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Disseminated Intravascular Coagulation

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161. CLOTTING CHANGES, INCLUDING DISSEMINATED INTRAVASCULAR COAGULATION, DURING RAPID RENAL-HOMOGRAFT REJECTION Full Text available with Trip Pro

CLOTTING CHANGES, INCLUDING DISSEMINATED INTRAVASCULAR COAGULATION, DURING RAPID RENAL-HOMOGRAFT REJECTION 4193841 1970 09 06 2018 11 13 0028-4793 283 8 1970 Aug 20 The New England journal of medicine N. Engl. J. Med. Clotting changes, including disseminated intravascular coagulation, during rapid renal-homograft rejection. 383-90 Starzl T E TE Boehmig H J HJ Amemiya H H Wilson C B CB Dixon F J FJ Giles G R GR Simpson K M KM Halgrimson C G CG eng A-6344 NIAAA NIH HHS United States T32 AI007007 (...) AI NIAID NIH HHS United States Journal Article United States N Engl J Med 0255562 0028-4793 0 Antibodies 0 Antibodies, Heterophile 0 Blood Coagulation Factors 0 Immunoglobulin G 0 Immunoglobulins 0 gamma-Globulins AIM IM Adult Antibodies analysis Antibodies, Heterophile analysis Antigen-Antibody Reactions Blood Cell Count Blood Coagulation Disorders etiology immunology Blood Coagulation Factors analysis Blood Coagulation Tests Blood Platelets Disseminated Intravascular Coagulation Female

1970 NEJM

162. Human Recombinant Antithrombin (ATryn®) Administration Improves Survival and Prevents Intravascular Coagulation after Intraportal Islet Transplantation in a Piglet Model Full Text available with Trip Pro

-mediated inflammatory reaction (IBMIR). Herein we hypothesized that portal venous administration of islet cells with human recombinant antithrombin (ATryn®), a serine protease inhibitor (serpin), which plays a central role in the physiological regulation of coagulation and exerts indirect anti-inflammatory activities, may offset coagulation abnormalities such as disseminated intravascular coagulation (DIC) and IBMIR. The current prospective, randomized experiment was conducted using an established (...) Human Recombinant Antithrombin (ATryn®) Administration Improves Survival and Prevents Intravascular Coagulation after Intraportal Islet Transplantation in a Piglet Model Human islet transplantation is a viable treatment option for type 1 diabetes mellitus (T1DM). However, pancreatic islet inflammation after transplantation induced by innate immune responses is likely to hinder graft function. This is mediated by incompatibility between islets and the blood interface, known as instant blood

2017 Cell transplantation

163. Disseminated intravascular coagulation score is associated with mortality for children with shock

Disseminated intravascular coagulation score is associated with mortality for children with shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2009 PedsCCM Evidence-Based Journal Club

164. Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Full Text available with Trip Pro

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remaining to be discovered. Mammalian (...) intravascular coagulation in larvae secondary to unopposed thrombin activity and fibrinogen consumption, which could be rescued by both human and zebrafish at3 complementary DNAs. Mutation of the human AT3-reactive center loop abolished the ability to rescue, but the heparin-binding site was dispensable. These results demonstrate overall conservation of AT3 function in zebrafish, but reveal developmental variances in the ability to tolerate excessive clot formation. The accessibility of early zebrafish

2014 Blood

165. A short contemporary history of disseminated intravascular coagulation. Full Text available with Trip Pro

A short contemporary history of disseminated intravascular coagulation. Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to a widespread deposition of fibrin in the circulation. There is ample experimental and pathological evidence that the fibrin deposition contributes to multiple organ failure. The massive and ongoing activation of coagulation may result in depletion of platelets and coagulation factors (...) , which may cause bleeding (consumption coagulopathy). The syndrome of DIC is well known in the medical literature for centuries, although a more precise description of the underlying mechanisms had to await the 20th century. Initial ideas on a role of the contact activation system as the primary trigger for the systemic activation of coagulation as well as a presumed hyperfibrinolytic response in DIC have been found to be misconceptions. Experimental and clinical evidence now indicate

2014 Seminars In Thrombosis And Hemostasis

166. Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan. (Abstract)

Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan. The current management of disseminated intravascular coagulation (DIC) is based on aggressive treatment of the underlying condition and resuscitation with appropriate blood products. Anticoagulant therapy has appeared and disappeared in the different guidelines and important documents detailing the treatment of DIC. For example, Surviving Sepsis Campaign (SSC) guidelines, the 'global (...) these agents possess and can prove beneficial in septic situations. Several studies have clearly shown the important cross-talk between coagulation and inflammation in patients with sepsis. More recently, neutrophil extracellular traps and damage-associated molecular patterns (DAMPs), especially histones, have been demonstrated to play a crucial role in the coagulopathy of sepsis. Once again, the natural anticoagulants have an important function in neutralizing the effects of DAMPs and histones

2014 Journal of Thrombosis and Haemostasis

167. Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study. (Abstract)

Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study. The association between antithrombin use and mortality in patients with sepsis-associated disseminated intravascular coagulation (DIC) remains controversial.To examine the hypothesis that antithrombin could be effective in the treatment of patients with sepsis-associated DIC following severe pneumonia.Propensity score and instrumental variable

