nitroglycerin Versus Milrinone for Perioperative Management of Pulmonary Hypertension in Mitral Valve Surgery. A Randomized Controlled Study. To compare the effects of dobutamine and nitroglycerin to milrinone in young patients with severe pulmonary hypertension undergoing mitral valve replacement.A prospective randomized, double-blinded, controlled study.Single university hospital.Forty patients had systolic pulmonary arterial pressure ≥60 mmHg and were scheduled for elective (...) mitral valve replacement. The patients were divided randomly into 2 equal groups according to the drugs given during the study.The patients in group I received 5 to 20 µg/kg/min of dobutamine and 0.5 to 3 µg/kg/min of nitroglycerin, and patients in group II received a loading dose of milrinone, 50 µg/kg over 10 minutes, followed by a maintenance dose of 0.25 to 0.75 µg/kg/min.The primary outcome was the effects of interventional drugs on mean pulmonary artery pressure. The secondary outcomes were

2018 Journal of cardiothoracic and vascular anesthesia

9. The Safety and Utility of Dobutamine Stress Echocardiography for Pre-operative Risk Stratification in Orthotopic Liver Transplantation (PubMed)

The Safety and Utility of Dobutamine Stress Echocardiography for Pre-operative Risk Stratification in Orthotopic Liver Transplantation 30088356 2018 11 14 1738-5520 48 9 2018 09 Korean circulation journal Korean Circ J The Safety and Utility of Dobutamine Stress Echocardiography for Pre-operative Risk Stratification in Orthotopic Liver Transplantation. 836-838 10.4070/kcj.2018.0144 Chung Hyemoon H 0000-0002-5615-6245 Department of Cardiology, Kyung Hee University Medical Center, Seoul, Korea

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2018 Korean circulation journal

10. Pathophysiological insights from dobutamine-induced Takotsubo syndrome (PubMed)

Pathophysiological insights from dobutamine-induced Takotsubo syndrome 30088490 2018 12 24 2018 12 24 2149-2271 20 2 2018 08 Anatolian journal of cardiology Anatol J Cardiol Pathophysiological insights from dobutamine-induced Takotsubo syndrome. 134 10.14744/AnatolJCardiol.2018.50708 Madias John E JE Department of Cardiology, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center; Elmhurst-NY-United States. eng Letter Comment Turkey Anatol J Cardiol 101652981 2149-2263 3S12J47372 (...) Dobutamine IM Anatol J Cardiol. 2018 Jun;19(6):412-416 29848925 Anatol J Cardiol. 2018 Aug;20(2):134 30088491 Dobutamine Humans Takotsubo Cardiomyopathy 2018 8 9 6 0 2018 8 9 6 0 2018 12 26 6 0 ppublish 30088490 10.14744/AnatolJCardiol.2018.50708 PMC6237951 Anatol J Cardiol. 2018 Jun;19(6):412-416 29848925

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2018 Anatolian journal of cardiology

11. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. (PubMed)

Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Dobutamine and milrinone are commonly used after open-heart surgery to prevent or treat low cardiac output syndrome. We sought to compare efficacy and safety of these drugs in pediatric patients.Prospective, single-center, double-blinded, randomized clinical pilot study.Tertiary-care university children's hospital postoperative pediatric (...) cardiac ICU.After written consent, 50 consecutive patients (age, 0.2-14.2 yr; median, 1.2 yr) undergoing open-heart surgery for congenital malformations were included.After cardiopulmonary bypass, a continuous infusion of either dobutamine or milrinone was administered for the first 36 postoperative hours. Maximum dose: dobutamine 6 µg/kg/min, milrinone 0.75 µg/kg/min.There were no significant differences in demographic data, complexity of surgery, and intraoperative characteristics between the two

2018 Pediatric Critical Care Medicine

12. Cardiac Events after Non-Cardiac Surgery in Patients Undergoing Pre-Operative Dobutamine Stress Echocardiography Findings From the Mayo Poce-DSE Investigators. (PubMed)

Cardiac Events after Non-Cardiac Surgery in Patients Undergoing Pre-Operative Dobutamine Stress Echocardiography Findings From the Mayo Poce-DSE Investigators. Current guidelines support the use of dobutamine stress echocardiography (DSE) prior to noncardiac surgery in higher-risk patients who are unable to perform at least 4 metabolic equivalents of physical activity. We evaluated postoperative outcomes of patients in different operative risk categories after preoperative DSE.We collected data

2018 American Journal of Medicine

13. Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia. (PubMed)

Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia. Impaired cerebral autoregulation in preterm infants makes circulatory management important to avoid cerebral hypoxic-ischemic injury. Dobutamine is frequently used as inotropic treatment in preterm neonates, but its effects on the brain exposed to cerebral hypoxia are unknown. We hypothesized that dobutamine would protect the immature brain from cerebral hypoxic injury.In preterm (0.6 gestation (...) ) fetal sheep, dobutamine (Dob, 10 μg/kg/min) or saline (Sal) was infused intravenously for 74 h. Two hours after the beginning of the infusion, umbilical cord occlusion (UCO) was performed to produce fetal asphyxia (Sal+UCO: n = 9, Dob+UCO: n = 7), or sham occlusion (Sal+sham: n = 7, Dob+sham: n = 6) was performed. Brains were collected 72 h later for neuropathology.Dobutamine did not induce cerebral changes in the sham UCO group. UCO increased apoptosis and microglia density in white matter

