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Disseminated Intravascular Coagulation

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21. Single Low Dose of Human Recombinant Antithrombin (Atryn®) Has no Impact on Endotoxin-induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study. (Abstract)

Single Low Dose of Human Recombinant Antithrombin (Atryn®) Has no Impact on Endotoxin-induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study. Antithrombin III physiological levels are decreased during septic shock, and supplementation therapy could therefore be beneficial.We hypothesized that the use of recombinant human antithrombin could reduce Disseminated Intravascular Coagulation (DIC) occurrence.We conducted a randomized open label (...) , fibrinogen level, thrombin-antithrombin complexes and von Willebrand factor). Interleukin 6 and Tumor Necrosis Factor alpha values were statistically the same for both groups throughout the study. Percentage of thrombosed glomeruli and percentage of thrombosed capillary in glomerulus were not significantly different between both groups.In our model of endotoxic shock, a single low dose of recombinant human Antithrombin did not prevent Disseminated Intravascular Coagulation occurrence, severity

2018 Shock (Augusta, Ga.) Controlled trial quality: uncertain

22. Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy Full Text available with Trip Pro

Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure.The frequency of DIC is higher than that of thrombotic thrombocytopenic purpura (TTP). Many patients with TMA are diagnosed with DIC, but only about 15% of DIC patients are diagnosed with TMA (...) . Hyperfibrinolysis is observed in most patients with DIC, and microangiopathic hemolytic anemia is observed in most patients with TMA. Markedly decreased ADAMTS13 activity, the presence of Shiga-toxin-producing Escherichia coli (STEC) and abnormality of the complement system are useful for the diagnosis of TTP, STEC-hemolytic uremic syndrome (HUS)and atypical HUS, respectively. However, there are no specific biomarkers for the diagnosis of DIC.Although DIC and TMA are similar appearances, all coagulation

2018 Thrombosis journal

23. Rupture of hidden abnormal myometrial vessels during cesarean delivery of a patient with subserosal leiomyoma: A possible pathogenesis of sudden‐onset disseminated intravascular coagulation Full Text available with Trip Pro

Rupture of hidden abnormal myometrial vessels during cesarean delivery of a patient with subserosal leiomyoma: A possible pathogenesis of sudden‐onset disseminated intravascular coagulation We report a case of sudden-onset disseminated intravascular coagulation during cesarean delivery for a patient with a subserosal leiomyoma. Rupture of hidden anastomotic vessels resulted in a significant decrease in fibrinogen levels and uncontrolled bleeding. Uterine venous flow disturbance caused

2018 Clinical Case Reports

24. ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation Full Text available with Trip Pro

ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis

2018 Case reports in hematology

25. Rare case of symmetrical peripheral gangrene due to septic shock, disseminated intravascular coagulation and inotropic use Full Text available with Trip Pro

Rare case of symmetrical peripheral gangrene due to septic shock, disseminated intravascular coagulation and inotropic use Symmetrical peripheral gangrene (SPG) is a rare syndrome defined by the peripheral ischemic lesion of two or more extremities in the absence of major vascular obstructive disease.A 45yo woman, admitted in intensive care unit due to urinary septic shock, in need of high doses of amines, developed cold extremities with acrocyanosis that rapidly progressed to gangrene (...) . Laboratory analysis revealed increased inflammatory parameters, liver shock, thrombocytopenia, prolonged coagulation times, increased D-Dimers and isolation of Acinetobacter baumanni in urine culture. An intravenous vasodilator was initiated with clinical benefits. After improvement and delimitation of the lesions, the patient underwent the amputation of the distal phalanges of the 2nd, 3rd and 4th fingers of the right hand and the toes of both feet.Even though there is no consensus regarding SPG

2018 Annals of Medicine and Surgery

26. Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation Full Text available with Trip Pro

Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation Thromboembolism (TE) and disseminated intravascular coagulation (DIC) are often present concomitantly. This study aimed to investigate the clinical features of patients with lung cancer and TE and/or DIC.Data on 716 patients with pathologically confirmed diagnoses of lung cancer were retrospectively analyzed for TE/DIC.TE was identified in 16 patients (2.2%) and DIC

