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Disseminated Intravascular Coagulation

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181. A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis Full Text available with Trip Pro

A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers in tertiary care hospitals.This study included 624 severe sepsis patients. JAAM DIC was scored

2013 Critical Care

182. Exogenous normal lymph alleviates microcirculation disturbances and abnormal hemorheological properties in rats with disseminated intravascular coagulation Full Text available with Trip Pro

Exogenous normal lymph alleviates microcirculation disturbances and abnormal hemorheological properties in rats with disseminated intravascular coagulation Disturbances of the microcirculation and abnormal hemorheological properties are important factors that play an important role in disseminated intravascular coagulation (DIC) and result in organ dysfunction or failure. In the present study, we established an animal model of DIC using intravenous Dextran 500 in rats, and used exogenous normal

2013 Brazilian Journal of Medical and Biological Research

183. Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study Full Text available with Trip Pro

Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study The present study aimed to investigate whether low-dose heparin improves the condition of patients suffering from early disseminated intravascular coagulation (pre-DIC) during sepsis. In total, 37 patients were randomly divided into low-dose heparin intervention and control groups. The heparin group received a low-dose of heparin for 5-7 days, while the other group received

2013 Experimental and therapeutic medicine Controlled trial quality: uncertain

184. The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation Full Text available with Trip Pro

The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency has been reported in patients with sepsis but its clinical relevance and pathophysiology remain unclear. Our objectives were to assess the clinical significance (...) , prognostic value and pathophysiology of ADAMTS13 deficiency in patients with septic shock with and without disseminated intravascular coagulation (DIC).This was a prospective monocenter cohort study of patients with septic shock. Von Willebrand Factor, ADAMTS13-related parameters and plasma IL-6 concentration were measured at inclusion to the study. Patients were categorized into three groups according to the presence of ADAMT13 deficiency (<30%) or DIC.This study included 72 patients with a median age

2013 Critical Care

185. Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis Full Text available with Trip Pro

Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adequately assess the presence of DIC but also have strong prognostic power for morbidity and mortality. In this issue of Critical Care, Gando and colleagues report on the prospective validation

2013 Critical Care

186. Renal thrombotic microangiopathy in a patient with septic disseminated intravascular coagulation. Full Text available with Trip Pro

Renal thrombotic microangiopathy in a patient with septic disseminated intravascular coagulation. The mechanism for the development of thrombotic microangiopathy (TMA) during sepsis has only been partially elucidated. TMA is recognized as a disease caused by various factors, and may be involved in the emergence of organ damage in severe sepsis. Here we report a case of TMA that followed disseminated intravascular coagulation (DIC) due to severe infection in a patient with a reduced ADAMTS-13 (...) activity level.An 86-year-old Japanese woman was admitted to our hospital because of low back pain and fever. A careful evaluation led to a diagnosis of acute obstructive pyelonephritis due to a ureteral stone. Proteus mirabilis was isolated from both blood and urine cultures. The patient developed systemic inflammatory response syndrome and DIC, and was treated with antibiotics and daily continuous hemodiafiltration. Although infection and the coagulation abnormalities due to DIC were successfully

2013 BMC Nephrology

187. A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Full Text available with Trip Pro

A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we conducted a prospective, randomized controlled multicenter trial at 13 critical care centers in tertiary care hospitals.We enrolled 60 DIC patients (...) response syndrome (SIRS) score, platelet count and global markers of coagulation and fibrinolysis were measured on day 0 and day 3.Antithrombin treatment resulted in significantly decreased DIC scores and better recovery rates from DIC compared with those observed in the control group on day 3. The incidence of minor bleeding complications did not increase, and no major bleeding related to antithrombin treatment was observed. The platelet count significantly increased; however, antithrombin did

2013 Critical care (London, England) Controlled trial quality: uncertain

188. Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. Full Text available with Trip Pro

Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. Disseminated intravascular coagulation (DIC) due to Plasmodium vivax is scarcely reported in comparison to Plasmodium falciparum. In complicated malaria, thrombocytopaenia and haemostatic alterations lead to increased activation of coagulation cascade and fibrinolytic system. Thromboelastography (TEG) is a haemostasis system which measures the viscoelastic strength of blood clot (...) in the coagulation pathway. It detects the initial derangement in clotting cascade involving in platelet interaction and fibrinolysis. Hence, it can document the early changes in coagulation in vitro, and thereby guide the management. The current study was aimed at detection of DIC in patients with P. vivax malaria based on TEG.Ethylene diamine tetraacetic acid (EDTA) blood samples from acute febrile patients were tested by microscopy and immunochromatographic test for malaria. A total of 31 confirmed cases

2013 Malaria journal

189. B. anthracis Cell Wall Peptidoglycan but not Lethal or Edema Toxins Produces Changes Consistent with Disseminated Intravascular Coagulation in a Rat Model. Full Text available with Trip Pro