2014 Journal of Thrombosis and Haemostasis

168. Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: A prospective, multicentre, observational study. Full Text available with Trip Pro

Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: A prospective, multicentre, observational study. Few prospective studies have described the prognostic accuracy of presepsin for 28-day mortality during days 0 to 7, or its role in the diagnosis of disseminated intravascular coagulation (DIC) in patients with infection.We aimed to evaluate the clinical usefulness of presepsin levels by comparing infection markers

2014 European Journal of Anaesthesiology

169. Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats. (Abstract)

Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats. Fufang Xueshuantong (FXST) Capsule is developed on a traditional Chinese medicine remedy, with a four-herb formula of Panax notoginseng, Radix astragali, Salvia miltiorrhizae and Radix scrophulariaceae. It has been used for treatment of the clinic cardiovascular disease for many years.Due to its complexity (...) the effects of FXST on the disorders of the blood coagulation system in a lipopolysaccharide-induced disseminated intravascular coagulation (DIC) rat model. The results showed that FXST could significantly ameliorate the activation of coagulation system, which is congruent with the cross-target prediction by NetPharm approach.The combined investigations provide more insight into better understanding of the pharmacological mechanisms of FXST, and may also offer an alternative avenue to further explore

2014 Journal of Ethnopharmacology

170. Evidence for Radiation-Induced Disseminated Intravascular Coagulation as a Major Cause of Radiation-Induced Death in Ferrets. Full Text available with Trip Pro

Evidence for Radiation-Induced Disseminated Intravascular Coagulation as a Major Cause of Radiation-Induced Death in Ferrets. The studies reported here were performed as part of a program in space radiation biology in which proton radiation like that present in solar particle events, as well as conventional gamma radiation, were being evaluated in terms of the ability to affect hemostasis.Ferrets were exposed to 0 to 2 Gy of whole-body proton or gamma radiation and monitored for 30 days. Blood (...) time points postirradiation when coagulopathies were present and becoming progressively more severe; platelet counts were greatly reduced at the time of the white blood cell nadir of 13 days.Data presented here provide evidence that death at the LD50 in ferrets is most likely due to disseminated intravascular coagulation (DIC). These data question the current hypothesis that death at relatively low doses of radiation is due solely to the cell-killing effects of hematopoietic cells. The recognition

2014 Biology and Physics

171. Avascular necrosis of the midface secondary to disseminated intravascular coagulation. (Abstract)

Avascular necrosis of the midface secondary to disseminated intravascular coagulation. To the authors' knowledge, avascular necrosis of the midface secondary to disseminated intravascular coagulation has yet to be described following a hypoxic syncopal episode secondary to 'heat stroke'. A slow, progressive loss of anterior maxillary bone and the collapse of the nasal dorsum in a healthy young man with no other known medical co-morbidities led to the diagnosis. Following debridement, a staged

2014 International Journal of Oral and Maxillofacial Surgery

172. Is early treatment of disseminated intravascular coagulation beneficial in septic patients? Full Text available with Trip Pro

Is early treatment of disseminated intravascular coagulation beneficial in septic patients? 25043475 2015 05 28 2018 12 02 1466-609X 18 4 2014 Jul 04 Critical care (London, England) Crit Care Is early treatment of disseminated intravascular coagulation beneficial in septic patients? 447 10.1186/cc13971 Wada Hideo H Matsumoto Takeshi T Yamashita Yoshiki Y Hatada Tsuyoshi T eng Letter Research Support, Non-U.S. Gov't Comment 2014 07 04 England Crit Care 9801902 1364-8535 IM Crit Care. 2013;17(3 (...) ):R111 23787004 Crit Care. 2014;18(4):447 25320744 Disseminated Intravascular Coagulation diagnosis epidemiology Female Humans Male Sepsis diagnosis epidemiology Severity of Illness Index Societies, Medical standards 2014 7 22 6 0 2014 7 22 6 0 2015 5 29 6 0 epublish 25043475 cc13971 10.1186/cc13971 PMC4095675 Nat Rev Immunol. 2013 Jan;13(1):34-45 23222502 J Thromb Haemost. 2013 Feb 4;:null 23379279 Crit Care. 2013;17(3):R111 23787004 Science. 2004 Mar 5;303(5663):1532-5 15001782 Crit Care Med. 2008

2014 Critical Care

173. Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation Full Text available with Trip Pro

Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation We tested two hypotheses that disseminated intravascular coagulation (DIC) and acute coagulopathy of trauma-shock (ACOTS) in the early phase of trauma are similar disease entities and that the DIC score on admission can be used to predict the prognosis of patients with coagulopathy of trauma.We conducted a retrospective study of 562 trauma patients, including 338 patients whose data were (...) obtained immediately after admission to the emergency department. We collected serial data for the platelet counts, global markers of coagulation and fibrinolysis, and antithrombin levels. DIC was diagnosed according to the Japanese Association for Acute Medicine (JAAM) DIC scoring system, and ACOTS was defined as a prothrombin-time ratio of >1.2.The higher levels of fibrin/fibrinogen degradation products (FDP) and D-dimer and greater FDP/D-dimer ratios in the DIC patients suggested DIC