2018 Therapeutics and clinical risk management

27. Impact of fetal maceration grade on risk of maternal disseminated intravascular coagulation after intrauterine fetal death – A retrospective cohort study Full Text available with Trip Pro

Impact of fetal maceration grade on risk of maternal disseminated intravascular coagulation after intrauterine fetal death – A retrospective cohort study Disseminated intravascular coagulation (DIC) is a life-threatening event that is the endpoint of a pathologically activated cascade leading to excessive consumption of platelets culminating in bleeding. Several diseases are known to be associated with DIC, some of which may also occur during pregnancy or the puerperium. One of the potential

2018 Scientific reports

28. Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study Full Text available with Trip Pro

Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study : Recently, new criteria for sepsis-induced coagulopathy (SIC) were developed, including the sequential organ failure assessment (SOFA) criteria. The objective of this study was to evaluate the new SIC criteria in patients diagnosed with sepsis 3.0. Data from patients (...) diagnosed with sepsis 3.0 after ICU admission were retrospectively obtained from July 2013 to June 2014. Relevant demographic, clinical, and laboratory parameters were noted. This study included 252 patients. The International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC), modified ISTH-DIC, and SIC scores were higher among nonsurvivors (P < 0.0001). The Acute Physiology and Chronic Health Evaluation II (P < 0.001), ISTH (P = 0.001), modified ISTH (P = 0.001

2018 Blood Coagulation & Fibrinolysis

29. Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know Full Text available with Trip Pro

Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know 29895296 2019 01 03 1466-609X 22 1 2018 06 13 Critical care (London, England) Crit Care Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know. 158 10.1186/s13054-018-2073-2 Vincent Jean-Louis JL 0000-0001-6011-6951 Department of Intensive Care, Erasme University Hospital, Université (...) , Instituto de Investigación Hospital 12 de Octubre (imas12), Complutense University of Madrid, Madrid, Spain. Rojas-Suarez Jose J Intensive Care Unit, Obstetric Medicine and Internal Medicine, Gestion Salud IPS Clinic, University of Cartagena, Cartagena, Colombia. Watanabe Eizo E Department of Emergency and Critical Care Medicine, Eastern Chiba Medical Center, Togane City, Japan. eng Editorial Research Support, Non-U.S. Gov't 2018 06 13 England Crit Care 9801902 1364-8535 Disseminated intravascular

2018 Critical Care

30. Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis Full Text available with Trip Pro

Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis Recently, recombinant human soluble thrombomodulin (rTM) has been developed as a new drug for disseminated intravascular coagulation (DIC). This study aims to evaluate the clinical benefit of rTM in patients with sepsis-induced DIC caused by acute cholangitis who underwent biliary drainage.Patients were divided into two groups: the rTM therapy group

2018 Gut and liver

31. Enterohemorrhagic colitis with disseminated intravascular coagulation Full Text available with Trip Pro

Enterohemorrhagic colitis with disseminated intravascular coagulation Gastroenteritis is a common illness in the pediatric population. Clinicians must be able to recognize severe disease in the milieu of common presentations. All forms of gastroenteritis can lead to significant dehydration and sequelae when considering causes. However, severe complications can occur with certain bacterial etiologies. We present a case of pediatric enterohemorrhagic colitis leading to disseminated intravascular (...) coagulation and patient demise.

2018 Proceedings (Baylor University. Medical Center)

32. Radical treatment of primary type B aortic dissection or after thoracic endovascular aortic repair to manage disseminated intravascular coagulation Full Text available with Trip Pro

Radical treatment of primary type B aortic dissection or after thoracic endovascular aortic repair to manage disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) secondary to type B aortic dissection is an unusual and fatal complication that has not been fully investigated. The aim of our study is to report a novel endovascular technique excluding all tears to manage DIC. From April 2017 to October 2017, we performed 2 cases of DIC complicated to type B aortic (...) to prevents continuous coagulation components consumption and thus to manage DIC effectively.