B. anthracis Cell Wall Peptidoglycan but not Lethal or Edema Toxins Produces Changes Consistent with Disseminated Intravascular Coagulation in a Rat Model. Disseminated intravascular coagulation (DIC) appears to be important in the pathogenesis of Bacillus anthracis infection, but its causes are unclear. Although lethal toxin (LT) and edema toxin (ET) could contribute, B. anthracis cell wall peptidoglycan (PGN), not the toxins, stimulates inflammatory responses associated with DIC.To better (...) understand the pathogenesis of DIC during anthrax, we compared the effects of 24-hour infusions of PGN, LT, ET, or diluent (control) on coagulation measures 6, 24, or 48 hours after infusion initiation in 135 rats. No control recipient died. Lethality rates (approximately 30%) did not differ among PGN, LT, and ET recipients (P = .78). Thirty-three of 35 deaths (94%) occurred between 6 and 24 hours after the start of challenge. Among challenge components, PGN most consistently altered coagulation measures

2013 Journal of Infectious Diseases

190. Operative and nonoperative management of chronic disseminated intravascular coagulation due to persistent aortic endoleak. Full Text available with Trip Pro

Operative and nonoperative management of chronic disseminated intravascular coagulation due to persistent aortic endoleak. Disseminated intravascular coagulation (DIC) due to endoleak is a rare complication following endovascular aneurysm repair. Two of the four previously reported cases occurred in patients with cirrhosis. We describe three patients with normal liver function who developed DIC due to delayed high-flow (type Ia or III) endoleaks. Two patients underwent successful surgical

2013 Journal of Vascular Surgery

191. Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). (Abstract)

Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). Two concepts have been proposed for the hemostatic changes occurring early after trauma. Disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype is characterized by activation of the coagulation pathways, insufficient anticoagulant mechanisms and increased fibrinolysis. Coagulopathy of trauma and acute (...) coagulopathy of trauma-shock (COT/ACOTS) occurs as a result of increased activation of the thrombomodulin and protein C pathways, leading to the suppression of coagulation and activation of fibrinolysis. Despite the differences between these two conditions, independent consideration of COT/ACOTS from DIC with the fibrinolytic phenotype is probably incorrect. Robust diagnostic criteria based on its pathophysiology are required to establish COT/ACOTS as a new independent disease concept. In addition

2013 Journal of Thrombosis and Haemostasis

192. Successful renal transplantation from a brain-dead deceased donor with head injury, disseminated intravascular coagulation and deranged renal functions Full Text available with Trip Pro

Successful renal transplantation from a brain-dead deceased donor with head injury, disseminated intravascular coagulation and deranged renal functions Deceased donors (DDs) with the brain death due to head injury are the major source of organs for transplantation. The incidence of post-head injury disseminated intravascular coagulation (DIC) ranges from 24% to 50%. Many centers do not accept organs from donors with DIC due to increased risk of primary graft non-function and/or high chances

2013 Indian Journal of Nephrology

193. Type IV renal tubular acidosis following resolution of acute kidney injury and disseminated intravascular coagulation due to hump-nosed viper bite Full Text available with Trip Pro

Type IV renal tubular acidosis following resolution of acute kidney injury and disseminated intravascular coagulation due to hump-nosed viper bite Hump-nosed viper bite can cause acute kidney injury (AKI) and disseminated intravascular coagulation. In some patients, it can cause chronic kidney disease necessitating life-long renal replacement therapy. Lack of effective antivenom makes the management of these patients difficult. A 51-year-old Sri Lankan male was admitted with AKI (...) and disseminated intravascular coagulation following a hump-nosed viper bite. He made a complete recovery with blood product support and hemodialysis. Renal biopsy was performed as his renal recovery was prolonged which revealed patchy tubular atrophy and interstitial inflammation suggestive of subacute interstitial nephritis. Later, he presented with hyperkalemic paralysis and acidosis. A diagnosis of late onset type 4 renal tubular acidosis was made and he responded well to a course of fludrocortisone.

2013 Indian Journal of Nephrology

194. Symmetrical peripheral gangrene and disseminated intravascular coagulation associated with pelvi-ureteric junction obstruction Full Text available with Trip Pro

Symmetrical peripheral gangrene and disseminated intravascular coagulation associated with pelvi-ureteric junction obstruction 23291920 2013 09 09 2018 11 13 1757-790X 2013 2013 Jan 04 BMJ case reports BMJ Case Rep Symmetrical peripheral gangrene and disseminated intravascular coagulation associated with pelvi-ureteric junction obstruction. 10.1136/bcr-2012-006519 bcr2012006519 Reid Victoria Louise VL School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK. victoria.reid@nhs.net (...) McLay James J eng Case Reports Journal Article 2013 01 04 England BMJ Case Rep 101526291 1757-790X Multicystic renal dysplasia, bilateral IM Aged, 80 and over Disseminated Intravascular Coagulation etiology Female Fingers pathology Gangrene Humans Hydronephrosis complications congenital Multicystic Dysplastic Kidney complications Proteus Infections etiology Sepsis etiology Toes pathology Ureteral Obstruction complications 2013 1 8 6 0 2013 1 8 6 0 2013 9 10 6 0 epublish 23291920 bcr-2012-006519

