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Disseminated Intravascular Coagulation

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141. Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field Full Text available with Trip Pro

Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field Recombinant human soluble thrombomodulin (rTM) was approved recently and has been used for treatment of disseminated intravascular coagulation (DIC). The aim of the present study was to evaluate the efficacy of rTM for DIC. The data of 53 inpatients with sepsis-induced DIC were retrospectively analyzed. Patients were classified into the rTM

2015 Biomedical reports

142. Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation Full Text available with Trip Pro

Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation Sepsis-induced disseminated intravascular coagulation (DIC) is a major cause of death in patients admitted to intensive care units. Endothelial injury with microparticle production is reported in the pathogenesis of sepsis. Endothelial microparticles (EMPs) present several cell-specific surface antigens with different bioactivities, for example, tissue

2015 Shock (Augusta, Ga.)

143. Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation Full Text available with Trip Pro

Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation To retrospectively validate the new Chinese DIC scoring system (CDSS).This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International

2015 PloS one

144. Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence Full Text available with Trip Pro

Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence 25369601 2015 05 11 2018 12 02 1723-2007 13 1 2015 Jan Blood transfusion = Trasfusione del sangue Blood Transfus Controversies regarding the use of antithrombin for sepsis-associated disseminated intravascular coagulation: an update of the evidence. 166 10.2450/2014.0164-14 Iba Toshiaki T Department of Emergency and Disaster Medicine, Graduate School

2015 Blood Transfusion

145. Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock Full Text available with Trip Pro

Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock Knowing the pathophysiology of trauma-induced coagulopathy is important for the management of severely injured trauma patients. The aims of this review are to provide a summary of the recent advances in our understanding of thrombosis and hemostasis following trauma and to discuss the pathogenesis of disseminated intravascular coagulation (DIC) at an early stage of trauma. Local (...) hemostasis and thrombosis respectively act to induce physiological wound healing of injuries and innate immune responses to damaged-self following trauma. However, if overwhelmed by systemic inflammation caused by extensive tissue damage and tissue hypoperfusion, both of these processes foster systemic DIC associated with pathological fibrin(ogen)olysis. This is called DIC with the fibrinolytic phenotype, which is characterized by the activation of coagulation, consumption coagulopathy, insufficient

2015 Critical Care

146. Tranexamic Acid to Treat Life-threatening Hemorrhage in Prostate Cancer Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Full Text available with Trip Pro

Tranexamic Acid to Treat Life-threatening Hemorrhage in Prostate Cancer Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis This case illustrates the acute onset of life-threatening bleeding in a 57-year-old male with treatment-resistant metastatic prostate cancer. Laboratory results confirmed the presence of disseminated intravascular coagulation (DIC). Despite aggressive transfusion support, his consumptive coagulopathy and persistent bleeding could not be controlled

2015 Cureus

147. Circulating tumor cell count as a biomarker of a specific gastric cancer subgroup characterized by bone metastasis and/or disseminated intravascular coagulation - an early indicator of chemotherapeutic response Full Text available with Trip Pro

Circulating tumor cell count as a biomarker of a specific gastric cancer subgroup characterized by bone metastasis and/or disseminated intravascular coagulation - an early indicator of chemotherapeutic response The incidence of gastric cancer coupled with multiple bone metastases, and/or disseminated intravascular coagulation (DIC), is characterized by the clinical presentation of rapid progression and a poor prognosis, and differs from typical gastric cancers. Circulating tumor cells (CTCs

2015 Oncology letters

148. A Case of Disseminated Intravascular Coagulation after Thoracic Endovascular Aortic Repair Full Text available with Trip Pro

A Case of Disseminated Intravascular Coagulation after Thoracic Endovascular Aortic Repair I report a hemorrhagic complication due to disseminated intravascular coagulation after thoracic endovascular aortic repair for a dissecting aortic aneurysm. A 74-year-old man underwent thoracic endovascular aortic repair and carotid-carotid artery bypass to close the primary entry site of the dissecting aortic aneurysm. Postoperatively, he developed a gradually expanding cervical hematoma. Laboratory (...) data showed disseminated intravascular coagulation. He could not extubated until postoperative day 6 because of the risk of airway obstruction. He was treated with transfusion to replenish the coagulation factor. Disseminated intravascular coagulation may occur secondary to thrombus formation in the false lumen after thoracic endovascular aortic repair.