2014 Critical Care

174. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study Full Text available with Trip Pro

New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study Inflammation and coagulation are closely interrelated pathophysiologic processes in the pathogenesis of sepsis. However, the diagnostic criteria of sepsis and disseminated intravascular coagulation (DIC) are different. This study aimed to define a biomarker panel to predict sepsis-induced DIC in emergency department patients.Eighty-two patients who were admitted

2014 Critical Care

175. New therapeutic options for patients with sepsis and disseminated intravascular coagulation. (Abstract)

New therapeutic options for patients with sepsis and disseminated intravascular coagulation. The severity of sepsis increases along with the degree of coagulation disorder, and a fulminant coagulation abnormality is recognized as disseminated intravascular coagulation (DIC). The mortality in sepsis‑associated DIC remains as high as 40%, which is comparable to that in septic shock. Even though intensive research is ongoing, there is currently no established therapy for this life‑threatening (...) withdrawn from the world market after the failure of the latest clinical trial. Recombinant thrombomodulin is newly developed and has been utilized in Japan since 2008; however, its efficacy has not yet been proved. As shown above, progress has not been as fast as expected, but some new agents are upcoming. The efficacy of anticoagulant therapy for septic DIC has long been discussed and aggressively studied, and we have finally realized that correcting the coagulation disorder is not sufficient

2014 Polskie Archiwum Medycyny Wewnetrznej

176. Treatment effects of xuebijing injection in severe septic patients with disseminated intravascular coagulation. Full Text available with Trip Pro

Treatment effects of xuebijing injection in severe septic patients with disseminated intravascular coagulation. The treatment effects of Xuebijing (XBJ) injection in severe septic patients with disseminated intravascular coagulation (DIC) were investigated in this study. 171 severe septic patients with DIC were divided into the control group (n = 83) or intervention group (n = 88). Routine therapies were administered in both groups, and XBJ injection was administered additionally (...) in the intervention group. Incidence of DIC, clinical severity scores, and coagulation parameters at 7 days after administration of XBJ injection were compared between the two groups, and short-term prognosis was evaluated by 28-day mortality. Compared with the control group, incidence of DIC in the intervention group was significantly lower at 7 days after administration of XBJ injection (P < 0.001). In addition, differences of platelet count and prothrombin time were significantly greater in the intervention

2014 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: uncertain

177. Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC). Full Text available with Trip Pro

Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC). Collectin kidney 1 (CL-K1) is a recently identified collectin that is synthesized in most organs and circulates in blood. CL-K1 is an innate immune molecule that may play a significant role in host defense. As some collectins also play a role in coagulation, we hypothesized that an effect of CL-K1 may be apparent in disseminated intravascular coagulation (DIC), a gross derangement (...) of the coagulation system that occurs in the setting of profound activation of the innate immune system. DIC is a grave medical condition with a high incidence of multiple organ failure and high mortality and yet there are no reliable biomarkers or risk factors. In our present study, we measured plasma CL-K1 concentration in a total of 659 specimens, including 549 DIC patients, 82 non-DIC patients and 27 healthy volunteers. The median plasma CL-K1 levels in these cohorts were 424, 238 and 245 ng/ml, respectively

2014 Journal of thrombosis and thrombolysis Controlled trial quality: uncertain

178. Disseminated Intravascular Coagulation (Overview)

Disseminated Intravascular Coagulation (Overview) Disseminated Intravascular Coagulation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTk5NjI3LW92ZXJ2aWV3 processing (...) > Disseminated Intravascular Coagulation Updated: Oct 07, 2018 Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP Share Email Print Feedback Close Sections Sections Disseminated Intravascular Coagulation Overview Background Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction

2014 eMedicine.com

179. Disseminated Intravascular Coagulation (Follow-up)

Disseminated Intravascular Coagulation (Follow-up) Disseminated Intravascular Coagulation Treatment & Management: Approach Considerations, Management of Underlying Disease, Administration of Blood Components and Coagulation Factors Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTk5NjI3LXRyZWF0bWVudA== processing > Disseminated Intravascular Coagulation Treatment & Management Updated: Oct 07, 2018 Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP Share Email Print Feedback Close Sections Sections Disseminated Intravascular Coagulation Treatment Approach Considerations Treatment of disseminated intravascular coagulation (DIC) is controversial, but treatment guidelines have been

2014 eMedicine.com

180. Disseminated Intravascular Coagulation (Treatment)

Disseminated Intravascular Coagulation (Treatment) Disseminated Intravascular Coagulation Treatment & Management: Approach Considerations, Management of Underlying Disease, Administration of Blood Components and Coagulation Factors Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTk5NjI3LXRyZWF0bWVudA== processing > Disseminated Intravascular Coagulation Treatment & Management Updated: Oct 07, 2018 Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP Share Email Print Feedback Close Sections Sections Disseminated Intravascular Coagulation Treatment Approach Considerations Treatment of disseminated intravascular coagulation (DIC) is controversial, but treatment guidelines have been

2014 eMedicine.com

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