2013 BMJ case reports

195. Ceftriaxone induced immune hemolytic anemia with disseminated intravascular coagulation Full Text available with Trip Pro

Ceftriaxone induced immune hemolytic anemia with disseminated intravascular coagulation 24501497 2014 02 06 2018 11 13 0972-5229 17 6 2013 Nov Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine Indian J Crit Care Med Ceftriaxone induced immune hemolytic anemia with disseminated intravascular coagulation. 394-5 10.4103/0972-5229.123465 Shrimali Jigar D JD Department of Nephrology and Clinical Transplantation, Transfusion

2013 Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

196. Primary angiosarcoma of the breast complicated by the syndrome of disseminated intravascular coagulation (DIC): Case report and literature review Full Text available with Trip Pro

Primary angiosarcoma of the breast complicated by the syndrome of disseminated intravascular coagulation (DIC): Case report and literature review Primary angiosarcoma of the breast (PAB) accounts for 0.04% of all breast malignant tumors. It affects young women usually at third or fourth decades of life. PAB clinically manifests as a painless, movable mass with sharp limits. A bluish red discoloration of the overlying skin is often observed. Enlargement of axillary lymph nodes generally does (...) not occur. Angiosarcoma of the breast has a very poor prognosis due to the tendency to metastasize haematogenously and high frequency of local recurrence. Mastectomy and chemotherapy are preferable treatment choices. This paper presents a case of primary angiosarcoma of the breast with a syndrome of disseminated intravascular coagulation (DIC).

2013 Reports of Practical Oncology and Radiotherapy

197. A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation* Full Text available with Trip Pro

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation* To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation.Phase 2b, international, multicenter, double-blind, randomized, placebo-controlled, parallel group (...) , screening trial.Two hundred and thirty-three ICUs in 17 countries.All adult patients admitted with sepsis and suspected disseminated intravascular coagulation as assessed using a modified International Society on Thrombosis and Hemostasis score.Patients were randomized to receive IV ART-123 (0.06 mg/kg/d) for 6 days or placebo, in addition to standard of care. The primary endpoint was reduction in mortality. Secondary endpoints included reversal of overt disseminated intravascular coagulation

2013 Critical care medicine

198. Disseminated intravascular coagulation and coagulation defects in the newborn. Full Text available with Trip Pro

Disseminated intravascular coagulation and coagulation defects in the newborn. 5491897 1971 02 24 2008 11 20 1468-2044 45 244 1970 Dec Archives of disease in childhood Arch. Dis. Child. Disseminated intravascular coagulation and coagulation defects in the newborn. 819 Chadd M M Gray O P OP eng Journal Article England Arch Dis Child 0372434 0003-9888 IM Autopsy Blood Coagulation Disorders Disseminated Intravascular Coagulation Humans Infant, Newborn Infant, Newborn, Diseases Retrospective

1970 Archives of Disease in Childhood

199. Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report. Full Text available with Trip Pro

of treatment with meropenem, minocycline, and micafungin. Although he refused bone marrow aspiration, isoniazid, rifampicin, ethambutol, and prednisolone were administered for a tentative diagnosis of miliary tuberculosis.His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission. During autopsy, the fungal burden was noted to be higher in the calcified nodule than in the disseminated nodules of the lung (...) Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report. Histoplasmosis occurs most commonly in Northern and Central America and Southeast Asia. Increased international travel in Japan has led to a few annual reports of imported histoplasmosis. Healed sites of histoplasmosis lung infection may remain as nodules and are often accompanied by calcification. Previous studies in endemic areas supported

2019 Medicine

200. Advanced Congestive Heart Failure Associated With Disseminated Intravascular Coagulopathy Full Text available with Trip Pro

Advanced Congestive Heart Failure Associated With Disseminated Intravascular Coagulopathy Background. Disseminated intravascular coagulopathy (DIC) is a complication of an underlying disease and not a primary illness. It is most commonly associated with sepsis, trauma, obstetrical complications, and malignancies. There are very few cases in the literature illustrating the association between DIC and congestive heart failure. Findings. In this report, we present a case of severe congestive heart (...) failure, leading to biventricular thrombi and subsequently DIC. Conclusion. We suggest that the association between congestive heart failure and DIC is an underrecognized one. Congestive heart failure continues to remain a major cause of morbidity and mortality despite advances in medical therapies. Thus far, the precise role of coagulation factors in congestive heart failure is unknown. Further investigations are needed to elucidate the pathophysiology of congestive heart failure and coagulation

2015 Journal of investigative medicine high impact case reports

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