2015 Annals of vascular diseases

149. Association Between Necropsy Evidence of Disseminated Intravascular Coagulation and Hemostatic Variables Before Death in Horses With Colic Full Text available with Trip Pro

Association Between Necropsy Evidence of Disseminated Intravascular Coagulation and Hemostatic Variables Before Death in Horses With Colic Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but studies relating these histopathological findings with antemortem hemostatic data are lacking.Antemortem classification of coagulopathy is related to the presence

2015 Journal of Veterinary Internal Medicine

150. Recombinant human soluble thrombomodulin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study. (Abstract)

Recombinant human soluble thrombomodulin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study. The association between recombinant human soluble thrombomodulin (rhTM) use and mortality in patients with sepsis-associated disseminated intravascular coagulation (DIC) remains controversial.To examine the hypothesis that rhTM could be effective in the treatment of patients with sepsis-associated DIC following

2015 Journal of Thrombosis and Haemostasis

152. Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model Full Text available with Trip Pro

Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model Sepsis is associated with substantial morbidity and mortality in dogs. Alterations in hemostasis by systemic inflammation play an important role in the pathophysiology of sepsis. To evaluate the functional hemostatic changes in sepsis, we evaluated coagulation profiles and flow cytometric measurement of P-selectin (CD62P) expression on platelets, as well as platelet-leukocyte aggregation from (...) and < 6 h for platelet-monocyte aggregation and at 3 h for platelet-neutrophil aggregation). Our results suggest that CD62P expression on platelets and platelet-leukocyte aggregation, as measured by flow cytometry, can be useful biomarkers of disseminated intravascular coagulation (DIC) in canine sepsis. These functional changes contribute to our understanding of the pathophysiology of hemostasis in endotoxemia.

2015 Canadian Journal of Veterinary Research

153. Prognosis of overt disseminated intravascular coagulation in patients admitted to a medical emergency department. (Abstract)

Prognosis of overt disseminated intravascular coagulation in patients admitted to a medical emergency department. To assess the prevalence, characteristics and prognosis of overt disseminated intravascular coagulation (DIC) in adult emergency department (ED) patients and identify markers of poor outcome.In a chart review study, we analysed the occurrence of overt DIC in all patients (n=1 001 727) attending the University's ED from 2003 to 2014 applying the ISTH DIC score. The primary outcome

2015 European Journal of Emergency Medicine

154. Potential diagnostic markers for disseminated intravascular coagulation of sepsis. (Abstract)

Potential diagnostic markers for disseminated intravascular coagulation of sepsis. Disseminated intravascular coagulation (DIC) is an acquired thrombo-haemorrhagic disorder which arises in clinical scenarios like sepsis, trauma and malignancies. The clinic-laboratory diagnosis of DIC is made in a patient who develops the combination of laboratory abnormalities in the appropriate clinical scenario. The most common laboratory parameters in this setting have been the clotting profile, platelet

2015 Blood reviews

155. Shock, acute disseminated intravascular coagulation and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis? Full Text available with Trip Pro

Shock, acute disseminated intravascular coagulation and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis? For unknown reasons, a small minority of critically ill patients with septic or cardiogenic shock, multiorgan failure, and disseminated intravascular coagulation develop symmetrical acral (distal extremity) limb loss due to microvascular thrombosis ('limb gangrene with pulses'). Case reports have described preceding 'shock liver' in some (...) limb necrosis in the majority of patients who develop this complication in the setting of acute disseminated intravascular coagulation complicating septic or cardiogenic shock. As shock liver precedes onset of limb ischemia by several days, therapeutic intervention may be possible. © 2015 International Society on Thrombosis and Haemostasis.

