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Disseminated Intravascular Coagulation

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21. Low molecular weight heparin versusunfractionated heparin for neonatal sepsis complicated with disseminated intravascular coagulation: a systematic review and meta-analysis

Low molecular weight heparin versusunfractionated heparin for neonatal sepsis complicated with disseminated intravascular coagulation: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2018 PROSPERO

22. International Prospective Registry of Disseminated Intravascular Coagulation

International Prospective Registry of Disseminated Intravascular Coagulation International Prospective Registry of Disseminated Intravascular Coagulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . International Prospective Registry of Disseminated Intravascular Coagulation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03577015 Recruitment Status : Recruiting First Posted : July 4, 2018 Last Update Posted : August 13

2018 Clinical Trials

23. Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient Full Text available with Trip Pro

Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation, hair loss and nail atrophy. Although the efficacy of corticosteroid and immunomodulatory agents has been demonstrated, no standard therapy regimen has been (...) established, and the prognosis of CCS is still poor due to various complications. We here in report a CCS patient complicated with severe sepsis and disseminated intravascular coagulation who was successfully treated by combined modality therapies, including recombinant human soluble thrombomodulin.

2018 Internal Medicine

24. An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome Full Text available with Trip Pro

An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome A recombinant form of antithrombin (AT), called AT gamma, is being developed as an alternative to AT derived from human plasma. To compare the efficacy and safety of AT gamma to plasma-derived AT (pAT), we conducted a randomized, open-label, multicenter trial in patients with sepsis-induced disseminated intravascular (...) coagulation (DIC).Eligible patients, recruited at 30 clinical sites, had been diagnosed with sepsis-induced DIC (by the Japanese Association for Acute Medicine [JAAM] DIC criteria) and AT activity at 70% or below. Patients were randomized 1:1 to either 36 IU/kg/day AT gamma (n = 110) or 30 IU/kg/day pAT (n = 112), both administered intravenously for 5 days. The primary endpoint was recovery from DIC at day 6 or early study withdrawal. DIC recovery was defined as a DIC score of less than four. Secondary

2018 Journal of intensive care Controlled trial quality: predicted high

25. Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis. Full Text available with Trip Pro

Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis. Disseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing (...) their clinical practice in critically ill settings. Approval from an ethics committee is not required. The findings will be disseminated through publication in a peer-reviewed journal.CRD42017079350.© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

2018 BMJ open

26. Platelet function in disseminated intravascular coagulation: A systematic review. (Abstract)

Platelet function in disseminated intravascular coagulation: A systematic review. Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been established. The present systematic review investigated reported associations between platelet

2018 Platelets

27. Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. Full Text available with Trip Pro

Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. Recently, two meta-analyses examined the effect of antithrombin on mortality in patients with sepsis and disseminated intravascular coagulation (DIC) with diverging results. In the meta-analysis observing no significant survival effect of antithrombin, the results of a large trial were included under the assumption that all 2314 participants of the trial had sepsis and DIC, which according

2018 Journal of Thrombosis and Haemostasis

28. Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: reevaluation of a "pendulum effect" drug using a nationwide database. Full Text available with Trip Pro

Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: reevaluation of a "pendulum effect" drug using a nationwide database. There are four systematic reviews and meta-analyses of trials of antithrombin use for sepsis or critically ill patients published to date with conflicting results. The two studies that showed positive results used data only from septic patients who were also diagnosed with disseminated intravascular coagulation (DIC), whereas the two

2018 Journal of Thrombosis and Haemostasis

29. No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. (Abstract)

No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. The diagnosis of disseminated intravascular coagulation (DIC) is often considered to be a contraindication to organ donation. The aim of this study was to evaluate the impact of DIC+ donors on kidney recipient (KR) evolution. We identified 169 KRs with DIC+ donation after brain death donors between January 1996 and December 2012 in 6 French

2018 American Journal of Transplantation

30. Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation Full Text available with Trip Pro

Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation Thromboembolism (TE) and disseminated intravascular coagulation (DIC) are often present concomitantly. This study aimed to investigate the clinical features of patients with lung cancer and TE and/or DIC.Data on 716 patients with pathologically confirmed diagnoses of lung cancer were retrospectively analyzed for TE/DIC.TE was identified in 16 patients (2.2%) and DIC

2018 Therapeutics and clinical risk management

31. Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma. Full Text available with Trip Pro

Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma. The present study aimed to analyze and compare the prognostic performances of the Japanese Ministry of Health and Welfare (JMHW) score, the Korean Society on Thrombosis and Hemostasis (KSTH) score, the International Society on Thrombosis and Haemostasis (ISTH) score, the Japanese Association for Acute Medicine (JAAM) score, and the revised JAAM (rJAAM) score, for 28-day

2018 Medicine

32. Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis. (Abstract)

Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis. Hemophagocytic lymphohistiocytosis poses significant challenges due to limited tools to guide clinical decisions in a population at high risk of death. We sought to assess whether disseminated intravascular coagulation and hepatobiliary dysfunction, significant comorbidities seen in critical care settings, would identify hemophagocytic (...) , or platelet counts less than 100,000/µL at initiation of dexamethasone were individually associated with mortality. Development of disseminated intravascular coagulation, hepatobiliary dysfunction, or both increased the likelihood of death in hemophagocytic lymphohistiocytosis patients (relative risk; 95% CI) (6; 1.4-34; p < 0.05), (4.1; 1.8-10; p < 0.05), and (7.5; 1.8-42; p < 0.05). Of 12 autopsies performed, 75% had at least one active infection, 66% had chronic lymphopenia, 50% had lymphocyte