2018 Pediatric Research

14. Dobutamine stress echocardiography in pulmonary arterial hypertension. (PubMed)

Dobutamine stress echocardiography in pulmonary arterial hypertension. There is a growing interest in exploring the concept of right ventricular functional reserve in patients with pulmonary arterial hypertension. However, it is still unclear how it should be assessed. Aim of the study was to investigate the determinants of the changes in cardiac output and in pulmonary pressure during dobutamine stress echocardiography in pulmonary arterial hypertension.Low-dose dobutamine stress (...) in cardiac output during dobutamine is associated with an improvement in longitudinal right ventricular function, a decrease in tricuspid regurgitation and an increase in heart rate. Changes in pulmonary pressure only reflect the changes in heart rate.Copyright © 2018 Elsevier B.V. All rights reserved.

2018 International journal of cardiology

15. Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis. (PubMed)

Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis. In the American College of Cardiology/American Heart Association guidelines, patients are considered to have true-severe stenosis when the mean gradient (MG) is ≥40 mm Hg with an aortic valve area (AVA) ≤1 cm2 during dobutamine stress echocardiography (DSE). However, these criteria have not been previously validated.The aim of this study was to assess the value of these criteria to predict the presence

2018 Journal of the American College of Cardiology

16. Dobutamine stress testing induced transient cardiomyopathy: A systematic review. (PubMed)

Dobutamine stress testing induced transient cardiomyopathy: A systematic review. 29450191 2018 11 13 2214-7632 4 2014 Sep International journal of cardiology. Heart & vessels Int J Cardiol Heart Vessel Dobutamine stress testing induced transient cardiomyopathy: A systematic review. 221-222 10.1016/j.ijchv.2014.07.005 Chandraprakasam Satish S Division of Cardiology, Creighton University School of Medicine, Omaha, NE 68131, United States. Alla Venkata M VM Division of Cardiology, Creighton (...) University School of Medicine, Omaha, NE 68131, United States. Mooss Aryan N AN Division of Cardiology, Creighton University School of Medicine, Omaha, NE 68131, United States. Hunter Claire B CB Division of Cardiology, Creighton University School of Medicine, Omaha, NE 68131, United States. eng Journal Article 2014 08 08 Ireland Int J Cardiol Heart Vessel 101640846 2214-7632 Catecholamines Dobutamine stress testing Echocardiogram Stress cardiomyopathy Takotsubo cardiomyopathy 2014 07 05 2014 07 29 2018

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2018 International journal of cardiology. Heart & vessels

17. Dobutamine stress echocardiography, myocardial perfusion scintigraphy, invasive coronary angiography, and post-liver transplantation events: Systematic review and meta-analysis.

Dobutamine stress echocardiography, myocardial perfusion scintigraphy, invasive coronary angiography, and post-liver transplantation events: Systematic review and meta-analysis. The impact of coronary artery disease on the clinical course of patients enrolled for liver transplantation (LT) has changed over the years as these patients become older and sicker. The purpose of this systematic review and meta-analysis was to investigate the value of dobutamine stress echocardiography (DSE

2018 Clinical transplantation

18. Real World Utility of Dobutamine Stress Echocardiography in Predicting Perioperative Cardiovascular Morbidity and Mortality after Orthotopic Liver Transplantation (PubMed)

Real World Utility of Dobutamine Stress Echocardiography in Predicting Perioperative Cardiovascular Morbidity and Mortality after Orthotopic Liver Transplantation Stress echocardiography is the current standard for cardiac risk stratification of patients undergoing orthotopic liver transplantation (OLT). We aim to evaluate the role of dobutamine stress echocardiography (DSE) in predicting perioperative major adverse cardiac event (MACE) in patients undergoing OLT.This was a single-center

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2018 Korean circulation journal

19. Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report (PubMed)

Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report 29848925 2018 12 21 2149-2271 19 6 2018 Jun Anatolian journal of cardiology Anatol J Cardiol Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report. 412-416 10.14744/AnatolJCardiol.2018.78642 Hajsadeghi Shokoufeh S Rahbar Mohammad Hossein MH Iranpour Aida A Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology

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2018 Anatolian journal of cardiology

20. The role of dobutamine stress echocardiography based projected aortic valve area in assessing patients with classical low-flow low-gradient aortic stenosis (PubMed)

The role of dobutamine stress echocardiography based projected aortic valve area in assessing patients with classical low-flow low-gradient aortic stenosis 30094262 2018 11 14 2305-5839 6 13 2018 Jul Annals of translational medicine Ann Transl Med The role of dobutamine stress echocardiography based projected aortic valve area in assessing patients with classical low-flow low-gradient aortic stenosis. 276 10.21037/atm.2018.06.07 Vindhyal Mohinder R MR Department of Internal Medicine, University

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2018 Annals of Translational Medicine

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