2015 Journal of Thrombosis and Haemostasis

156. Disseminated Intravascular Coagulation Syndromes in Obstetrics. Full Text available with Trip Pro

Disseminated Intravascular Coagulation Syndromes in Obstetrics. Disseminated intravascular coagulation (DIC) is a syndrome that can be initiated by a myriad of medical, surgical, and obstetric disorders. Also known as consumptive coagulopathy, DIC is a common contributor to maternal morbidity and mortality and is associated with up to 25% of maternal deaths. The etiopathogenesis of DIC is complex and currently thought to be initiated by tissue factor or thromboplastin, which is released from (...) trophoblastic or fetal tissue, or maternal decidua or endothelium. Tissue factor activates the coagulation sequence to cause fibrin clotting and its dissolution by the fibrinolysin system. The result of this process can range from mild, clinically insignificant laboratory derangements to marked coagulopathy with bleeding at sites of minimal trauma. Although clinical recognition varies by disease severity, several organizations have attempted to standardize the diagnosis through development of scoring

2015 Obstetrics and Gynecology

157. Asphyxia by Drowning Induces Massive Bleeding Due To Hyperfibrinolytic Disseminated Intravascular Coagulation. Full Text available with Trip Pro

Asphyxia by Drowning Induces Massive Bleeding Due To Hyperfibrinolytic Disseminated Intravascular Coagulation. To date, no study has systematically investigated the impact of drowning-induced asphyxia on hemostasis. Our objective was to test the hypothesis that asphyxia induces bleeding by hyperfibrinolytic disseminated intravascular coagulation.Observational study.A 2,100-bed tertiary care facility in Vienna, Austria, Europe.All cases of drowning-induced asphyxia (n=49) were compared (...) with other patients with cardiopulmonary resuscitation (n=116) and to patients with acute promyelocytic leukemia (n=83). Six drowning victims were investigated prospectively. To study the mechanism, a forearm-ischemia model was used in 20 volunteers to investigate whether hypoxia releases tissue plasminogen activator.None.Eighty percent of patients with drowning-induced asphyxia developed overt disseminated intravascular coagulation within 24 hours. When compared with nondrowning cardiac arrest patients

2015 Critical Care Medicine

158. Use of an Obstetric Balloon for Postabortion Hemorrhage With Disseminated Intravascular Coagulation. (Abstract)

Use of an Obstetric Balloon for Postabortion Hemorrhage With Disseminated Intravascular Coagulation. Postabortion hemorrhage occurs in up to 2% of second-trimester pregnancy terminations. Postabortion hemorrhage is the leading cause of postabortion maternal mortality. We report the successful use of an obstetric balloon for second-trimester postabortion hemorrhage complicated by disseminated intravascular coagulation.A 38-year-old multigravid woman presented with hypovolemic shock from (...) disseminated intravascular coagulation after second-trimester termination of an anomalous fetus. An intrauterine Foley catheter filled with 60 mL of fluid failed to tamponade bleeding. An obstetric balloon filled with 330 mL of fluid temporized bleeding until the patient's coagulopathy was corrected.An obstetric balloon should be considered in the management of second-trimester postabortion hemorrhage complicated by disseminated intravascular coagulation while coagulopathy is corrected.

2015 Obstetrics and Gynecology

159. Dysregulation of inflammatory and hemostatic markers in sepsis and suspected disseminated intravascular coagulation. (Abstract)

Dysregulation of inflammatory and hemostatic markers in sepsis and suspected disseminated intravascular coagulation. Inflammatory mediators and hemostatic markers were evaluated in patients enrolled in a phase-2b study evaluating the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with sepsis and suspected disseminated intravascular coagulation (DIC). In contrast to controls, patients with sepsis and suspected DIC showed an increase in the circulating levels

2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Controlled trial quality: uncertain

160. [Comparison of the effect of low molecular weight heparin sodium and that of heparin sodium on pre-disseminated intravascular coagulation stage in patients suffering from exertional heat stroke]. (Abstract)

[Comparison of the effect of low molecular weight heparin sodium and that of heparin sodium on pre-disseminated intravascular coagulation stage in patients suffering from exertional heat stroke]. To study the effect of low molecular weight heparin sodium ( LMWHS ) therapy for exertional heat stroke ( EHS ) patients with pre-disseminated intravascular coagulation ( pre-DIC ).A prospective randomized controlled trial ( RCT ) was conducted. Thirty-six patients with EHS with pre-DIC admitted (...) to Department of Critical Care Medicine of 180th Hospital of Chinese PLA from April 2012 to November 2014 were divided into heparin sodium group ( n = 20 ) and LMWHS group ( n = 16 ) in accordance with the random number table. All patients received bundle treatment after being admitted to the hospital, including rapid cooling, fluid resuscitation, organ support ( mechanical ventilation, hemopurification if necessary ), supplement of pro-coagulation factors, etc. The patients in heparin sodium group were

2015 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: uncertain

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