2018 Pediatric Critical Care Medicine

33. Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study Full Text available with Trip Pro

Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study : Recently, new criteria for sepsis-induced coagulopathy (SIC) were developed, including the sequential organ failure assessment (SOFA) criteria. The objective of this study was to evaluate the new SIC criteria in patients diagnosed with sepsis 3.0. Data from patients (...) diagnosed with sepsis 3.0 after ICU admission were retrospectively obtained from July 2013 to June 2014. Relevant demographic, clinical, and laboratory parameters were noted. This study included 252 patients. The International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC), modified ISTH-DIC, and SIC scores were higher among nonsurvivors (P < 0.0001). The Acute Physiology and Chronic Health Evaluation II (P < 0.001), ISTH (P = 0.001), modified ISTH (P = 0.001

2018 Blood Coagulation & Fibrinolysis

34. Impact of fetal maceration grade on risk of maternal disseminated intravascular coagulation after intrauterine fetal death – A retrospective cohort study Full Text available with Trip Pro

Impact of fetal maceration grade on risk of maternal disseminated intravascular coagulation after intrauterine fetal death – A retrospective cohort study Disseminated intravascular coagulation (DIC) is a life-threatening event that is the endpoint of a pathologically activated cascade leading to excessive consumption of platelets culminating in bleeding. Several diseases are known to be associated with DIC, some of which may also occur during pregnancy or the puerperium. One of the potential

2018 Scientific reports

35. Rare case of symmetrical peripheral gangrene due to septic shock, disseminated intravascular coagulation and inotropic use Full Text available with Trip Pro

Rare case of symmetrical peripheral gangrene due to septic shock, disseminated intravascular coagulation and inotropic use Symmetrical peripheral gangrene (SPG) is a rare syndrome defined by the peripheral ischemic lesion of two or more extremities in the absence of major vascular obstructive disease.A 45yo woman, admitted in intensive care unit due to urinary septic shock, in need of high doses of amines, developed cold extremities with acrocyanosis that rapidly progressed to gangrene (...) . Laboratory analysis revealed increased inflammatory parameters, liver shock, thrombocytopenia, prolonged coagulation times, increased D-Dimers and isolation of Acinetobacter baumanni in urine culture. An intravenous vasodilator was initiated with clinical benefits. After improvement and delimitation of the lesions, the patient underwent the amputation of the distal phalanges of the 2nd, 3rd and 4th fingers of the right hand and the toes of both feet.Even though there is no consensus regarding SPG

2018 Annals of Medicine and Surgery

36. Successful treatment of disseminated intravascular coagulation by recombinant human soluble thrombomodulin in patients with acute myeloid leukemia. Full Text available with Trip Pro

Successful treatment of disseminated intravascular coagulation by recombinant human soluble thrombomodulin in patients with acute myeloid leukemia. Disseminated intravascular coagulation (DIC) is a life-threatening condition that frequently occurs in patients with hematologic malignancies. Currently, recombinant human soluble thrombomodulin (rTM) is a therapeutic DIC drug that is manufactured and sold in Japan only. We evaluated the efficacy of rTM compared to that of gabexate mesilate (GM

2018 Medicine

37. Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors Full Text available with Trip Pro

Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors Recombinant human soluble thrombomodulin (rTM) has been established and introduced in the clinic as a standard treatment for disseminated intravascular coagulation (DIC). However, the efficacy and safety of rTM for DIC associated with solid tumors (DIC-STs) have not been fully established. Here, we performed a retrospective

2018 International journal of clinical oncology

38. Enterohemorrhagic colitis with disseminated intravascular coagulation Full Text available with Trip Pro

Enterohemorrhagic colitis with disseminated intravascular coagulation Gastroenteritis is a common illness in the pediatric population. Clinicians must be able to recognize severe disease in the milieu of common presentations. All forms of gastroenteritis can lead to significant dehydration and sequelae when considering causes. However, severe complications can occur with certain bacterial etiologies. We present a case of pediatric enterohemorrhagic colitis leading to disseminated intravascular (...) coagulation and patient demise.

2018 Proceedings (Baylor University. Medical Center)

39. Radical treatment of primary type B aortic dissection or after thoracic endovascular aortic repair to manage disseminated intravascular coagulation Full Text available with Trip Pro

Radical treatment of primary type B aortic dissection or after thoracic endovascular aortic repair to manage disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) secondary to type B aortic dissection is an unusual and fatal complication that has not been fully investigated. The aim of our study is to report a novel endovascular technique excluding all tears to manage DIC. From April 2017 to October 2017, we performed 2 cases of DIC complicated to type B aortic (...) to prevents continuous coagulation components consumption and thus to manage DIC effectively.

2018 Journal of thoracic disease

40. Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know Full Text available with Trip Pro

Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know 29895296 2019 01 03 1466-609X 22 1 2018 06 13 Critical care (London, England) Crit Care Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know. 158 10.1186/s13054-018-2073-2 Vincent Jean-Louis JL 0000-0001-6011-6951 Department of Intensive Care, Erasme University Hospital, Université (...) , Instituto de Investigación Hospital 12 de Octubre (imas12), Complutense University of Madrid, Madrid, Spain. Rojas-Suarez Jose J Intensive Care Unit, Obstetric Medicine and Internal Medicine, Gestion Salud IPS Clinic, University of Cartagena, Cartagena, Colombia. Watanabe Eizo E Department of Emergency and Critical Care Medicine, Eastern Chiba Medical Center, Togane City, Japan. eng Editorial Research Support, Non-U.S. Gov't 2018 06 13 England Crit Care 9801902 1364-8535 Disseminated intravascular

2018 Critical Care

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