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Disseminated Intravascular Coagulation

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141. Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation

Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02654561 Recruitment Status : Unknown Verified August 2015

2015 Clinical Trials

142. Tranexamic Acid to Treat Life-threatening Hemorrhage in Prostate Cancer Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Full Text available with Trip Pro

Tranexamic Acid to Treat Life-threatening Hemorrhage in Prostate Cancer Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis This case illustrates the acute onset of life-threatening bleeding in a 57-year-old male with treatment-resistant metastatic prostate cancer. Laboratory results confirmed the presence of disseminated intravascular coagulation (DIC). Despite aggressive transfusion support, his consumptive coagulopathy and persistent bleeding could not be controlled

2015 Cureus

143. [Comparison of the effect of low molecular weight heparin sodium and that of heparin sodium on pre-disseminated intravascular coagulation stage in patients suffering from exertional heat stroke]. (Abstract)

[Comparison of the effect of low molecular weight heparin sodium and that of heparin sodium on pre-disseminated intravascular coagulation stage in patients suffering from exertional heat stroke]. To study the effect of low molecular weight heparin sodium ( LMWHS ) therapy for exertional heat stroke ( EHS ) patients with pre-disseminated intravascular coagulation ( pre-DIC ).A prospective randomized controlled trial ( RCT ) was conducted. Thirty-six patients with EHS with pre-DIC admitted (...) to Department of Critical Care Medicine of 180th Hospital of Chinese PLA from April 2012 to November 2014 were divided into heparin sodium group ( n = 20 ) and LMWHS group ( n = 16 ) in accordance with the random number table. All patients received bundle treatment after being admitted to the hospital, including rapid cooling, fluid resuscitation, organ support ( mechanical ventilation, hemopurification if necessary ), supplement of pro-coagulation factors, etc. The patients in heparin sodium group were

2015 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: uncertain

144. Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation Full Text available with Trip Pro

Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation Sepsis-induced disseminated intravascular coagulation (DIC) is a major cause of death in patients admitted to intensive care units. Endothelial injury with microparticle production is reported in the pathogenesis of sepsis. Endothelial microparticles (EMPs) present several cell-specific surface antigens with different bioactivities, for example, tissue

2015 Shock (Augusta, Ga.)

145. Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management. (Abstract)

Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management. Disseminated intravascular coagulation (DIC) is a life-threatening situation that can arise from a variety of obstetrical and nonobstetrical causes. Obstetrical DIC has been associated with a series of pregnancy complications including the following: (1) acute peripartum hemorrhage (uterine atony, cervical and vaginal lacerations, and uterine rupture); (2) placental abruption; (3

2015 American Journal of Obstetrics and Gynecology

146. Prediction of survival in patients suspected of disseminated intravascular coagulation. (Abstract)

Prediction of survival in patients suspected of disseminated intravascular coagulation. Although antithrombin (AT), protein C (PC), and antiplasmin (AP) are consumed during disseminated intravascular coagulation (DIC), their association with mortality in patients initially suspected of acute DIC is unknown. We examined how these proteins associate with mortality in consecutive patients initially suspected of DIC, fulfilling or not fulfilling overt DIC criteria.All consecutive patients

2015 Acta Anaesthesiologica Scandinavica

147. Orbital Compartment Syndrome as the Presenting Sign of Disseminated Intravascular Coagulation From Metastatic Prostatic Cancer to the Orbit. (Abstract)

Orbital Compartment Syndrome as the Presenting Sign of Disseminated Intravascular Coagulation From Metastatic Prostatic Cancer to the Orbit. A 70-year-old man with castrate-resistant metastatic prostate cancer to the lumbar spine presented with sudden onset of left orbital compartment syndrome. Hematologic workup revealed disseminated intravascular coagulation with isolated left orbital hemorrhage. A canthotomy and blood product transfusions failed to control the bleeding and restore vision

2015 Urology

148. Disseminated Intravascular Coagulation Complicating the Conservative Management of Placenta Percreta. (Abstract)

Disseminated Intravascular Coagulation Complicating the Conservative Management of Placenta Percreta. Retention of the placenta is an option in the management of placenta percreta; however, it may be associated with significant morbidity.We present a case of conservative management of placenta percreta. Disseminated intravascular coagulation (DIC) developed 49 days after delivery. An urgent hysterectomy was performed, followed by rapid normalization of coagulation parameters.Disseminated (...) intravascular coagulation may complicate the conservative management of placenta percreta and can manifest weeks after delivery in the absence of antecedent hemorrhage or infection. The time course and presentation of this case are similar to the development of DIC after prolonged retention of a fetal demise with a probable shared pathophysiology. Close follow-up may facilitate prompt diagnosis of DIC, thereby minimizing associated morbidity.