2018 Journal of thoracic disease

33. A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation Full Text available with Trip Pro

A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation 29662872 2019 02 26 2287-979X 53 1 2018 Mar Blood research Blood Res A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation. 92-94 10.5045/br.2018.53.1.92 Safavi Moeinadin M Department of Molecular Pathology and Cytogenetic, School of Medicine

2018 Blood research

34. Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: reevaluation of a "pendulum effect" drug using a nationwide database. Full Text available with Trip Pro

Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: reevaluation of a "pendulum effect" drug using a nationwide database. There are four systematic reviews and meta-analyses of trials of antithrombin use for sepsis or critically ill patients published to date with conflicting results. The two studies that showed positive results used data only from septic patients who were also diagnosed with disseminated intravascular coagulation (DIC), whereas the two

2018 Journal of Thrombosis and Haemostasis

35. No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. Full Text available with Trip Pro

No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. The diagnosis of disseminated intravascular coagulation (DIC) is often considered to be a contraindication to organ donation. The aim of this study was to evaluate the impact of DIC+ donors on kidney recipient (KR) evolution. We identified 169 KRs with DIC+ donation after brain death donors between January 1996 and December 2012 in 6 French

2018 American Journal of Transplantation

36. Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report. Full Text available with Trip Pro

Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report. Hepatic angiosarcoma is a rare endothelial cell tumor that may lead to concurrent consumptive coagulopathies including disseminated intravascular coagulation (DIC). This report details a multifaceted approach to managing DIC in a patient with advanced-stage hepatic angiosarcoma, which continued to progress after a brief response to taxane-based chemotherapy.A 55-year-old man with a recent

2018 Medicine

37. Successful treatment of disseminated intravascular coagulation by recombinant human soluble thrombomodulin in patients with acute myeloid leukemia. Full Text available with Trip Pro

Successful treatment of disseminated intravascular coagulation by recombinant human soluble thrombomodulin in patients with acute myeloid leukemia. Disseminated intravascular coagulation (DIC) is a life-threatening condition that frequently occurs in patients with hematologic malignancies. Currently, recombinant human soluble thrombomodulin (rTM) is a therapeutic DIC drug that is manufactured and sold in Japan only. We evaluated the efficacy of rTM compared to that of gabexate mesilate (GM

2018 Medicine

38. Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient Full Text available with Trip Pro

Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation, hair loss and nail atrophy. Although the efficacy of corticosteroid and immunomodulatory agents has been demonstrated, no standard therapy regimen has been (...) established, and the prognosis of CCS is still poor due to various complications. We here in report a CCS patient complicated with severe sepsis and disseminated intravascular coagulation who was successfully treated by combined modality therapies, including recombinant human soluble thrombomodulin.

2018 Internal Medicine

39. An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome Full Text available with Trip Pro

An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome A recombinant form of antithrombin (AT), called AT gamma, is being developed as an alternative to AT derived from human plasma. To compare the efficacy and safety of AT gamma to plasma-derived AT (pAT), we conducted a randomized, open-label, multicenter trial in patients with sepsis-induced disseminated intravascular (...) coagulation (DIC).Eligible patients, recruited at 30 clinical sites, had been diagnosed with sepsis-induced DIC (by the Japanese Association for Acute Medicine [JAAM] DIC criteria) and AT activity at 70% or below. Patients were randomized 1:1 to either 36 IU/kg/day AT gamma (n = 110) or 30 IU/kg/day pAT (n = 112), both administered intravenously for 5 days. The primary endpoint was recovery from DIC at day 6 or early study withdrawal. DIC recovery was defined as a DIC score of less than four. Secondary

2018 Journal of intensive care Controlled trial quality: predicted high

40. International Prospective Registry of Disseminated Intravascular Coagulation

International Prospective Registry of Disseminated Intravascular Coagulation International Prospective Registry of Disseminated Intravascular Coagulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . International Prospective Registry of Disseminated Intravascular Coagulation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03577015 Recruitment Status : Recruiting First Posted : July 4, 2018 Last Update Posted : August 13

2018 Clinical Trials

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