2015 Obstetrics and Gynecology

149. Laboratory evidence of disseminated intravascular coagulation is associated with fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. Full Text available with Trip Pro

Laboratory evidence of disseminated intravascular coagulation is associated with fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. A procoagulant state is implicated in cerebral malaria (CM) pathogenesis, but whether disseminated intravascular coagulation (DIC) is present or associated with a fatal outcome is unclear.To determine the frequency of overt DIC, according to ISTH criteria, in children with fatal and non-fatal CM.Malawian (...) patients (48.0 μg mL(-1) [95% CI 37.7-58.2]; P = 0.032), but, in multivariate logistic regression, thrombomodulin was the only coagulation-related marker that was independently associated with a fatal outcome (OR 1.084 for each ng mL(-1) increase [95% CI 1.017-1.156]; P = 0.014). Despite these laboratory derangements, no child in the study had clinically evident bleeding or thrombosis. An overt DIC score and high thrombomodulin levels are associated with a fatal outcome in CM, but infrequently indicate

2015 Journal of Thrombosis and Haemostasis

150. Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field Full Text available with Trip Pro

Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field Recombinant human soluble thrombomodulin (rTM) was approved recently and has been used for treatment of disseminated intravascular coagulation (DIC). The aim of the present study was to evaluate the efficacy of rTM for DIC. The data of 53 inpatients with sepsis-induced DIC were retrospectively analyzed. Patients were classified into the rTM

2015 Biomedical reports

151. Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model Full Text available with Trip Pro

Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model Sepsis is associated with substantial morbidity and mortality in dogs. Alterations in hemostasis by systemic inflammation play an important role in the pathophysiology of sepsis. To evaluate the functional hemostatic changes in sepsis, we evaluated coagulation profiles and flow cytometric measurement of P-selectin (CD62P) expression on platelets, as well as platelet-leukocyte aggregation from (...) and < 6 h for platelet-monocyte aggregation and at 3 h for platelet-neutrophil aggregation). Our results suggest that CD62P expression on platelets and platelet-leukocyte aggregation, as measured by flow cytometry, can be useful biomarkers of disseminated intravascular coagulation (DIC) in canine sepsis. These functional changes contribute to our understanding of the pathophysiology of hemostasis in endotoxemia.

2015 Canadian Journal of Veterinary Research

152. Adequate application of recombinant thrombomodulin for sepsis-associated disseminated intravascular coagulation Full Text available with Trip Pro

Adequate application of recombinant thrombomodulin for sepsis-associated disseminated intravascular coagulation 26002185 2015 12 02 2018 12 02 1466-609X 19 2015 May 22 Critical care (London, England) Crit Care Adequate application of recombinant thrombomodulin for sepsis-associated disseminated intravascular coagulation. 233 10.1186/s13054-015-0944-3 Iba Toshiaki T Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113 (...) -8421, Japan. toshiiba@cf6.so-net.ne.jp. eng Journal Article Comment 2015 05 22 England Crit Care 9801902 1364-8535 0 Thrombomodulin IM Crit Care. 2015;19:78 25883031 Disseminated Intravascular Coagulation drug therapy Female Humans Male Sepsis complications Thrombomodulin therapeutic use 2015 5 24 6 0 2015 5 24 6 0 2015 12 15 6 0 epublish 26002185 10.1186/s13054-015-0944-3 10.1186/s13054-015-0944-3 PMC4488984 J Thromb Haemost. 2014 Sep;12(9):1470-9 24943516 Front Med (Lausanne). 2015 Feb 26;2:7

2015 Critical Care

153. Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation Full Text available with Trip Pro

Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation To retrospectively validate the new Chinese DIC scoring system (CDSS).This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International

2015 PloS one

154. Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock Full Text available with Trip Pro

Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock Knowing the pathophysiology of trauma-induced coagulopathy is important for the management of severely injured trauma patients. The aims of this review are to provide a summary of the recent advances in our understanding of thrombosis and hemostasis following trauma and to discuss the pathogenesis of disseminated intravascular coagulation (DIC) at an early stage of trauma. Local (...) hemostasis and thrombosis respectively act to induce physiological wound healing of injuries and innate immune responses to damaged-self following trauma. However, if overwhelmed by systemic inflammation caused by extensive tissue damage and tissue hypoperfusion, both of these processes foster systemic DIC associated with pathological fibrin(ogen)olysis. This is called DIC with the fibrinolytic phenotype, which is characterized by the activation of coagulation, consumption coagulopathy, insufficient

2015 Critical Care

155. Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence Full Text available with Trip Pro

Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence 25369601 2015 05 11 2018 12 02 1723-2007 13 1 2015 Jan Blood transfusion = Trasfusione del sangue Blood Transfus Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence. 166 10.2450/2014.0164-14 Iba Toshiaki T Department of Emergency and Disaster Medicine, Graduate School

2015 Blood Transfusion

156. CLOTTING CHANGES, INCLUDING DISSEMINATED INTRAVASCULAR COAGULATION, DURING RAPID RENAL-HOMOGRAFT REJECTION Full Text available with Trip Pro

CLOTTING CHANGES, INCLUDING DISSEMINATED INTRAVASCULAR COAGULATION, DURING RAPID RENAL-HOMOGRAFT REJECTION 4193841 1970 09 06 2018 11 13 0028-4793 283 8 1970 Aug 20 The New England journal of medicine N. Engl. J. Med. Clotting changes, including disseminated intravascular coagulation, during rapid renal-homograft rejection. 383-90 Starzl T E TE Boehmig H J HJ Amemiya H H Wilson C B CB Dixon F J FJ Giles G R GR Simpson K M KM Halgrimson C G CG eng A-6344 NIAAA NIH HHS United States T32 AI007007 (...) AI NIAID NIH HHS United States Journal Article United States N Engl J Med 0255562 0028-4793 0 Antibodies 0 Antibodies, Heterophile 0 Blood Coagulation Factors 0 Immunoglobulin G 0 Immunoglobulins 0 gamma-Globulins AIM IM Adult Antibodies analysis Antibodies, Heterophile analysis Antigen-Antibody Reactions Blood Cell Count Blood Coagulation Disorders etiology immunology Blood Coagulation Factors analysis Blood Coagulation Tests Blood Platelets Disseminated Intravascular Coagulation Female

1970 NEJM

157. Disseminated intravascular coagulation score is associated with mortality for children with shock

Disseminated intravascular coagulation score is associated with mortality for children with shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2009 PedsCCM Evidence-Based Journal Club

158. Is early treatment of disseminated intravascular coagulation beneficial in septic patients? Full Text available with Trip Pro

Is early treatment of disseminated intravascular coagulation beneficial in septic patients? 25043475 2015 05 28 2018 12 02 1466-609X 18 4 2014 Jul 04 Critical care (London, England) Crit Care Is early treatment of disseminated intravascular coagulation beneficial in septic patients? 447 10.1186/cc13971 Wada Hideo H Matsumoto Takeshi T Yamashita Yoshiki Y Hatada Tsuyoshi T eng Letter Research Support, Non-U.S. Gov't Comment 2014 07 04 England Crit Care 9801902 1364-8535 IM Crit Care. 2013;17(3 (...) ):R111 23787004 Crit Care. 2014;18(4):447 25320744 Disseminated Intravascular Coagulation diagnosis epidemiology Female Humans Male Sepsis diagnosis epidemiology Severity of Illness Index Societies, Medical standards 2014 7 22 6 0 2014 7 22 6 0 2015 5 29 6 0 epublish 25043475 cc13971 10.1186/cc13971 PMC4095675 Nat Rev Immunol. 2013 Jan;13(1):34-45 23222502 J Thromb Haemost. 2013 Feb 4;:null 23379279 Crit Care. 2013;17(3):R111 23787004 Science. 2004 Mar 5;303(5663):1532-5 15001782 Crit Care Med. 2008

2014 Critical Care

159. Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation Full Text available with Trip Pro

Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation We tested two hypotheses that disseminated intravascular coagulation (DIC) and acute coagulopathy of trauma-shock (ACOTS) in the early phase of trauma are similar disease entities and that the DIC score on admission can be used to predict the prognosis of patients with coagulopathy of trauma.We conducted a retrospective study of 562 trauma patients, including 338 patients whose data were (...) obtained immediately after admission to the emergency department. We collected serial data for the platelet counts, global markers of coagulation and fibrinolysis, and antithrombin levels. DIC was diagnosed according to the Japanese Association for Acute Medicine (JAAM) DIC scoring system, and ACOTS was defined as a prothrombin-time ratio of >1.2.The higher levels of fibrin/fibrinogen degradation products (FDP) and D-dimer and greater FDP/D-dimer ratios in the DIC patients suggested DIC

2014 Critical Care

160. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study Full Text available with Trip Pro

New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study Inflammation and coagulation are closely interrelated pathophysiologic processes in the pathogenesis of sepsis. However, the diagnostic criteria of sepsis and disseminated intravascular coagulation (DIC) are different. This study aimed to define a biomarker panel to predict sepsis-induced DIC in emergency department patients.Eighty-two patients who were admitted

2014 Critical Care

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